Sivelestat (BioDeep_00000183843)
human metabolite blood metabolite
代谢物信息卡片
2-[(2-{4-[(2,2-dimethylpropanoyl)oxy]benzenesulfonamido}phenyl)formamido]acetic acid
化学式: C20H22N2O7S (434.1147662)
中文名称: 西维来司他
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC1=CC=CC=C1C(=O)NCC(O)=O
InChI: InChI=1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24)
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015842 - Serine Proteinase Inhibitors
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:135704
- PubChem: 107706
- HMDB: HMDB0258320
- DrugBank: DB12863
- ChEMBL: CHEMBL76688
- Wikipedia: Sivelestat
- chemspider: 96875
- CAS: 127373-66-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ertao Jia, Zhiling Li, Hongling Geng, Haiqiong Zhu, Yadong Wang, Feng Lin, Yubao Jiang, Jianyong Zhang. Neutrophil extracellular traps induce the bone erosion of gout.
BMC musculoskeletal disorders.
2022 Dec; 23(1):1128. doi:
10.1186/s12891-022-06115-w. [PMID: 36567343] - Aykut Colakerol, Serhat Suzan, Mustafa Zafer Temiz, Serkan Gonultas, Serdar Aykan, Sule Ozsoy, Suat Hayri Kucuk, Emrah Yuruk, Engin Kandırali, Atilla Semercioz. Tissue neutrophil elastase contributes to extracorporeal shock wave lithotripsy-induced kidney damage and the neutrophil elastase inhibitor, sivelestat, attenuates kidney damage with gratifying immunohistopathological and biochemical findings: an experimental study.
Urolithiasis.
2022 Feb; 50(1):103-112. doi:
10.1007/s00240-021-01287-x. [PMID: 34778918] - Yali Sun, Xianfei Ding, Yuqing Cui, Hongyi Li, Dong Wang, Huoyan Liang, Shaohua Liu, Xiaojuan Zhang, Haixu Wang, Tongwen Sun. Positive Effects of Neutrophil Elastase Inhibitor (Sivelestat) on Gut Microbiome and Metabolite Profiles of Septic Rats.
Frontiers in cellular and infection microbiology.
2022; 12(?):818391. doi:
10.3389/fcimb.2022.818391. [PMID: 35372122] - Mingzhou Liu, Jing Zhang, Lingfang Dong, Wenhua Xue, Qilin He, Wenzhong Liang, Xing Liu, Jingying Zhang, Li Gu, Yinghua Feng, Jie Yang, Haibo Wang, Yaqin Wang, Kun Li, Yuanlong Li, Weiqin Kong, Xiaojian Zhang, Mengying Yao, Kai Wang, Peizhi Ma, Wei Zhang. Detection of sivelestat and its metabolite in small volumes of plasma from Chinese ALI/ARDS patients with SIRS via high-throughput UPLC-MS/MS: A pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2021 Feb; 195(?):113876. doi:
10.1016/j.jpba.2020.113876. [PMID: 33429252] - Ravi Prakash, Rakesh Kumar Mishra, Anas Ahmad, Mohsin Ali Khan, Rehan Khan, Syed Shadab Raza. Sivelestat-loaded nanostructured lipid carriers modulate oxidative and inflammatory stress in human dental pulp and mesenchymal stem cells subjected to oxygen-glucose deprivation.
Materials science & engineering. C, Materials for biological applications.
2021 Jan; 120(?):111700. doi:
10.1016/j.msec.2020.111700. [PMID: 33545859] - Adeleh Sahebnasagh, Fatemeh Saghafi, Mohammadreza Safdari, Masoud Khataminia, Afsaneh Sadremomtaz, Zeinab Talaei, Hassan Rezai Ghaleno, Mahdi Bagheri, Solomon Habtemariam, Razieh Avan. Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
Journal of clinical pharmacy and therapeutics.
2020 Dec; 45(6):1515-1519. doi:
10.1111/jcpt.13251. [PMID: 32860252] - Brice Korkmaz, Adam Lesner, Sylvain Marchand-Adam, Celia Moss, Dieter E Jenne. Lung Protection by Cathepsin C Inhibition: A New Hope for COVID-19 and ARDS?.
Journal of medicinal chemistry.
2020 11; 63(22):13258-13265. doi:
10.1021/acs.jmedchem.0c00776. [PMID: 32692176] - Safaa M Kishk, Rania M Kishk, Asmaa S A Yassen, Mohamed S Nafie, Nader A Nemr, Gamal ElMasry, Salim Al-Rejaie, Claire Simons. Molecular Insights into Human Transmembrane Protease Serine-2 (TMPS2) Inhibitors against SARS-CoV2: Homology Modelling, Molecular Dynamics, and Docking Studies.
Molecules (Basel, Switzerland).
2020 Oct; 25(21):. doi:
10.3390/molecules25215007. [PMID: 33137894] - Tetsuya Fukuta, Hideshi Okada, Genzou Takemura, Kodai Suzuki, Chihiro Takada, Hiroyuki Tomita, Akio Suzuki, Kazumasa Oda, Akihiro Uchida, Saori Matsuo, Hirotsugu Fukuda, Hirohisa Yano, Isamu Muraki, Ryogen Zaikokuji, Ayumi Kuroda, Ayane Nishio, So Sampei, Nagisa Miyazaki, Yasuaki Hotta, Noriaki Yamada, Takatomo Watanabe, Kentaro Morishita, Tomoaki Doi, Takahiro Yoshida, Hiroaki Ushikoshi, Shozo Yoshida, Yoichi Maekawa, Shinji Ogura. Neutrophil Elastase Inhibition Ameliorates Endotoxin-induced Myocardial Injury Accompanying Degradation of Cardiac Capillary Glycocalyx.
Shock (Augusta, Ga.).
2020 09; 54(3):386-393. doi:
10.1097/shk.0000000000001482. [PMID: 31764619] - Mireille Laforge, Carole Elbim, Corinne Frère, Miryana Hémadi, Charbel Massaad, Philippe Nuss, Jean-Jacques Benoliel, Chrystel Becker. Tissue damage from neutrophil-induced oxidative stress in COVID-19.
Nature reviews. Immunology.
2020 09; 20(9):515-516. doi:
10.1038/s41577-020-0407-1. [PMID: 32728221] - Peng Zhou, Tao Li, Jiaqi Jin, Yingmiao Liu, Baorong Li, Quanye Sun, Jiawei Tian, Hongtao Zhao, Zhihui Liu, Shuai Ma, Shuoqi Zhang, Valerie A Novakovic, Jialan Shi, Shaoshan Hu. Interactions between neutrophil extracellular traps and activated platelets enhance procoagulant activity in acute stroke patients with ICA occlusion.
EBioMedicine.
2020 Mar; 53(?):102671. doi:
10.1016/j.ebiom.2020.102671. [PMID: 32114386] - Sarah Raevens, Sanne Van Campenhout, Pieter-Jan Debacker, Sander Lefere, Xavier Verhelst, Anja Geerts, Hans Van Vlierberghe, Isabelle Colle, Lindsey Devisscher. Combination of sivelestat and N-acetylcysteine alleviates the inflammatory response and exceeds standard treatment for acetaminophen-induced liver injury.
Journal of leukocyte biology.
2020 02; 107(2):341-355. doi:
10.1002/jlb.5a1119-279r. [PMID: 31841237] - J-Q Zheng, G-R Zhang, J Li, H-W Bi. Neutrophil elastase inhibitor suppresses oxidative stress in obese asthmatic rats by activating Keap1/Nrf2 signaling pathway.
European review for medical and pharmacological sciences.
2019 Jan; 23(1):361-369. doi:
10.26355/eurrev_201901_16784. [PMID: 30657578] - Ken-Ichiro Tanaka, Fumiya Tamura, Toshifumi Sugizaki, Masahiro Kawahara, Keiji Kuba, Yumiko Imai, Tohru Mizushima. Evaluation of Lecithinized Superoxide Dismutase for the Prevention of Acute Respiratory Distress Syndrome in Animal Models.
American journal of respiratory cell and molecular biology.
2017 Feb; 56(2):179-190. doi:
10.1165/rcmb.2016-0158oc. [PMID: 27668315] - Guofu Li, Jia Jia, Kaiqiang Ji, Xiaoying Gong, Rui Wang, Xiaoli Zhang, Haiyuan Wang, Bin Zang. The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats.
International journal of molecular medicine.
2016 Sep; 38(3):767-75. doi:
10.3892/ijmm.2016.2665. [PMID: 27430552] - X-G Xiao, H-G Zu, Q-G Li, P Huang. Sivelestat sodium hydrate attenuates acute lung injury by decreasing systemic inflammation in a rat model of severe burns.
European review for medical and pharmacological sciences.
2016; 20(3):528-36. doi:
NULL. [PMID: 26914130] - Shufei Zang, Lei Wang, Xiaojie Ma, Geli Zhu, Zhenjie Zhuang, Yunhao Xun, Falin Zhao, Wenjun Yang, Juan Liu, Yan Luo, Yinlan Liu, Dewei Ye, Junping Shi. Neutrophils Play a Crucial Role in the Early Stage of Nonalcoholic Steatohepatitis via Neutrophil Elastase in Mice.
Cell biochemistry and biophysics.
2015 Nov; 73(2):479-487. doi:
10.1007/s12013-015-0682-9. [PMID: 27352342] - Jing Wang, Xiao-jian Dai, Yi-fan Zhang, Da-fang Zhong, Yu-lin Wu, Xiao-yan Chen. [Simultaneous determination of sivelestat and its metabolite XW-IMP-A in human plasma using HPLC-MS/MS].
Yao xue xue bao = Acta pharmaceutica Sinica.
2015 Oct; 50(10):1318-23. doi:
NULL. [PMID: 26837180] - Tsong-Long Hwang, Wen-Hui Wang, Ting-Yi Wang, Huang-Ping Yu, Pei-Wen Hsieh. Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3.
Bioorganic & medicinal chemistry.
2015 Mar; 23(5):1123-34. doi:
10.1016/j.bmc.2014.12.056. [PMID: 25650311] - Seisho Sakai, Hidehiro Tajima, Tomoharu Miyashita, Shin-Ichi Nakanuma, Isamu Makino, Hironori Hayashi, Hisatoshi Nakagawara, Hirohisa Kitagawa, Sachio Fushida, Takashi Fujimura, Hidehito Saito, Seiichi Munesue, Yasuhiko Yamamoto, Tetsuo Ohta. Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury.
Digestive diseases and sciences.
2014 Apr; 59(4):787-94. doi:
10.1007/s10620-013-2963-8. [PMID: 24318803] - Ai-Sheng Ho, Chien-Hsin Chen, Chun-Chia Cheng, Chia-Chi Wang, Hua-Ching Lin, Tsai-Yueh Luo, Gi-Shih Lien, Jungshan Chang. Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers.
Oncotarget.
2014 Jan; 5(2):473-80. doi:
10.18632/oncotarget.1631. [PMID: 24457622] - Norikazu Nomura, Miki Asano, Takayuki Saito, Takuya Nakayama, Akira Mishima. Sivelestat attenuates lung injury in surgery for congenital heart disease with pulmonary hypertension.
The Annals of thoracic surgery.
2013 Dec; 96(6):2184-91. doi:
10.1016/j.athoracsur.2013.07.017. [PMID: 24075485] - Jun Cao, Quanyan Liu. Protective effects of sivelestat in a caerulein-induced rat acute pancreatitis model.
Inflammation.
2013 Dec; 36(6):1348-56. doi:
10.1007/s10753-013-9674-3. [PMID: 23794035] - Koshi Kumagai, Yoshiro Saikawa, Hiroya Takeuchi, Koichi Suda, Kazumasa Fukuda, Rieko Nakamura, Tsunehiro Takahashi, Hirofumi Kawakubo, Norihito Wada, Taku Miyasho, Yuko Kitagawa. The neutrophil elastase inhibitor sivelestat suppresses accelerated gastrointestinal tumor growth via peritonitis after cecal ligation and puncture.
Anticancer research.
2013 Sep; 33(9):3653-9. doi:
NULL. [PMID: 24023292] - Jia-ke Chai, Jian-hua Cai, Hu-ping Deng, Xiao-fang Zou, Wei Liu, Qing-gang Hu, Chuan-an Shen, Hui-nan Yin, Xi-bo Zhang, Yun-fei Chi, Li Ma, Rui Feng. Role of neutrophil elastase in lung injury induced by burn-blast combined injury in rats.
Burns : journal of the International Society for Burn Injuries.
2013 Jun; 39(4):745-53. doi:
10.1016/j.burns.2012.08.005. [PMID: 22999209] - Naoki Fujimura, Hideaki Obara, Koichi Suda, Hiroya Takeuchi, Taku Miyasho, Kazufumi Kawasako, Wenlin Du, Shingo Yamada, Shigeshi Ono, Kenji Matsumoto, Sachiko Matsuda, Hiroshi Yagi, Minoru Kitago, Masahiro Shinoda, Osamu Itano, Minoru Tanabe, Michiie Sakamoto, Ikuro Maruyama, Yuko Kitagawa. Neutrophil elastase inhibitor improves survival rate after ischemia reperfusion injury caused by supravisceral aortic clamping in rats.
The Journal of surgical research.
2013 Mar; 180(1):e31-6. doi:
10.1016/j.jss.2012.04.037. [PMID: 22595015] - Seigo Miyoshi, Hironobu Hamada, Ryoji Ito, Hitoshi Katayama, Kazunori Irifune, Toshimitsu Suwaki, Norihiko Nakanishi, Takanori Kanematsu, Kentaro Dote, Mayuki Aibiki, Takafumi Okura, Jitsuo Higaki. Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
Drug design, development and therapy.
2013; 7(?):305-16. doi:
10.2147/dddt.s42004. [PMID: 23596346] - Nguyen The Cuong, Chikara Abe, Nguyen Huy Binh, Akira Hara, Hironobu Morita, Shinji Ogura. Sivelestat improves outcome of crush injury by inhibiting high-mobility group box 1 in rats.
Shock (Augusta, Ga.).
2013 Jan; 39(1):89-95. doi:
10.1097/shk.0b013e31827a2412. [PMID: 23247125] - Li Feng, Xiaoyu Liu, Weiliang Zhu, Fujiang Guo, Yingchun Wu, Rui Wang, Kaixian Chen, Cheng Huang, Yiming Li. Inhibition of human neutrophil elastase by pentacyclic triterpenes.
PloS one.
2013; 8(12):e82794. doi:
10.1371/journal.pone.0082794. [PMID: 24376583] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Hou-Hong Wang, A-Mao Tang, Li Chen, Meng-Tao Zhou. Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats.
Experimental lung research.
2012 Nov; 38(9-10):445-52. doi:
10.3109/01902148.2012.721860. [PMID: 23005337] - Li Feng, Weiliang Zhu, Cheng Huang, Yiming Li. Direct interaction of ONO-5046 with human neutrophil elastase through ¹H NMR and molecular docking.
International journal of biological macromolecules.
2012 Oct; 51(3):196-200. doi:
10.1016/j.ijbiomac.2012.04.023. [PMID: 22579959] - Wei Tao, Qian-Bing Miao, Ya-Bing Zhu, Yu-Sheng Shu. Inhaled neutrophil elastase inhibitor reduces oleic acid-induced acute lung injury in rats.
Pulmonary pharmacology & therapeutics.
2012 Feb; 25(1):99-103. doi:
10.1016/j.pupt.2011.12.006. [PMID: 22210005] - T Stevens, K Ekholm, M Gränse, M Lindahl, V Kozma, C Jungar, T Ottosson, H Falk-Håkansson, A Churg, J L Wright, H Lal, A Sanfridson. AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase.
The Journal of pharmacology and experimental therapeutics.
2011 Oct; 339(1):313-20. doi:
10.1124/jpet.111.182139. [PMID: 21791628] - Ono Shinichiro, Tamotsu Kuroki, Tomohiko Adachi, Taichiro Kosaka, Tatsuya Okamoto, Takayuki Tanaka, Yoshitsugu Tajima, Takashi Kanematsu, Susumu Eguchi. The effect of selective neutrophil elastase inhibitor on pancreatic islet yields and functions in rat with hypercytokinemia.
Annals of transplantation.
2011 Oct; 16(4):99-106. doi:
10.12659/aot.882225. [PMID: 22210428] - Kenji Mimatsu, Takatsugu Oida, Atsushi Kawasaki, Hisao Kano, Youichi Kuboi, Sadao Amano. Influence of neutrophil elastase inhibitor on the postoperative course in patients with esophageal cancer after transthoracic esophagectomy.
Hepato-gastroenterology.
2011 Sep; 58(110-111):1583-7. doi:
10.5754/hge09545. [PMID: 22086688] - H Makino, C Kunisaki, T Kosaka, H Akiyama, S Morita, I Endo. Perioperative use of a neutrophil elastase inhibitor in video-assisted thoracoscopic oesophagectomy for cancer.
The British journal of surgery.
2011 Jul; 98(7):975-82. doi:
10.1002/bjs.7499. [PMID: 21557207] - Makoto Iwahashi, Mikihito Nakamori, Masaki Nakamura, Toshiyasu Ojima, Teiji Naka, Hiroki Yamaue. Optimal period for the prophylactic administration of neutrophil elastase inhibitor for patients with esophageal cancer undergoing esophagectomy.
World journal of surgery.
2011 Jul; 35(7):1573-9. doi:
10.1007/s00268-011-1095-6. [PMID: 21479682] - Esther K Wolthuis, Alexander P J Vlaar, Jorrit-Jan H Hofstra, Joris J T H Roelofs, Vivian de Waard, Nicole P Juffermans, Marcus J Schultz. Plasminogen activator inhibitor-type I gene deficient mice show reduced influx of neutrophils in ventilator-induced lung injury.
Critical care research and practice.
2011; 2011(?):217896. doi:
10.1155/2011/217896. [PMID: 21789277] - Daisuke Osaka, Yoko Shibata, Kazunori Kanouchi, Michiko Nishiwaki, Tomomi Kimura, Hiroyuki Kishi, Shuichi Abe, Sumito Inoue, Yoshikane Tokairin, Akira Igarashi, Keiko Yamauchi, Yasuko Aida, Takako Nemoto, Keiko Nunomiya, Koji Fukuzaki, Isao Kubota. Soluble endothelial selectin in acute lung injury complicated by severe pneumonia.
International journal of medical sciences.
2011; 8(4):302-8. doi:
10.7150/ijms.8.302. [PMID: 21611111] - Kazuhiko Fukatsu, Kazuya Tanabe, Yoshinori Maeshima, Jiro Omata, Hiroshi Yasuhara, Daizoh Saitoh. Neutrophil elastase inhibitor restores gut ischemia reperfusion-induced impairment of gut immunity with reduced plasma interleukin-6 concentrations in mice.
Surgical infections.
2010 Dec; 11(6):517-22. doi:
10.1089/sur.2010.001. [PMID: 20969469] - Shunsaku Takahashi, Norimasa Miura, Tomomi Harada, ZhongZhi Wang, Xinhui Wang, Hideyuki Tsubokura, Yoshiaki Oshima, Junichi Hasegawa, Yoshimi Inagaki, Goshi Shiota. Prognostic impact of clinical course-specific mRNA expression profiles in the serum of perioperative patients with esophageal cancer in the ICU: a case control study.
Journal of translational medicine.
2010 Oct; 8(?):103. doi:
10.1186/1479-5876-8-103. [PMID: 20969744] - Tomoko Ishii, Kent Doi, Koji Okamoto, Mitsuru Imamura, Makoto Dohi, Kazuhiko Yamamoto, Toshiro Fujita, Eisei Noiri. Neutrophil elastase contributes to acute lung injury induced by bilateral nephrectomy.
The American journal of pathology.
2010 Oct; 177(4):1665-73. doi:
10.2353/ajpath.2010.090793. [PMID: 20709801] - M Kobayashi, T Irinoda, Y Akiyama, E Meguro, Y Hayakawa, O Funato, A Takagane. Effect of a selective neutrophil elastase inhibitor on early recovery from body water imbalance after transthoracic esophagectomy.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus.
2010 Sep; 23(7):565-71. doi:
10.1111/j.1442-2050.2010.01053.x. [PMID: 20353442] - Yoichiro Uchida, Maria Cecilia S Freitas, Danyun Zhao, Ronald W Busuttil, Jerzy W Kupiec-Weglinski. The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury.
Transplantation.
2010 May; 89(9):1050-6. doi:
10.1097/tp.0b013e3181d45a98. [PMID: 20160675] - Y Kawahara, I Ninomiya, T Fujimura, H Funaki, H Nakagawara, H Takamura, K Oyama, H Tajima, S Fushida, H Inaba, M Kayahara. Prospective randomized controlled study on the effects of perioperative administration of a neutrophil elastase inhibitor to patients undergoing video-assisted thoracoscopic surgery for thoracic esophageal cancer.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus.
2010 May; 23(4):329-39. doi:
10.1111/j.1442-2050.2009.01010.x. [PMID: 19788440] - Koichi Suda, Hiroya Takeuchi, Tomoko Hagiwara, Taku Miyasho, Minoru Okamoto, Kazufumi Kawasako, Shingo Yamada, Kazuhiro Suganuma, Norihito Wada, Yoshiro Saikawa, Koichi Fukunaga, Yosuke Funakoshi, Satoru Hashimoto, Hiroshi Yokota, Ikuro Maruyama, Akitoshi Ishizaka, Yuko Kitagawa. Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis.
Shock (Augusta, Ga.).
2010 May; 33(5):526-31. doi:
10.1097/shk.0b013e3181cc064b. [PMID: 19953005] - Tim T Lögters, Jens Altrichter, Adnana Paunel-Görgülü, Martin Sager, Ingo Witte, Annina Ott, Sarah Sadek, Jessica Baltes, José Bitu-Moreno, Alberto Schek, Wolfram Müller, Teresa Jeri, Joachim Windolf, Martin Scholz. Extracorporeal immune therapy with immobilized agonistic anti-Fas antibodies leads to transient reduction of circulating neutrophil numbers and limits tissue damage after hemorrhagic shock/resuscitation in a porcine model.
Journal of inflammation (London, England).
2010 Apr; 7(?):18. doi:
10.1186/1476-9255-7-18. [PMID: 20406470] - Shigekiyo Matsumoto, Chihiro Shingu, Hironori Koga, Seigo Hidaka, Koji Goto, Satoshi Hagiwara, Hideo Iwasaka, Takayuki Noguchi, Isao Yokoi. The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury: an electron spin resonance study.
The Journal of trauma.
2010 Apr; 68(4):796-801. doi:
10.1097/ta.0b013e3181bb80d4. [PMID: 20065874] - Yoritaka Nakano, Tadashi Kondo, Ryota Matsuo, Soichiro Murata, Kiyoshi Fukunaga, Nobuhiro Ohkohchi. Prevention of leukocyte activation by the neutrophil elastase inhibitor, sivelestat, in the hepatic microcirculation after ischemia-reperfusion.
The Journal of surgical research.
2009 Aug; 155(2):311-7. doi:
10.1016/j.jss.2008.07.025. [PMID: 19482311] - Hiroaki Matayoshi, Takao Hirata, Satoshi Yamashita, Kazuyoshi Ishida, Yoichi Mizukami, Toshikazu Gondo, Mishiya Matsumoto, Takefumi Sakabe. Neutrophil elastase inhibitor attenuates hippocampal neuronal damage after transient forebrain ischemia in rats.
Brain research.
2009 Mar; 1259(?):98-106. doi:
10.1016/j.brainres.2008.12.070. [PMID: 19168036] - Zhaoxi Wang, Feng Chen, Rihong Zhai, Lingsong Zhang, Li Su, Xihong Lin, Taylor Thompson, David C Christiani. Plasma neutrophil elastase and elafin imbalance is associated with acute respiratory distress syndrome (ARDS) development.
PloS one.
2009; 4(2):e4380. doi:
10.1371/journal.pone.0004380. [PMID: 19197381] - Tetsuya Hagio, Katsuya Kishikawa, Kazuhito Kawabata, Sadatomo Tasaka, Satoru Hashimoto, Naoki Hasegawa, Akitoshi Ishizaka. Inhibition of neutrophil elastase reduces lung injury and bacterial count in hamsters.
Pulmonary pharmacology & therapeutics.
2008 Dec; 21(6):884-91. doi:
10.1016/j.pupt.2008.10.002. [PMID: 18992355] - Taishin Ito, Shinji Kusunoki, Masashi Kawamoto. [Case of transfusion-related acute lung injury associated with severe intraoperative hypoxemia].
Masui. The Japanese journal of anesthesiology.
2008 Oct; 57(10):1265-8. doi:
NULL. [PMID: 18975546] - Satoshi Hagiwara, Hideo Iwasaka, Kazumi Togo, Takayuki Noguchi. A neutrophil elastase inhibitor, sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1.
Inflammation.
2008 Aug; 31(4):227-34. doi:
10.1007/s10753-008-9069-z. [PMID: 18536984] - Shunsuke Hara, Kayo Nemoto, Norifumi Ninomiya, Minoru Kubota, Masamune Kuno, Yasuhiro Yamamoto. Continuous infusion of sivelestat sodium hydrate prevents lipopolysaccharide-induced intestinal paralysis and hypotension in conscious guinea-pigs.
Clinical and experimental pharmacology & physiology.
2008 Jul; 35(7):841-5. doi:
10.1111/j.1440-1681.2008.04921.x. [PMID: 18346172] - Satoru Hashimoto, Yoko Okayama, Nobuaki Shime, Akio Kimura, Yosuke Funakoshi, Kazuhito Kawabata, Akitoshi Ishizaka, Fumimasa Amaya. Neutrophil elastase activity in acute lung injury and respiratory distress syndrome.
Respirology (Carlton, Vic.).
2008 Jun; 13(4):581-4. doi:
10.1111/j.1440-1843.2008.01283.x. [PMID: 18410258] - Ryuichiro Kumasaka, Norio Nakamura, Takeshi Fujita, Reiichi Murakami, Michiko Shimada, Hiroshi Osawa, Hideaki Yamabe, Ken Okumura. Beneficial effect of neutrophil elastase inhibitor on anti-Thy1.1 nephritis in rats.
Nephrology (Carlton, Vic.).
2008 Feb; 13(1):27-32. doi:
10.1111/j.1440-1797.2007.00843.x. [PMID: 18199098] - Hideaki Mori, Itaru Nagahiro, Tomohiko Osaragi, Kazutoshi Kotani, Hidehiro Nakanishi, Yoshifumi Sano, Hiroshi Date, Nobuyoshi Shimizu. Addition of a neutrophil elastase inhibitor to the organ flushing solution decreases lung reperfusion injury in rat lung transplantation.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.
2007 Nov; 32(5):791-5. doi:
10.1016/j.ejcts.2007.07.017. [PMID: 17888675] - Akihiro Sakashita, Yoshihiro Nishimura, Teruaki Nishiuma, Kaori Takenaka, Kazuyuki Kobayashi, Yoshikazu Kotani, Mitsuhiro Yokoyama. Neutrophil elastase inhibitor (sivelestat) attenuates subsequent ventilator-induced lung injury in mice.
European journal of pharmacology.
2007 Sep; 571(1):62-71. doi:
10.1016/j.ejphar.2007.05.053. [PMID: 17599828] - Mari Nakamura, Takashi Ogura, Naoki Miyazawa, Akihiro Tagawa, Satoko Kozawa, Yuji Watanuki, Hiroshi Takahashi. [Outcome of patients with acute exacerbation of idiopathic interstitial fibrosis (IPF) treated with sivelestat and the prognostic value of serum KL-6 and surfactant protein D].
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society.
2007 Jun; 45(6):455-9. doi:
NULL. [PMID: 17644940] - Yusuke Narita, Katsuhiko Naoki, Nao Horiuchi, Naoya Hida, Hiroaki Okamoto, Hiroshi Kunikane, Koshiro Watanabe. [A case of legionella pneumonia associated with acute respiratory distress syndrome (ARDS) and acute renal failure treated with methylprednisolone and sivelestat].
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society.
2007 May; 45(5):413-8. doi:
. [PMID: 17554986] - A-H Kwon, Z Qiu. Neutrophil elastase inhibitor prevents endotoxin-induced liver injury following experimental partial hepatectomy.
The British journal of surgery.
2007 May; 94(5):609-19. doi:
10.1002/bjs.5625. [PMID: 17315175] - Tadatomo Kodama, Hidekazu Yukioka, Takayuki Kato, Noboru Kato, Fumihiko Hato, Seiichi Kitagawa. Neutrophil elastase as a predicting factor for development of acute lung injury.
Internal medicine (Tokyo, Japan).
2007; 46(11):699-704. doi:
10.2169/internalmedicine.46.6182. [PMID: 17541219] - Fuminori Wakayama, Ikuo Fukuda, Yasuyuki Suzuki, Norihiro Kondo. Neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury after cardiopulmonary bypass in the rabbit endotoxemia model.
The Annals of thoracic surgery.
2007 Jan; 83(1):153-60. doi:
10.1016/j.athoracsur.2006.08.023. [PMID: 17184651] - K Suda, Y Kitagawa, S Ozawa, T Miyasho, M Okamoto, Y Saikawa, M Ueda, S Yamada, S Tasaka, Y Funakoshi, S Hashimoto, H Yokota, I Maruyama, A Ishizaka, M Kitajima. Neutrophil elastase inhibitor improves postoperative clinical courses after thoracic esophagectomy.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus.
2007; 20(6):478-86. doi:
10.1111/j.1442-2050.2007.00699.x. [PMID: 17958722] - Shintaro Akamoto, Keiichi Okano, Takanori Sano, Shinichi Yachida, Kunihiko Izuishi, Hisashi Usuki, Hisao Wakabayashi, Yasuyuki Suzuki. Neutrophil elastase inhibitor (sivelestat) preserves antitumor immunity and reduces the inflammatory mediators associated with major surgery.
Surgery today.
2007; 37(5):359-65. doi:
10.1007/s00595-006-3409-0. [PMID: 17468814] - Hirokazu Nakajima, Hirochiyo Sawaguchi, Shigenori Nakajima. [Survival by a young woman with malnutrition due to alcoholism and eating disorders and with acute respiratory distress syndrome due to severe pneumonia who showed increased serum neutrophil elastase activity].
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases.
2006 Nov; 80(6):711-5. doi:
10.11150/kansenshogakuzasshi1970.80.711. [PMID: 17176860] - T Hayama, M Matsuyama, K Funao, T Tanaka, K Tsuchida, Y Takemoto, Y Kawahito, H Sano, T Nakatani, R Yoshimura. Benefical effect of neutrophil elastase inhibitor on renal warm ischemia-reperfusion injury in the rat.
Transplantation proceedings.
2006 Sep; 38(7):2201-2. doi:
10.1016/j.transproceed.2006.06.094. [PMID: 16980042] - Yuichi Morohoshi, Katsuyoshi Matsuoka, Hiroshi Chinen, Nobuhiko Kamada, Toshiro Sato, Tadakazu Hisamatsu, Susumu Okamoto, Nagamu Inoue, Hiromasa Takaishi, Haruhiko Ogata, Yasushi Iwao, Toshifumi Hibi. Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis.
Journal of gastroenterology.
2006 Apr; 41(4):318-24. doi:
10.1007/s00535-005-1768-8. [PMID: 16741610] - Masahiro Ryugo, Yoshiki Sawa, Hiroshi Takano, Goro Matsumiya, Shigemitsu Iwai, Masamichi Ono, Hiroki Hata, Takashi Yamauchi, Masaji Nishimura, Yuji Fujino, Hikaru Matsuda. Effect of a polymorphonuclear elastase inhibitor (sivelestat sodium) on acute lung injury after cardiopulmonary bypass: findings of a double-blind randomized study.
Surgery today.
2006; 36(4):321-6. doi:
10.1007/s00595-005-3160-y. [PMID: 16554988] - Masaru Ando, Eishi Miyazaki, Shigeo Hiroshige, Yoshinori Ashihara, Toshiyuki Okubo, Mami Ueo, Tetsujiro Fukami, Katsunori Sugisaki, Tomiyasu Tsuda, Kazunari Ohishi, Shigenori Yoshitake, Takayuki Noguchi, Toshihide Kumamoto. Virus associated hemophagocytic syndrome accompanied by acute respiratory failure caused by influenza A (H3N2).
Internal medicine (Tokyo, Japan).
2006; 45(20):1183-6. doi:
10.2169/internalmedicine.45.1736. [PMID: 17106167] - Ei Yamaki, Kyoichi Ogata, Hiroshi Hinohara, Yuji Kadoi, Fumio Kunimoto, Hiroyuki Kuwano. [Effects of neutrophil elastase inhibitor on postoperative cytokine levels in patients after esophagectomy].
Masui. The Japanese journal of anesthesiology.
2005 Aug; 54(8):884-8. doi:
NULL. [PMID: 16104542] - Yoshiaki Inoue, Akitoshi Seiyama, Hiroshi Tanaka, Isao Ukai, Pavel Akimau, Masato Nishino, Takeshi Shimazu, Hisashi Sugimoto. Protective effects of a selective neutrophil elastase inhibitor (sivelestat) on lipopolysaccharide-induced acute dysfunction of the pulmonary microcirculation.
Critical care medicine.
2005 Aug; 33(8):1814-22. doi:
10.1097/01.ccm.0000172547.54086.ad. [PMID: 16096460] - Yoshifumi Kotake, Michiko Yamamoto, Midori Matsumoto, Hiroshi Morisaki, Junzo Takeda. Sivelestat, a neutrophil elastase inhibitor, attenuates neutrophil priming after hepatoenteric ischemia in rabbits.
Shock (Augusta, Ga.).
2005 Feb; 23(2):156-60. doi:
10.1097/01.shk.0000148074.42060.f8. [PMID: 15665731] - Hiroshi Tomiyama, Itaru Takara, Joho Tokumine, Kazuhiro Sugahara. [Sivelestat sodium hydrate was effective for ARDS in a patient suffering from chronic rheumatoid arthritis with acute exacerbation after failing to respond to high dose steroid pulse therapy].
Masui. The Japanese journal of anesthesiology.
2004 Sep; 53(9):1042-6. doi:
NULL. [PMID: 15500109] - Ken-Ichiro Ishii, Yoshiya Ito, Hiroyuki Katagiri, Yutaka Matsumoto, Akira Kakita, Masataka Majima. Neutrophil elastase inhibitor attenuates lipopolysaccharide-induced hepatic microvascular dysfunction in mice.
Shock (Augusta, Ga.).
2002 Aug; 18(2):163-8. doi:
10.1097/00024382-200208000-00013. [PMID: 12166781] - N Yoshida, N Sugimoto, J Ochiai, Y Nakamura, H Ichikawa, Y Naito, T Yoshikawa. Role of elastase and active oxygen species in gastric mucosal injury induced by aspirin administration in Helicobacter pylori-infected Mongolian gerbils.
Alimentary pharmacology & therapeutics.
2002 Apr; 16 Suppl 2(?):191-7. doi:
10.1046/j.1365-2036.16.s2.32.x. [PMID: 11966541] - T Hagio, S Nakao, H Matsuoka, S Matsumoto, K Kawabata, H Ohno. Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster.
European journal of pharmacology.
2001 Aug; 426(1-2):131-8. doi:
10.1016/s0014-2999(01)01191-8. [PMID: 11525781] - A Shimakura, Y Kamanaka, Y Ikeda, K Kondo, Y Suzuki, K Umemura. Neutrophil elastase inhibition reduces cerebral ischemic damage in the middle cerebral artery occlusion.
Brain research.
2000 Mar; 858(1):55-60. doi:
10.1016/s0006-8993(99)02431-2. [PMID: 10700596] - H M Chen, J C Chen, M H Shyr, M F Chen, T L Hwang, L L Fan, T Y Chi, C P Chi. Neutrophil elastase inhibitor (ONO-5046) attenuates reperfusion-induced hepatic microcirculatory derangement, energy depletion and lipid peroxidation in rats.
Shock (Augusta, Ga.).
1999 Dec; 12(6):462-7. doi:
10.1097/00024382-199912000-00008. [PMID: 10588515] - Y Yamaguchi, F Matsumura, J Liang, K Okabe, H Ohshiro, K Ishihara, T Matsuda, K Mori, M Ogawa. Neutrophil elastase and oxygen radicals enhance monocyte chemoattractant protein- expression after ischemia/reperfusion in rat liver.
Transplantation.
1999 Nov; 68(10):1459-68. doi:
10.1097/00007890-199911270-00005. [PMID: 10589939] - Y Soejima, K Yanaga, T Nishizaki, T Yoshizumi, H Uchiyama, K Sugimachi. Effect of specific neutrophil elastase inhibitor on ischemia/reperfusion injury in rat liver transplantation.
The Journal of surgical research.
1999 Sep; 86(1):150-4. doi:
10.1006/jsre.1999.5661. [PMID: 10452882] - T Nishimura, Y Nakagawa, M Sakai, S Sugai, N Chihara, R Shirakawa, T Sakamoto, Y Ikeda, I Itagaki, Y Ozeki, K Shinomiya, T Fujita. [Reproductive and developmental toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (3). Teratogenicity study in rabbits].
The Journal of toxicological sciences.
1998 Jul; 23 Suppl 3(?):531-8. doi:
10.2131/jts.23.supplementiii_531. [PMID: 9760410] - K Yamaguchi, H Yanagi, K Shimizu, Y Shichino, K Nishiyama, H Mori, Y Suzuki, H Oida, K Nishibata, M Tanaka, H Yonezawa, T Fujita. [Toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (3). 4-week repeated dose intravenous toxicity study in dogs with 4-week recovery test].
The Journal of toxicological sciences.
1998 Jul; 23 Suppl 3(?):435-55. doi:
10.2131/jts.23.supplementiii_435. [PMID: 9760405] - H Yanagi, K Yamaguchi, K Shimizu, Y Shichino, K Nishiyama, H Mori, K Shinomiya, H Ueda, Y Suzuki, H Oida, K Nishibata, M Tanaka, H Yonezawa, T Fujita. [Toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (2). 4-week repeated dose intravenous toxicity study in rats with 4-week recovery test].
The Journal of toxicological sciences.
1998 Jul; 23 Suppl 3(?):415-34. doi:
10.2131/jts.23.supplementiii_415. [PMID: 9760404] - S Suzuki, F Gejyo, T Kuroda, J J Kazama, N Imai, H Kimura, M Arakawa. Effects of a novel elastase inhibitor, ONO-5046, on nephrotoxic serum nephritis in rats.
Kidney international.
1998 May; 53(5):1201-8. doi:
10.1046/j.1523-1755.1998.00872.x. [PMID: 9573534] - T Murakami, M Sato, F Higashikawa, A Okochi, Y Higashi, N Yata, M Takano. Hepatic clearance of ONO-5046, a novel neutrophil elastase inhibitor, in rats and in the rat perfused liver.
The Journal of pharmacy and pharmacology.
1998 Apr; 50(4):425-30. doi:
10.1111/j.2042-7158.1998.tb06883.x. [PMID: 9625488] - M Imamura, Y Mikami, H Takahashi, H Yamauchi. Effect of a specific synthetic inhibitor of neutrophil elastase (ONO-5046) on the course of acute hemorrhagic pancreatitis in dogs.
Journal of hepato-biliary-pancreatic surgery.
1998; 5(4):422-8. doi:
10.1007/s005340050067. [PMID: 9931392] - Y Miyazaki, T Inoue, M Kyi, M Sawada, S Miyake, Y Yoshizawa. Effects of a neutrophil elastase inhibitor (ONO-5046) on acute pulmonary injury induced by tumor necrosis factor alpha (TNFalpha) and activated neutrophils in isolated perfused rabbit lungs.
American journal of respiratory and critical care medicine.
1998 Jan; 157(1):89-94. doi:
10.1164/ajrccm.157.1.9612021. [PMID: 9445283] - S Ishioka. [Strategy of therapy for interstitial lung disease due to chemotherapeutic drugs or radiation].
Gan to kagaku ryoho. Cancer & chemotherapy.
1997 Oct; 24 Suppl 3(?):432-8. doi:
NULL. [PMID: 9369919] - F Watanabe, M Sato, A Kato, T Murakami, Y Higashi, N Yata. First-pass metabolism of ONO-5046 (N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino]benzoyl]aminoacetic acid), a novel elastase inhibitor, in rats.
Biological & pharmaceutical bulletin.
1997 Apr; 20(4):392-6. doi:
10.1248/bpb.20.392. [PMID: 9145216] - Y Yamaguchi, E Akizuki, O Ichiguchi, F Matsumura, M Goto, N Miyanari, K Mori, S Yamada, M Ogawa. Neutrophil elastase inhibitor reduces neutrophil chemoattractant production after ischemia-reperfusion in rat liver.
Gastroenterology.
1997 Feb; 112(2):551-60. doi:
10.1053/gast.1997.v112.pm9024309. [PMID: 9024309] - J Kobayashi, S Kitamura. [How can we monitor and treat patients with acute exacerbations of idiopathic interstitial pneumonia].
Nihon Kyobu Shikkan Gakkai zasshi.
1996 Dec; 34 Suppl(?):195-9. doi:
NULL. [PMID: 9216215] - S Kushimoto, K Okajima, M Uchiba, K Murakami, N Harada, H Okabe, K Takatsuki. Role of granulocyte elastase in ischemia/reperfusion injury of rat liver.
Critical care medicine.
1996 Nov; 24(11):1908-12. doi:
10.1097/00003246-199611000-00023. [PMID: 8917044] - F S Wang, Y Yamaguchi, E Akizuki, N Miyanari, O Ichiguchi, M Goto, K Mori, S Yamada, M Ogawa. Neutrophil elastase inhibitor (ONO-5046) decreases cytokine-induced neutrophil chemoattractant after reperfusion of pancreaticoduodenal transplantation in rats.
Transplantation.
1996 Apr; 61(7):1103-7. doi:
10.1097/00007890-199604150-00020. [PMID: 8623193] - F Sakamaki, A Ishizaka, T Urano, K Sayama, H Nakamura, T Terashima, Y Waki, S Tasaka, N Hasegawa, K Sato, N Nakagawa, T Obata, M Kanazawa. Effect of a specific neutrophil elastase inhibitor, ONO-5046, on endotoxin-induced acute lung injury.
American journal of respiratory and critical care medicine.
1996 Jan; 153(1):391-7. doi:
10.1164/ajrccm.153.1.8542148. [PMID: 8542148] - L Guo, Y Yamaguchi, S Ikei, H Sugita, M Ogawa. Neutrophil elastase inhibitor (ONO-5046) prevents lung hemorrhage induced by lipopolysaccharide in rat model of cerulein pancreatitis.
Digestive diseases and sciences.
1995 Oct; 40(10):2177-83. doi:
10.1007/bf02209002. [PMID: 7587785] - M Uchiba, K Okajima, K Murakami, H Okabe, K Takatsuki. Endotoxin-induced pulmonary vascular injury is mainly mediated by activated neutrophils in rats.
Thrombosis research.
1995 Apr; 78(2):117-25. doi:
10.1016/0049-3848(95)00040-2. [PMID: 7482429]