3-Tyr-octreotide (BioDeep_00000183744)

   

human metabolite blood metabolite


代谢物信息卡片


19-[(2-Amino-1-hydroxy-3-phenylpropylidene)amino]-10-(4-aminobutyl)-N-(1,3-dihydroxybutan-2-yl)-6,9,12,15,18-pentahydroxy-7-(1-hydroxyethyl)-16-[(4-hydroxyphenyl)methyl]-13-[(1H-indol-3-yl)methyl]-1,2-dithia-5,8,11,14,17-pentaazacycloicosa-5,8,11,14,17-pentaene-4-carboximidate

化学式: C49H66N10O11S2 (1034.4353726000002)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 92.86%

分子结构信息

SMILES: CC(C1C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=CC=C5)N)C(=O)NC(CO)C(C)O)O
InChI: InChI=1S/C49H66N10O11S2/c1-27(61)39(24-60)56-48(69)41-26-72-71-25-40(57-43(64)34(51)20-29-10-4-3-5-11-29)47(68)54-37(21-30-15-17-32(63)18-16-30)45(66)55-38(22-31-23-52-35-13-7-6-12-33(31)35)46(67)53-36(14-8-9-19-50)44(65)59-42(28(2)62)49(70)58-41/h3-7,10-13,15-18,23,27-28,34,36-42,52,60-63H,8-9,14,19-22,24-26,50-51H2,1-2H3,(H,53,67)(H,54,68)(H,55,66)(H,56,69)(H,57,64)(H,58,70)(H,59,65)

描述信息

同义名列表

7 个代谢物同义名

19-[(2-Amino-1-hydroxy-3-phenylpropylidene)amino]-10-(4-aminobutyl)-N-(1,3-dihydroxybutan-2-yl)-6,9,12,15,18-pentahydroxy-7-(1-hydroxyethyl)-16-[(4-hydroxyphenyl)methyl]-13-[(1H-indol-3-yl)methyl]-1,2-dithia-5,8,11,14,17-pentaazacycloicosa-5,8,11,14,17-pentaene-4-carboximidate; 19-(2-amino-3-phenylpropanamido)-10-(4-aminobutyl)-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-16-[(4-hydroxyphenyl)methyl]-13-[(1H-indol-3-yl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide; 19-(2-amino-3-phenylpropanamido)-10-(4-aminobutyl)-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide; (Tyr(3))octreotide; 3-Tyr-octreotide; Tyr-3-octreotide; Tyr(3)-SMS



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Indranil Banerjee, Kakali De, Dibyanti Mukherjee, Goutam Dey, Sankha Chattopadhyay, Manabendra Mukherjee, Mahitosh Mandal, Amal Kumar Bandyopadhyay, Amit Gupta, Santanu Ganguly, Mridula Misra. Paclitaxel-loaded solid lipid nanoparticles modified with Tyr-3-octreotide for enhanced anti-angiogenic and anti-glioma therapy. Acta biomaterialia. 2016 07; 38(?):69-81. doi: 10.1016/j.actbio.2016.04.026. [PMID: 27109765]
  • A Faron-Górecka, M Kuśmider, M Kolasa, D Żurawek, K Szafran-Pilch, P Gruca, P Pabian, J Solich, M Papp, M Dziedzicka-Wasylewska. Chronic mild stress alters the somatostatin receptors in the rat brain. Psychopharmacology. 2016 Jan; 233(2):255-66. doi: 10.1007/s00213-015-4103-y. [PMID: 26462807]
  • Kevin P Maresca, John C Marquis, Shawn M Hillier, Genliang Lu, Frank J Femia, Craig N Zimmerman, William C Eckelman, John L Joyal, John W Babich. Novel polar single amino acid chelates for technetium-99m tricarbonyl-based radiopharmaceuticals with enhanced renal clearance: application to octreotide. Bioconjugate chemistry. 2010 Jun; 21(6):1032-42. doi: 10.1021/bc900517x. [PMID: 20402463]
  • Bea Waser, Maria-Luisa Tamma, Renzo Cescato, Helmut R Maecke, Jean Claude Reubi. Highly efficient in vivo agonist-induced internalization of sst2 receptors in somatostatin target tissues. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2009 Jun; 50(6):936-41. doi: 10.2967/jnumed.108.061457. [PMID: 19443580]
  • P P Surujpaul, C Gutiérrez-Wing, B Ocampo-García, F de M Ramírez, C Arteaga de Murphy, M Pedraza-López, M A Camacho-López, G Ferro-Flores. Gold nanoparticles conjugated to [Tyr3]octreotide peptide. Biophysical chemistry. 2008 Dec; 138(3):83-90. doi: 10.1016/j.bpc.2008.09.005. [PMID: 18819743]
  • Margret Schottelius, Hans-Jürgen Wester, Jean Claude Reubi, Reingard Senekowitsch-Schmidtke, Markus Schwaiger. Improvement of pharmacokinetics of radioiodinated Tyr(3)-octreotide by conjugation with carbohydrates. Bioconjugate chemistry. 2002 Sep; 13(5):1021-30. doi: 10.1021/bc0200069. [PMID: 12236784]
  • Theodosia Maina, Berthold Nock, Anastasia Nikolopoulou, Petros Sotiriou, George Loudos, Dimitrios Maintas, Paul Cordopatis, Efstratios Chiotellis. [99mTc]Demotate, a new 99mTc-based [Tyr3]octreotate analogue for the detection of somatostatin receptor-positive tumours: synthesis and preclinical results. European journal of nuclear medicine and molecular imaging. 2002 Jun; 29(6):742-53. doi: 10.1007/s00259-002-0782-9. [PMID: 12029547]
  • Klaus-Peter Eisenwiener, M I M Prata, I Buschmann, Han-Wen Zhang, A C Santos, Sandra Wenger, Jean Claude Reubi, Helmut R Mäcke. NODAGATOC, a new chelator-coupled somatostatin analogue labeled with [67/68Ga] and [111In] for SPECT, PET, and targeted therapeutic applications of somatostatin receptor (hsst2) expressing tumors. Bioconjugate chemistry. 2002 May; 13(3):530-41. doi: 10.1021/bc010074f. [PMID: 12009943]
  • Hans-Jürgen Wester, Margret Schottelius, Klemens Scheidhauer, Jean-Claude Reubi, Ingo Wolf, Markus Schwaiger. Comparison of radioiodinated TOC, TOCA and Mtr-TOCA: the effect of carbohydration on the pharmacokinetics. European journal of nuclear medicine and molecular imaging. 2002 Jan; 29(1):28-38. doi: 10.1007/s00259-001-0669-1. [PMID: 11807604]
  • M de Jong, W A Breeman, B F Bernard, W H Bakker, M Schaar, A van Gameren, J E Bugaj, J Erion, M Schmidt, A Srinivasan, E P Krenning. [177Lu-DOTA(0),Tyr3] octreotate for somatostatin receptor-targeted radionuclide therapy. International journal of cancer. 2001 Jun; 92(5):628-33. doi: 10.1002/1097-0215(20010601)92:5<628::aid-ijc1244>3.0.co;2-l. [PMID: 11340564]
  • S Froidevaux, M Meier, M Häusler, H Mäcke, C Beglinger, A N Eberle. A microplate binding assay for the somatostatin type-2 receptor (SSTR2). Journal of receptor and signal transduction research. 1999 Jan; 19(1-4):167-80. doi: 10.3109/10799899909036643. [PMID: 10071756]
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