Bronica (BioDeep_00000183787)

   

human metabolite blood metabolite


代谢物信息卡片


7-phenyl-7-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)heptanoic acid

化学式: C22H26O4 (354.18309960000005)
中文名称: 塞曲司特
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C1=O)=C(C(C(C)=C1C)=O)C(C2=CC=CC=C2)CCCCCC(O)=O
InChI: InChI=1S/C22H26O4/c1-14-15(2)22(26)20(16(3)21(14)25)18(17-10-6-4-7-11-17)12-8-5-9-13-19(23)24/h4,6-7,10-11,18H,5,8-9,12-13H2,1-3H3,(H,23,24)

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D011448 - Prostaglandin Antagonists
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents
R - Respiratory system > R03 - Drugs for obstructive airway diseases
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
Seratrodast (AA 2414), an orally active antiasthmatic agent, is a thromboxane A2 receptor (TP) antagonist and ferroptosis inhibitor. Seratrodast reduces lipid ROS production, modulates the systemic xc-/GSH/GPX4 axis, and inhibits JNK phosphorylation and p53 expression. Seratrodast exhibits anti-asthmatic and anti-epileptic activity[1][2][3].

同义名列表

6 个代谢物同义名

7-phenyl-7-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)heptanoic acid; 7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid; Seratrodast; Bronica; ABT-001; AA 2414



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ying Hao, Yitao Ou, Cheng Zhang, Hao Chen, Hu Yue, Zhongjin Yang, Xiaofen Zhong, Wenhui Hu, Ping Sun. Seratrodast, a thromboxane A2 receptor antagonist, inhibits neuronal ferroptosis by promoting GPX4 expression and suppressing JNK phosphorylation. Brain research. 2022 11; 1795(?):148073. doi: 10.1016/j.brainres.2022.148073. [PMID: 36075466]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Yasutomo Nakanishi, Takeshi Nabe, Nobuaki Mizutani, Hiroshi Takenaka, Shigekatsu Kohno. Synergism between cysteinyl leukotrienes and thromboxane A2 to induce allergic late phase nasal blockage in guinea pigs. Prostaglandins & other lipid mediators. 2004 Oct; 74(1-4):125-37. doi: 10.1016/j.prostaglandins.2004.07.006. [PMID: 15560121]
  • Toshihiko Fukuoka, Shuji Miyake, Takeshi Umino, Naohiko Inase, Naoko Tojo, Yasuyuki Yoshizawa. The effect of seratrodast on eosinophil cationic protein and symptoms in asthmatics. The Journal of asthma : official journal of the Association for the Care of Asthma. 2003 May; 40(3):257-64. doi: 10.1081/jas-120018322. [PMID: 12807169]
  • Kenji Baba, Ayako Sakakibara, Takeo Yagi, Sayaka Niwa, Hideo Wakayama, Kenzo Takagi. Long-term observations of the clinical course after step down of corticosteroid inhalation therapy in adult chronic asthmatics: correlation with serum levels of eosinophil cationic protein. Respirology (Carlton, Vic.). 2002 Sep; 7(3):255-66. doi: 10.1046/j.1440-1843.2002.00389.x. [PMID: 12153692]
  • Takahiko Horiguchi, Soichi Tachikawa, Rieko Kondo, Mamoru Shiga, Masahiro Hirose, Koji Fukumoto. Study on the usefulness of seratrodast in the treatment of chronic pulmonary emphysema. Arzneimittel-Forschung. 2002; 52(10):764-8. doi: 10.1055/s-0031-1299963. [PMID: 12442639]
  • H Muramatsu, R Kotajima, T Sato. [Correlation between the clinical effects of Seratrodast and the level of 11-dehydrothromboxane B2 in urine/sputum in bronchial asthma patients]. Arerugi = [Allergy]. 2001 Jun; 50(6):540-6. doi: . [PMID: 11517517]
  • Y Arakida, K Ohga, Y Okada, H Morio, K Suwa, M Yokota, T Yamada. Effect of combined leukotriene D(4) and thromboxane A(2) receptor antagonist on mediator-controlled resistance in guinea pigs. European journal of pharmacology. 2000 Sep; 403(1-2):169-79. doi: 10.1016/s0014-2999(00)00583-5. [PMID: 10969159]
  • Y Arakida, K Ohga, K Suwa, Y Okada, H Morio, M Yokota, K Miyata, T Yamada, K Honda. Effect of YM158, a dual lipid mediator antagonist, on immediate and late asthmatic responses, and on airway hyper-responsiveness in guinea pigs. Japanese journal of pharmacology. 2000 Apr; 82(4):287-94. doi: 10.1254/jjp.82.287. [PMID: 10875747]
  • H Tanaka, T Igarashi, T Saitoh, S Teramoto, N Miyazaki, S Kaneko, M Ohmichi, S Abe. Can urinary eicosanoids be a potential predictive marker of clinical response to thromboxane A2 receptor antagonist in asthmatic patients?. Respiratory medicine. 1999 Dec; 93(12):891-7. doi: 10.1016/s0954-6111(99)90055-0. [PMID: 10653051]
  • M Fujimura, M Abo, Y Kamio, S Myou, Y Ishiura, T Hashimoto, T Matsuda. Effect of leukotriene and thromboxane antagonist on propranolol-induced bronchoconstriction. American journal of respiratory and critical care medicine. 1999 Dec; 160(6):2100-3. doi: 10.1164/ajrccm.160.6.9902110. [PMID: 10588635]
  • S W Walsh, Y Wang, A Killian. AA-2414, an antioxidant and thromboxane receptor blocker, completely inhibits peroxide-induced vasoconstriction in the human placenta. The Journal of pharmacology and experimental therapeutics. 1999 Jul; 290(1):220-6. doi: ". [PMID: 10381779]
  • M Takami, W Tsukada. A possible involvement of thromboxane A2 and peptide leukotrienes in hyperresponsiveness of Sephadex-treated rat lung parenchyma. Prostaglandins, leukotrienes, and essential fatty acids. 1999 Jan; 60(1):65-71. doi: 10.1054/plef.1998.0009. [PMID: 10319919]
  • R Ohta, T Amano, K Yamashita, M Motohashi. High-performance liquid chromatographic determination of seratrodast and its metabolites in human serum and urine. Journal of chromatography. B, Biomedical sciences and applications. 1997 Dec; 704(1-2):325-31. doi: 10.1016/s0378-4347(97)00432-5. [PMID: 9518166]
  • E Samara, G Cao, C Locke, G R Granneman, R Dean, A Killian. Population analysis of the pharmacokinetics and pharmacodynamics of seratrodast in patients with mild to moderate asthma. Clinical pharmacology and therapeutics. 1997 Oct; 62(4):426-35. doi: 10.1016/s0009-9236(97)90121-1. [PMID: 9357394]
  • Z Hussein, E Samara, C S Locke, M A Orchard, G L Ringham, G R Granneman. Characterization of the pharmacokinetics and pharmacodynamics of a new oral thromboxane A2-receptor antagonist AA-2414 in normal subjects: population analysis. Clinical pharmacology and therapeutics. 1994 Apr; 55(4):441-50. doi: 10.1038/clpt.1994.54. [PMID: 8162671]
  • H Nagai, M Kumimoto, K Yoshitake, T Iwama, A Arimura, A Koda. The effect of three novel thromboxane A2 receptor antagonists (S-1452, AA-2414 and ONO-3708) on the increase in pulmonary pressure caused by Forssman anaphylaxis in guinea-pigs. Prostaglandins, leukotrienes, and essential fatty acids. 1992 Mar; 45(3):233-8. doi: 10.1016/0952-3278(92)90119-4. [PMID: 1534171]
  • Y Imura, Z Terashita, K Nishikawa. The role of thromboxane (TX) A2 in rabbit arterial thrombosis induced by endothelial damage. Thrombosis research. 1990 Jul; 59(1):195-205. doi: 10.1016/0049-3848(90)90284-j. [PMID: 2119075]
  • M Hashizume, D Kurokawa, S Nishii, F Yoshioka, S Hada, K Yasunaga. [Clinical study on the inhibitory effect of AA-2414 on platelet function in asthmatic patients]. Arerugi = [Allergy]. 1990 Jun; 39(6):509-19. doi: NULL. [PMID: 2145822]