17-Beta-Estradiol-3,17-beta-sulfate (BioDeep_00000018385)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


[(1S,10R,11S,14S,15S)-15-methyl-5-(sulfooxy)tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-2,4,6-trien-14-yl]oxidanesulfonic acid

化学式: C18H24O8S2 (432.09125439999997)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: CC12CCC3C(C1CCC2OS(=O)(=O)O)CCC4=C3C=CC(=C4)OS(=O)(=O)O
InChI: InChI=1S/C18H24O8S2/c1-18-9-8-14-13-5-3-12(25-27(19,20)21)10-11(13)2-4-15(14)16(18)6-7-17(18)26-28(22,23)24/h3,5,10,14-17H,2,4,6-9H2,1H3,(H,19,20,21)(H,22,23,24)/t14-,15-,16+,17+,18+/m1/s1

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
17-Beta-Estradiol-3,17-beta-sulfate is found in milk.

同义名列表

19 个代谢物同义名

[(1S,10R,11S,14S,15S)-15-methyl-5-(sulfooxy)tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-2,4,6-trien-14-yl]oxidanesulfonic acid; Estradiol 3,17-disulfate, dipotassium salt, (17beta)-isomer; Estradiol 3,17-disulfate, disodium salt, (17beta)-isomer; 17-beta-Estradiol-3,17-beta-sulphuric acid; Estradiol 3,17-disulfate, (17alpha)-isomer; 17-beta-Estradiol-3,17-beta-sulfuric acid; 17-beta-Estradiol-3,17-beta-sulphate; 17-Β-estradiol-3,17-β-sulphuric acid; 17-b-Estradiol-3,17-b-sulphuric acid; 17-Β-estradiol-3,17-β-sulfuric acid; 17-Beta-Estradiol-3,17-beta-sulfate; 17-b-Estradiol-3,17-b-sulfuric acid; 17beta-Estradiol-3,17-disulfate; 17-Β-estradiol-3,17-β-sulphate; 17-b-Estradiol-3,17-b-sulphate; 17-b-Estradiol-3,17-b-sulfate; 17-Β-estradiol-3,17-β-sulfate; Estradiol 3,17-disulfate; e2-3S-17S



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jennifer B Gadd, Louis A Tremblay, Grant L Northcott. Steroid estrogens, conjugated estrogens and estrogenic activity in farm dairy shed effluents. Environmental pollution (Barking, Essex : 1987). 2010 Mar; 158(3):730-6. doi: 10.1016/j.envpol.2009.10.015. [PMID: 19913339]
  • Gregory Kaler, David M Truong, Akash Khandelwal, Megha Nagle, Satish A Eraly, Peter W Swaan, Sanjay K Nigam. Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. The Journal of biological chemistry. 2007 Aug; 282(33):23841-53. doi: 10.1074/jbc.m703467200. [PMID: 17553798]
  • Fanfan Zhou, Nicholas P Illsley, Guofeng You. Functional characterization of a human organic anion transporter hOAT4 in placental BeWo cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2006 Apr; 27(5):518-23. doi: 10.1016/j.ejps.2005.09.008. [PMID: 16257192]
  • Noam Zelcer, Glen Reid, Peter Wielinga, Annemieke Kuil, Ingrid van der Heijden, John D Schuetz, Piet Borst. Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). The Biochemical journal. 2003 Apr; 371(Pt 2):361-7. doi: 10.1042/bj20021886. [PMID: 12523936]
  • H Matsuda, H Shimoda, T Morikawa, M Yoshikawa. Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity. Bioorganic & medicinal chemistry letters. 2001 Jul; 11(14):1839-42. doi: 10.1016/s0960-894x(01)00318-3. [PMID: 11459643]
  • J D Bain, L H Kasman, A B Bercovitz, B L Lasley. A comparison of three methods of hydrolysis for estrogen conjugates. Steroids. 1984 Jun; 43(6):603-19. doi: 10.1016/0039-128x(84)90023-0. [PMID: 6099920]