Sipoglitazar (BioDeep_00000183839)

   

human metabolite blood metabolite


代谢物信息卡片


3-[3-ethoxy-1-({4-[(2-phenyl-1,3-thiazol-4-yl)methoxy]phenyl}methyl)-1H-pyrazol-4-yl]propanoic acid

化学式: C25H25N3O4S (463.1566)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOC1=NN(C=C1CCC(=O)O)CC2=CC=C(C=C2)OCC3=CSC(=N3)C4=CC=CC=C4
InChI: InChI=1S/C25H25N3O4S/c1-2-31-24-20(10-13-23(29)30)15-28(27-24)14-18-8-11-22(12-9-18)32-16-21-17-33-25(26-21)19-6-4-3-5-7-19/h3-9,11-12,15,17H,2,10,13-14,16H2,1H3,(H,29,30)

描述信息

C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C154291 - Peroxisome Proliferator-Activated Receptor Agonist

同义名列表

4 个代谢物同义名

3-[3-ethoxy-1-({4-[(2-phenyl-1,3-thiazol-4-yl)methoxy]phenyl}methyl)-1H-pyrazol-4-yl]propanoic acid; 3-(3-Ethoxy-1-((4-((2-phenyl-1,3-thiazol-4-yl)methoxy)phenyl)methyl)pyrazol-4-yl)propanoic acid; 3-[3-Ethoxy-1-({4-[(2-phenyl-1,3-thiazol-4-yl)methoxy]phenyl}methyl)-1H-pyrazol-4-yl]propanoate; Sipoglitazar



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Frances Stringer, Joost DeJongh, Graham Scott, Meindert Danhof. A model-based approach to analyze the influence of UGT2B15 polymorphism driven pharmacokinetic differences on the pharmacodynamic response of the PPAR agonist sipoglitazar. Journal of clinical pharmacology. 2014 Apr; 54(4):453-61. doi: 10.1002/jcph.227. [PMID: 24214217]
  • Frances Stringer, Graham Scott, Marian Valbuena, Judith Kinley, Mitsuhiro Nishihara, Richard Urquhart. The effect of genetic polymorphisms in UGT2B15 on the pharmacokinetic profile of sipoglitazar, a novel anti-diabetic agent. European journal of clinical pharmacology. 2013 Mar; 69(3):423-30. doi: 10.1007/s00228-012-1382-7. [PMID: 22960998]
  • Mitsuhiro Nishihara, Miyako Sudo, Naohiro Kawaguchi, Junzo Takahashi, Yutaka Kiyota, Takahiro Kondo, Satoru Asahi. An unusual metabolic pathway of sipoglitazar, a novel antidiabetic agent: cytochrome P450-catalyzed oxidation of sipoglitazar acyl glucuronide. Drug metabolism and disposition: the biological fate of chemicals. 2012 Feb; 40(2):249-58. doi: 10.1124/dmd.111.040105. [PMID: 22028317]
  • Mitsuhiro Nishihara, Miyako Sudo, Hidenori Kamiguchi, Naohiro Kawaguchi, Yoshihiro Maeshiba, Yutaka Kiyota, Junzo Takahashi, Yoshihiko Tagawa, Takahiro Kondo, Satoru Asahi. Metabolic fate of sipoglitazar, a novel oral PPAR agonist with activities for PPAR-γ, -α and -δ, in rats and monkeys and comparison with humans in vitro. Drug metabolism and pharmacokinetics. 2012; 27(2):223-31. doi: 10.2133/dmpk.dmpk-11-rg-061. [PMID: 22123126]
  • C T Lin, J P Chang, J P Chen. Ultrastructural localization of gamma-chain and immunoglobulin G in human lymphocytes using enzyme-labeled Fab fragment. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 1975 Aug; 23(8):624-31. doi: 10.1177/23.8.51039. [PMID: 51039]