Semax (BioDeep_00000183771)

   

human metabolite blood metabolite


代谢物信息卡片


1-[2-({1-[2-(2-{2-[2-amino-4-(methylsulfanyl)butanamido]-4-carboxybutanamido}-3-(3H-imidazol-4-yl)propanamido)-3-phenylpropanoyl]pyrrolidin-2-yl}formamido)acetyl]pyrrolidine-2-carboxylic acid

化学式: C37H51N9O10S (813.3479)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 100%

分子结构信息

SMILES: CSCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CCCC3C(=O)NCC(=O)N4CCCC4C(=O)O)N
InChI: InChI=1S/C37H51N9O10S/c1-57-16-13-24(38)32(50)42-25(11-12-31(48)49)33(51)43-26(18-23-19-39-21-41-23)34(52)44-27(17-22-7-3-2-4-8-22)36(54)46-15-5-9-28(46)35(53)40-20-30(47)45-14-6-10-29(45)37(55)56/h2-4,7-8,19,21,24-29H,5-6,9-18,20,38H2,1H3,(H,39,41)(H,40,53)(H,42,50)(H,43,51)(H,44,52)(H,48,49)(H,55,56)

描述信息

同义名列表

5 个代谢物同义名

1-[2-({1-[2-(2-{2-[2-amino-4-(methylsulfanyl)butanamido]-4-carboxybutanamido}-3-(3H-imidazol-4-yl)propanamido)-3-phenylpropanoyl]pyrrolidin-2-yl}formamido)acetyl]pyrrolidine-2-carboxylic acid; 1-[2-({1-[2-(2-{2-[2-amino-4-(methylsulfanyl)butanamido]-4-carboxybutanamido}-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanoyl]pyrrolidin-2-yl}formamido)acetyl]pyrrolidine-2-carboxylic acid; H-DL-Met-DL-Glu-DL-His-DL-Phe-DL-Pro-Gly-DL-Pro-OH; Pro-gly-pro-acth (4-7); Semax



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • M V Svishcheva, Ye S Mishina, O A Medvedeva, I I Bobyntsev, A Y Mukhina, P V Kalutskii, L A Andreeva, N F Myasoedov. Morphofunctional State of the Large Intestine in Rats under Conditions of Restraint Stress and Administration of Peptide ACTH(4-7)-PGP (Semax). Bulletin of experimental biology and medicine. 2021 Jan; 170(3):384-388. doi: 10.1007/s10517-021-05072-z. [PMID: 33459919]
  • E I Gusev, M Yu Martynov, E V Kostenko, L V Petrova, S N Bobyreva. [The efficacy of semax in the tretament of patients at different stages of ischemic stroke]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2018 ; 118(3. Vyp. 2):61-68. doi: 10.17116/jnevro20181183261-68. [PMID: 29798983]
  • A G Kobylyanskii, Yu A Zolotarev, L A Andreeva, I A Grivennikov, N F Myasoedov. Studying the Toxic Effects of Some Biologically Active Peptides on the Model of Mouse Embryonic Stem Cells. Bulletin of experimental biology and medicine. 2017 Oct; 163(6):731-736. doi: 10.1007/s10517-017-3891-y. [PMID: 29063333]
  • A V Ivanov, I I Bobyntsev, O M Shepeleva, A A Kryukov, L A Andreeva, N F Myasoedov. Influence of ACTG4-7-PGP (Semax) on Morphofunctional State of Hepatocytes in Chronic Emotional and Painful Stress. Bulletin of experimental biology and medicine. 2017 May; 163(1):105-108. doi: 10.1007/s10517-017-3748-4. [PMID: 28577097]
  • T V Vyunova, L A Andreeva, K V Shevchenko, N F Myasoedov. Synacton and individual activity of synthetic and natural corticotropins. Journal of molecular recognition : JMR. 2017 05; 30(5):. doi: 10.1002/jmr.2597. [PMID: 27921334]
  • I I Bobyntsev, O M Shepeleva, A A Kryukov, A V Ivanov, A E Belykh. [The effect of peptide ACTH4-7-PGP on functional hepatocyte state in rats in acute and chronic foot-shock stress]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 2015 Feb; 101(2):171-9. doi: NULL. [PMID: 26012109]
  • I Bobyntsev, A A Kryukov, M Shepeleva, A V Ivanov. [THE EFFECT OF ACTH-(4-7)-PGP PEPTIDE ON LIPID PEROXIDATION IN LIVER AND ACTIVITY OF SERUM TRANSAMINASES IN RATS UNDER ACUTE AND CHRONIC IMMOBILIZATION STRESS CONDITIONS]. Eksperimental'naia i klinicheskaia farmakologiia. 2015; 78(8):18-21. doi: NULL. [PMID: 26591577]
  • E V Dontsova. [POSSIBLE DRUG CORRECTION OF LIPID METABOLISM DISTURBANCES ASSOCIATED WITH METABOLIC SYNDROME IN PATIENTS WITH PSORIASIS]. Eksperimental'naia i klinicheskaia farmakologiia. 2015; 78(12):30-3. doi: NULL. [PMID: 27051926]
  • T V Vyunova, L A Andreeva, K V Shevchenko, V P Shevchenko, M Yu Bobrov, V V Bezuglov, N F Myasoedov. Characteristic features of specific binding of pentapeptide HFPGP labeled at the C-terminal proline residue to rat forebrain plasma membranes. Doklady. Biochemistry and biophysics. 2014 May; 456(1):101-3. doi: 10.1134/s1607672914030077. [PMID: 24993966]
  • A V Golubeva, S A Gavrilova, T V Lipina, M V Shornikova, A B Postnikov, L A Andreeva, Iu S Chentsov, V B Koshelev. [Protective effect of peptide semax the rat heart in acute myocardial infarction]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 2006 Jun; 92(6):732-45. doi: NULL. [PMID: 16967870]
  • Iu A Zolotarev, A K Dadaian, O V Dolotov, V S Kozik, N V Kost, O Iu Sokolov, E M Dorokhova, V K Meshavkin, L S Inozemtseva, M V Gabaeva, L A Andreeva, L Iu Alfeeva, T S Pavlov, K E Badmaeva, S E Badmaeva, Z V Bakaeva, G N Kopylova, G E Samonina, B V Vas'kovskiĭ, I A Grivennikov, A A Zozulia, N F Miasoedov. [Evenly tritium-labeled peptides and their in vivo and in vitro biodegradation]. Bioorganicheskaia khimiia. 2006 Mar; 32(2):183-91. doi: NULL. [PMID: 16637290]
  • L A Liapina, V E Pastorova, T Iu Obergan, G E Samonina, I P Ashmarin, N F Miasoedov. [Comparison of anticoagulant effects of regulatory proline-containing oligopeptides. Specificity of glyprolines, semax, and selank and potential of their practical application]. Izvestiia Akademii nauk. Seriia biologicheskaia. 2006 Mar; ?(2):193-203. doi: NULL. [PMID: 16634437]
  • O V Dolotov, Iu A Zolotarev, E M Dorokhova, L A Andreeva, L Iu Alfeeva, I A Grivennikov, N F Miasoedov. [The binding of Semax, ACTH 4-10 heptapeptide, to plasma membranes of the rat forebrain basal nuclei and its biodegradation]. Bioorganicheskaia khimiia. 2004 May; 30(3):241-6. doi: 10.1023/b:rubi.0000030127.46845.f0. [PMID: 15344653]
  • E V Koplik, Yu A Gryzunov, G E Dobretsov. Blood albumin in the mechanisms of individual resistance of rats to emotional stress. Neuroscience and behavioral physiology. 2003 Oct; 33(8):827-32. doi: 10.1023/a:1025109717945. [PMID: 14636000]
  • E V Koplik, Iu A Grysunov, G E Dobretsov. [Blood albumin in mechanisms of individual resistance of rats to emotional stress]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 2002 Jun; 88(6):707-14. doi: NULL. [PMID: 12154567]
  • E R Safarova, S I Shram, I A Grivennikov, N F Myasoedov. Trophic effects of nootropic peptide preparations cerebrolysin and semax on cultured rat pheochromocytoma. Bulletin of experimental biology and medicine. 2002 Apr; 133(4):401-3. doi: 10.1023/a:1016270626439. [PMID: 12124658]
  • K A Cherkasova, L A Lyapina, I P Ashmarin. Comparative study of modulatory effects of Semax and primary proline-containing peptides on hemostatic reactions. Bulletin of experimental biology and medicine. 2001 Jul; 132(1):625-6. doi: 10.1023/a:1012503606536. [PMID: 11687836]
  • N V Kost, O Iu Sokolov, M V Gabaeva, I A Grivennikov, L A Andreeva, N F Miasoedov, A A Zozulia. [Semax and selank inhibit the enkephalin-degrading enzymes from human serum]]. Bioorganicheskaia khimiia. 2001 May; 27(3):180-3. doi: 10.1023/a:1011373002885. [PMID: 11443939]
  • N A Bastrikova, S V Shestakova, S V Antonova, Ia V Krushinskaia, E N Goncharenko, N Iu Kudriashova, I S Novoderzhkina, N A Sokolova, V L Kozhura. [The biogenic amine content of rat tissues in the postresuscitation period following hemorrhagic shock and the effect of the preparation semax]. Patologicheskaia fiziologiia i eksperimental'naia terapiia. 1999 Jul; ?(3):19-22. doi: NULL. [PMID: 10498989]
  • V N Potaman, L Y Alfeeva, A A Kamensky, V N Nezavibatko. Degradation of ACTH/MSH(4-10) and its synthetic analog semax by rat serum enzymes: an inhibitor study. Peptides. 1993 May; 14(3):491-5. doi: 10.1016/0196-9781(93)90137-6. [PMID: 8392718]
  • V N Potaman, L Y Alfeeva, A A Kamensky, N G Levitzkaya, V N Nezavibatko. N-terminal degradation of ACTH(4-10) and its synthetic analog semax by the rat blood enzymes. Biochemical and biophysical research communications. 1991 Apr; 176(2):741-6. doi: 10.1016/s0006-291x(05)80247-5. [PMID: 1851003]