4-Amino-5-oxopentanamide (BioDeep_00000183726)
human metabolite blood metabolite
代谢物信息卡片
化学式: C5H10N2O2 (130.07422400000002)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 4.11%
分子结构信息
SMILES: C(CC(=O)N)C(C=O)N
InChI: InChI=1S/C5H10N2O2/c6-4(3-8)1-2-5(7)9/h3-4H,1-2,6H2,(H2,7,9)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Effie S Mutasa-Göttgens, Anagha Joshi, Helen F Holmes, Peter Hedden, Berthold Göttgens. A new RNASeq-based reference transcriptome for sugar beet and its application in transcriptome-scale analysis of vernalization and gibberellin responses.
BMC genomics.
2012 Mar; 13(?):99. doi:
10.1186/1471-2164-13-99
. [PMID: 22429863] - Stephan Schilling, Stephanie Kohlmann, Christoph Bäuscher, Reinhard Sedlmeier, Birgit Koch, Rico Eichentopf, Andreas Becker, Holger Cynis, Torsten Hoffmann, Sabine Berg, Ernst-Joachim Freyse, Stephan von Hörsten, Steffen Rossner, Sigrid Graubner, Hans-Ulrich Demuth. Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development.
The Journal of biological chemistry.
2011 Apr; 286(16):14199-208. doi:
10.1074/jbc.m111.229385
. [PMID: 21330373] - David Ruiz Carrillo, Christoph Parthier, Nadine Jänckel, Julia Grandke, Marco Stelter, Stephan Schilling, Mathias Boehme, Piotr Neumann, Raik Wolf, Hans-Ulrich Demuth, Milton T Stubbs, Jens-Ulrich Rahfeld. Kinetic and structural characterization of bacterial glutaminyl cyclases from Zymomonas mobilis and Myxococcus xanthus.
Biological chemistry.
2010 Dec; 391(12):1419-28. doi:
10.1515/bc.2010.130
. [PMID: 20868223] - Manjeet Deshmukh, Yashveer Singh, Simi Gunaseelan, Dayuan Gao, Stanley Stein, Patrick J Sinko. Biodegradable poly(ethylene glycol) hydrogels based on a self-elimination degradation mechanism.
Biomaterials.
2010 Sep; 31(26):6675-84. doi:
10.1016/j.biomaterials.2010.05.021
. [PMID: 20561680] - Wei-Lin Huang, Yu-Ruei Wang, Tzu-Ping Ko, Cho-Yun Chia, Kai-Fa Huang, Andrew H-J Wang. Crystal structure and functional analysis of the glutaminyl cyclase from Xanthomonas campestris.
Journal of molecular biology.
2010 Aug; 401(3):374-88. doi:
10.1016/j.jmb.2010.06.012
. [PMID: 20558177] - Enrico Cappellini, M Thomas P Gilbert, Filippo Geuna, Girolamo Fiorentino, Allan Hall, Jane Thomas-Oates, Peter D Ashton, David A Ashford, Paul Arthur, Paula F Campos, Johan Kool, Eske Willerslev, Matthew J Collins. A multidisciplinary study of archaeological grape seeds.
Die Naturwissenschaften.
2010 Feb; 97(2):205-17. doi:
10.1007/s00114-009-0629-3
. [PMID: 20033124] - Sara Monteiro, Regina Freitas, Baru T Rajasekhar, Artur R Teixeira, Ricardo B Ferreira. The unique biosynthetic route from lupinus beta-conglutin gene to blad.
PloS one.
2010 Jan; 5(1):e8542. doi:
10.1371/journal.pone.0008542
. [PMID: 20066045] - Maike Hartlage-Rübsamen, Katharina Staffa, Alexander Waniek, Michael Wermann, Torsten Hoffmann, Holger Cynis, Stephan Schilling, Hans-Ulrich Demuth, Steffen Rossner. Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.
2009 Dec; 27(8):825-35. doi:
10.1016/j.ijdevneu.2009.08.007
. [PMID: 19699792] - Ahmed Besheer, Thomas C Hertel, Jörg Kressler, Karsten Mäder, Markus Pietzsch. Enzymatically catalyzed HES conjugation using microbial transglutaminase: Proof of feasibility.
Journal of pharmaceutical sciences.
2009 Nov; 98(11):4420-8. doi:
10.1002/jps.21675
. [PMID: 19156844] - Stephan Schilling, Claus Wasternack, Hans-Ulrich Demuth. Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution.
Biological chemistry.
2008 Aug; 389(8):983-91. doi:
10.1515/bc.2008.111
. [PMID: 18979624] - Holger Cynis, Eike Scheel, Takaomi C Saido, Stephan Schilling, Hans-Ulrich Demuth. Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta.
Biochemistry.
2008 Jul; 47(28):7405-13. doi:
10.1021/bi800250p
. [PMID: 18570439] - Stephan Schilling, Irene Stenzel, Alex von Bohlen, Michael Wermann, Katrin Schulz, Hans-Ulrich Demuth, Claus Wasternack. Isolation and characterization of the glutaminyl cyclases from Solanum tuberosum and Arabidopsis thaliana: implications for physiological functions.
Biological chemistry.
2007 Feb; 388(2):145-53. doi:
10.1515/bc.2007.016
. [PMID: 17261077] - René Wintjens, Hassan Belrhali, Bernard Clantin, Mohamed Azarkan, Coralie Bompard, Danielle Baeyens-Volant, Yvan Looze, Vincent Villeret. Crystal structure of papaya glutaminyl cyclase, an archetype for plant and bacterial glutaminyl cyclases.
Journal of molecular biology.
2006 Mar; 357(2):457-70. doi:
10.1016/j.jmb.2005.12.029
. [PMID: 16438985] - Lihua Huang, Jirong Lu, Victor J Wroblewski, John M Beals, Ralph M Riggin. In vivo deamidation characterization of monoclonal antibody by LC/MS/MS.
Analytical chemistry.
2005 Mar; 77(5):1432-9. doi:
10.1021/ac0494174
. [PMID: 15732928] - Mohamed Azarkan, Bernard Clantin, Coralie Bompard, Hassan Belrhali, Danielle Baeyens-Volant, Yvan Looze, Vincent Villeret, René Wintjens. Crystallization and preliminary X-ray diffraction studies of the glutaminyl cyclase from Carica papaya latex.
Acta crystallographica. Section F, Structural biology and crystallization communications.
2005 Jan; 61(Pt 1):59-61. doi:
10.1107/s1744309104025904
. [PMID: 16508091] - Mohamed Azarkan, René Wintjens, Yvan Looze, Danielle Baeyens-Volant. Detection of three wound-induced proteins in papaya latex.
Phytochemistry.
2004 Mar; 65(5):525-34. doi:
10.1016/j.phytochem.2003.12.006
. [PMID: 15003415] - Stephan Schilling, Susanne Manhart, Torsten Hoffmann, Hans-Henning Ludwig, Claus Wasternack, Hans-Ulrich Demuth. Substrate specificity of glutaminyl cyclases from plants and animals.
Biological chemistry.
2003 Dec; 384(12):1583-92. doi:
10.1515/bc.2003.175
. [PMID: 14719800] - Stephan Schilling, Torsten Hoffmann, Fred Rosche, Susanne Manhart, Claus Wasternack, Hans-Ulrich Demuth. Heterologous expression and characterization of human glutaminyl cyclase: evidence for a disulfide bond with importance for catalytic activity.
Biochemistry.
2002 Sep; 41(35):10849-57. doi:
10.1021/bi0260381
. [PMID: 12196024]