senkyunolide I (BioDeep_00000183781)
human metabolite blood metabolite
代谢物信息卡片
3-butylidene-6,7-dihydroxy-1,3,4,5,6,7-hexahydro-2-benzofuran-1-one
化学式: C12H16O4 (224.10485359999998)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 6%
分子结构信息
SMILES: CCCC=C1OC(=O)C2=C1CCC(O)C2O
InChI: InChI=1S/C12H16O4/c1-2-3-4-9-7-5-6-8(13)11(14)10(7)12(15)16-9/h4,8,11,13-14H,2-3,5-6H2,1H3
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Min Wang, Hideki Hayashi, Ichiro Horinokita, Mayumi Asada, Yui Iwatani, Jun-Guo Ren, Jian-Xun Liu, Norio Takagi. Role of senkyunolide I in the promotion of neural stem/progenitor cell proliferation via the Akt/β-catenin pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Dec; 168(?):115683. doi:
10.1016/j.biopha.2023.115683. [PMID: 37832402] - Kaiwen Zhao, Hongqiao Zhu, Xiaomin He, Pengcheng Du, Taiping Liang, Yudong Sun, Zaiping Jing, Jian Zhou. Senkyunolide I ameliorates thoracic aortic aneurysm and dissection in mice via inhibiting the oxidative stress and apoptosis of endothelial cells.
Biochimica et biophysica acta. Molecular basis of disease.
2023 10; 1869(7):166819. doi:
10.1016/j.bbadis.2023.166819. [PMID: 37499930] - Yan Huang, Yan Wu, Hongxiang Yin, Leilei Du, Chu Chen. Senkyunolide I: A Review of Its Phytochemistry, Pharmacology, Pharmacokinetics, and Drug-Likeness.
Molecules (Basel, Switzerland).
2023 Apr; 28(8):. doi:
10.3390/molecules28083636. [PMID: 37110869] - Ya-Lin Zhu, Jie Huang, Xue-Ying Chen, Jian Xie, Qing Yang, Jia-Feng Wang, Xiao-Ming Deng. Senkyunolide I alleviates renal Ischemia-Reperfusion injury by inhibiting oxidative stress, endoplasmic reticulum stress and apoptosis.
International immunopharmacology.
2022 Jan; 102(?):108393. doi:
10.1016/j.intimp.2021.108393. [PMID: 34857480] - Yi-Feng Zha, Jian Xie, Peng Ding, Cheng-Long Zhu, Peng Li, Zhen-Zhen Zhao, Yong-Hua Li, Jia-Feng Wang. Senkyunolide I protect against lung injury via inhibiting formation of neutrophil extracellular trap in a murine model of cecal ligation and puncture.
International immunopharmacology.
2021 Oct; 99(?):107922. doi:
10.1016/j.intimp.2021.107922. [PMID: 34224996] - Min Wang, Hideki Hayashi, Ichiro Horinokita, Mayumi Asada, Yui Iwatani, Jian-Xun Liu, Norio Takagi. Neuroprotective effects of Senkyunolide I against glutamate-induced cells death by attenuating JNK/caspase-3 activation and apoptosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Aug; 140(?):111696. doi:
10.1016/j.biopha.2021.111696. [PMID: 34044281] - Qing Yang, Zhen-Zhen Zhao, Jian Xie, Yun-Peng Wang, Kai Yang, Yu Guo, Jia-Feng Wang, Xiao-Ming Deng. Senkyunolide I attenuates hepatic ischemia/reperfusion injury in mice via anti-oxidative, anti-inflammatory and anti-apoptotic pathways.
International immunopharmacology.
2021 Aug; 97(?):107717. doi:
10.1016/j.intimp.2021.107717. [PMID: 33933846] - Langdong Chen, Diya Lv, Shaozhan Wang, Dongyao Wang, Xiaofei Chen, Yue Liu, Zhanying Hong, Zhenyu Zhu, Yan Cao, Yifeng Chai. Surface Plasmon Resonance-Based Membrane Protein-Targeted Active Ingredients Recognition Strategy: Construction and Implementation in Ligand Screening from Herbal Medicines.
Analytical chemistry.
2020 03; 92(5):3972-3980. doi:
10.1021/acs.analchem.9b05479. [PMID: 32045214] - Xiaoqiong Xu, Tiantian Zhu, Tingting Shi, Juan Chen, Ling Jin. Quality suitability regionalization analysis of Angelica sinensis in Gansu, China.
PloS one.
2020; 15(12):e0243750. doi:
10.1371/journal.pone.0243750. [PMID: 33315941] - Lan Luo, Jiazhen Kang, Weijun Zhao, Yue Qi, Shengwang Liang. Validated LC-MS/MS method for simultaneous quantification of seven components of Naodesheng in rat serum after oral administration and its application to a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2019 Sep; 174(?):1-7. doi:
10.1016/j.jpba.2019.05.036. [PMID: 31153133] - Feipeng Duan, Wenjuan Xu, Jie Liu, Zhixin Jia, Kuikui Chen, Yijun Chen, Mingxia Wang, Kaiyue Ma, Jiaojiao Dong, Lianming Chen, Hongbin Xiao. Preparing the key metabolite of Z-ligustilide in vivo by a specific electrochemical reaction.
Journal of separation science.
2018 Jul; 41(13):2799-2807. doi:
10.1002/jssc.201800164. [PMID: 29663726] - Nating Zhang, Chen Cheng, Olajide E Olaleye, Yan Sun, Li Li, Yühong Huang, Feifei Du, Junling Yang, Fengqing Wang, Yanhong Shi, Fang Xu, Yanfen Li, Qi Wen, Naixia Zhang, Chuan Li. Pharmacokinetics-Based Identification of Potential Therapeutic Phthalides from XueBiJing, a Chinese Herbal Injection Used in Sepsis Management.
Drug metabolism and disposition: the biological fate of chemicals.
2018 06; 46(6):823-834. doi:
10.1124/dmd.117.079673. [PMID: 29523601] - Jin-Qi Li, Jia-Feng Wang, Jie Li, Shu-Han Zhang, Dan He, Rong-Sheng Tong, Shu-Ya She. A validated LC-MS/MS method for the determination of senkyunolide I in dog plasma and its application to a pharmacokinetic and bioavailability studies.
Biomedical chromatography : BMC.
2018 May; 32(5):e4182. doi:
10.1002/bmc.4182. [PMID: 29314089] - Qin Zheng, Yu Tang, Peng-Yi Hu, Dan Liu, Delin Zhang, Pengfei Yue, Yuanyuan Guo, Ming Yang. The influence and mechanism of ligustilide, senkyunolide I, and senkyunolide A on echinacoside transport through MDCK-MDR1 cells as blood-brain barrier in vitro model.
Phytotherapy research : PTR.
2018 Mar; 32(3):426-435. doi:
10.1002/ptr.5985. [PMID: 29193364] - Qiang Ma, Cong Ma, Fei Wu, Yao-Kun Xiong, Yi Feng, Shuang Liang. Preparation and structural determination of four metabolites of senkyunolide I in rats using ultra performance liquid chromatography/quadrupole-time-of-flight tandem mass and nuclear magnetic resonance spectra.
BMC complementary and alternative medicine.
2016 Dec; 16(1):504. doi:
10.1186/s12906-016-1472-7. [PMID: 27919258] - Peng-Yi Hu, Dan Liu, Qin Zheng, Qing Wu, Yu Tang, Ming Yang. Elucidation of Transport Mechanism of Paeoniflorin and the Influence of Ligustilide, Senkyunolide I and Senkyunolide A on Paeoniflorin Transport through Mdck-Mdr1 Cells as Blood-Brain Barrier in Vitro Model.
Molecules (Basel, Switzerland).
2016 Mar; 21(3):300. doi:
10.3390/molecules21030300. [PMID: 26950101] - Xu Zhao, Tiancheng Ma, Chenning Zhang, Shaohuai Shi, Sijiao Cui, Kaishun Bi, Ying Jia. Simultaneous determination of senkyunolide I and senkyunolide H in rat plasma by LC-MS: application to a comparative pharmacokinetic study in normal and migrainous rats after oral administration of Chuanxiong Rhizoma extract.
Biomedical chromatography : BMC.
2015 Sep; 29(9):1297-303. doi:
10.1002/bmc.3420. [PMID: 25620053] - Yangye Hu, Muyin Duan, Shuang Liang, Yuan Wang, Yi Feng. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3.
Brain research.
2015 Apr; 1605(?):39-48. doi:
10.1016/j.brainres.2015.02.015. [PMID: 25698615] - Ke Pei, Hao Cai, Xiao Liu, Sicong Tu, Gang Cao, Huan Li, Yingying Zhao, Xiaoqing Song, Yajing Lou, Fengxian Qiao, Baochang Cai. Evaluation of the influence of sulfur fumigation on the pharmacokinetics of four active ingredients in Si Wu Tang.
Journal of separation science.
2015 Jan; 38(1):25-33. doi:
10.1002/jssc.201400874. [PMID: 25354295] - Yanan Gai, Han Chen, Wenyuan Liu, Feng Feng, Ning Xie. The metabolism of YiGan San and subsequent pharmacokinetic evaluation of four metabolites in rat based on liquid chromatography with tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Dec; 972(?):22-8. doi:
10.1016/j.jchromb.2014.09.033. [PMID: 25306115] - Xiaochen Huang, Shulan Su, Wenxia Cui, Pei Liu, Jin-Ao Duan, Jianming Guo, Zhenhao Li, Erxin Shang, Dawei Qian, Zhijun Huang. Simultaneous determination of paeoniflorin, albiflorin, ferulic acid, tetrahydropalmatine, protopine, typhaneoside, senkyunolide I in Beagle dogs plasma by UPLC-MS/MS and its application to a pharmacokinetic study after Oral Administration of Shaofu Zhuyu Decoction.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Jul; 962(?):75-81. doi:
10.1016/j.jchromb.2014.05.032. [PMID: 24907546] - Jin-Liang Liu, Shun-Lin Zheng, Qiao-Jia Fan, Ji-Chao Yuan, Shi-Min Yang, Fan-Lei Kong. Optimization of high-pressure ultrasonic-assisted simultaneous extraction of six major constituents from Ligusticum chuanxiong rhizome using response surface methodology.
Molecules (Basel, Switzerland).
2014 Feb; 19(2):1887-911. doi:
10.3390/molecules19021887. [PMID: 24518807] - Xiao-Lin Zhang, Li-Fang Liu, Ling-Ying Zhu, Ying-Jia Bai, Qian Mao, Song-Lin Li, Shi-Lin Chen, Hong-Xi Xu. A high performance liquid chromatography fingerprinting and ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry chemical profiling approach to rapidly find characteristic chemical markers for quality evaluation of dispensing granules, a case study on Chuanxiong Rhizoma.
Journal of pharmaceutical and biomedical analysis.
2014 Jan; 88(?):391-400. doi:
10.1016/j.jpba.2013.09.023. [PMID: 24176743] - Yao-kun Xiong, Xiao Lin, Shuang Liang, Yan-long Hong, Lan Shen, Yi Feng. Identification of senkyunolide I metabolites in rats using ultra performance liquid chromatography/quadrupole-time-of-flight tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2013 Jul; 81-82(?):178-86. doi:
10.1016/j.jpba.2013.04.012. [PMID: 23666254] - Yao-Kun Xiong, Shuang Liang, Yan-Long Hong, Xiu-Juan Yang, Lan Shen, Yan Du, Yi Feng. [Preparation of ferulic acid, senkyunolide I and senkyunolide H from Ligusticum chuanxiong by preparative HPLC].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2013 Jun; 38(12):1947-50. doi:
". [PMID: 24066590] - Ai-Hua Zuo, Meng-Chun Cheng, Rong-Jie Zhuo, Li Wang, Hong-Bin Xiao. Structure elucidation of degradation products of Z-ligustilide by UPLC-QTOF-MS and NMR spectroscopy.
Yao xue xue bao = Acta pharmaceutica Sinica.
2013 Jun; 48(6):911-6. doi:
". [PMID: 23984528] - Wen-Juan Gao, Xue Wang, Chun-Jing Ma, Rong-Hua Dai, Kai-Shun Bi, Xiao-Hui Chen. [Comparative study on pharmacokinetics of senkyunolide I after administration of simple recipe and compound recipe in rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2013 Feb; 38(3):427-31. doi:
NULL. [PMID: 23668023] - Chun-Yong He, Shuo Wang, Yi Feng, Shuang Liang, Xiao Lin, De-Sheng Xu, Ke-Feng Ruan. Pharmacokinetics, tissue distribution and metabolism of senkyunolide I, a major bioactive component in Ligusticum chuanxiong Hort. (Umbelliferae).
Journal of ethnopharmacology.
2012 Aug; 142(3):706-13. doi:
10.1016/j.jep.2012.05.047. [PMID: 22668502] - Yi-Han Wang, Yan-Long Hong, Yi Feng, De-Sheng Xu, Shuang Liang, Xiao Lin, Lan Shen. Comparative pharmacokinetics of senkyunolide I in a rat model of migraine versus normal controls.
European journal of drug metabolism and pharmacokinetics.
2012 Jun; 37(2):91-7. doi:
10.1007/s13318-011-0073-6. [PMID: 22322984]