Secnidazole (BioDeep_00000183754)
human metabolite blood metabolite
代谢物信息卡片
1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
化学式: C7H11N3O3 (185.0800376)
中文名称: 塞克硝唑
谱图信息:
最多检出来源 Homo sapiens(blood) 7.69%
分子结构信息
SMILES: CC(O)CN1C(C)=NC=C1N(=O)=O
InChI: InChI=1S/C7H11N3O3/c1-5(11)4-9-6(2)8-3-7(9)10(12)13/h3,5,11H,4H2,1-2H3
描述信息
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01A - Agents against amoebiasis and other protozoal diseases > P01AB - Nitroimidazole derivatives
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:140628
- ChEBI: CHEBI:94433
- PubChem: 71815
- HMDB: HMDB0258202
- DrugBank: DB12834
- ChEMBL: CHEMBL498847
- Wikipedia: Secnidazole
- chemspider: 64839
- CAS: 3366-95-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Neveen Madbouly, Azza El Amir, Asmaa Abdel Kader, Ibraheem Rabee, Alyaa Farid. The immunomodulatory activity of secnidazole-nitazoxanide in a murine cryptosporidiosis model.
Journal of medical microbiology.
2021 Mar; 70(3):. doi:
10.1099/jmm.0.001327. [PMID: 33625354] - Oday T Ali, Wafaa S Hassan, Ahdab N Khayyat, Ahmad J Almalki, Mahmoud M Sebaiy. HPLC Determination of Imidazoles with Variant Anti-Infective Activity in Their Dosage Forms and Human Plasma.
Molecules (Basel, Switzerland).
2020 Dec; 26(1):. doi:
10.3390/molecules26010129. [PMID: 33396585] - Md Jamal Hossain, Mohammad A Rashid, Md Zakir Sultan. Transition Metal Chelation Augments the Half-life of Secnidazole: Molecular Docking and Fluorescence Spectroscopic Approaches.
Drug research.
2020 Dec; 70(12):583-592. doi:
10.1055/a-1252-2322. [PMID: 33098081] - R Cañete, A L Noda, M Rodríguez, K Brito, E Herrera, P-E Kofoed, J Ursing. 5-Nitroimidazole refractory giardiasis is common in Matanzas, Cuba and effectively treated by secnidazole plus high-dose mebendazole or quinacrine: a prospective observational cohort study.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2020 Aug; 26(8):1092.e1-1092.e6. doi:
10.1016/j.cmi.2019.12.017. [PMID: 31901492] - Andreia Volpato, Aleksandro S Da Silva, Regiane B Crecencio, Thainã Tomasi, Bruno F Fortuoso, Marluciana P Ribeiro, Rodrigo Secco, Wanderson A B Pereira, Nathieli B Bottari, Maria Rosa C Schetinger, Vera Maria M Morsch, Matheus D Baldissera, Lenita M Stefani, Gustavo Machado. A prophylactic protocol to stimulate the immune response also controls infectious disease and, consequently, minimizes diarrhea in newborn heifers.
Microbial pathogenesis.
2018 Aug; 121(?):262-268. doi:
10.1016/j.micpath.2018.05.031. [PMID: 29800701] - Andreia Volpato, Bruno F Fortuoso, Gabriela Campigotto, Patrícia Glombowsky, Nathieli B Bottari, Leandro S Lopes, Aleksandro Schafer Da Silva. Secnidazole for control of giardiasis in dairy calves.
Experimental parasitology.
2018 Jun; 189(?):16-18. doi:
10.1016/j.exppara.2018.04.008. [PMID: 29684664] - Helen S Pentikis, Nikki Adetoro. Two Phase 1, Open-Label, Single-Dose, Randomized, Crossover Studies to Assess the Pharmacokinetics, Safety, and Tolerability of Orally Administered Granules of Secnidazole (2 g) in Healthy Female Volunteers Under Different Administration Conditions.
Clinical pharmacology in drug development.
2018 06; 7(5):543-553. doi:
10.1002/cpdd.406. [PMID: 29125715] - Borje Darpo, Hongqi Xue, Nikki Adetoro, Barbara G Matthews, Helen S Pentikis. Thorough QT/QTc Evaluation of the Cardiac Safety of Secnidazole at Therapeutic and Supratherapeutic Doses in Healthy Individuals.
Journal of clinical pharmacology.
2018 03; 58(3):286-293. doi:
10.1002/jcph.1014. [PMID: 28967984] - M Li, R Li, Q Jin, J Pang, Z Xu. The efficacy of proanthocyanidins and secnidazole in the treatment of chronic periodontitis after scaling and root planing therapy.
Journal of biological regulators and homeostatic agents.
2017 Jan; 31(1):93-97. doi:
". [PMID: 28337876] - Jiangbo Du, Yifan Zhang, Yao Chen, Dongqin Liu, Xiaoyan Chen, Dafang Zhong. Enantioselective HPLC determination and pharmacokinetic study of secnidazole enantiomers in rats.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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10.1016/j.jchromb.2014.06.036. [PMID: 25049211] - Taufiqur R Bhuiyan, Feroza K Choudhury, Farhana Khanam, Amit Saha, Md Abu Sayeed, Umme Salma, Anna Lundgren, David A Sack, Ann-Mari Svennerholm, Firdausi Qadri. Evaluation of immune responses to an oral typhoid vaccine, Ty21a, in children from 2 to 5 years of age in Bangladesh.
Vaccine.
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Journal of medical microbiology.
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Veterinary parasitology.
2013 Sep; 196(1-2):203-5. doi:
10.1016/j.vetpar.2013.01.017. [PMID: 23394797] - Maria Elisabete A Moraes, Gilmara H Cunha, Mirna M Bezerra, Francisco V Fechine, Andréa V Pontes, Wanda S Andrade, Fernando A Frota Bezerra, Manoel O Moraes, Pacífica P Cavalcanti. Efficacy of the Mentha crispa in the treatment of women with Trichomonas vaginalis infection.
Archives of gynecology and obstetrics.
2012 Jul; 286(1):125-30. doi:
10.1007/s00404-012-2251-4. [PMID: 22350328] - Aleksandro S Da Silva, Verônica S P Castro, Alexandre A Tonin, Sabrina Brendler, Marcio M Costa, Jeandre A Jaques, Bianca Bertoletti, Régis A Zanette, Alceu G Raiser, Cinthia M Mazzanti, Sonia T A Lopes, Silvia G Monteiro. Secnidazole for the treatment of giardiasis in naturally infected cats.
Parasitology international.
2011 Dec; 60(4):429-32. doi:
10.1016/j.parint.2011.06.024. [PMID: 21763779] - Naracélia S B Teles, Francisco V Fechine, Fernando André C Viana, Ismenia O L Viana, Demétrius F Nascimento, Ana Lourdes A S Leite, Fernando Antônio Frota Bezerra, Manoel Odorico Moraes, Maria Elisabete A Moraes. Evaluation of the therapeutic efficacy of Mentha crispa in the treatment of giardiasis.
Contemporary clinical trials.
2011 Nov; 32(6):809-13. doi:
10.1016/j.cct.2011.08.005. [PMID: 21872682] - Luis Quihui, Gloria G Morales, Rosa O Méndez, Johanna G Leyva, Julián Esparza, Mauro E Valencia. Could giardiasis be a risk factor for low zinc status in schoolchildren from northwestern Mexico? A cross-sectional study with longitudinal follow-up.
BMC public health.
2010 Feb; 10(1):85. doi:
10.1186/1471-2458-10-85. [PMID: 20170531] - C Q Bilal, M S Khan, M Avais, M Ijaz, J A Khan. Prevalence and chemotherapy of Balantidium coli in cattle in the River Ravi region, Lahore (Pakistan).
Veterinary parasitology.
2009 Jul; 163(1-2):15-7. doi:
10.1016/j.vetpar.2009.04.023. [PMID: 19428186] - Rie Goto, C G Nicholas Mascie-Taylor, Peter G Lunn. Impact of anti-Giardia and anthelminthic treatment on infant growth and intestinal permeability in rural Bangladesh: a randomised double-blind controlled study.
Transactions of the Royal Society of Tropical Medicine and Hygiene.
2009 May; 103(5):520-9. doi:
10.1016/j.trstmh.2008.07.020. [PMID: 18789466] - Juan C Jiménez, Anthony Pinon, Daniel Dive, Monique Capron, Eduardo Dei-Cas, Jacinto Convit. Antibody response in children infected with Giardia intestinalis before and after treatment with Secnidazole.
The American journal of tropical medicine and hygiene.
2009 Jan; 80(1):11-5. doi:
10.4269/ajtmh.2009.80.11. [PMID: 19141831] - Xiaoyu Li, Jianguo Sun, Guangji Wang, Yuanting Zheng, Bei Yan, Haitang Xie, Yi Gu, Hongchan Ren. Determination of secnidazole in human plasma by high-performance liquid chromatography with UV detection and its application to the bioequivalence studies.
Biomedical chromatography : BMC.
2007 Mar; 21(3):304-9. doi:
10.1002/bmc.758. [PMID: 17221933] - De Qiu Zhu, Kai Li Hu, Wei Xing Tao, Liang Feng, Hu Duan, Xin Guo Jiang, Jun Chen. Evaluation of the bioequivalence and pharmacokinetics of two formulations of secnidazole after single oral administration in healthy volunteers.
Arzneimittel-Forschung.
2007; 57(11):723-6. doi:
10.1055/s-0031-1296674. [PMID: 18193695] - Leonila F Dans, Elizabeth G Martínez. Amoebic dysentery.
BMJ clinical evidence.
2007 Jan; 2007(?):. doi:
. [PMID: 19454043] - A A Escobedo, R Cañete, M E Gonzalez, A Pareja, S Cimerman, P Almirall. A randomized trial comparing mebendazole and secnidazole for the treatment of giardiasis.
Annals of tropical medicine and parasitology.
2003 Jul; 97(5):499-504. doi:
10.1179/000349803235002380. [PMID: 12930613] - N Girginkardeşler, S Coşkun, I Cüneyt Balcioğlu, P Ertan, U Z Ok. Dientamoeba fragilis, a neglected cause of diarrhea, successfully treated with secnidazole.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2003 Feb; 9(2):110-3. doi:
10.1046/j.1469-0691.2003.00504.x. [PMID: 12588330] - M C Di Prisco, J C Jiménez, N Rodríguez, V Costa, J Villamizar, A Silvera, M Carrillo, C Lira, E Zerpa, Y López. Clinical trial with Secnidazole in a single dose in Venezuelan children infected by Giardia intestinalis.
Investigacion clinica.
2000 Sep; 41(3):179-88. doi:
NULL. [PMID: 11029834] - A E Radi, A Hassanein. Determination of secnidazole in urine by adsorptive stripping voltammetry.
Chemical & pharmaceutical bulletin.
2000 May; 48(5):600-2. doi:
10.1248/cpb.48.600. [PMID: 10823692] - H Qureshi, R Baqai, I Mehdi, W Ahmed. Secnidazole response in amoebiasis and giardiasis.
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit.
1999 Mar; 5(2):389-90. doi:
NULL. [PMID: 10793818] - C C Cruz, L Ferrari, R Sogayar. [A therapeutic trial in Giardia muris infection in the mouse with metronidazole, tinidazole, secnidazole and furazolidone].
Revista da Sociedade Brasileira de Medicina Tropical.
1997 May; 30(3):223-8. doi:
10.1590/s0037-86821997000300009. [PMID: 9273569] - S K Ravi, M U Naidu, E C Sekhar, T R Rao, J C Shobha, P U Rani, K J Surya. Rapid and selective analysis of secnidazole in human plasma using high-performance liquid chromatography with ultraviolet detection.
Journal of chromatography. B, Biomedical sciences and applications.
1997 Mar; 691(1):208-11. doi:
10.1016/s0378-4347(96)00419-7. [PMID: 9140777] - R Baqai, H Qureshi, S J Zuberi. Secnidazole in the treatment of giardiasis.
JPMA. The Journal of the Pakistan Medical Association.
1995 Oct; 45(10):288. doi:
NULL. [PMID: 8714630] - G Omrani, A Rastegar-Lari, M Khamseh. Effect of single dose of secnidazole in treatment of intestinal amoebiasis.
JPMA. The Journal of the Pakistan Medical Association.
1995 Jun; 45(6):159. doi:
NULL. [PMID: 7474292] - H Tenenbaum, F J Cuisinier, A Le Liboux, E Pichard, G Montay, A Frydman. Secnidazole concentrations in plasma and crevicular fluid after a single oral dose.
Journal of clinical periodontology.
1993 Aug; 20(7):505-8. doi:
10.1111/j.1600-051x.1993.tb00398.x. [PMID: 8354725] - P Populaire, B Decouvelaere, A Renard, P Pasquier. [Study of serum concentrations and urinary excretion of secnidazole after oral administration in man. Comparison with tinidazole].
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