2-Cyano-3-oxo-n-[4-(trifluoromethyl)phenyl]butanamide (BioDeep_00000183453)
human metabolite blood metabolite
代谢物信息卡片
化学式: C12H9F3N2O2 (270.0616)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F
InChI: InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,10H,1H3,(H,17,19)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Lieuko Nguyen, Robert B McClellan, Abanti Chaudhuri, Steven R Alexander, Sharon F Chen, Waldo Concepcion, Paul Grimm. Conversion from tacrolimus/mycophenolic acid to tacrolimus/leflunomide to treat cutaneous warts in a series of four pediatric renal allograft recipients.
Transplantation.
2012 Sep; 94(5):450-5. doi:
10.1097/tp.0b013e318264351e. [PMID: 22960763] - C Balagué, M Pont, N Prats, N Godessart. Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study.
British journal of pharmacology.
2012 Jun; 166(4):1320-32. doi:
10.1111/j.1476-5381.2012.01836.x. [PMID: 22229697] - S Agarwal, A Das, D Ghosh, A K Sarkar, T K Chattaraj, T K Pal. Comparative bioequivalence study of leflunomide tablets in Indian healthy volunteers.
Arzneimittel-Forschung.
2012 Mar; 62(3):145-8. doi:
10.1055/s-0031-1298024. [PMID: 22278631] - Isabelle Hubeek, Alferso C Abrahams, Michiel de Bruin, Hans Kemperman. Falsely decreased ionized calcium results due to analytical interference by teriflunomide, the active metabolite of leflunomide (Arava®).
Clinical chemistry and laboratory medicine.
2012 Feb; 50(4):755-6. doi:
10.1515/cclm-2011-0781. [PMID: 22505564] - Halima Rakhila, Tomas Rozek, Ashley Hopkins, Susanna Proudman, Les Cleland, Michael James, Michael Wiese. Quantitation of total and free teriflunomide (A77 1726) in human plasma by LC-MS/MS.
Journal of pharmaceutical and biomedical analysis.
2011 May; 55(2):325-31. doi:
10.1016/j.jpba.2011.01.034. [PMID: 21349677] - Jignesh M Parekh, Rajendrasinh N Vaghela, Dipen K Sutariya, Mallika Sanyal, Manish Yadav, Pranav S Shrivastav. Chromatographic separation and sensitive determination of teriflunomide, an active metabolite of leflunomide in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Aug; 878(24):2217-25. doi:
10.1016/j.jchromb.2010.06.028. [PMID: 20643586] - Numsen Hail, Ping Chen, Jadwiga J Kepa, Lane R Bushman, Colin Shearn. Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis.
Free radical biology & medicine.
2010 Jul; 49(1):109-16. doi:
10.1016/j.freeradbiomed.2010.04.006. [PMID: 20399851] - Kimia Sobhani, Danette A Garrett, Dong-Pei Liu, Petrie M Rainey. A rapid and simple high-performance liquid chromatography assay for the leflunomide metabolite, teriflunomide (A77 1726), in renal transplant recipients.
American journal of clinical pathology.
2010 Mar; 133(3):454-7. doi:
10.1309/ajcpr23yaoyfsztx. [PMID: 20154284] - Carlos E Araya, Eduardo H Garin, Richard E Neiberger, Vikas R Dharnidharka. Leflunomide therapy for BK virus allograft nephropathy in pediatric and young adult kidney transplant recipients.
Pediatric transplantation.
2010 Feb; 14(1):145-50. doi:
10.1111/j.1399-3046.2009.01183.x. [PMID: 19344337] - Petra Bohanec Grabar, Iztok Grabnar, Blaz Rozman, Dusan Logar, Matija Tomsic, Dasa Suput, Tina Trdan, Lucija Peterlin Masic, Ales Mrhar, Vita Dolzan. Investigation of the influence of CYP1A2 and CYP2C19 genetic polymorphism on 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide (A77 1726) pharmacokinetics in leflunomide-treated patients with rheumatoid arthritis.
Drug metabolism and disposition: the biological fate of chemicals.
2009 Oct; 37(10):2061-8. doi:
10.1124/dmd.109.027482. [PMID: 19581389]
