1-(2,5-Dimethoxy-4-iodophenyl)-1-methylethylamine (BioDeep_00000183469)
human metabolite blood metabolite
代谢物信息卡片
化学式: C11H16INO2 (321.0226)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C1=CC(=C(C=C1OC)I)OC)N
InChI: InChI=1S/C11H16INO2/c1-11(2,13)7-5-10(15-4)8(12)6-9(7)14-3/h5-6H,13H2,1-4H3
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- V S Naumenko, A S Tsybko, D V Bazovkina, N K Popova. [Implication of 5-HT2A receptors in the genetic mechanisms of the brain 5-HT system autoregulation].
Molekuliarnaia biologiia.
2012 May; 46(3):416-22. doi:
NULL
. [PMID: 22888631] - A B Klein, M A Santini, S Aznar, G M Knudsen, M Rios. Changes in 5-HT2A-mediated behavior and 5-HT2A- and 5-HT1A receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice.
Neuroscience.
2010 Sep; 169(3):1007-16. doi:
10.1016/j.neuroscience.2010.05.054
. [PMID: 20576498] - Tomonori Fujiwara, Masumi Snada, Takefumi Kofuji, Takeo Yoshikawa, Kimio Akagawa. HPC-1/syntaxin 1A gene knockout mice show abnormal behavior possibly related to a disruption in 5-HTergic systems.
The European journal of neuroscience.
2010 Jul; 32(1):99-107. doi:
10.1111/j.1460-9568.2010.07269.x
. [PMID: 20576034] - Kyle A Rasbach, Jason A Funk, Tamilselvan Jayavelu, Peter T Green, Rick G Schnellmann. 5-hydroxytryptamine receptor stimulation of mitochondrial biogenesis.
The Journal of pharmacology and experimental therapeutics.
2010 Feb; 332(2):632-9. doi:
10.1124/jpet.109.159947
. [PMID: 19875674] - Mireille Basselin, Meredith A Fox, Lisa Chang, Jane M Bell, Dede Greenstein, Mei Chen, Dennis L Murphy, Stanley I Rapoport. Imaging elevated brain arachidonic acid signaling in unanesthetized serotonin transporter (5-HTT)-deficient mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2009 Jun; 34(7):1695-709. doi:
10.1038/npp.2008.227
. [PMID: 19145225] - K A Jennings, W J Sheward, A J Harmar, T Sharp. Evidence that genetic variation in 5-HT transporter expression is linked to changes in 5-HT2A receptor function.
Neuropharmacology.
2008 Apr; 54(5):776-83. doi:
10.1016/j.neuropharm.2007.12.001
. [PMID: 18241894] - Simona Bertoni, Paola Ghizzardi, Fiore Cattaruzza, Vigilio Ballabeni, Mariannina Impicciatore, Massimiliano Tognolini, Costanza A M Lagrasta, Elisabetta Barocelli. Evidence for the involvement of 5-HT2A receptors in mild mesenteric ischemia/reperfusion dysfunctions in mice.
Pharmacological research.
2007 Dec; 56(6):550-5. doi:
10.1016/j.phrs.2007.10.004
. [PMID: 18024056] - Yingjie Wang, Werner Beck, Reinhold Deppisch, Sally M Marshall, Nicholas A Hoenich, Michael G Thompson. Advanced glycation end products elicit externalization of phosphatidylserine in a subpopulation of platelets via 5-HT2A/2C receptors.
American journal of physiology. Cell physiology.
2007 Jul; 293(1):C328-36. doi:
10.1152/ajpcell.00560.2006
. [PMID: 17625040] - Husameldin El-Nour, Lena Lundeberg, Nada Abdel-Magid, Sol-Britt Lonne-Rahm, Efrain C Azmitia, Klas Nordlind. Serotonergic mechanisms in human allergic contact dermatitis.
Acta dermato-venereologica.
2007; 87(5):390-6. doi:
10.2340/00015555-0288
. [PMID: 17721644] - Ying Qu, Lisa Chang, Justin Klaff, Ruth Seemann, Deanna Greenstein, Stanley I Rapoport. Chronic fluoxetine upregulates arachidonic acid incorporation into the brain of unanesthetized rats.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2006 Dec; 16(8):561-71. doi:
10.1016/j.euroneuro.2006.01.008
. [PMID: 16517130] - Mireille Basselin, Lisa Chang, Ruth Seemann, Jane M Bell, Stanley I Rapoport. Chronic lithium administration to rats selectively modifies 5-HT2A/2C receptor-mediated brain signaling via arachidonic acid.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2005 Mar; 30(3):461-72. doi:
10.1038/sj.npp.1300611
. [PMID: 15562295] - Shigeo Miyata, Shoko Hirano, Junzo Kamei. Diabetes inhibits the DOI-induced head-twitch response in mice.
Psychopharmacology.
2004 Dec; 177(1-2):224-9. doi:
10.1007/s00213-004-1942-3
. [PMID: 15290007] - Zhuo Chen, Kate Waimey, Louis D Van de Kar, Gonzalo A Carrasco, Michelle Landry, George Battaglia. Prenatal cocaine exposure potentiates paroxetine-induced desensitization of 5-HT2A receptor function in adult male rat offspring.
Neuropharmacology.
2004 Jun; 46(7):942-53. doi:
10.1016/j.neuropharm.2004.01.013
. [PMID: 15081791] - K J Damjanoska, B A Heidenreich, G H Kindel, D N D'Souza, Y Zhang, F Garcia, G Battaglia, W A Wolf, L D Van de Kar, N A Muma. Agonist-induced serotonin 2A receptor desensitization in the rat frontal cortex and hypothalamus.
The Journal of pharmacology and experimental therapeutics.
2004 Jun; 309(3):1043-50. doi:
10.1124/jpet.103.062067
. [PMID: 14976228] - Jens D Mikkelsen, Anders Hay-Schmidt, Alexander Kiss. Serotonergic stimulation of the rat hypothalamo-pituitary-adrenal axis: interaction between 5-HT1A and 5-HT2A receptors.
Annals of the New York Academy of Sciences.
2004 Jun; 1018(?):65-70. doi:
10.1196/annals.1296.007
. [PMID: 15240353] - Leonor Pinilla, Lucas C Gonzalez, Manuel Tena-Sempere, Enrique Aguilar. 5-HT1 and 5-HT2 receptor activation reduces N-methyl-D-aspartate (NMDA)-stimulated LH secretion in prepubertal male and female rats.
European journal of endocrinology.
2003 Jan; 148(1):121-7. doi:
10.1530/eje.0.1480121
. [PMID: 12534365] - Yahong Zhang, Katerina J Damjanoska, Gonzalo A Carrasco, Bertalan Dudas, Deborah N D'Souza, Julie Tetzlaff, Francisca Garcia, Nicole R Sullivan Hanley, Kumar Scripathirathan, Brett R Petersen, Thackery S Gray, George Battaglia, Nancy A Muma, Louis D Van de Kar. Evidence that 5-HT2A receptors in the hypothalamic paraventricular nucleus mediate neuroendocrine responses to (-)DOI.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2002 Nov; 22(21):9635-42. doi:
10.1523/jneurosci.22-21-09635.2002
. [PMID: 12417689] - Yolanda Zea-Ponce, Lawrence S Kegeles, Ningning Guo, Leonid Raskin, Venkatesalu Bakthavachalam, Marc Laruelle. Pharmacokinetics and brain distribution in non human primate of R(-)[123I]DOI, A 5HT(2A/2C) serotonin agonist.
Nuclear medicine and biology.
2002 Jul; 29(5):575-83. doi:
10.1016/s0969-8051(02)00306-2
. [PMID: 12088728] - Yoshito Matsuda, Hitoshi Hirano, Yoshifumi Watanabe. Effects of estrogen on acetylcholine release in frontal cortex of female rats: involvement of serotonergic neuronal systems.
Brain research.
2002 May; 937(1-2):58-65. doi:
10.1016/s0006-8993(02)02465-4
. [PMID: 12020863] - Kevin C F Fone, Ian A Topham. Alteration in 5-hydroxytryptamine agonist-induced behaviour following a corticosterone implant in adult rats.
Pharmacology, biochemistry, and behavior.
2002 Apr; 71(4):815-23. doi:
10.1016/s0091-3057(01)00706-7
. [PMID: 11888572] - Susan K Hemrick-Luecke, David C Evans. Comparison of the potency of MDL 100,907 and SB 242084 in blocking the serotonin (5-HT)(2) receptor agonist-induced increases in rat serum corticosterone concentrations: evidence for 5-HT(2A) receptor mediation of the HPA axis.
Neuropharmacology.
2002 Feb; 42(2):162-9. doi:
10.1016/s0028-3908(01)00166-6
. [PMID: 11804612] - M Franklin, P J Cowen. Effect of a low tryptophan diet on the prolactin responses to the 5-HT2A agonist DOI in the rat.
Pharmacopsychiatry.
2001 Jul; 34(4):147-9. doi:
10.1055/s-2001-15875
. [PMID: 11518476] - E B Larson, L M Schrott, L Bordone, S B Sparber. Embryonic cocaine exposure and corticosterone: serotonin(2) receptor mediation.
Pharmacology, biochemistry, and behavior.
2001 May; 69(1-2):71-5. doi:
10.1016/s0091-3057(01)00502-0
. [PMID: 11420070] - S Kouhata, A Kagaya, S Nakae, Y Nakata, S Yamawaki. Effect of acute lipopolysaccharide administration on (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane-induced wet dog shake behavior in rats: comparison with body weight change and locomotor activity.
Progress in neuro-psychopharmacology & biological psychiatry.
2001 Feb; 25(2):395-407. doi:
10.1016/s0278-5846(00)00172-x
. [PMID: 11294484]