2-[[4-[(2-Amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]-4-methylpentanedioic acid (BioDeep_00000183549)
human metabolite blood metabolite
代谢物信息卡片
化学式: C20H21N7O6 (455.15532460000003)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CC(C(=O)O)NC(=O)C1=CC=C(C=C1)NCC2=CN=C3C(=N2)C(=O)NC(=N3)N)C(=O)O
InChI: InChI=1S/C20H21N7O6/c1-9(18(30)31)6-13(19(32)33)25-16(28)10-2-4-11(5-3-10)22-7-12-8-23-15-14(24-12)17(29)27-20(21)26-15/h2-5,8-9,13,22H,6-7H2,1H3,(H,25,28)(H,30,31)(H,32,33)(H3,21,23,26,27,29)
描述信息
同义名列表
5 个代谢物同义名
2-[(4-{[(4-hydroxy-2-imino-1,2-dihydropteridin-6-yl)methyl]amino}phenyl)formamido]-4-methylpentanedioate; 2-[(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}phenyl)formamido]-4-methylpentanedioic acid; 2-[(4-{[(2-amino-4-oxo-3H-pteridin-6-yl)methyl]amino}phenyl)formamido]-4-methylpentanedioic acid; 2-[[4-[(2-Amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]-4-methylpentanedioic acid; 2-[[4-[(2-Amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]-4-methylpentanedioate
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Glenn Tisman, April Garcia. Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case report.
Journal of medical case reports.
2011 Aug; 5(?):413. doi:
10.1186/1752-1947-5-413. [PMID: 21867542] - Yasue Uchida, Saiko Sugiura, Fujiko Ando, Tsutomu Nakashima, Hiroshi Shimokata. Hearing impairment risk and interaction of folate metabolism related gene polymorphisms in an aging study.
BMC medical genetics.
2011 Mar; 12(?):35. doi:
10.1186/1471-2350-12-35. [PMID: 21385350] - Steven F Werder. Cobalamin deficiency, hyperhomocysteinemia, and dementia.
Neuropsychiatric disease and treatment.
2010 May; 6(?):159-95. doi:
10.2147/ndt.s6564. [PMID: 20505848] - Cinzia Scambi, Lucia De Franceschi, Patrizia Guarini, Fabio Poli, Angela Siciliano, Patrizia Pattini, Andrea Biondani, Valentina La Verde, Oscar Bortolami, Francesco Turrini, Franco Carta, Ciro D'Orazio, Baroukh M Assael, Giovanni Faccini, Lisa M Bambara. Preliminary evidence for cell membrane amelioration in children with cystic fibrosis by 5-MTHF and vitamin B12 supplementation: a single arm trial.
PloS one.
2009; 4(3):e4782. doi:
10.1371/journal.pone.0004782. [PMID: 19277125] - Hyesun Min. Effects of dietary supplementation of high-dose folic acid on biomarkers of methylating reaction in vitamin B(12)-deficient rats.
Nutrition research and practice.
2009; 3(2):122-7. doi:
10.4162/nrp.2009.3.2.122. [PMID: 20016712] - Jane Durga, Lucien J C Anteunis, Evert G Schouten, Michiel L Bots, Frans J Kok, Petra Verhoef. Association of folate with hearing is dependent on the 5,10-methylenetetrahdyrofolate reductase 677C-->T mutation.
Neurobiology of aging.
2006 Mar; 27(3):482-9. doi:
10.1016/j.neurobiolaging.2005.03.002. [PMID: 16464657] - John T Brosnan, Rene L Jacobs, Lori M Stead, Margaret E Brosnan. Methylation demand: a key determinant of homocysteine metabolism.
Acta biochimica Polonica.
2004; 51(2):405-13. doi:
035001405. [PMID: 15218538] - Jukka Hintikka, Tommi Tolmunen, Antti Tanskanen, Heimo Viinamäki. High vitamin B12 level and good treatment outcome may be associated in major depressive disorder.
BMC psychiatry.
2003 Dec; 3(?):17. doi:
10.1186/1471-244x-3-17. [PMID: 14641930] - Carole Tonetti, Jean-Marie Saudubray, Bernard Echenne, Pierre Landrieu, Stéphane Giraudier, Jacqueline Zittoun. Relations between molecular and biological abnormalities in 11 families from siblings affected with methylenetetrahydrofolate reductase deficiency.
European journal of pediatrics.
2003 Jul; 162(7-8):466-475. doi:
10.1007/s00431-003-1196-9. [PMID: 12733064] - Isabelle Quéré, Thomas V Perneger, Jacqueline Zittoun, Hélène Bellet, Jean-Christophe Gris, Jean-Pierre Daurès, Jean-François Schved, Eric Mercier, Jean-Pierre Laroche, Michel Dauzat, Henri Bounameaux, Charles Janbon, Philippe de Moerloose. Red blood cell methylfolate and plasma homocysteine as risk factors for venous thromboembolism: a matched case-control study.
Lancet (London, England).
2002 Mar; 359(9308):747-52. doi:
10.1016/s0140-6736(02)07876-5. [PMID: 11888585]