5-alpha-Dihydrotestosterone glucuronide (BioDeep_00000018348)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


(2S,3S,4S,5R,6R)-6-{[(1S,2S,7S,10R,11S,14S,15S)-2,15-dimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acid

化学式: C25H38O8 (466.2567)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 49.15%

分子结构信息

SMILES: CC12CCC(=O)CC1CCC1C2CCC2(C)C(OC3OC(C(=O)O)C(O)C(O)C3O)CCC12
InChI: InChI=1S/C25H38O8/c1-24-9-7-13(26)11-12(24)3-4-14-15-5-6-17(25(15,2)10-8-16(14)24)32-23-20(29)18(27)19(28)21(33-23)22(30)31/h12,14-21,23,27-29H,3-11H2,1-2H3,(H,30,31)/t12-,14-,15-,16-,17-,18-,19-,20+,21-,23+,24-,25-/m0/s1

描述信息

5-alpha-Dihydrotestosterone glucuronide is a natural human metabolite of 5alpha-Dihydrotestosterone generated in the liver by UDP glucuonyltransferase. Glucuronidation is used to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source. Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys.
5-alpha-Dihydrotestosterone glucuronide is a natural human metabolite of 5alpha-Dihydrotestosterone generated in the liver by UDP glucuonyltransferase.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

39 个代谢物同义名

(2S,3S,4S,5R,6R)-6-{[(1S,2S,7S,10R,11S,14S,15S)-2,15-dimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acid; (5alpha,17beta)-3-Oxoandrostan-17-yl beta-D-glucopyranosiduronic acid; (5alpha,17beta)-3-Oxoandrostan-17-yl beta-D-glucopyranosiduronate; (5a,17b)-3-Oxoandrostan-17-yl b-D-glucopyranosiduronic acid; (5Α,17β)-3-oxoandrostan-17-yl β-D-glucopyranosiduronic acid; 5alpha-Dihydrotestosterone 17-O-(beta-D-glucuronic acid); (5a,17b)-3-Oxoandrostan-17-yl b-D-glucopyranosiduronate; (5Α,17β)-3-oxoandrostan-17-yl β-D-glucopyranosiduronate; Dihydrotestosterone glucuronide, (5beta,17beta)-isomer; 5alpha-Dihydrotestosterone 17-O-(beta-D-glucuronate); 5alpha-Dihydrotestosterone 17-(beta-D-glucuronide); 5a-Dihydrotestosterone 17-O-(b-D-glucuronic acid); 17beta-Hydroxy-5alpha-androstan-3-one glucuronide; 5Α-dihydrotestosterone 17-O-(β-D-glucuronic acid); 5alpha-Dihydrotestosterone 17-beta-glucuronide; 5a-Dihydrotestosterone 17-O-(b-D-glucuronate); 5Α-dihydrotestosterone 17-O-(β-D-glucuronate); 5a-Dihydrotestosterone 17-(b-D-glucuronide); 5Α-dihydrotestosterone 17-(β-D-glucuronide); 17b-Hydroxy-5a-androstan-3-one glucuronide; 17Β-hydroxy-5α-androstan-3-one glucuronide; 5-alpha-Dihydrotestosterone glucuronide; 5Α-dihydrotestosterone 17-β-glucuronide; 5a-Dihydrotestosterone 17-b-glucuronide; 5alpha-Dihydrotestosterone glucuronide; 5-a-Dihydrotestosterone glucuronide; 5-Α-dihydrotestosterone glucuronide; 5a-Dihydrotestosterone glucuronide; 5Α-dihydrotestosterone glucuronide; Dihydrotestosterone 17-Glucuronide; Dihydrotestosterone diglucuronide; Dihydrotestosterone glucuronide; 5alpha-Dihydrotestosterone-17g; 5a-Dihydrotestosterone-17g; 5Α-dihydrotestosterone-17g; Stanolone glucuronic acid; Stanolone 17-glucuronide; Stanolone glucuronate; FT-0662178



数据库引用编号

7 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Hannah Colldén, Andreas Landin, Ville Wallenius, Erik Elebring, Lars Fändriks, Maria E Nilsson, Henrik Ryberg, Matti Poutanen, Klara Sjögren, Liesbeth Vandenput, Claes Ohlsson. The gut microbiota is a major regulator of androgen metabolism in intestinal contents. American journal of physiology. Endocrinology and metabolism. 2019 12; 317(6):E1182-E1192. doi: 10.1152/ajpendo.00338.2019. [PMID: 31689143]
  • Man Ho Choi, Jung Nyun Kim, Bong Chul Chung. Rapid HPLC-electrospray tandem mass spectrometric assay for urinary testosterone and dihydrotestosterone glucuronides from patients with benign prostate hyperplasia. Clinical chemistry. 2003 Feb; 49(2):322-5. doi: 10.1373/49.2.322. [PMID: 12560362]
  • V A Giagulli, L Verdonck, J P Deslypere, R Giorgino, A Vermeulen. Comparison of plasma androgen glucuronide levels after percutaneous or peroral androgen treatment in men: evidence for important splanchnic contribution to plasma 17 beta-hydroxyandrogen glucuronides. The Journal of clinical endocrinology and metabolism. 1993 Feb; 76(2):429-31. doi: 10.1210/jcem.76.2.8432786. [PMID: 8432786]
  • C B Whorwood, H Ueshiba, P del Blazo. Plasma levels of C19 steroid glucuronides in pre-menopausal women with non-classical congenital adrenal hyperplasia. The Journal of steroid biochemistry and molecular biology. 1992 Apr; 42(2):211-21. doi: 10.1016/0960-0760(92)90030-m. [PMID: 1314640]
  • M J Scanlon, C B Whorwood, S Franks, M J Reed, V H James. Serum androstanediol glucuronide concentrations in normal and hirsute women and patients with thyroid dysfunction. Clinical endocrinology. 1988 Nov; 29(5):529-38. doi: 10.1111/j.1365-2265.1988.tb03702.x. [PMID: 3253032]