GlcCer(d18:1/16:0) (BioDeep_00000018378)

   

human metabolite Endogenous


代谢物信息卡片


N-[(2S,3R,4E)-3-hydroxy-1-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}octadec-4-en-2-yl]hexadecanamide

化学式: C40H77NO8 (699.5648882)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(feces) 88.86%

分子结构信息

SMILES: CCCCCCCCCCCCCC=CC(O)C(COC1OC(CO)C(O)C(O)C1O)NC(=O)CCCCCCCCCCCCCCC
InChI: InChI=1S/C40H77NO8/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-34(43)33(32-48-40-39(47)38(46)37(45)35(31-42)49-40)41-36(44)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h27,29,33-35,37-40,42-43,45-47H,3-26,28,30-32H2,1-2H3,(H,41,44)/b29-27+/t33-,34+,35+,37+,38-,39+,40+/m0/s1

描述信息

GlcCer(d18:1/16:0) is a glycosphingolipid (ceramide and oligosaccharide)or oligoglycosylceramide with one or more sialic acids (i.e. n-acetylneuraminic acid) linked on the sugar chain. It is a component the cell plasma membrane which modulates cell signal transduction events. Gangliosides have been found to be highly important in immunology. Ganglioside GL1a carries a net-negative charge at pH 7.0 and is acidic. Gangliosides can amount to 6\\% of the weight of lipids from brain, but they are found at low levels in all animal tissues.Cerebrosides are glycosphingolipids. There are four types of glycosphingolipids, the cerebrosides, sulfatides, globosides and gangliosides. Cerebrosides have a single sugar group linked to ceramide. The most common are galactocerebrosides (containing galactose), the least common are glucocerebrosides (containing glucose). Galactocerebrosides are found predominantly in neuronal cell membranes. In contrast glucocerebrosides are not normally found in membranes. Instead, they are typically intermediates in the synthesis or degradation of more complex glycosphingolipids. Galactocerebrosides are synthesized from ceramide and UDP-galactose. Excess lysosomal accumulation of glucocerebrosides is found in Gaucher disease.
A glycosphingolipid (ceramide and oligosaccharide)or oligoglycosylceramide with one or more sialic acids (i.e. n-acetylneuraminic acid) linked on the sugar chain. It is a component the cell plasma membrane which modulates cell signal transduction events. Gangliosides have been found to be highly important in immunology. Ganglioside GL1a carries a net-negative charge at pH 7.0 and is acidic. Gangliosides can amount to 6\\% of the weight of lipids from brain, but they are found at low levels in all animal tissues.

同义名列表

23 个代谢物同义名

N-[(2S,3R,4E)-3-hydroxy-1-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}octadec-4-en-2-yl]hexadecanamide; N-(hexadecanoyl)-1-beta-glucosyl-sphing-4-enine; beta-D-Glucosyl-N-hexadecanoylsphing-4E-enine; N-(Hexadecanoyl)-1-β-glucosyl-sphing-4-enine; N-(Hexadecanoyl)-1-b-glucosyl-sphing-4-enine; b-D-Glucosyl-N-hexadecanoylsphing-4E-enine; Β-D-glucosyl-N-hexadecanoylsphing-4E-enine; beta-D-Glucosyl-N-palmitoylsphinganine; b-D-Glucosyl-N-hexadecanoylsphingosine; 1-O-beta-delta-Glucopyranosyl-ceramide; Β-D-glucosyl-N-hexadecanoylsphingosine; Β-D-glucosyl-N-palmitoylsphinganine; b-D-Glucosyl-N-palmitoylsphinganine; 1-O-b-D-Glucopyranosyl-ceramide; Glucosylceramide (d18:1/16:0); Gaucher cerebroside; GlcCer(d18:1/16:0); Ganglioside GL1a; glucosylceramide; Glucocerebroside; GLC-beta1->1cer; GlcCeramide; FT-0668937



数据库引用编号

6 个数据库交叉引用编号

分类词条

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • K Saxena, R I Duclos, P K Sripada, G G Shipley. Unusual hydration properties of C16:0 sulfatide bilayer membranes. Biophysical journal. 2000 Jul; 79(1):385-93. doi: 10.1016/s0006-3495(00)76300-4. [PMID: 10866964]
  • K Saxena, R I Duclos, P Zimmermann, R R Schmidt, G G Shipley. Structure and properties of totally synthetic galacto- and gluco-cerebrosides. Journal of lipid research. 1999 May; 40(5):839-49. doi: 10.1016/s0022-2275(20)32119-2. [PMID: 10224153]
  • M J Ruocco, D J Siminovitch, J R Long, S K Das Gupta, R G Griffin. 2H and 13C nuclear magnetic resonance study of N-palmitoylgalactosylsphingosine (cerebroside)/cholesterol bilayers. Biophysical journal. 1996 Oct; 71(4):1776-88. doi: 10.1016/s0006-3495(96)79378-5. [PMID: 8889154]
  • J B Speyer, R T Weber, S K Das Gupta, R G Griffin. Anisotropic 2H NMR spin-lattice relaxation in L alpha-phase cerebroside bilayers. Biochemistry. 1989 Dec; 28(25):9569-74. doi: 10.1021/bi00451a003. [PMID: 2611249]
  • D J Siminovitch, M J Ruocco, E T Olejniczak, S K Das Gupta, R G Griffin. Anisotropic 2H-nuclear magnetic resonance spin-lattice relaxation in cerebroside- and phospholipid-cholesterol bilayer membranes. Biophysical journal. 1988 Sep; 54(3):373-81. doi: 10.1016/s0006-3495(88)82970-9. [PMID: 3207831]
  • M J Ruocco, G G Shipley. Interaction of cholesterol with galactocerebroside and galactocerebroside-phosphatidylcholine bilayer membranes. Biophysical journal. 1984 Dec; 46(6):695-707. doi: 10.1016/s0006-3495(84)84068-0. [PMID: 6518252]
  • M J Ruocco, D Atkinson, D M Small, R P Skarjune, E Oldfield, G G Shipley. X-ray diffraction and calorimetric study of anhydrous and hydrated N-palmitoylgalactosylsphingosine (cerebroside). Biochemistry. 1981 Oct; 20(21):5957-66. doi: 10.1021/bi00524a006. [PMID: 7306486]