2-Cyano-3-oxo-N-[4-(trifluoromethyl)phenyl]hept-6-ynamide (BioDeep_00000183439)
human metabolite blood metabolite
代谢物信息卡片
2-Cyano-3-oxo-N-[4-(trifluoromethyl)phenyl]hept-6-ynamide
化学式: C15H11F3N2O2 (308.0773)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C#CCCC(=O)C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F
InChI: InChI=1S/C15H11F3N2O2/c1-2-3-4-13(21)12(9-19)14(22)20-11-7-5-10(6-8-11)15(16,17)18/h1,5-8,12H,3-4H2,(H,20,22)
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相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Zbigniew Wlodarczyk, Yves Vanrenterghem, Bernhard K Krämer, Jean-Paul Squifflet, Marek Ostrowski. A multicenter, randomized, double-blind study comparing different FK778 doses (manitimus) with tacrolimus and steroids vs. MMF with tacrolimus and steroids in renal transplantation.
BMC nephrology.
2012 Jul; 13(?):68. doi:
10.1186/1471-2369-13-68. [PMID: 22835011] - Antonio Guasch, Prabir Roy-Chaudhury, E Steve Woodle, William Fitzsimmons, John Holman, M Roy First. Assessment of efficacy and safety of FK778 in comparison with standard care in renal transplant recipients with untreated BK nephropathy.
Transplantation.
2010 Oct; 90(8):891-7. doi:
10.1097/tp.0b013e3181f2c94b. [PMID: 20811320] - S Bloudícková, J Rajnoch, A Lodererová, E Honsová, O Viklický. Leflunomide derivate FK 778 in accelerated renal injury in transgenic rat.
Folia biologica.
2010; 56(2):72-7. doi:
. [PMID: 20492759] - M Molinaro, C Carazzone, D Barbano, F Abbiati, M Alessiani, M Regazzi. Assessment of an LC-MS method for plasma quantification of the new immunosuppressant FK778 through comparison with HPLC-UV.
Transplantation proceedings.
2005 Jul; 37(6):2722-7. doi:
10.1016/j.transproceed.2005.06.069. [PMID: 16182794] - David L Evers, Xin Wang, Shu-Mei Huong, Kenneth A Andreoni, Eng-Shang Huang. Inhibition of human cytomegalovirus signaling and replication by the immunosuppressant FK778.
Antiviral research.
2005 Jan; 65(1):1-12. doi:
10.1016/j.antiviral.2004.03.007. [PMID: 15652966] - Yu-Luan Chen, Shahzad Akhtar, Hidetsugu Murai, Masakazu Kobayashi. In vivo metabolism for the hydroxylation of FK778 to the metabolite M3 in humans studied by enantioselective liquid chromatography/tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2005; 19(18):2681-8. doi:
10.1002/rcm.2115. [PMID: 16124029] - Yves Vanrenterghem, Johannes P van Hooff, Marian Klinger, Zbigniew Wlodarczyk, Jean-Paul Squifflet, Georges Mourad, Peter Neuhaus, Adam Jurewicz, Lionel Rostaing, Bernard Charpentier, Leszek Paczek, Henri Kreis, Rene Chang, Leendert C Paul, Josep M Grinyó, Colin Short. The effects of FK778 in combination with tacrolimus and steroids: a phase II multicenter study in renal transplant patients.
Transplantation.
2004 Jul; 78(1):9-14. doi:
10.1097/01.tp.0000132562.54089.62. [PMID: 15257032] - Jonathan Fawcett, David W Johnson. FK778: a powerful immunosuppressive, but will it really be good for you?.
Transplantation.
2004 Jul; 78(1):7-8. doi:
10.1097/01.tp.0000132563.08111.88. [PMID: 15257031] - Michael Fischereder, Matthias Kretzler. New immunosuppressive strategies in renal transplant recipients.
Journal of nephrology.
2004 Jan; 17(1):9-18. doi:
NULL. [PMID: 15151254] - Tudor Bîrsan, Camille Dambrin, Jochen Klupp, Mario Stalder, Michael J Larson, William E Fitzsimmons, Randall E Morris. In vivo pharmacokinetic and pharmacodynamic evaluation of the malononitrilamide FK778 in non-human primates.
Transplant international : official journal of the European Society for Organ Transplantation.
2003 May; 16(5):354-60. doi:
10.1007/s00147-003-0591-5. [PMID: 12712238] - Andrew E Kyles, Clare R Gregory, Stephen M Griffey, Lynda Bernsteen, Randall E Morris. Modified noble plication for the prevention of intestinal intussusception after renal transplantation in dogs.
Journal of investigative surgery : the official journal of the Academy of Surgical Research.
2003 May; 16(3):161-6. doi:
10.1080/08941930390205791. [PMID: 12775432] - Andrew E Kyles, Clare R Gregory, Stephen M Griffey, Lynda Bernsteen, Jon Pierce, Herman S Lilja, Randall E Morris. Immunosuppression with a combination of the leflunomide analog, FK778, and microemulsified cyclosporine for renal transplantation in mongrel dogs.
Transplantation.
2003 Apr; 75(8):1128-33. doi:
10.1097/01.tp.0000061789.97072.12. [PMID: 12717190] - Shijie Qi, Shengyun Zhu, Dasheng Xu, Xiang Wang, Jun Ouyang, Wenlei Jiang, Minh Diem Vu, Kupa Bilolo, Anlun Ma, Stephane Johnson, Pierre Daloze, Ihor Bekersky, William E Fitzsimmons, Huifang Chen. Significant prolongation of renal allograft survival by delayed combination therapy of FK778 with tacrolimus in nonhuman primates.
Transplantation.
2003 Apr; 75(8):1124-8. doi:
10.1097/01.tp.0000061787.68121.4d. [PMID: 12717189] - Andrew E Kyles, Clare R Gregory, Stephen M Griffey, Joshua Jackson, Lynda Bernsteen, Randall E Morris. An evaluation of combined immunosuppression with MNA 715 and microemulsified cyclosporine on renal allograft rejection in mismatched mongrel dogs.
Veterinary surgery : VS.
2002 Jul; 31(4):358-66. doi:
10.1053/jvet.2002.33615. [PMID: 12094350] - A E Kyles, C R Gregory, S M Griffey, L Bernsteen, J Jackson, R E Morris. Leflunomide analog, MNA-715, plus cyclosporine reduces renal allograft rejection in mismatched dogs.
Transplantation proceedings.
2001 Feb; 33(1-2):368-9. doi:
10.1016/s0041-1345(00)02051-0. [PMID: 11266865]
