2-Amino-2-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic Acid (BioDeep_00000183321)
human metabolite blood metabolite
代谢物信息卡片
2-amino-2-(5-methyl-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)propanoic acid
化学式: C7H10N2O4 (186.064054)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 66.67%
分子结构信息
SMILES: CC1=C(C(=O)NO1)C(C)(C(=O)O)N
InChI: InChI=1S/C7H10N2O4/c1-3-4(5(10)9-13-3)7(2,8)6(11)12/h8H2,1-2H3,(H,9,10)(H,11,12)
描述信息
同义名列表
5 个代谢物同义名
2-amino-2-(5-methyl-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)propanoic acid; 2-amino-2-(5-methyl-3-oxo-2H-1,2-oxazol-4-yl)propanoic acid; 2-Amino-2-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic Acid; 2-Amino-2-(3-hydroxy-5-methyl-1,2-oxazol-4-yl)propanoate; 2-Amino-2-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoate
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kent Jardemark, Monica M Marcus, Anna Malmerfelt, Mohammed Shahid, Torgny H Svensson. Differential effects of AMPA receptor potentiators and glycine reuptake inhibitors on antipsychotic efficacy and prefrontal glutamatergic transmission.
Psychopharmacology.
2012 May; 221(1):115-31. doi:
10.1007/s00213-011-2554-3. [PMID: 22068461] - Liang-Wu Fu, Zhi-Ling Guo, John C Longhurst. Ionotropic glutamate receptors in the external lateral parabrachial nucleus participate in processing cardiac sympathoexcitatory reflexes.
American journal of physiology. Heart and circulatory physiology.
2012 Apr; 302(7):H1444-53. doi:
10.1152/ajpheart.00984.2011. [PMID: 22268111] - Hana Malá, Yuxia Chen, Vivi Hu Worm, Julie Kure, Birgitte H Kaae, Ulf Madsen, Lassina Badolo, Darryl S Pickering, Jesper Mogensen. Cognitive enhancing effects of an AMPA receptor positive modulator on place learning in mice.
Behavioural brain research.
2012 Jan; 226(1):18-25. doi:
10.1016/j.bbr.2011.08.036. [PMID: 21906629] - Robert Jesky, Chen Hailong. Are herbal compounds the next frontier for alleviating learning and memory impairments? An integrative look at memory, dementia and the promising therapeutics of traditional chinese medicines.
Phytotherapy research : PTR.
2011 Aug; 25(8):1105-18. doi:
10.1002/ptr.3388. [PMID: 21305632] - Matthew F Roberts, David W Taylor, Vinzenz M Unger. Two modes of interaction between the membrane-embedded TARP stargazin's C-terminal domain and the bilayer visualized by electron crystallography.
Journal of structural biology.
2011 Jun; 174(3):542-51. doi:
10.1016/j.jsb.2011.03.012. [PMID: 21426941] - M Van Moorhem, F Lambein, L Leybaert. Unraveling the mechanism of β-N-oxalyl-α,β-diaminopropionic acid (β-ODAP) induced excitotoxicity and oxidative stress, relevance for neurolathyrism prevention.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2011 Mar; 49(3):550-5. doi:
10.1016/j.fct.2010.03.054. [PMID: 20510327] - Jing Ai, Li-Hong Wang, Rong Zhang, Guo-Fen Qiao, Ning Wang, Li-Hua Sun, Guan-Yi Lu, Chao Sun, Bao-Feng Yang. Protective effect of the daming capsule on impaired baroreflexes in STZ-induced diabetic rats with hyperlipoidemia.
BMC complementary and alternative medicine.
2010 Dec; 10(?):80. doi:
10.1186/1472-6882-10-80. [PMID: 21176164] - Wenying Jin, Chong Shen, Lan Jing, Xiang-ming Zha, Jun Xia. PICK1 regulates the trafficking of ASIC1a and acidotoxicity in a BAR domain lipid binding-dependent manner.
Molecular brain.
2010 Dec; 3(?):39. doi:
10.1186/1756-6606-3-39. [PMID: 21176140] - Noelia Granado, Sara Ares-Santos, Esther O'Shea, Carlos Vicario-Abejón, M Isabel Colado, Rosario Moratalla. Selective vulnerability in striosomes and in the nigrostriatal dopaminergic pathway after methamphetamine administration : early loss of TH in striosomes after methamphetamine.
Neurotoxicity research.
2010 Jul; 18(1):48-58. doi:
10.1007/s12640-009-9106-1. [PMID: 19760475] - Lei Xue, Fan Zhang, Xianhua Chen, Junji Lin, Jian Shi. PDZ protein mediated activity-dependent LTP/LTD developmental switch at rat retinocollicular synapses.
American journal of physiology. Cell physiology.
2010 Jun; 298(6):C1572-82. doi:
10.1152/ajpcell.00012.2010. [PMID: 20457829] - Takahiro Yaguchi, Tetsu Nagata, Tomoyuki Nishizaki. 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine improves cognitive decline by enhancing long-term depression.
Behavioural brain research.
2009 Dec; 204(1):129-32. doi:
10.1016/j.bbr.2009.05.027. [PMID: 19482045] - Takeshi Kanno, Takahiro Yaguchi, Tetsu Nagata, Akito Tanaka, Tomoyuki Nishizaki. DCP-LA stimulates AMPA receptor exocytosis through CaMKII activation due to PP-1 inhibition.
Journal of cellular physiology.
2009 Oct; 221(1):183-8. doi:
10.1002/jcp.21838. [PMID: 19492412] - Daniel Tapken, Michael Hollmann. Arabidopsis thaliana glutamate receptor ion channel function demonstrated by ion pore transplantation.
Journal of molecular biology.
2008 Oct; 383(1):36-48. doi:
10.1016/j.jmb.2008.06.076. [PMID: 18625242] - Hyunjeong Yang, Hiroshi Takagi, Yoshiyuki Konishi, Hiroshi Ageta, Koji Ikegami, Ikuko Yao, Showbu Sato, Ken Hatanaka, Kaoru Inokuchi, Dae-Hyun Seog, Mitsutoshi Setou. Transmembrane and ubiquitin-like domain-containing protein 1 (Tmub1/HOPS) facilitates surface expression of GluR2-containing AMPA receptors.
PloS one.
2008 Jul; 3(7):e2809. doi:
10.1371/journal.pone.0002809. [PMID: 18665261] - Grégory Rasier, Anne-Simone Parent, Arlette Gérard, Raphaël Denooz, Marie-Christine Lebrethon, Corinne Charlier, Jean-Pierre Bourguignon. Mechanisms of interaction of endocrine-disrupting chemicals with glutamate-evoked secretion of gonadotropin-releasing hormone.
Toxicological sciences : an official journal of the Society of Toxicology.
2008 Mar; 102(1):33-41. doi:
10.1093/toxsci/kfm285. [PMID: 18032409] - Christoph Körber, Markus Werner, Jutta Hoffmann, Charlotte Sager, Monique Tietze, Sabine M Schmid, Sabine Kott, Michael Hollmann. Stargazin interaction with alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors is critically dependent on the amino acid at the narrow constriction of the ion channel.
The Journal of biological chemistry.
2007 Jun; 282(26):18758-66. doi:
10.1074/jbc.m611182200. [PMID: 17483093] - Elisa A Waxman, Isabelle Baconguis, David R Lynch, Michael B Robinson. N-methyl-D-aspartate receptor-dependent regulation of the glutamate transporter excitatory amino acid carrier 1.
The Journal of biological chemistry.
2007 Jun; 282(24):17594-607. doi:
10.1074/jbc.m702278200. [PMID: 17459877] - Margarida V Caldeira, Carlos V Melo, Daniela B Pereira, Ricardo Carvalho, Susana S Correia, Donald S Backos, Ana Luísa Carvalho, José A Esteban, Carlos B Duarte. Brain-derived neurotrophic factor regulates the expression and synaptic delivery of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons.
The Journal of biological chemistry.
2007 Apr; 282(17):12619-28. doi:
10.1074/jbc.m700607200. [PMID: 17337442] - Carsten Schmidt, Markus Werner, Michael Hollmann. Revisiting the postulated 'unitary glutamate receptor': electrophysiological and pharmacological analysis in two heterologous expression systems fails to detect evidence for its existence.
Molecular pharmacology.
2006 Jan; 69(1):119-29. doi:
10.1124/mol.105.016840. [PMID: 16214956] - Luigi Francesco Agnati, Sergi Ferre, Raffaella Burioni, Amina Woods, Susanna Genedani, Rafael Franco, Kjell Fuxe. Existence and theoretical aspects of homomeric and heteromeric dopamine receptor complexes and their relevance for neurological diseases.
Neuromolecular medicine.
2005; 7(1-2):61-78. doi:
10.1385/nmm:7:1-2:061. [PMID: 16052039] - Yi Nong, Yue-Qiao Huang, Michael W Salter. NMDA receptors are movin' in.
Current opinion in neurobiology.
2004 Jun; 14(3):353-61. doi:
10.1016/j.conb.2004.05.001. [PMID: 15194116] - Nathalie Strutz-Seebohm, Markus Werner, David M Madsen, Guiscard Seebohm, Yi Zheng, Craig S Walker, Andres V Maricq, Michael Hollmann. Functional analysis of Caenorhabditis elegans glutamate receptor subunits by domain transplantation.
The Journal of biological chemistry.
2003 Nov; 278(45):44691-701. doi:
10.1074/jbc.m305497200. [PMID: 12930835] - Pavel V Perestenko, Jeremy M Henley. Characterization of the intracellular transport of GluR1 and GluR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons.
The Journal of biological chemistry.
2003 Oct; 278(44):43525-32. doi:
10.1074/jbc.m306206200. [PMID: 12909632] - A Makatsori, R Duncko, M Schwendt, F Moncek, B B Johansson, D Jezova. Voluntary wheel running modulates glutamate receptor subunit gene expression and stress hormone release in Lewis rats.
Psychoneuroendocrinology.
2003 Jul; 28(5):702-14. doi:
10.1016/s0306-4530(02)00062-8. [PMID: 12727136] - Jan-Willem Elting, Geert A Sulter, Markku Kaste, Kennedy R Lees, Hans C Diener, Marc Hommel, Mark Versavel, Albert W Teelken, Jacques De Keyser. AMPA antagonist ZK200775 in patients with acute ischemic stroke: possible glial cell toxicity detected by monitoring of S-100B serum levels.
Stroke.
2002 Dec; 33(12):2813-8. doi:
10.1161/01.str.0000043823.37955.fb. [PMID: 12468775] - Eileen McCracken, Jill H Fowler, Deborah Dewar, Steve Morrison, James McCulloch. Grey matter and white matter ischemic damage is reduced by the competitive AMPA receptor antagonist, SPD 502.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2002 Sep; 22(9):1090-7. doi:
10.1097/00004647-200209000-00006. [PMID: 12218414] - Stefan Kölker, Georg Köhr, Barbara Ahlemeyer, Jürgen G Okun, Verena Pawlak, Friederike Hörster, Ertan Mayatepek, Josef Krieglstein, Georg F Hoffmann. Ca(2+) and Na(+) dependence of 3-hydroxyglutarate-induced excitotoxicity in primary neuronal cultures from chick embryo telencephalons.
Pediatric research.
2002 Aug; 52(2):199-206. doi:
10.1203/00006450-200208000-00011. [PMID: 12149496] - Sylvie Poluch, Norbert König. AMPA receptor activation induces GABA release from neurons migrating tangentially in the intermediate zone of embryonic rat neocortex.
The European journal of neuroscience.
2002 Jul; 16(2):350-4. doi:
10.1046/j.1460-9568.2002.02068.x. [PMID: 12169116] - Jae Hoon Bae, Kyo Cheol Mun, Won Kyun Park, Seung-Ryong Lee, Seong-Il Suh, Won Ki Baek, Man-Bin Yim, Taeg Kyu Kwon, Dae-Kyu Song. EGCG attenuates AMPA-induced intracellular calcium increase in hippocampal neurons.
Biochemical and biophysical research communications.
2002 Feb; 290(5):1506-12. doi:
10.1006/bbrc.2002.6372. [PMID: 11820792] - C Sommer, S U Roth, M Kiessling. Kainate-induced epilepsy alters protein expression of AMPA receptor subunits GluR1, GluR2 and AMPA receptor binding protein in the rat hippocampus.
Acta neuropathologica.
2001 May; 101(5):460-8. doi:
10.1007/s004010000310. [PMID: 11484817]