3-Hydroxy-3-methylpentanedial (BioDeep_00000183508)
human metabolite blood metabolite
代谢物信息卡片
3-Hydroxy-3-methylpentanedial
化学式: C6H10O3 (130.063)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: CC(CC=O)(CC=O)O
InChI: InChI=1S/C6H10O3/c1-6(9,2-4-7)3-5-8/h4-5,9H,2-3H2,1H3
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
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Diabetes care.
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Nutrition research and practice.
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Diabetes.
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Diabetes care.
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Investigative ophthalmology & visual science.
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Arteriosclerosis, thrombosis, and vascular biology.
2008 Jun; 28(6):1200-6. doi:
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TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik.
2008 May; 116(8):1051-61. doi:
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BMC plant biology.
2008 Apr; 8(?):46. doi:
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Vascular health and risk management.
2008; 4(2):341-53. doi:
10.2147/vhrm.s1653. [PMID: 18561510] - Cathy B Wilcox, Grace O Feddes, Joan E Willett-Brozick, Lih-Ching Hsu, Julie A DeLoia, Bora E Baysal. Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer.
BMC cancer.
2007 Dec; 7(?):223. doi:
10.1186/1471-2407-7-223. [PMID: 18070364] - Zoltán Kevei, Géraldine Lougnon, Peter Mergaert, Gábor V Horváth, Attila Kereszt, Dhileepkumar Jayaraman, Najia Zaman, Fabian Marcel, Krzysztof Regulski, György B Kiss, Adam Kondorosi, Gabriella Endre, Eva Kondorosi, Jean-Michel Ané. 3-hydroxy-3-methylglutaryl coenzyme a reductase 1 interacts with NORK and is crucial for nodulation in Medicago truncatula.
The Plant cell.
2007 Dec; 19(12):3974-89. doi:
10.1105/tpc.107.053975. [PMID: 18156218] - Jesús Muñoz-Bertomeu, Ester Sales, Roc Ros, Isabel Arrillaga, Juan Segura. Up-regulation of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase enhances production of essential oils and sterols in transgenic Lavandula latifolia.
Plant biotechnology journal.
2007 Nov; 5(6):746-58. doi:
10.1111/j.1467-7652.2007.00286.x. [PMID: 17714440] - Sung-Won Min, Dong-Hyun Kim. Kakkalide and irisolidone: HMG-CoA reductase inhibitors isolated from the flower of Pueraria thunbergiana.
Biological & pharmaceutical bulletin.
2007 Oct; 30(10):1965-8. doi:
10.1248/bpb.30.1965. [PMID: 17917273] - Maura Heverin, Steve Meaney, Anat Brafman, Millicent Shafir, Maria Olin, Marjan Shafaati, Sara von Bahr, Lilian Larsson, Anita Lövgren-Sandblom, Ulf Diczfalusy, Paolo Parini, Elena Feinstein, Ingemar Björkhem. Studies on the cholesterol-free mouse: strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol.
Arteriosclerosis, thrombosis, and vascular biology.
2007 Oct; 27(10):2191-7. doi:
10.1161/atvbaha.107.149823. [PMID: 17761942] - Carole Rasmusen, Christophe Moinard, Chantal Martin, Viviane Tricottet, Luc Cynober, Rémy Couderc. L-arginine plus atorvastatin for prevention of atheroma formation in genetically hypercholesterolaemic rabbits.
The British journal of nutrition.
2007 Jun; 97(6):1083-9. doi:
10.1017/s0007114507659066. [PMID: 17391569] - Ikuko Takeda, Shin-Ichiro Maruya, Takashi Shirasaki, Hiroki Mizukami, Takenori Takahata, Jeffrey N Myers, Seiji Kakehata, Soroku Yagihashi, Hideichi Shinkawa. Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells.
Cancer science.
2007 Jun; 98(6):890-9. doi:
10.1111/j.1349-7006.2007.00471.x. [PMID: 17428261] - Ester Sales, Jesús Muñoz-Bertomeu, Isabel Arrillaga, Juan Segura. Enhancement of cardenolide and phytosterol levels by expression of an N-terminally truncated 3-hydroxy-3-methylglutaryl CoA reductase in Transgenic digitalis minor.
Planta medica.
2007 Jun; 73(6):605-10. doi:
10.1055/s-2007-967199. [PMID: 17516328] - Masashi Suzuki, Toshiya Muranaka. Molecular genetics of plant sterol backbone synthesis.
Lipids.
2007 Feb; 42(1):47-54. doi:
10.1007/s11745-006-1000-5. [PMID: 17393210] - Nidia Noemí Gomez, Verónica Silvina Biaggio, Esteban Javier Rozzen, Silvina Mónica Alvarez, María Sofía Gimenez. Zn-limited diet modifies the expression of the rate-regulatory enzymes involved in phosphatidylcholine and cholesterol synthesis.
The British journal of nutrition.
2006 Dec; 96(6):1038-46. doi:
10.1017/bjn20061951. [PMID: 17181878] - Umasundari Sivaprasad, Tarek Abbas, Anindya Dutta. Differential efficacy of 3-hydroxy-3-methylglutaryl CoA reductase inhibitors on the cell cycle of prostate cancer cells.
Molecular cancer therapeutics.
2006 Sep; 5(9):2310-6. doi:
10.1158/1535-7163.mct-06-0175. [PMID: 16985065] - Gregory Proctor, Tao Jiang, Mieko Iwahashi, Zhuowei Wang, Jinping Li, Moshe Levi. Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes.
Diabetes.
2006 Sep; 55(9):2502-9. doi:
10.2337/db05-0603. [PMID: 16936198] - Yanwen Wang, Peter J H Jones, Laura A Woollett, Donna D Buckley, Lihang Yao, Norman A Granholm, Elizabeth A Tolley, James E Heubi. Effects of chenodeoxycholic acid and deoxycholic acid on cholesterol absorption and metabolism in humans.
Translational research : the journal of laboratory and clinical medicine.
2006 Jul; 148(1):37-45. doi:
10.1016/j.lab.2006.03.009. [PMID: 16887497] - Giuseppe D'Amico. Statins and renal diseases: from primary prevention to renal replacement therapy.
Journal of the American Society of Nephrology : JASN.
2006 Apr; 17(4 Suppl 2):S148-52. doi:
10.1681/asn.2005121341. [PMID: 16565241] - Karin M Thelen, Katharina M Rentsch, Ursula Gutteck, Maura Heverin, Maria Olin, Ulla Andersson, Arnold von Eckardstein, Ingemar Björkhem, Dieter Lütjohann. Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin.
The Journal of pharmacology and experimental therapeutics.
2006 Mar; 316(3):1146-52. doi:
10.1124/jpet.105.094136. [PMID: 16282522] - U K Khanzada, O E Pardo, C Meier, J Downward, M J Seckl, A Arcaro. Potent inhibition of small-cell lung cancer cell growth by simvastatin reveals selective functions of Ras isoforms in growth factor signalling.
Oncogene.
2006 Feb; 25(6):877-87. doi:
10.1038/sj.onc.1209117. [PMID: 16170339] - Phil-Sun Oh, Sei-Jung Lee, Kye-Taek Lim. Hypolipidemic and antioxidative effects of the plant glycoprotein (36 kDa) from Rhus verniciflua stokes fruit in Triton WR-1339-induced hyperlipidemic mice.
Bioscience, biotechnology, and biochemistry.
2006 Feb; 70(2):447-56. doi:
10.1271/bbb.70.447. [PMID: 16495662] - Kazuki Akira, Masayasu Amano, Fumitaka Okajima, Fuminobu Okajima, Takao Hashimoto, Shinichi Oikawa. Inhibitory effects of amlodipine and fluvastatin on the deposition of advanced glycation end products in aortic wall of cholesterol and fructose-fed rabbits.
Biological & pharmaceutical bulletin.
2006 Jan; 29(1):75-81. doi:
10.1248/bpb.29.75. [PMID: 16394514] - Leelavinothan Pari, Muniappan Latha. Antihyperlipidemic effect of Scoparia dulcis (sweet broomweed) in streptozotocin diabetic rats.
Journal of medicinal food.
2006; 9(1):102-7. doi:
10.1089/jmf.2006.9.102. [PMID: 16579736] - Anne R Kinderlerer, Rivka Steinberg, Michael Johns, Sarah K Harten, Elaine A Lidington, Dorian O Haskard, Patrick H Maxwell, Justin C Mason. Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis.
Arthritis research & therapy.
2006; 8(4):R130. doi:
10.1186/ar2019. [PMID: 16859540] - Kyu-Ho Han, Miharu Iijuka, Ken-ichiro Shimada, Mitsuo Sekikawa, Katsuhisa Kuramochi, Kiyoshi Ohba, Liyanage Ruvini, Hideyuki Chiji, Michihiro Fukushima. Adzuki resistant starch lowered serum cholesterol and hepatic 3-hydroxy-3-methylglutaryl-CoA mRNA levels and increased hepatic LDL-receptor and cholesterol 7alpha-hydroxylase mRNA levels in rats fed a cholesterol diet.
The British journal of nutrition.
2005 Dec; 94(6):902-8. doi:
10.1079/bjn20051598. [PMID: 16351766] - Kari T Kivistö, Olaf Grisk, Ute Hofmann, Konrad Meissner, Klaus-Uwe Möritz, Christoph Ritter, Katja A Arnold, Dieter Lutjöohann, Klaus von Bergmann, Ingrid Klöting, Michel Eichelbaum, Heyo K Kroemer. Disposition of oral and intravenous pravastatin in MRP2-deficient TR- rats.
Drug metabolism and disposition: the biological fate of chemicals.
2005 Nov; 33(11):1593-6. doi:
10.1124/dmd.105.006262. [PMID: 16107564] - Hirotaka Tsubouchi, Toyoshi Inoguchi, Toshiyo Sonta, Naoichi Sato, Naotaka Sekiguchi, Kunihisa Kobayashi, Hideki Sumimoto, Hideo Utsumi, Hajime Nawata. Statin attenuates high glucose-induced and diabetes-induced oxidative stress in vitro and in vivo evaluated by electron spin resonance measurement.
Free radical biology & medicine.
2005 Aug; 39(4):444-52. doi:
10.1016/j.freeradbiomed.2005.03.031. [PMID: 16043016] - Kensaku Maeda, Kenichi Yasunari, Eisuke F Sato, Masayasu Inoue. Enhanced oxidative stress in neutrophils from hyperlipidemic guinea pig.
Atherosclerosis.
2005 Jul; 181(1):87-92. doi:
10.1016/j.atherosclerosis.2004.12.044. [PMID: 15939058] - Claire Arnaud, Fabienne Burger, Sabine Steffens, Niels R Veillard, Tuan Huy Nguyen, Didier Trono, François Mach. Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins.
Arteriosclerosis, thrombosis, and vascular biology.
2005 Jun; 25(6):1231-6. doi:
10.1161/01.atv.0000163840.63685.0c. [PMID: 15790934] - Hironori Matsuyama, Kan Sato, Yumi Nakamura, Katsumi Suzuki, Yukio Akiba. Modulation of regulatory factors involved in cholesterol metabolism in response to feeding of pravastatin- or cholesterol-supplemented diet in chickens.
Biochimica et biophysica acta.
2005 May; 1734(2):136-42. doi:
10.1016/j.bbalip.2005.03.006. [PMID: 15904870] - Ana B Rodríguez-Peña, Eugenio Santos, Miguel Arévalo, José M López-Novoa. Activation of small GTPase Ras and renal fibrosis.
Journal of nephrology.
2005 May; 18(3):341-9. doi:
NULL. [PMID: 16013027] - J W Fenton, D V Brezniak, F A Ofosu, G X Shen, J R Jacobson, J G N Garcia. Statins and thrombin.
Current drug targets. Cardiovascular & haematological disorders.
2005 Apr; 5(2):115-20. doi:
10.2174/1568006043586189. [PMID: 15853752] - K Liang, C H Kim, N D Vaziri. HMG-CoA reductase inhibition reverses LCAT and LDL receptor deficiencies and improves HDL in rats with chronic renal failure.
American journal of physiology. Renal physiology.
2005 Mar; 288(3):F539-44. doi:
10.1152/ajprenal.00074.2004. [PMID: 15507547] - Anetta Undas, Kathleen E Brummel-Ziedins, Kenneth G Mann. Statins and blood coagulation.
Arteriosclerosis, thrombosis, and vascular biology.
2005 Feb; 25(2):287-94. doi:
10.1161/01.atv.0000151647.14923.ec. [PMID: 15569822]
