4-Fluoro-1-[2-[(4-methyl-1-methylsulfonylpiperidin-4-yl)amino]acetyl]pyrrolidine-2-carbonitrile (BioDeep_00000183589)

   

human metabolite blood metabolite


代谢物信息卡片


4-Fluoro-1-{2-[(1-methanesulphonyl-4-methylpiperidin-4-yl)amino]acetyl}pyrrolidine-2-carbonitrile

化学式: C14H23FN4O3S (346.1475)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(CCN(CC1)S(=O)(=O)C)NCC(=O)N2CC(CC2C#N)F
InChI: InChI=1S/C14H23FN4O3S/c1-14(3-5-18(6-4-14)23(2,21)22)17-9-13(20)19-10-11(15)7-12(19)8-16/h11-12,17H,3-7,9-10H2,1-2H3



数据库引用编号

3 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Atsuo Tahara, Akiko Matsuyama-Yokono, Ryosuke Nakano, Yuka Someya, Masahiko Hayakawa, Masayuki Shibasaki. Antihyperglycemic effects of ASP8497 in streptozotocin-nicotinamide induced diabetic rats: comparison with other dipeptidyl peptidase-IV inhibitors. Pharmacological reports : PR. 2009 Sep; 61(5):899-908. doi: 10.1016/s1734-1140(09)70147-1. [PMID: 19904014]
  • Akiko Matsuyama-Yokono, Atsuo Tahara, Ryosuke Nakano, Yuka Someya, Katsuhisa Shiraki, Masahiko Hayakawa, Masayuki Shibasaki. Antidiabetic effects of dipeptidyl peptidase-IV inhibitors and sulfonylureas in streptozotocin-nicotinamide-induced mildly diabetic mice. Metabolism: clinical and experimental. 2009 Mar; 58(3):379-86. doi: 10.1016/j.metabol.2008.10.012. [PMID: 19217455]
  • Atsuo Tahara, Akiko Matsuyama-Yokono, Ryosuke Nakano, Yuka Someya, Masahiko Hayakawa, Masayuki Shibasaki. Effects of the combination of dipeptidyl peptidase-IV inhibitor ASP8497 and antidiabetic drugs in streptozotocin-nicotinamide-induced mildly diabetic mice. European journal of pharmacology. 2009 Mar; 605(1-3):170-6. doi: 10.1016/j.ejphar.2008.12.040. [PMID: 19171131]
  • Akiko Matsuyama-Yokono, Atsuo Tahara, Ryosuke Nakano, Yuka Someya, Masahiko Hayakawa, Masayuki Shibasaki. Chronic inhibition of dipeptidyl peptidase-IV with ASP8497 improved the HbA(1c) level, glucose intolerance, and lipid parameter level in streptozotocin-nicotinamide-induced diabetic mice. Naunyn-Schmiedeberg's archives of pharmacology. 2009 Feb; 379(2):191-9. doi: 10.1007/s00210-008-0348-x. [PMID: 18762913]
  • Atsuo Tahara, Akiko Matsuyama-Yokono, Ryosuke Nakano, Yuka Someya, Masahiko Hayakawa, Masayuki Shibasaki. Evaluation of the antidiabetic effects of dipeptidyl peptidase-IV inhibitor ASP8497 in streptozotocin-nicotinamide-induced mildly diabetic mice. Pharmacology. 2009; 83(3):177-87. doi: 10.1159/000196813. [PMID: 19176982]
  • Akiko Matsuyama-Yokono, Atsuo Tahara, Ryosuke Nakano, Yuka Someya, Itsuro Nagase, Masahiko Hayakawa, Masayuki Shibasaki. ASP8497 is a novel selective and competitive dipeptidyl peptidase-IV inhibitor with antihyperglycemic activity. Biochemical pharmacology. 2008 Jul; 76(1):98-107. doi: 10.1016/j.bcp.2008.03.021. [PMID: 18468582]
  • Yuka Someya, Atsuo Tahara, Ryosuke Nakano, Akiko Matsuyama-Yokono, Itsuro Nagase, Yasuhisa Fukunaga, Toshiyuki Takasu, Masahiko Hayakawa, Masayuki Shibasaki. Pharmacological profile of ASP8497, a novel, selective, and competitive dipeptidyl peptidase-IV inhibitor, in vitro and in vivo. Naunyn-Schmiedeberg's archives of pharmacology. 2008 May; 377(3):209-17. doi: 10.1007/s00210-008-0277-8. [PMID: 18398600]