4-(Nitrosomethylidene)-1-[[4-(nitrosomethylidene)pyridin-1-yl]methoxymethyl]pyridine (BioDeep_00000183647)
human metabolite blood metabolite
代谢物信息卡片
4-(nitrosomethylidene)-1-({[4-(nitrosomethylidene)-1,4-dihydropyridin-1-yl]methoxy}methyl)-1,4-dihydropyridine
化学式: C14H14N4O3 (286.1066)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 74.46%
分子结构信息
SMILES: C1=CN(C=CC1=CN=O)COCN2C=CC(=CN=O)C=C2
InChI: InChI=1S/C14H14N4O3/c19-15-9-13-1-5-17(6-2-13)11-21-12-18-7-3-14(4-8-18)10-16-20/h1-10H,11-12H2
描述信息
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Michael D Costa, Mayara L Freitas, Félix Alexandre Antunes Soares, Vanessa Santana Carratu, Ricardo Brandão. Potential of two new oximes in reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by organophosphate compounds: an in vitro study.
Toxicology in vitro : an international journal published in association with BIBRA.
2011 Dec; 25(8):2120-3. doi:
10.1016/j.tiv.2011.09.018. [PMID: 21983245] - Horst Thiermann, Dirk Steinritz, Franz Worek, Maria Radtke, Peter Eyer, Florian Eyer, Norbert Felgenhauer, Thomas Zilker. Atropine maintenance dosage in patients with severe organophosphate pesticide poisoning.
Toxicology letters.
2011 Sep; 206(1):77-83. doi:
10.1016/j.toxlet.2011.07.006. [PMID: 21771644] - Miriam Dadparvar, Sylvia Wagner, Sascha Wien, Jürgen Kufleitner, Franz Worek, Hagen von Briesen, Jörg Kreuter. HI 6 human serum albumin nanoparticles--development and transport over an in vitro blood-brain barrier model.
Toxicology letters.
2011 Sep; 206(1):60-6. doi:
10.1016/j.toxlet.2011.06.027. [PMID: 21726608] - Rory Cochran, Jaroslaw Kalisiak, Tuba Küçükkilinç, Zoran Radic, Edzna Garcia, Limin Zhang, Kwok-Yiu Ho, Gabriel Amitai, Zrinka Kovarik, Valery V Fokin, K Barry Sharpless, Palmer Taylor. Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging.
The Journal of biological chemistry.
2011 Aug; 286(34):29718-24. doi:
10.1074/jbc.m111.264739. [PMID: 21730071] - Sylvia Wagner, Jürgen Kufleitner, Anja Zensi, Miriam Dadparvar, Sascha Wien, Judith Bungert, Tikva Vogel, Franz Worek, Jörg Kreuter, Hagen von Briesen. Nanoparticulate transport of oximes over an in vitro blood-brain barrier model.
PloS one.
2010 Dec; 5(12):e14213. doi:
10.1371/journal.pone.0014213. [PMID: 21151975] - Marloes J A Joosen, Marcel J van der Schans, Herman P M van Helden. Percutaneous exposure to the nerve agent VX: Efficacy of combined atropine, obidoxime and diazepam treatment.
Chemico-biological interactions.
2010 Oct; 188(1):255-63. doi:
10.1016/j.cbi.2010.06.010. [PMID: 20599844] - H Thiermann, F Eyer, N Felgenhauer, R Pfab, T Zilker, P Eyer, F Worek. Pharmacokinetics of obidoxime in patients poisoned with organophosphorus compounds.
Toxicology letters.
2010 Sep; 197(3):236-42. doi:
10.1016/j.toxlet.2010.06.005. [PMID: 20542100] - Daniel Jun, Lucie Musilova, Miroslav Pohanka, Young-Sik Jung, Pavel Bostik, Kamil Kuca. Reactivation of human acetylcholinesterase and butyrylcholinesterase inhibited by leptophos-oxon with different oxime reactivators in vitro.
International journal of molecular sciences.
2010 Aug; 11(8):2856-63. doi:
10.3390/ijms11082856. [PMID: 21152278] - Jana Zdarova Karasova, Ladislav Novotny, Karel Antos, Helena Zivna, Kamil Kuca. Time-dependent changes in concentration of two clinically used acetylcholinesterase reactivators (HI-6 and obidoxime) in rat plasma determined by HPLC techniques after in vivo administration.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2010 Jan; 26(1):63-7. doi:
10.2116/analsci.26.63. [PMID: 20065589] - Jürgen Kufleitner, Sylvia Wagner, Franz Worek, Hagen von Briesen, Jörg Kreuter. Adsorption of obidoxime onto human serum albumin nanoparticles: drug loading, particle size and drug release.
Journal of microencapsulation.
2010; 27(6):506-13. doi:
10.3109/02652041003681406. [PMID: 20214419] - Jürgen Kufleitner, Franz Worek, Jörg Kreuter. Incorporation of obidoxime into human serum albumin nanoparticles: optimisation of preparation parameters for the development of a stable formulation.
Journal of microencapsulation.
2010; 27(7):594-601. doi:
10.3109/02652048.2010.501395. [PMID: 20923399] - H Thiermann, T Zilker, F Eyer, N Felgenhauer, P Eyer, F Worek. Monitoring of neuromuscular transmission in organophosphate pesticide-poisoned patients.
Toxicology letters.
2009 Dec; 191(2-3):297-304. doi:
10.1016/j.toxlet.2009.09.013. [PMID: 19793545] - Florian Eyer, Franz Worek, Peter Eyer, Norbert Felgenhauer, Mike Haberkorn, Thomas Zilker, Horst Thiermann. Obidoxime in acute organophosphate poisoning: 1 - clinical effectiveness.
Clinical toxicology (Philadelphia, Pa.).
2009 Sep; 47(8):798-806. doi:
10.1080/15563650903206828. [PMID: 19778163] - Horst Thiermann, Franz Worek, Peter Eyer, Florian Eyer, Norbert Felgenhauer, Thomas Zilker. Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships.
Clinical toxicology (Philadelphia, Pa.).
2009 Sep; 47(8):807-13. doi:
10.1080/15563650903206836. [PMID: 19778190] - Florian Eyer, Darren M Roberts, Nicholas A Buckley, Michael Eddleston, Horst Thiermann, Franz Worek, Peter Eyer. Extreme variability in the formation of chlorpyrifos oxon (CPO) in patients poisoned by chlorpyrifos (CPF).
Biochemical pharmacology.
2009 Sep; 78(5):531-7. doi:
10.1016/j.bcp.2009.05.004. [PMID: 19433070] - Miroslav Pohanka, Jana Zdarova Karasova, Kamil Musilek, Kamil Kuca, Jiri Kassa. Effect of five acetylcholinesterase reactivators on tabun-intoxicated rats: induction of oxidative stress versus reactivation efficacy.
Journal of applied toxicology : JAT.
2009 Aug; 29(6):483-8. doi:
10.1002/jat.1432. [PMID: 19338015] - Jana Zdarova Karasova, Jiri Kassa, Kamil Musilek, Miroslav Pohanka, Ladislav Novotny, Kamil Kuca. Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats.
International journal of molecular sciences.
2009 Jul; 10(7):3065-75. doi:
10.3390/ijms10073065. [PMID: 19742125] - Lucie Musilova, Kamil Kuca, Young-Sik Jung, Daniel Jun. In vitro oxime-assisted reactivation of paraoxon-inhibited human acetylcholinesterase and butyrylcholinesterase.
Clinical toxicology (Philadelphia, Pa.).
2009 Jul; 47(6):545-50. doi:
10.1080/15563650903058914. [PMID: 19586353] - N Aurbek, H Thiermann, F Eyer, P Eyer, F Worek. Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis.
Toxicology.
2009 May; 259(3):133-9. doi:
10.1016/j.tox.2009.02.014. [PMID: 19428953] - Patrick Masson, Daniel Rochu. Catalytic bioscavengers against toxic esters, an alternative approach for prophylaxis and treatments of poisonings.
Acta naturae.
2009 Apr; 1(1):68-79. doi:
NULL. [PMID: 22649587] - Jana Zdarova Karasova, Jiri Kassa, Young-Sik Jung, Kamil Musilek, Miroslav Pohanka, Kamil Kuca. Effect of several new and currently available oxime cholinesterase reactivators on tabun-intoxicated rats.
International journal of molecular sciences.
2008 Nov; 9(11):2243-52. doi:
10.3390/ijms9112243. [PMID: 19330072] - D Jun, L Musilova, K Kuca, J Kassa, J Bajgar. Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro.
Chemico-biological interactions.
2008 Sep; 175(1-3):421-4. doi:
10.1016/j.cbi.2008.05.004. [PMID: 18617161] - Jaroslav Pejchal, Jan Osterreicher, Kamil Kuca, Daniel Jun, Jiri Bajgar, Jiri Kassa. The influence of acetylcholinesterase reactivators on selected hepatic functions in rats.
Basic & clinical pharmacology & toxicology.
2008 Aug; 103(2):119-23. doi:
10.1111/j.1742-7843.2008.00249.x. [PMID: 18816293] - J Stenzel, F Worek, P Eyer. Preparation and characterization of dialkylphosphoryl-obidoxime conjugates, potent anticholinesterase derivatives that are quickly hydrolyzed by human paraoxonase (PON1192Q).
Biochemical pharmacology.
2007 Nov; 74(9):1390-400. doi:
10.1016/j.bcp.2007.07.013. [PMID: 17714697] - D E Lorke, M Y Hasan, S M Nurulain, R Sheen, K Kuca, G A Petroianu. Entry of two new asymmetric bispyridinium oximes (K-27 and K-48) into the rat brain: comparison with obidoxime.
Journal of applied toxicology : JAT.
2007 Sep; 27(5):482-90. doi:
10.1002/jat.1229. [PMID: 17309042] - Peter Eyer, Ladislaus Szinicz, Horst Thiermann, Franz Worek, Thomas Zilker. Testing of antidotes for organophosphorus compounds: experimental procedures and clinical reality.
Toxicology.
2007 Apr; 233(1-3):108-19. doi:
10.1016/j.tox.2006.08.033. [PMID: 17010492] - A Bartling, F Worek, L Szinicz, H Thiermann. Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase.
Toxicology.
2007 Apr; 233(1-3):166-72. doi:
10.1016/j.tox.2006.07.003. [PMID: 16904809] - J Bajgar, J Fusek, L Bartosova, D Jun, K Kuca. Evaluation of reactivation test in anaesthetized dogs with experimental intoxication with nerve agents.
Journal of applied toxicology : JAT.
2006 Sep; 26(5):439-43. doi:
10.1002/jat.1158. [PMID: 16915560] - Daniel Jun, Kamil Kuca, Miloslav Hronek, Lubomir Opletal. Effect of some acetylcholinesterase reactivators on human platelet aggregation in vitro.
Journal of applied toxicology : JAT.
2006 May; 26(3):258-61. doi:
10.1002/jat.1126. [PMID: 16307468] - D Kiderlen, P Eyer, F Worek. Formation and disposition of diethylphosphoryl-obidoxime, a potent anticholinesterase that is hydrolyzed by human paraoxonase (PON1).
Biochemical pharmacology.
2005 Jun; 69(12):1853-67. doi:
10.1016/j.bcp.2005.04.003. [PMID: 15876422] - Yedidia Bentur, Bianca Raikhlin-Eisenkraft, Pierre Singer. Beneficial late administration of obidoxime in malathion poisoning.
Veterinary and human toxicology.
2003 Feb; 45(1):33-5. doi:
". [PMID: 12583695] - Florian Eyer, Veronika Meischner, Daniela Kiderlen, Horst Thiermann, Franz Worek, Michael Haberkorn, Norbert Felgenhauer, Thomas Zilker, Peter Eyer. Human parathion poisoning. A toxicokinetic analysis.
Toxicological reviews.
2003; 22(3):143-63. doi:
10.2165/00139709-200322030-00003. [PMID: 15181664] - Peter Eyer. The role of oximes in the management of organophosphorus pesticide poisoning.
Toxicological reviews.
2003; 22(3):165-90. doi:
10.2165/00139709-200322030-00004. [PMID: 15181665] - E M A W Vos, J J H Hens, H S Lau, E S Boon, A K M Bartelink. [Poisoning with organophosphate compounds].
Nederlands tijdschrift voor geneeskunde.
2002 Jan; 146(1):34-7. doi:
NULL. [PMID: 11802337] - M Sungur, M Güven. Intensive care management of organophosphate insecticide poisoning.
Critical care (London, England).
2001 Aug; 5(4):211-5. doi:
10.1186/cc1025. [PMID: 11511334] - C Grasshoff, H Thiermann, T Gillessen, T Zilker, L Szinicz. Internal standard high-performance liquid chromatography method for the determination of obidoxime in urine of organophosphate-poisoned patients.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Apr; 753(2):203-8. doi:
10.1016/s0378-4347(00)00543-0. [PMID: 11334332]
