5-(4-Methylphenyl)-7-tert-butyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-d]pyrimidine-4-amine (BioDeep_00000183555)
human metabolite blood metabolite
代谢物信息卡片
化学式: C16H23N5 (285.1953358)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC=C(C=C1)N1CN(C2=C(C=NN2)C1N)C(C)(C)C
InChI: InChI=1S/C16H23N5/c1-11-5-7-12(8-6-11)20-10-21(16(2,3)4)15-13(14(20)17)9-18-19-15/h5-9,14H,10,17H2,1-4H3,(H,18,19)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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Plant Reactome(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Kimberly D Fisher, Juan Codina, Snezana Petrovic, Thomas D DuBose. Pyk2 regulates H+-ATPase-mediated proton secretion in the outer medullary collecting duct via an ERK1/2 signaling pathway.
American journal of physiology. Renal physiology.
2012 Nov; 303(9):F1353-62. doi:
10.1152/ajprenal.00008.2012
. [PMID: 22811489] - Leigh Anne Swayne, Alexandre Mezghrani, Annie Varrault, Jean Chemin, Gyslaine Bertrand, Stephane Dalle, Emmanuel Bourinet, Philippe Lory, Richard J Miller, Joel Nargeot, Arnaud Monteil. The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic beta-cell line.
EMBO reports.
2009 Aug; 10(8):873-80. doi:
10.1038/embor.2009.125
. [PMID: 19575010] - Lingling Zhang, Da Xing, Xuejuan Gao, Shengnan Wu. Low-power laser irradiation promotes cell proliferation by activating PI3K/Akt pathway.
Journal of cellular physiology.
2009 Jun; 219(3):553-62. doi:
10.1002/jcp.21697
. [PMID: 19142866] - Dor Salomon, Arale Bonshtien, Maya Mayrose, Chao Zhang, Kevan M Shokat, Guido Sessa. Bypassing kinase activity of the tomato Pto resistance protein with small molecule ligands.
The Journal of biological chemistry.
2009 May; 284(22):15289-98. doi:
10.1074/jbc.m809724200
. [PMID: 19332544] - Jeong-Su Do, Kang-Seo Park, Hyo-Jung Seo, Jun-Hee Kim, Jin-Ki Hwang, Eun-Jung Song, Sang-Yun Nam. Therapeutic target validation of protein kinase C(PKC)-zeta for asthma using a mouse model.
International journal of molecular medicine.
2009 Apr; 23(4):561-6. doi:
10.3892/ijmm_00000165
. [PMID: 19288034] - Naoki Ichikawa, Kazuhisa Iwabuchi, Hidetake Kurihara, Kumiko Ishii, Toshihide Kobayashi, Takako Sasaki, Nobutaka Hattori, Yoshikuni Mizuno, Kentaro Hozumi, Yoshihiko Yamada, Eri Arikawa-Hirasawa. Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth.
Journal of cell science.
2009 Jan; 122(Pt 2):289-99. doi:
10.1242/jcs.030338
. [PMID: 19118221] - Karim Dib, Lena Axelsson, Tommy Andersson. Beta2 integrins target Rap GTPases to the plasma membrane by means of degranulation.
Biochemical and biophysical research communications.
2008 Nov; 376(4):642-6. doi:
10.1016/j.bbrc.2008.08.160
. [PMID: 18789886] - Vitaly Margulis, Christopher G Wood. Cytoreductive nephrectomy in the era of targeted molecular agents: is it time to consider presurgical systemic therapy?.
European urology.
2008 Sep; 54(3):489-92. doi:
10.1016/j.eururo.2007.12.041
. [PMID: 18206292] - Hong Wang, Aileen X Wang, Zhenqi Liu, Eugene J Barrett. Insulin signaling stimulates insulin transport by bovine aortic endothelial cells.
Diabetes.
2008 Mar; 57(3):540-7. doi:
10.2337/db07-0967
. [PMID: 17977956] - Lakshmi C Wijeyewickrema, Elizabeth E Gardiner, Masaaki Moroi, Michael C Berndt, Robert K Andrews. Snake venom metalloproteinases, crotarhagin and alborhagin, induce ectodomain shedding of the platelet collagen receptor, glycoprotein VI.
Thrombosis and haemostasis.
2007 Dec; 98(6):1285-90. doi:
. [PMID: 18064326]
- Monique L Baldwin, Martín Cammarota, Alistair T R Sim, John A P Rostas. Src family tyrosine kinases differentially modulate exocytosis from rat brain nerve terminals.
Neurochemistry international.
2006 Jul; 49(1):80-6. doi:
10.1016/j.neuint.2006.01.002
. [PMID: 16500731] - Yuko Yonezawa, Yoji Nagashima, Hiromi Sato, Nantiga Virgona, Keiko Fukumoto, Sumiko Shirai, Hiromi Hagiwara, Taiichiro Seki, Toyohiko Ariga, Hironobu Senba, Kazuyuki Suzuki, Ryuji Asano, Kiyokazu Hagiwara, Tomohiro Yano. Contribution of the Src family of kinases to the appearance of malignant phenotypes in renal cancer cells.
Molecular carcinogenesis.
2005 Aug; 43(4):188-97. doi:
10.1002/mc.20109
. [PMID: 15864803] - Shougang Zhuang, Yan Yan, Jiahuai Han, Rick G Schnellmann. p38 kinase-mediated transactivation of the epidermal growth factor receptor is required for dedifferentiation of renal epithelial cells after oxidant injury.
The Journal of biological chemistry.
2005 Jun; 280(22):21036-42. doi:
10.1074/jbc.m413300200
. [PMID: 15797859] - Eriko Fujimoto, Hiromi Sato, Yoji Nagashima, Etsuko Negishi, Sumiko Shirai, Keiko Fukumoto, Hiromi Hagiwara, Kiyokazu Hagiwara, Koichi Ueno, Tomohiro Yano. A Src family inhibitor (PP1) potentiates tumor-suppressive effect of connexin 32 gene in renal cancer cells.
Life sciences.
2005 Apr; 76(23):2711-20. doi:
10.1016/j.lfs.2004.10.049
. [PMID: 15792837] - Mahito Sato, Keiko Kawai-Kowase, Hiroko Sato, Yuko Oyama, Hiroyoshi Kanai, Yoshio Ohyama, Tatsuo Suga, Toshitaka Maeno, Yasuhiro Aoki, Junichi Tamura, Hironosuke Sakamoto, Ryozo Nagai, Masahiko Kurabayashi. c-Src and hydrogen peroxide mediate transforming growth factor-beta1-induced smooth muscle cell-gene expression in 10T1/2 cells.
Arteriosclerosis, thrombosis, and vascular biology.
2005 Feb; 25(2):341-7. doi:
10.1161/01.atv.0000152608.29351.8f
. [PMID: 15591224] - Daniela A Capiati, Ana M Rossi, Gabriela Picotto, Silvia Benassati, Ricardo L Boland. Inhibition of serum-stimulated mitogen activated protein kinase by 1alpha,25(OH)2-vitamin D3 in MCF-7 breast cancer cells.
Journal of cellular biochemistry.
2004 Oct; 93(2):384-97. doi:
10.1002/jcb.20165
. [PMID: 15368364] - Rohan Samarakoon, Paul J Higgins. Pp60c-src mediates ERK activation/nuclear localization and PAI-1 gene expression in response to cellular deformation.
Journal of cellular physiology.
2003 Jun; 195(3):411-20. doi:
10.1002/jcp.10247
. [PMID: 12704650] - Jian Zhou, A Sue Menko. The role of Src family kinases in cortical cataract formation.
Investigative ophthalmology & visual science.
2002 Jul; 43(7):2293-300. doi:
NULL
. [PMID: 12091430] - Barbara Tolloczko, Petra Turkewitsch, Sofia Choudry, Sandra Bisotto, Elizabeth D Fixman, James G Martin. Src modulates serotonin-induced calcium signaling by regulating phosphatidylinositol 4,5-bisphosphate.
American journal of physiology. Lung cellular and molecular physiology.
2002 Jun; 282(6):L1305-13. doi:
10.1152/ajplung.00304.2001
. [PMID: 12003787] - Frédéric Barabé, Emmanuelle Rollet-Labelle, Caroline Gilbert, Maria J G Fernandes, Samia N Naccache, Paul H Naccache. Early events in the activation of Fc gamma RIIA in human neutrophils: stimulated insolubilization, translocation to detergent-resistant domains, and degradation of Fc gamma RIIA.
Journal of immunology (Baltimore, Md. : 1950).
2002 Apr; 168(8):4042-9. doi:
10.4049/jimmunol.168.8.4042
. [PMID: 11937562] - Stuart J Marshall, Naoki Asazuma, Denise Best, Peter Wonerow, Gary Salmon, Robert K Andrews, Steve P Watson. Glycoprotein IIb-IIIa-dependent aggregation by glycoprotein Ibalpha is reinforced by a Src family kinase inhibitor (PP1)-sensitive signalling pathway.
The Biochemical journal.
2002 Jan; 361(Pt 2):297-305. doi:
10.1042/0264-6021:3610297
. [PMID: 11772401] - H Kenneth Kramer, Irma Onoprishvili, Matthew L Andria, Kayane Hanna, Karina Sheinkman, Lisa B Haddad, Eric J Simon. Delta opioid activation of the mitogen-activated protein kinase cascade does not require transphosphorylation of receptor tyrosine kinases.
BMC pharmacology.
2002; 2(?):5. doi:
10.1186/1471-2210-2-5
. [PMID: 11897012] - J L Weiss, R D Burgoyne. Voltage-independent inhibition of P/Q-type Ca2+ channels in adrenal chromaffin cells via a neuronal Ca2+ sensor-1-dependent pathway involves Src family tyrosine kinase.
The Journal of biological chemistry.
2001 Nov; 276(48):44804-11. doi:
10.1074/jbc.m103262200
. [PMID: 11583988] - O Katsumata, M Hara-Yokoyama, C Sautès-Fridman, Y Nagatsuka, T Katada, Y Hirabayashi, K Shimizu, J Fujita-Yoshigaki, H Sugiya, S Furuyama. Association of FcgammaRII with low-density detergent-resistant membranes is important for cross-linking-dependent initiation of the tyrosine phosphorylation pathway and superoxide generation.
Journal of immunology (Baltimore, Md. : 1950).
2001 Nov; 167(10):5814-23. doi:
10.4049/jimmunol.167.10.5814
. [PMID: 11698455]