2-Azabicyclo[4.1.0]hept-2-en-3-amine, 7-chloro-5-methyl-, (1S,5S,6R,7R)- (BioDeep_00000183316)
human metabolite blood metabolite
代谢物信息卡片
2-Azabicyclo[4.1.0]hept-2-en-3-amine, 7-chloro-5-methyl-, (1S,5S,6R,7R)-
化学式: C7H11ClN2 (158.0610716)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 75%
分子结构信息
SMILES: CC1CC(=NC2C1C2Cl)N
InChI: InChI=1S/C7H11ClN2/c1-3-2-4(9)10-7-5(3)6(7)8/h3,5-7H,2H2,1H3,(H2,9,10)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hiroyuki Kohno, Mami Takahashi, Yumiko Yasui, Rikako Suzuki, Shingo Miyamoto, Yoshihisa Kamanaka, Masao Naka, Takayuki Maruyama, Keiji Wakabayashi, Takuji Tanaka. A specific inducible nitric oxide synthase inhibitor, ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) mice.
International journal of cancer.
2007 Aug; 121(3):506-13. doi:
10.1002/ijc.22736. [PMID: 17417780] - Masayoshi Abe, Yuri Hayashi, Akira Murai, Kazuhiko Shibata, Noriyuki Sakata, Rie Igarashi, Takeshi Katsuragi, Keiichi Tanaka. Effects of inducible nitric oxide synthase inhibitors on asthma depending on administration schedule.
Free radical biology & medicine.
2006 Mar; 40(6):1083-95. doi:
10.1016/j.freeradbiomed.2005.10.057. [PMID: 16540403] - Yuji Takamatsu, Kazuo Shimada, Koji Yamaguchi, Syoji Kuroki, Kazuo Chijiiwa, Masao Tanaka. Inhibition of inducible nitric oxide synthase prevents hepatic, but not pulmonary, injury following ischemia-reperfusion of rat liver.
Digestive diseases and sciences.
2006 Mar; 51(3):571-9. doi:
10.1007/s10620-006-3172-5. [PMID: 16614969] - Kazuma Kukita, Tadashi Katsuramaki, Hitoshi Kikuchi, Makoto Meguro, Minoru Nagayama, Hitoshi Kimura, Masato Isobe, Koichi Hirata. Remnant liver injury after hepatectomy with the pringle maneuver and its inhibition by an iNOS inhibitor (ONO-1714) in a pig model.
The Journal of surgical research.
2005 May; 125(1):78-87. doi:
10.1016/j.jss.2004.11.015. [PMID: 15836854] - Ming-Yuan Jian, Tomonobu Koizumi, Keishi Kubo. Effects of nitric oxide synthase inhibitor on acid aspiration-induced lung injury in rats.
Pulmonary pharmacology & therapeutics.
2005; 18(1):33-9. doi:
10.1016/j.pupt.2004.07.007. [PMID: 15607125] - Masaharu Komeno, Akira Akimoto, Tsuneo Fujita, Nobuo Katsube. Effects of a selective inhibitor of inducible nitric oxide synthase, ONO-1714, on experimental hemodialysis-related hypotension in renal dysfunctional dogs.
Journal of pharmacological sciences.
2004 Nov; 96(3):343-6. doi:
10.1254/jphs.scz040430. [PMID: 15539758] - Tomonobu Koizumi, Hitoshi Ogasawara, Hiroshi Yamamato, Kenji Tsushima, Zonghai Ruan, Mingyuan Jian, Keisaku Fujimoto, Keishi Kubo. Effect of ONO1714, a specific inducible nitric oxide synthase inhibitor, on lung lymph filtration and gas exchange during endotoxemia in unanesthetized sheep.
Anesthesiology.
2004 Jul; 101(1):59-65. doi:
10.1097/00000542-200407000-00011. [PMID: 15220772] - Yuji Naito, Tomohisa Takagi, Hiroshi Ichikawa, Naoya Tomatsuri, Masaaki Kuroda, Yutaka Isozaki, Kazuhiro Katada, Kazuhiko Uchiyama, Satoshi Kokura, Norimasa Yoshida, Takeshi Okanoue, Toshikazu Yoshikawa. A novel potent inhibitor of inducible nitric oxide inhibitor, ONO-1714, reduces intestinal ischemia-reperfusion injury in rats.
Nitric oxide : biology and chemistry.
2004 May; 10(3):170-7. doi:
10.1016/j.niox.2004.04.002. [PMID: 15158697] - Yoshihisa Kamanaka, Atsufumi Kawabata, Hidekazu Matsuya, Chiyomi Taga, Fumiko Sekiguchi, Naoyuki Kawao. Effect of a potent iNOS inhibitor (ONO-1714) on acetaminophen-induced hepatotoxicity in the rat.
Life sciences.
2003 Dec; 74(6):793-802. doi:
10.1016/j.lfs.2003.09.036. [PMID: 14654171] - Makoto Meguro, Tadashi Katsuramaki, Hitoshi Kimura, Masato Isobe, Minoru Nagayama, Kazuma Kukita, Akihiro Nui, Koichi Hirata. Apoptosis and necrosis after warm ischemia-reperfusion injury of the pig liver and their inhibition by ONO-1714.
Transplantation.
2003 Mar; 75(5):703-10. doi:
10.1097/01.tp.0000053400.42842.5c. [PMID: 12640313] - Daisuke Ogawa, Kenichi Shikata, Mitsuhiro Matsuda, Shinichi Okada, Hitomi Usui, Jun Wada, Naoyuki Taniguchi, Hirofumi Makino. Protective effect of a novel and selective inhibitor of inducible nitric oxide synthase on experimental crescentic glomerulonephritis in WKY rats.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2002 Dec; 17(12):2117-21. doi:
10.1093/ndt/17.12.2117. [PMID: 12454221] - Makoto Meguro, Tadashi Katsuramaki, Minoru Nagayama, Hitoshi Kimura, Masato Isobe, Yasutoshi Kimura, Takashi Matsuno, Akihiro Nui, Koichi Hirata. A novel inhibitor of inducible nitric oxide synthase (ONO-1714) prevents critical warm ischemia-reperfusion injury in the pig liver.
Transplantation.
2002 May; 73(9):1439-46. doi:
10.1097/00007890-200205150-00013. [PMID: 12023622] - C Mitaka, Y Hirata, K Yokoyama, K Makita, T Imai. A selective inhibitor for inducible nitric oxide synthase improves hypotension and lactic acidosis in canine endotoxic shock.
Critical care medicine.
2001 Nov; 29(11):2156-61. doi:
10.1097/00003246-200111000-00018. [PMID: 11700413] - K Mikawa, S I Kodama, K Nishina, H Obara. ONO-1714, a new inducible nitric oxide synthase inhibitor, attenuates diaphragmatic dysfunction associated with cerulein-induced pancreatitis in rats.
Critical care medicine.
2001 Jun; 29(6):1215-21. doi:
10.1097/00003246-200106000-00027. [PMID: 11395607] - K Nishina, K Mikawa, S Kodama , H Obara. ONO1714, a new inducible nitric oxide synthase inhibitor, attenuates sepsis-induced diaphragmatic dysfunction in hamsters.
Anesthesia and analgesia.
2001 Apr; 92(4):959-66. doi:
10.1097/00000539-200104000-00031. [PMID: 11273934] - Y Naito, T Takagi, T Ishikawa, O Handa, N Matsumoto, N Yagi, K Matsuyama, N Yoshida, T Yoshikawa. The inducible nitric oxide synthase inhibitor ONO-1714 blunts dextran sulfate sodium colitis in mice.
European journal of pharmacology.
2001 Jan; 412(1):91-9. doi:
10.1016/s0014-2999(00)00926-2. [PMID: 11166740]