9-(6-Sulfanylidene-3H-purin-9-yl)-3H-purine-6-thione (BioDeep_00000183339)
human metabolite blood metabolite
代谢物信息卡片
9-(6-Sulphanylidene-3H-purin-9-yl)-3H-purine-6-thione
化学式: C10H6N8S2 (302.0157)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=NC(=S)C2=C(N1)N(C=N2)N3C=NC4=C3NC=NC4=S
InChI: InChI=1S/C10H6N8S2/c19-9-5-7(11-1-13-9)17(3-15-5)18-4-16-6-8(18)12-2-14-10(6)20/h1-4H,(H,11,13,19)(H,12,14,20)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Jianxiu Du, Yadi Wang, Weimin Zhang. Label-free, non-derivatization CRET detection platform for 6-mercaptopurine based on the distance-dependent optical properties of gold nanoparticles.
Chemistry (Weinheim an der Bergstrasse, Germany).
2012 Jul; 18(27):8540-6. doi:
10.1002/chem.201200013. [PMID: 22639371] - Lun Wang, Bo Ling, Hongqi Chen, Ani Liang, Binbin Qian, Jie Fu. Flow injection chemiluminescence determination of 6-mercaptopurine based on a new system of potassium permanganate-thioacetamide-sodium hexametaphosphate.
Luminescence : the journal of biological and chemical luminescence.
2010 Nov; 25(6):431-5. doi:
10.1002/bio.1171. [PMID: 19743527] - Ritesh Parajuli, Jessica Altman, Timothy Kuzel, Maria Perdekamp, Martin Tallman. Renal cell carcinoma and acute promyelocytic leukemia: a nonrandom association?.
American journal of hematology.
2010 Oct; 85(10):829. doi:
10.1002/ajh.21813. [PMID: 20721888] - Chih-Zen Chang, Aij-Lie Kwan, Shen-Long Howng. 6-Mercaptopurine exerts an immunomodulatory and neuroprotective effect on permanent focal cerebral occlusion in rats.
Acta neurochirurgica.
2010 Aug; 152(8):1383-90; discussion 1390. doi:
10.1007/s00701-010-0608-7. [PMID: 20464434] - Chih-Zen Chang, Chih-Lung Lin, Neal F Kassel, Aij-Lie Kwan, Shen-Long Howng. 6-Mercaptopurine attenuates adhesive molecules in experimental vasospasm.
Acta neurochirurgica.
2010 May; 152(5):861-7. doi:
10.1007/s00701-010-0602-0. [PMID: 20195653] - Allison Wong, Dorsey Bass. Laboratory evaluation of inflammatory bowel disease.
Current opinion in pediatrics.
2008 Oct; 20(5):566-70. doi:
10.1097/mop.0b013e32830d3aaf. [PMID: 18781120] - Li Wang, Zhujun Zhang. The study of oxidization fluorescence sensor with molecular imprinting polymer and its application for 6-mercaptopurine (6-MP) determination.
Talanta.
2008 Aug; 76(4):768-71. doi:
10.1016/j.talanta.2008.04.024. [PMID: 18656656] - Farha A El-Chennawi, Youssef A Al-Tonbary, Youssef M Mossad, Mona A Ahmed. Immune reconstitution during maintenance therapy in children with acute lymphoblastic leukemia, relation to co-existing infection.
Hematology (Amsterdam, Netherlands).
2008 Aug; 13(4):203-9. doi:
10.1179/102453308x316086. [PMID: 18796245] - A Potthoff, K Deterding, C Trautwein, P Flemming, C P Strassburg, M P Manns, H Wedemeyer, M J Bahr. Steroid treatment for severe acute cryptogenic hepatitis.
Zeitschrift fur Gastroenterologie.
2007 Jan; 45(1):15-9. doi:
10.1055/s-2006-927280. [PMID: 17236116] - Jonathan R T Lakey, Tatsuya Kin, Garth L Warnock, A M James Shapiro, Panagiotis Tsapogas, Sharleen Imes, Gregory S Korbutt, Norman M Kneteman, Ray V Rajotte, Edmond A Ryan. Long-term graft function after allogeneic islet transplantation.
Cell transplantation.
2007; 16(4):441-6. doi:
NULL. [PMID: 17658134] - N P Juffermans, A Jager, M J Kersten, M H van Oers, D W Hommes. [Epstein-Barr virus-related lymphomas in patients with inflammatory bowel disease].
Nederlands tijdschrift voor geneeskunde.
2005 Aug; 149(33):1859-63. doi:
NULL. [PMID: 16128185] - Hua-Wen Xin, Christine Fischer, Matthias Schwab, Ulrich Klotz. Thiopurine S-methyltransferase as a target for drug interactions.
European journal of clinical pharmacology.
2005 Jul; 61(5-6):395-8. doi:
10.1007/s00228-005-0950-5. [PMID: 15952020] - Chang-Tai Xu, Shu-Yong Meng, Bo-Rong Pan. Drug therapy for ulcerative colitis.
World journal of gastroenterology.
2004 Aug; 10(16):2311-7. doi:
10.3748/wjg.v10.i16.2311. [PMID: 15285010] - Barrett H Barnes, Stephen M Borowitz, Frank T Saulsbury, Martha Hellems, James L Sutphen. Discordant erythrocyte sedimentation rate and C-reactive protein in children with inflammatory bowel disease taking azathioprine or 6-mercaptopurine.
Journal of pediatric gastroenterology and nutrition.
2004 May; 38(5):509-12. doi:
10.1097/00005176-200405000-00009. [PMID: 15097439] - Kenji Ishitsuka, Akihiko Shirahashi, Yasuhiro Iwao, Mikiko Shishime, Yasushi Takamatsu, Yoshifusa Takatsuka, Atae Utsunomiya, Junji Suzumiya, Syuji Hara, Kazuo Tamura. Bone marrow necrosis in a patient with acute promyelocytic leukemia during re-induction therapy with arsenic trioxide.
European journal of haematology.
2004 Apr; 72(4):280-4. doi:
10.1111/j.0902-4441.2003.00206.x. [PMID: 15089767] - Thierry Dervieux, Michael L Hancock, Ching-Hon Pui, Gaston K Rivera, John T Sandlund, Raul C Ribeiro, James Boyett, William E Evans, Mary V Relling. Antagonism by methotrexate on mercaptopurine disposition in lymphoblasts during up-front treatment of acute lymphoblastic leukemia.
Clinical pharmacology and therapeutics.
2003 Jun; 73(6):506-16. doi:
10.1016/s0009-9236(03)00063-8. [PMID: 12811360] - P R Wielinga, G Reid, E E Challa, I van der Heijden, L van Deemter, M de Haas, C Mol, A J Kuil, E Groeneveld, J D Schuetz, C Brouwer, R A De Abreu, J Wijnholds, J H Beijnen, P Borst. Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells.
Molecular pharmacology.
2002 Dec; 62(6):1321-31. doi:
10.1124/mol.62.6.1321. [PMID: 12435799] - H Mawatari, K Unei, S Nishimura, N Sakura, K Ueda. Comparative pharmacokinetics of oral 6-mercaptopurine and intravenous 6-mercaptopurine riboside in children.
Pediatrics international : official journal of the Japan Pediatric Society.
2001 Dec; 43(6):673-7. doi:
10.1046/j.1442-200x.2001.01475.x. [PMID: 11737747] - E J Estlin. Continuing therapy for childhood acute lymphoblastic leukaemia: clinical and cellular pharmacology of methotrexate, 6-mercaptopurine and 6-thioguanine.
Cancer treatment reviews.
2001 Dec; 27(6):351-63. doi:
10.1053/ctrv.2002.0245. [PMID: 11908928] - L Kopecna. Late effects of anticancer therapy on kidney function in children with acute lymphoblastic leukemia.
Bratislavske lekarske listy.
2001; 102(8):357-60. doi:
NULL. [PMID: 11763664]
