N,N-Diethyl-6-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-amine (BioDeep_00000183491)
human metabolite blood metabolite
代谢物信息卡片
N,N-Diethyl-6-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-amine
化学式: C10H15N5 (205.13273900000002)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 66.67%
分子结构信息
SMILES: CCN(CC)C1=NC2=NC=NN2C=C1C
InChI: InChI=1S/C10H15N5/c1-4-14(5-2)9-8(3)6-15-10(13-9)11-7-12-15/h6-7H,4-5H2,1-3H3
数据库引用编号
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
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COVID-19 Disease Map(0)
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PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sergei V Jargin. Testing of serum atherogenicity in cell cultures: questionable data published.
German medical science : GMS e-journal.
2012; 10(?):Doc02. doi:
10.3205/000153. [PMID: 22355278] - Yutaka Nagata, Hirozo Goto, Hiroaki Hikiami, Tatsuya Nogami, Makoto Fujimoto, Naotoshi Shibahara, Yutaka Shimada. Effect of keishibukuryogan on endothelial function in patients with at least one component of the diagnostic criteria for metabolic syndrome: a controlled clinical trial with crossover design.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):359282. doi:
10.1155/2012/359282. [PMID: 22675380] - Takako Nakagawa, Izumi Tashiro, Makoto Fujimoto, Michiko Jo, Shinya Sakai, Hiroshi Oka, Hirozo Goto, Yutaka Shimada, Naotoshi Shibahara. Keishibukuryogan reduces renal injury in the early stage of renal failure in the remnant kidney model.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):914249. doi:
10.1093/ecam/nep089. [PMID: 19633031] - Hamit Yíldíz, Ali Said Durmus, Halil Simşek, Mine Yaman. Protective effect of sildenafil citrate on contralateral testis injury after unilateral testicular torsion/detorsion.
Clinics (Sao Paulo, Brazil).
2011; 66(1):137-42. doi:
10.1590/s1807-59322011000100024. [PMID: 21437450] - Daniele Iaccarino, Luigi Politi, Rosario Rossi, Fabio Sgura, Daniel Monopoli, Maria Grazia Modena, Giuseppe M Sangiorgi. Rationale and study design of the OISTER trial: optical coherence tomography evaluation of stent struts re-endothelialization in patients with non-ST-elevation acute coronary syndromes--a comparison of the intrEpide tRapidil eluting stent vs. taxus drug-eluting stent implantation.
Journal of cardiovascular medicine (Hagerstown, Md.).
2010 Jul; 11(7):536-43. doi:
10.2459/jcm.0b013e32833499c4. [PMID: 20090547] - Neveen A Salem, Emad A Salem, Aref M Maarouf, Mostafa Kamel, Hazem Elgalaly, Mohamed Radwan, Walid A Abd El-Dayem, Mahmoud Eladl. Protective effect of trapidil and l-arginine against renal and hepatic toxicity induced by cyclosporine in rats.
Renal failure.
2010; 32(8):959-68. doi:
10.3109/0886022x.2010.501933. [PMID: 20722564] - Yoko Yoshihisa, Megumi Furuichi, Mati Ur Rehman, Chieko Ueda, Teruhiko Makino, Tadamichi Shimizu. The traditional Japanese formula keishibukuryogan inhibits the production of inflammatory cytokines by dermal endothelial cells.
Mediators of inflammation.
2010; 2010(?):804298. doi:
10.1155/2010/804298. [PMID: 21253500] - Hisao Ogawa, Sunao Kojima. Clinical evidence for Japanese population based on prospective studies--linking clinical trials and clinical practice.
Journal of cardiology.
2009 Oct; 54(2):171-82. doi:
10.1016/j.jjcc.2009.05.001. [PMID: 19782253] - Ute Reisinger, Stefan Schwaiger, Iris Zeller, Barbara Messner, Robert Stigler, Dominik Wiedemann, Tobias Mayr, Christoph Seger, Thomas Schachner, Verena M Dirsch, Angelika M Vollmar, Johannes O Bonatti, Hermann Stuppner, Günther Laufer, David Bernhard. Leoligin, the major lignan from Edelweiss, inhibits intimal hyperplasia of venous bypass grafts.
Cardiovascular research.
2009 Jun; 82(3):542-9. doi:
10.1093/cvr/cvp059. [PMID: 19228707] - Chinami Matsumoto, Tetsuko Kojima, Kazuo Ogawa, Satoshi Kamegai, Takuya Oyama, Yukari Shibagaki, Tetsuo Kawasaki, Hiroshi Fujinaga, Kozo Takahashi, Hiroaki Hikiami, Hirozo Goto, Chizuru Kiga, Keiichi Koizumi, Hiroaki Sakurai, Hiroshi Muramoto, Yutaka Shimada, Masahiro Yamamoto, Katsutoshi Terasawa, Shuichi Takeda, Ikuo Saiki. A Proteomic Approach for the Diagnosis of 'Oketsu' (blood stasis), a Pathophysiologic Concept of Japanese Traditional (Kampo) Medicine.
Evidence-based complementary and alternative medicine : eCAM.
2008 Dec; 5(4):463-74. doi:
10.1093/ecam/nem049. [PMID: 18955217] - Jian Wang, Michael Weiss, David Z D'Argenio. A note on population analysis of dissolution-absorption models using the inverse Gaussian function.
Journal of clinical pharmacology.
2008 Jun; 48(6):719-25. doi:
10.1177/0091270008315956. [PMID: 18359921] - Salih Somuncu, Murat Cakmak, Gunnur Dikmen, Hülya Akman, Murat Kaya. Ischemia-reperfusion injury of rabbit ovary and protective effect of trapidil: an experimental study.
Pediatric surgery international.
2008 Mar; 24(3):315-8. doi:
10.1007/s00383-007-2079-3. [PMID: 18060415] - Gaetano Ragno, Antonella Risoli, Michele De Luca, Giuseppina Ioele, Filomena Oliverio. Determination of trapidil in human serum and urine by derivative UV spectrophotometry after selective solid-phase extraction.
Analytical and bioanalytical chemistry.
2007 Oct; 389(3):923-9. doi:
10.1007/s00216-007-1481-y. [PMID: 17676316] - Rainer Voisard, Svenja Zellmann, Fabian Müller, Felicitas Fahlisch, Lutz von Müller, Regine Baur, Jürgen Braun, Jürgen Gschwendt, Margaratis Kountides, Vinzenz Hombach, Joachim Kamenz. Sirolimus inhibits key events of restenosis in vitro/ex vivo: evaluation of the clinical relevance of the data by SI/MPL- and SI/DES-ratios.
BMC cardiovascular disorders.
2007 May; 7(?):15. doi:
10.1186/1471-2261-7-15. [PMID: 17498286] - Dinçer Avlan, Lilüfer Tamer, Lokman Ayaz, Ayşe Polat, Candan Oztürk, Hakan Ozturhan, Handan Camdeviren, Selim Aksöyek. Effects of trapidil on renal ischemia-reperfusion injury.
Journal of pediatric surgery.
2006 Oct; 41(10):1686-93. doi:
10.1016/j.jpedsurg.2006.05.064. [PMID: 17011270] - I S Jovin, U Taborski, Z Szalay, A Friedel, I Segieth, A Jovin, K Heidinger, K Schreiner, O Frass, W-P Klövekorn, G Müller-Berghaus. Trapidil decreases the aggregation of platelets from heart transplant recipients ex vivo.
Transplantation proceedings.
2006 Jun; 38(5):1523-5. doi:
10.1016/j.transproceed.2006.02.088. [PMID: 16797349] - Dinçer Avlan, Hakan Taşkinlar, Lilüfer Tamer, Handan Camdeviren, Hakan Ozturhan, Candan Oztürk, Selim Aksöyek. Protective effect of trapidil against oxidative organ damage in burn injury.
Burns : journal of the International Society for Burn Injuries.
2005 Nov; 31(7):859-65. doi:
10.1016/j.burns.2005.04.013. [PMID: 15963644] - Zeliha Kurtoglu, Ahmet Hakan Ozturk, Celal Bagdatoglu, Gurbuz Polat, Mustafa Aktekin, Deniz Uzmansel, Handan Camdeviren, Ozlen Bagdatoglu, Mustafa Sargon. Effects of trapidil after crush injury in peripheral nerve.
Acta medica Okayama.
2005 Apr; 59(2):37-44. doi:
10.18926/amo/31967. [PMID: 16049553] - Gürbüz Polat, Derya Umit Talas, Ayşe Polat, Ali Nayci, Sibel Atiş, Ozlen Bağdatoğlu, Ulkü Cömelekoğlu, Uğur Atik. Effects of triazolopyrimidine on lipid peroxidation and nitric oxide levels in the corticosteroid-impaired healing of rat tracheal anastomoses.
Cell biochemistry and function.
2005 Jan; 23(1):39-45. doi:
10.1002/cbf.1126. [PMID: 15386539] - Tahsin Colak, Ali Nayci, Gurbuz Polat, Ayse Polat, Ulku Comelekoglu, Arzu Kanik, Ozgur Turkmenoglu, Suha Aydin. Effects of trapidil on the healing of colonic anastomoses in an experimental rat model.
ANZ journal of surgery.
2003 Nov; 73(11):916-21. doi:
10.1046/j.1445-2197.2003.02683.x. [PMID: 14616570] - B H Ali. Agents ameliorating or augmenting experimental gentamicin nephrotoxicity: some recent research.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2003 Nov; 41(11):1447-52. doi:
10.1016/s0278-6915(03)00186-8. [PMID: 12962996] - Mikiko Takikita-Suzuki, Masakazu Haneda, Masakiyo Sasahara, M Koji Owada, Takahiko Nakagawa, Motohide Isono, Shoichi Takikita, Daisuke Koya, Kazumasa Ogasawara, Ryuichi Kikkawa. Activation of Src kinase in platelet-derived growth factor-B-dependent tubular regeneration after acute ischemic renal injury.
The American journal of pathology.
2003 Jul; 163(1):277-86. doi:
10.1016/s0002-9440(10)63651-6. [PMID: 12819032] - Tahsin Colak, Ayse Polat, Ozlen Bagdatoglu, Arzu Kanik, Ozgur Turkmenoglu, Suha Aydin. Effect of trapidil in ischemia/reperfusion injury on rat small intestine.
Journal of investigative surgery : the official journal of the Academy of Surgical Research.
2003 May; 16(3):167-76. doi:
10.1080/08941930390205809. [PMID: 12775433] - K Büyükafşar, A Yazar, D Düşmez, H Oztürk, G Polat, A Levent. Effect of trapidil, an antiplatelet and vasodilator agent on gentamicin-induced nephrotoxicity in rats.
Pharmacological research.
2001 Oct; 44(4):321-8. doi:
10.1006/phrs.2001.0864. [PMID: 11592868] - A I Göçer, F Ildan, M Tuna, S Polat, L Tamer, T Erman, M Kaya. Effects of trapidil on ATPase, lipid peroxidation, and correlation with ultrastructure in experimental spinal cord injury.
Neurosurgical review.
2001 Jul; 24(2-3):136-42. doi:
10.1007/pl00012398. [PMID: 11485236]