2-Amino-4-methylsulfanylbutanal (BioDeep_00000183701)
human metabolite blood metabolite
代谢物信息卡片
2-amino-4-(methylsulfanyl)butanal
化学式: C5H11NOS (133.05613160000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CSCCC(C=O)N
InChI: InChI=1S/C5H11NOS/c1-8-3-2-5(6)4-7/h4-5H,2-3,6H2,1H3
描述信息
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Camille Vatier, Jean-François Gautier, Corinne Vigouroux. Therapeutic use of recombinant methionyl human leptin.
Biochimie.
2012 Oct; 94(10):2116-25. doi:
10.1016/j.biochi.2012.03.013. [PMID: 22464954] - Aaron J Oakley, Surabhi Bhatia, Heath Ecroyd, Brett Garner. Molecular dynamics analysis of apolipoprotein-D-lipid hydroperoxide interactions: mechanism for selective oxidation of Met-93.
PloS one.
2012; 7(3):e34057. doi:
10.1371/journal.pone.0034057. [PMID: 22479522] - Elizabeth Sienkiewicz, Faidon Magkos, Konstantinos N Aronis, Mary Brinkoetter, John P Chamberland, Sharon Chou, Kalliopi M Arampatzi, Chuanyun Gao, Anastasia Koniaris, Christos S Mantzoros. Long-term metreleptin treatment increases bone mineral density and content at the lumbar spine of lean hypoleptinemic women.
Metabolism: clinical and experimental.
2011 Sep; 60(9):1211-21. doi:
10.1016/j.metabol.2011.05.016. [PMID: 21741057] - Bettina Mittendorfer, Jeffrey F Horowitz, Alex M DePaoli, Mark A McCamish, Bruce W Patterson, Samuel Klein. Recombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetes.
Diabetes.
2011 May; 60(5):1474-7. doi:
10.2337/db10-1302. [PMID: 21411512] - G Paz-Filho, M-L Wong, J Licinio. Ten years of leptin replacement therapy.
Obesity reviews : an official journal of the International Association for the Study of Obesity.
2011 May; 12(5):e315-23. doi:
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Clinical pharmacokinetics.
2011 May; 50(5):295-306. doi:
10.2165/11586040-000000000-00000. [PMID: 21456630] - Wen-Cheng Li, Kuang-Yu Hsiao, I-Chuan Chen, Yu-Che Chang, Shih-Hao Wang, Kuan-Han Wu. Serum leptin is associated with cardiometabolic risk and predicts metabolic syndrome in Taiwanese adults.
Cardiovascular diabetology.
2011 Apr; 10(?):36. doi:
10.1186/1475-2840-10-36. [PMID: 21526991] - Olav A Christophersen, Anna Haug. Animal products, diseases and drugs: a plea for better integration between agricultural sciences, human nutrition and human pharmacology.
Lipids in health and disease.
2011 Jan; 10(?):16. doi:
10.1186/1476-511x-10-16. [PMID: 21247506] - Jörg Hofmann, Frederik Börnke, Alfred Schmiedl, Tatjana Kleine, Uwe Sonnewald. Detecting functional groups of Arabidopsis mutants by metabolic profiling and evaluation of pleiotropic responses.
Frontiers in plant science.
2011; 2(?):82. doi:
10.3389/fpls.2011.00082. [PMID: 22639613] - Hee-Jeong Jeong, Jeong Sheop Shin, Sung Han Ok. Barley DNA-binding methionine aminopeptidase, which changes the localization from the nucleus to the cytoplasm by low temperature, is involved in freezing tolerance.
Plant science : an international journal of experimental plant biology.
2011 Jan; 180(1):53-60. doi:
10.1016/j.plantsci.2010.09.004. [PMID: 21421347] - Eugenia Villa-Cuesta, Joan M Boylan, Marc Tatar, Philip A Gruppuso. Resveratrol inhibits protein translation in hepatic cells.
PloS one.
2011; 6(12):e29513. doi:
10.1371/journal.pone.0029513. [PMID: 22242130] - Lisa A Brennan, Wanda Lee, Marc Kantorow. TXNL6 is a novel oxidative stress-induced reducing system for methionine sulfoxide reductase a repair of α-crystallin and cytochrome C in the eye lens.
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2010 Nov; 5(11):e15421. doi:
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The FEBS journal.
2010 Sep; 277(17):3596-607. doi:
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The Plant journal : for cell and molecular biology.
2010 Aug; 63(4):636-50. doi:
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European journal of nuclear medicine and molecular imaging.
2010 Feb; 37(2):250-9. doi:
10.1007/s00259-009-1263-1. [PMID: 19763566] - Sara Monteiro, Regina Freitas, Baru T Rajasekhar, Artur R Teixeira, Ricardo B Ferreira. The unique biosynthetic route from lupinus beta-conglutin gene to blad.
PloS one.
2010 Jan; 5(1):e8542. doi:
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Diabetologia.
2010 Jan; 53(1):27-35. doi:
10.1007/s00125-009-1502-9. [PMID: 19727665] - Shane C Hardin, Clayton T Larue, Man-Ho Oh, Vanita Jain, Steven C Huber. Coupling oxidative signals to protein phosphorylation via methionine oxidation in Arabidopsis.
The Biochemical journal.
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PloS one.
2009 Jul; 4(7):e6464. doi:
10.1371/journal.pone.0006464. [PMID: 19649253] - V P Andreev, G Paz-Filho, M-L Wong, J Licinio. Deconvolution of insulin secretion, insulin hepatic extraction post-hepatic delivery rates and sensitivity during 24-hour standardized meals: time course of glucose homeostasis in leptin replacement treatment.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2009 Feb; 41(2):142-51. doi:
10.1055/s-0028-1082048. [PMID: 18726828] - Andre Schmoller, Michaela Voss, Hartmut Gehring, Sebastian Rudolf, Ulrich Schweiger, Bernd Schultes, Kerstin M Oltmanns. Short Hypoxia Does not Affect Plasma Leptin in Healthy Men under Euglycemic Clamp Conditions.
International journal of endocrinology.
2009; 2009(?):270698. doi:
10.1155/2009/270698. [PMID: 19946426] - Heinz Lubenau, Peter Bias, Anne-Katrin Maly, Karl Ernst Siegler, Kai Mehltretter. Pharmacokinetic and pharmacodynamic profile of new biosimilar filgrastim XM02 equivalent to marketed filgrastim Neupogen: single-blind, randomized, crossover trial.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy.
2009; 23(1):43-51. doi:
10.2165/00063030-200923010-00005. [PMID: 19344191] - Caitriona McLean, Catherine M Greene, Noel G McElvaney. Gene targeted therapeutics for liver disease in alpha-1 antitrypsin deficiency.
Biologics : targets & therapy.
2009; 3(?):63-75. doi:
10.2147/btt.s4718. [PMID: 19707397] - Sanghamitra Mitra, Kathleen M Job, Lu Meng, Brian Bennett, Richard C Holz. Analyzing the catalytic role of Asp97 in the methionine aminopeptidase from Escherichia coli.
The FEBS journal.
2008 Dec; 275(24):6248-59. doi:
10.1111/j.1742-4658.2008.06749.x. [PMID: 19019076] - Jean-Marc Guettier, Jean Y Park, Elaine K Cochran, Christine Poitou, Arnaud Basdevant, Muriel Meier, Karine Clément, Jocelyne Magré, Phillip Gorden. Leptin therapy for partial lipodystrophy linked to a PPAR-gamma mutation.
Clinical endocrinology.
2008 Apr; 68(4):547-554. doi:
10.1111/j.1365-2265.2007.03095.x. [PMID: 18076675] - Max Andresen, Tomas Regueira, Alejandro Bruhn, Druso Perez, Pablo Strobel, Alberto Dougnac, Guillermo Marshall, Federico Leighton. Lipoperoxidation and protein oxidative damage exhibit different kinetics during septic shock.
Mediators of inflammation.
2008; 2008(?):168652. doi:
10.1155/2008/168652. [PMID: 18566692] - Jean L Chan, Shekman L Wong, Christos S Mantzoros. Pharmacokinetics of subcutaneous recombinant methionyl human leptin administration in healthy subjects in the fed and fasting states: regulation by gender and adiposity.
Clinical pharmacokinetics.
2008; 47(11):753-64. doi:
10.2165/00003088-200847110-00006. [PMID: 18840030] - Julien Dutheil, Nicolas Galtier. Detecting groups of coevolving positions in a molecule: a clustering approach.
BMC evolutionary biology.
2007 Nov; 7(?):242. doi:
10.1186/1471-2148-7-242. [PMID: 18053141] - Xiaoyi Hu, Yongjun Dang, Karen Tenney, Phillip Crews, Chiawei W Tsai, Katherine M Sixt, Philip A Cole, Jun O Liu. Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases.
Chemistry & biology.
2007 Jul; 14(7):764-74. doi:
10.1016/j.chembiol.2007.05.010. [PMID: 17656313] - Jean Y Park, Edward D Javor, Elaine K Cochran, Alex M DePaoli, Phillip Gorden. Long-term efficacy of leptin replacement in patients with Dunnigan-type familial partial lipodystrophy.
Metabolism: clinical and experimental.
2007 Apr; 56(4):508-16. doi:
10.1016/j.metabol.2006.11.010. [PMID: 17379009] - Eric O Uthus, Jackob Moskovitz. Specific activity of methionine sulfoxide reductase in CD-1 mice is significantly affected by dietary selenium but not zinc.
Biological trace element research.
2007 Mar; 115(3):265-76. doi:
10.1007/bf02686001. [PMID: 17625247] - Jean L Chan, Joseph E Mietus, Patricia M Raciti, Ary L Goldberger, Christos S Mantzoros. Short-term fasting-induced autonomic activation and changes in catecholamine levels are not mediated by changes in leptin levels in healthy humans.
Clinical endocrinology.
2007 Jan; 66(1):49-57. doi:
10.1111/j.1365-2265.2006.02684.x. [PMID: 17201801] - Eunju Park, Min-Jeong Shin, Namsik Chung. The associations between serum leptin, adiponectin and intercellular adhesion molecule-1 in hypercholesterolemic patients.
Nutrition research and practice.
2007; 1(1):65-9. doi:
10.4162/nrp.2007.1.1.65. [PMID: 20535388] - Jennifer H Lee, Jean L Chan, Epaminondas Sourlas, Vassilios Raptopoulos, Christos S Mantzoros. Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy.
The Journal of clinical endocrinology and metabolism.
2006 Jul; 91(7):2605-11. doi:
10.1210/jc.2005-1545. [PMID: 16636130] - CongHui You, HongYan Lu, Agnieszka Sekowska, Gang Fang, YiPing Wang, Anne-Marie Gilles, Antoine Danchin. The two authentic methionine aminopeptidase genes are differentially expressed in Bacillus subtilis.
BMC microbiology.
2005 Oct; 5(?):57. doi:
10.1186/1471-2180-5-57. [PMID: 16207374] - Bridget Canavan, Raneem O Salem, Sunita Schurgin, Polyxeni Koutkia, Izabella Lipinska, Michael Laposata, Steven Grinspoon. Effects of physiological leptin administration on markers of inflammation, platelet activation, and platelet aggregation during caloric deprivation.
The Journal of clinical endocrinology and metabolism.
2005 Oct; 90(10):5779-85. doi:
10.1210/jc.2005-0780. [PMID: 16076944] - Edward D Javor, Elaine K Cochran, Carla Musso, Janice Ryan Young, Alex M Depaoli, Phillip Gorden. Long-term efficacy of leptin replacement in patients with generalized lipodystrophy.
Diabetes.
2005 Jul; 54(7):1994-2002. doi:
10.2337/diabetes.54.7.1994. [PMID: 15983199] - Edward D Javor, Marc G Ghany, Elaine K Cochran, Elif Arioglu Oral, Alex M DePaoli, Ahalya Premkumar, David E Kleiner, Phillip Gorden. Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy.
Hepatology (Baltimore, Md.).
2005 Apr; 41(4):753-60. doi:
10.1002/hep.20672. [PMID: 15791619] - Jean L Chan, Stergios J Moschos, John Bullen, Kathleen Heist, Xian Li, Young-Bum Kim, Barbara B Kahn, Christos S Mantzoros. Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-alpha receptor levels in humans with relative leptin deficiency.
The Journal of clinical endocrinology and metabolism.
2005 Mar; 90(3):1625-31. doi:
10.1210/jc.2004-1823. [PMID: 15613409] - Jean L Chan, John Bullen, Violeta Stoyneva, Alex M Depaoli, Carol Addy, Christos S Mantzoros. Recombinant methionyl human leptin administration to achieve high physiologic or pharmacologic leptin levels does not alter circulating inflammatory marker levels in humans with leptin sufficiency or excess.
The Journal of clinical endocrinology and metabolism.
2005 Mar; 90(3):1618-24. doi:
10.1210/jc.2004-1921. [PMID: 15613407] - Carla Musso, Elaine Cochran, Edward Javor, Janice Young, Alex M Depaoli, Phillip Gorden. The long-term effect of recombinant methionyl human leptin therapy on hyperandrogenism and menstrual function in female and pituitary function in male and female hypoleptinemic lipodystrophic patients.
Metabolism: clinical and experimental.
2005 Feb; 54(2):255-63. doi:
10.1016/j.metabol.2004.08.021. [PMID: 15690321] - Alina Gavrila, Jean L Chan, Lisa C Miller, Kathleen Heist, Nikos Yiannakouris, Christos S Mantzoros. Circulating melanin-concentrating hormone, agouti-related protein, and alpha-melanocyte-stimulating hormone levels in relation to body composition: alterations in response to food deprivation and recombinant human leptin administration.
The Journal of clinical endocrinology and metabolism.
2005 Feb; 90(2):1047-54. doi:
10.1210/jc.2004-1124. [PMID: 15546902] - Simon Ross, Carmela Giglione, Michèle Pierre, Christelle Espagne, Thierry Meinnel. Functional and developmental impact of cytosolic protein N-terminal methionine excision in Arabidopsis.
Plant physiology.
2005 Feb; 137(2):623-37. doi:
10.1104/pp.104.056861. [PMID: 15681659] - Corrine K Welt, Jean L Chan, John Bullen, Robyn Murphy, Patricia Smith, Alex M DePaoli, Aspasia Karalis, Christos S Mantzoros. Recombinant human leptin in women with hypothalamic amenorrhea.
The New England journal of medicine.
2004 Sep; 351(10):987-97. doi:
10.1056/nejmoa040388. [PMID: 15342807] - Jennifer R McDuffie, Patti A Riggs, Karim A Calis, Renee J Freedman, Elif A Oral, Alex M DePaoli, Jack A Yanovski. Effects of exogenous leptin on satiety and satiation in patients with lipodystrophy and leptin insufficiency.
The Journal of clinical endocrinology and metabolism.
2004 Sep; 89(9):4258-63. doi:
10.1210/jc.2003-031868. [PMID: 15356018] - Elaine Cochran, Janice Ryan Young, Nancy Sebring, Alex DePaoli, Elif Arioglu Oral, Phillip Gorden. Efficacy of recombinant methionyl human leptin therapy for the extreme insulin resistance of the Rabson-Mendenhall syndrome.
The Journal of clinical endocrinology and metabolism.
2004 Apr; 89(4):1548-54. doi:
10.1210/jc.2003-031952. [PMID: 15070911] - Alexandre Serero, Carmela Giglione, Alessandro Sardini, Juan Martinez-Sanz, Thierry Meinnel. An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway.
The Journal of biological chemistry.
2003 Dec; 278(52):52953-63. doi:
10.1074/jbc.m309770200. [PMID: 14532271] - Danielle N McLennan, Christopher J H Porter, Glenn A Edwards, Maria Brumm, Steven W Martin, Susan A Charman. Pharmacokinetic model to describe the lymphatic absorption of r-metHu-leptin after subcutaneous injection to sheep.
Pharmaceutical research.
2003 Aug; 20(8):1156-62. doi:
10.1023/a:1025036611949. [PMID: 12948012] - Jean L Chan, Kathleen Heist, Alex M DePaoli, Johannes D Veldhuis, Christos S Mantzoros. The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men.
The Journal of clinical investigation.
2003 May; 111(9):1409-21. doi:
10.1172/jci17490. [PMID: 12727933] - Satoru Koyanagi, Hiroo Nakagawa, Yukako Kuramoto, Shigehiro Ohdo, Shinji Soeda, Hiroshi Shimeno. Optimizing the dosing schedule of TNP-470 [O-(chloroacetyl-carbamoyl) fumagillol] enhances its antitumor and antiangiogenic efficacies.
The Journal of pharmacology and experimental therapeutics.
2003 Feb; 304(2):669-74. doi:
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The Journal of clinical endocrinology and metabolism.
2002 Nov; 87(11):4942-5. doi:
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Equine veterinary journal. Supplement.
2002 Sep; ?(34):496-501. doi:
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Protein and peptide letters.
2002 Aug; 9(4):295-303. doi:
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Brain research.
2002 Jul; 944(1-2):195-9. doi:
10.1016/s0006-8993(02)02881-0. [PMID: 12106680] - Elif Arioglu Oral, Vinaya Simha, Elaine Ruiz, Alexa Andewelt, Ahalya Premkumar, Peter Snell, Anthony J Wagner, Alex M DePaoli, Marc L Reitman, Simeon I Taylor, Phillip Gorden, Abhimanyu Garg. Leptin-replacement therapy for lipodystrophy.
The New England journal of medicine.
2002 Feb; 346(8):570-8. doi:
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