Hydromorphone-3-glucuronide (BioDeep_00000018353)

   

human metabolite Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


3,4,5-trihydroxy-6-({4-methyl-14-oxo-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10-trien-10-yl}oxy)oxane-2-carboxylic acid

化学式: C23H27NO9 (461.1685732000001)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 1.75%

分子结构信息

SMILES: CN1CCC23C4C1CC5=C2C(=C(C=C5)OC6C(C(C(C(O6)C(=O)O)O)O)O)OC3C(=O)CC4
InChI: InChI=1S/C23H27NO9/c1-24-7-6-23-10-3-4-12(25)20(23)32-18-13(5-2-9(14(18)23)8-11(10)24)31-22-17(28)15(26)16(27)19(33-22)21(29)30/h2,5,10-11,15-17,19-20,22,26-28H,3-4,6-8H2,1H3,(H,29,30)

描述信息

Hydromorphone-3-glucuronide is a metabolite of hydromorphone. Hydromorphone, a more common synonym for dihydromorphinone, commonly a hydrochloride (brand names Palladone, Dilaudid, and numerous others) is a very potent centrally acting analgesic drug of the opioid class. It is a derivative of morphine, to be specific, a hydrogenated ketone thereof and, therefore, a semi-synthetic drug. It is, in medical terms, an opioid analgesic and, in legal terms, a narcotic. (Wikipedia)

同义名列表

2 个代谢物同义名

3,4,5-trihydroxy-6-({4-methyl-14-oxo-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10-trien-10-yl}oxy)oxane-2-carboxylic acid; Hydromorphone-3-glucuronide



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Terhi J Lohela, Satu Poikola, Mikko Neuvonen, Mikko Niemi, Janne T Backman, Klaus T Olkkola, Tuomas O Lilius. Rifampin Reduces the Plasma Concentrations of Oral and Intravenous Hydromorphone in Healthy Volunteers. Anesthesia and analgesia. 2021 08; 133(2):423-434. doi: 10.1213/ane.0000000000005229. [PMID: 33177323]
  • Kaoru Toyama, Naoki Uchida, Hitoshi Ishizuka, Takehiko Sambe, Shinichi Kobayashi. Single-dose evaluation of safety, tolerability and pharmacokinetics of newly formulated hydromorphone immediate-release and hydrophilic matrix extended-release tablets in healthy Japanese subjects without co-administration of an opioid antagonist. Journal of clinical pharmacology. 2015 Sep; 55(9):975-84. doi: 10.1002/jcph.501. [PMID: 25807927]
  • Joris Vandenbossche, Henry Richards, Stephan Francke, An Van Den Bergh, Chih Cherng Lu, Monique A Franc. The effect of UGT2B7*2 polymorphism on the pharmacokinetics of OROS® hydromorphone in Taiwanese subjects. Journal of clinical pharmacology. 2014 Oct; 54(10):1170-9. doi: 10.1002/jcph.305. [PMID: 24706503]
  • Justin Kullgren, Vy Le, Warren Wheeler. Incidence of hydromorphone-induced neuroexcitation in hospice patients. Journal of palliative medicine. 2013 Oct; 16(10):1205-9. doi: 10.1089/jpm.2012.0467. [PMID: 23930920]
  • Robert Meatherall, Colin Lee, Susan Phillips. Accidental death from hydromorphone ingestion. Journal of forensic sciences. 2011 Jan; 56 Suppl 1(?):S271-4. doi: 10.1111/j.1556-4029.2010.01618.x. [PMID: 21077877]
  • Shawn McCann, Tony L Yaksh, Charles F von Gunten. Correlation between myoclonus and the 3-glucuronide metabolites in patients treated with morphine or hydromorphone: a pilot study. Journal of opioid management. 2010 Mar; 6(2):87-94. doi: 10.5055/jom.2010.0008. [PMID: 20481173]
  • Sara N Davison, Patrick R Mayo. Pain management in chronic kidney disease: the pharmacokinetics and pharmacodynamics of hydromorphone and hydromorphone-3-glucuronide in hemodialysis patients. Journal of opioid management. 2008 Nov; 4(6):335-6, 339. doi: 10.5055/jom.2008.0037. [PMID: 19192761]
  • Ming Zheng, Keith M McErlane, May C Ong. Identification and synthesis of norhydromorphone, and determination of antinociceptive activities in the rat formalin test. Life sciences. 2004 Nov; 75(26):3129-46. doi: 10.1016/j.lfs.2004.06.008. [PMID: 15488893]
  • M Zheng, K M McErlane, M C Ong. Hydromorphone metabolites: isolation and identification from pooled urine samples of a cancer patient. Xenobiotica; the fate of foreign compounds in biological systems. 2002 May; 32(5):427-39. doi: 10.1080/00498250110119090. [PMID: 12065064]
  • M Zheng, K M McErlane, M C Ong. LC-MS-MS analysis of hydromorphone and hydromorphone metabolites with application to a pharmacokinetic study in the male Sprague-Dawley rat. Xenobiotica; the fate of foreign compounds in biological systems. 2002 Feb; 32(2):141-51. doi: 10.1080/00498250110091767. [PMID: 11868970]