Pyrrolidin-1-yl N,N-bis(sulfanyl)carbamate (BioDeep_00000183315)
human metabolite blood metabolite
代谢物信息卡片
Pyrrolidin-1-yl N,N-bis(sulphanyl)carbamic acid
化学式: C5H10N2O2S2 (194.0184)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 16.43%
分子结构信息
SMILES: C1CCN(C1)OC(=O)N(S)S
InChI: InChI=1S/C5H10N2O2S2/c8-5(7(10)11)9-6-3-1-2-4-6/h10-11H,1-4H2
描述信息
同义名列表
8 个代谢物同义名
Pyrrolidin-1-yl N,N-bis(sulphanyl)carbamic acid; Pyrrolidin-1-yl N,N-bis(sulfanyl)carbamic acid; Pyrrolidin-1-yl N,N-disulphanylcarbamic acid; Pyrrolidin-1-yl N,N-bis(sulphanyl)carbamate; Pyrrolidin-1-yl N,N-disulfanylcarbamic acid; Pyrrolidin-1-yl N,N-bis(sulfanyl)carbamate; Pyrrolidin-1-yl N,N-disulphanylcarbamate; pyrrolidin-1-yl N,N-disulfanylcarbamate
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
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Urological research.
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Talanta.
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Experimental physiology.
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Journal of hypertension.
2011 Jun; 29(6):1160-6. doi:
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Hypertension (Dallas, Tex. : 1979).
2011 Feb; 57(2):261-8. doi:
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PloS one.
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British journal of anaesthesia.
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Journal of andrology.
2009 Sep; 30(5):505-14. doi:
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Life sciences.
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Journal of biomedical science.
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International journal of impotence research.
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2009 Jun; 16(?):57. doi:
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The Korean journal of internal medicine.
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Cardiovascular research.
2009 Jun; 82(3):503-12. doi:
10.1093/cvr/cvp073. [PMID: 19246475] - Hyo-Jin An, Hong-Kun Rim, Hwan-Suck Chung, In-Young Choi, Na-Hyung Kim, Su-Jin Kim, Phil-Dong Moon, Noh-Yil Myung, Hyun-Ja Jeong, Chang-Hyun Jeong, Seok-Hee Chung, Jae-Young Um, Seung-Heon Hong, Hyung-Min Kim. Expression of inducible nitric oxide synthase by Corydalis turtschaninovii on interferon-gamma stimulated macrophages.
Journal of ethnopharmacology.
2009 Apr; 122(3):573-8. doi:
10.1016/j.jep.2008.12.030. [PMID: 19429329] - Yi Lin Wang, Yun Jiang Zheng, Zi Ping Zhang, Jing Ying Su, Ruo Qing Lei, Yao Qing Tang, Sheng Dao Zhang. Effects of gut barrier dysfunction and NF-kappaB activation on aggravating mechanism of severe acute pancreatitis.
Journal of digestive diseases.
2009 Feb; 10(1):30-40. doi:
10.1111/j.1751-2980.2008.00360.x. [PMID: 19236545] - Carrie M Elks, Nithya Mariappan, Masudul Haque, Anuradha Guggilam, Dewan S A Majid, Joseph Francis. Chronic NF-{kappa}B blockade reduces cytosolic and mitochondrial oxidative stress and attenuates renal injury and hypertension in SHR.
American journal of physiology. Renal physiology.
2009 Feb; 296(2):F298-305. doi:
10.1152/ajprenal.90628.2008. [PMID: 19073636] - Yong-Yu Li, Xin-Yuan Lu, Xue-Jin Li, Yan-Na Li, Kun Li, Chang-Jie Chen. Intervention of pyrrolidine dithiocarbamate and tetrandrine on cellular calcium overload of pancreatic acinar cells induced by serum and ascitic fluid from rats with acute pancreatitis.
Journal of gastroenterology and hepatology.
2009 Jan; 24(1):155-65. doi:
10.1111/j.1440-1746.2008.05592.x. [PMID: 19196399] - Jung Ok Ban, Ju Hoon Oh, Tae Myoung Kim, Dae Joong Kim, Heon-Sang Jeong, Sang Bae Han, Jin Tae Hong. Anti-inflammatory and arthritic effects of thiacremonone, a novel sulfur compound isolated from garlic via inhibition of NF-kappaB.
Arthritis research & therapy.
2009; 11(5):R145. doi:
10.1186/ar2819. [PMID: 19788760] - Christudas Morais, Glenda Gobe, David W Johnson, Helen Healy. Anti-angiogenic actions of pyrrolidine dithiocarbamate, a nuclear factor kappa B inhibitor.
Angiogenesis.
2009; 12(4):365-79. doi:
10.1007/s10456-009-9158-0. [PMID: 19882112] - Jin Zhao, Wen-Bin Dong, Peng-yun Li, Chun-liang Deng. Mechanism of intracellular signal transduction during injury of renal tubular cells induced by postasphyxial serum in neonates with asphyxia.
Neonatology.
2009; 96(1):33-42. doi:
10.1159/000201737. [PMID: 19204408] - Xiuli Chang, Chunfeng Shao, Qing Wu, Qiangen Wu, Min Huang, Zhijun Zhou. Pyrrolidine dithiocarbamate attenuates paraquat-induced lung injury in rats.
Journal of biomedicine & biotechnology.
2009; 2009(?):619487. doi:
10.1155/2009/619487. [PMID: 19639047] - Hyo-Jin An, Min-Jun Seo, In-Young Choi, Rae-Kil Park, Sejin Jeong, Ju-Young Lee, Hyung-Min Kim, Jae-Young Um, Seung-Heon Hong. Induction of nitric oxide & tumour necrosis factor-alpha by Psoralea corylifolia.
The Indian journal of medical research.
2008 Dec; 128(6):752-8. doi:
". [PMID: 19246800] - Wenqiang Liao, Yanling Wei, Changan Yu, Jianzhi Zhou, Shuhui Li, Yan Pang, Geng Li, Xiaohui Li. Prenatal exposure to zymosan results in hypertension in adult offspring rats.
Clinical and experimental pharmacology & physiology.
2008 Dec; 35(12):1413-8. doi:
10.1111/j.1440-1681.2008.05062.x. [PMID: 18983578] - Shijun Kang, Chunlan Yang, Rongcheng Luo. LysoPtdOH enhances CXCL16 production stimulated by LPS from macrophages and regulates T cell migration.
Lipids.
2008 Nov; 43(11):1075-83. doi:
10.1007/s11745-008-3238-6. [PMID: 18830732] - Alex L Pearson, Paul Colville-Nash, Jonathan T C Kwan, Mark E C Dockrell. Albumin induces interleukin-6 release from primary human proximal tubule epithelial cells.
Journal of nephrology.
2008 Nov; 21(6):887-93. doi:
NULL. [PMID: 19034873] - Edilia Tapia, Dolores J Sánchez-González, Omar N Medina-Campos, Virgilia Soto, Carmen Avila-Casado, Claudia M Martínez-Martínez, Richard J Johnson, Bernardo Rodríguez-Iturbe, José Pedraza-Chaverrí, Martha Franco, Laura G Sánchez-Lozada. Treatment with pyrrolidine dithiocarbamate improves proteinuria, oxidative stress, and glomerular hypertension in overload proteinuria.
American journal of physiology. Renal physiology.
2008 Nov; 295(5):F1431-9. doi:
10.1152/ajprenal.90201.2008. [PMID: 18753301] - Chan-Ho Lee, Sung-Ho Kim, Sun-Mee Lee. Effect of pyrrolidine dithiocarbamate on hepatic vascular stress gene expression during ischemia and reperfusion.
European journal of pharmacology.
2008 Oct; 595(1-3):100-7. doi:
10.1016/j.ejphar.2008.07.064. [PMID: 18722366] - Hui Fu, Wen-Bin Dong, Han-An Long, Cun-Liang Deng, Ming-Yong Wang, Kai-Gui Xu. [Role of serum from asphyxiated neonates in the inducement of human renal tubular cell adhesion to neutrophils].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.
2008 Oct; 10(5):633-6. doi:
NULL. [PMID: 18947488] - Hyo-Jin An, Hong-Kun Rim, Jong-Hyun Lee, Se-Eun Suh, Ji-Hyun Lee, Na-Hyung Kim, In-Young Choi, Hyun-Ja Jeong, Il Kwang Kim, Ju-Young Lee, Nyeon-Hyoung An, Hyung-Ryong Kim, Jae-Young Um, Hyung-Min Kim, Seung-Heon Hong. Leonurus sibiricus induces nitric oxide and tumor necrosis factor-alpha in mouse peritoneal macrophages.
Canadian journal of physiology and pharmacology.
2008 Oct; 86(10):682-90. doi:
10.1139/y08-074. [PMID: 18841173] - Chun-Feng Shao, Xiu-Li Chang, Qiang-En Wu, Ting-Ting Ban, Nan Jiang, Xin-Min Yao, Zhi-Jun Zhou. [Influence of pyrrolidine dithiocarbamate (PDTC) on expression of transforming growth factor beta(1), matrix metalloproteinase-2 and tissue inhibitor-1 of metalloproteinase in rats with pulmonary damage induced by paraquat].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.
2008 Oct; 26(10):577-82. doi:
NULL. [PMID: 19272247] - Zi-qing Hei, Xiao-liang Gan, Pin-jie Huang, Jing Wei, Ning Shen, Wan-ling Gao. Influence of Ketotifen, Cromolyn Sodium, and Compound 48/80 on the survival rates after intestinal ischemia reperfusion injury in rats.
BMC gastroenterology.
2008 Sep; 8(?):42. doi:
10.1186/1471-230x-8-42. [PMID: 18808687] - Xue-Lian Ma, Yue-Hua Li, Jian-Xin Gao, Jing Li, Lin Guo, Cui-Zhen Wu. Expression of inducible nitric oxide synthase in the liver is under the control of nuclear factor kappa B in concanavalin A-induced hepatitis.
Journal of gastroenterology and hepatology.
2008 Jul; 23(7 Pt 2):e231-5. doi:
10.1111/j.1440-1746.2007.05083.x. [PMID: 17683476] - Changguo Chen, Hoonbae Jeon, Thomas D Johnston, Roberto Gedaly, Patrick P McHugh, Dinesh Ranjan. Cyclosporin A-induced lipid and protein oxidation in human B-cells and in Epstein-Barr virus-infected B-cells is prevented by antioxidants.
Journal of investigative surgery : the official journal of the Academy of Surgical Research.
2008 Jul; 21(4):201-8. doi:
10.1080/08941930802262223. [PMID: 18615317] - Jinghui Luo, Takayuki Tsuji, Hideo Yasuda, Yuan Sun, Yoshihide Fujigaki, Akira Hishida. The molecular mechanisms of the attenuation of cisplatin-induced acute renal failure by N-acetylcysteine in rats.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2008 Jul; 23(7):2198-205. doi:
10.1093/ndt/gfn090. [PMID: 18385389] - H Wang, X M Jiang, J H Xu, J Xu, J X Tong, Y W Wang. The profile of gene expression and role of nuclear factor kappa B on glomerular injury in rats with Thy-1 nephritis.
Clinical and experimental immunology.
2008 Jun; 152(3):559-67. doi:
10.1111/j.1365-2249.2008.03654.x. [PMID: 18422731] - Shoshiro Okada, Naoko Yamaguchi-Shima, Takahiro Shimizu, Junichi Arai, Mieko Yorimitsu, Kunihiko Yokotani. Brain nuclear factor kappa B is involved in the corticotropin-releasing factor-induced central activation of sympatho-adrenomedullary outflow in rats.
European journal of pharmacology.
2008 Apr; 584(1):207-12. doi:
10.1016/j.ejphar.2008.01.037. [PMID: 18304530] - Hua Fang, Jin Liu, Chang-Xi Li, Quan-Yun Wang, Yun-Xia Zuo. [Protective effect of pyrrolidine dithiocarbamate on erythrocytes during canine cardiopulmonary bypass].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.
2008 Apr; 30(2):165-9. doi:
NULL. [PMID: 18505118] - Roberto Bini, Giorgio Olivero, Antonella Trombetta, Elisabetta Castagna, Paolo Cotogni. Effects of dimethyl sulfoxide, pyrrolidine dithiocarbamate, and methylprednisolone on nuclear factor-kappaB and heat shock protein 70 in a rat model of hemorrhagic shock.
The Journal of trauma.
2008 Apr; 64(4):1048-54. doi:
10.1097/ta.0b013e318059362e. [PMID: 18404074] - Mary M Kavurma, Michael Schoppet, Yuri V Bobryshev, Levon M Khachigian, Martin R Bennett. TRAIL stimulates proliferation of vascular smooth muscle cells via activation of NF-kappaB and induction of insulin-like growth factor-1 receptor.
The Journal of biological chemistry.
2008 Mar; 283(12):7754-62. doi:
10.1074/jbc.m706927200. [PMID: 18178561] - Yanhua Zeng, Yimou Wu, Minjun Yu, Jie Liu, Xiaoxing You, Shuangyang Tang. [Mycoplasma penetrans lipid-associated membrane proteins induce nuclear factor kappaB activation-mediated apoptosis in mouse macrophage].
Wei sheng wu xue bao = Acta microbiologica Sinica.
2008 Mar; 48(3):355-61. doi:
". [PMID: 18479063] - Xiaoxing You, Yimou Wu, Yanhua Zeng, Zhongliang Deng, Hong Qiu, Minjun Yu. Mycoplasma genitalium-derived lipid-associated membrane proteins induce activation of MAPKs, NF-kappaB and AP-1 in THP-1 cells.
FEMS immunology and medical microbiology.
2008 Mar; 52(2):228-36. doi:
10.1111/j.1574-695x.2007.00366.x. [PMID: 18177344] - Jin-Wei Lu, Hua Wang, Ji Yan-Li, Cheng Zhang, Huan Ning, Xiang-Yun Li, Heng Zhang, Zi-Hao Duan, Lei Zhao, Wei Wei, De-Xiang Xu. Differential effects of pyrrolidine dithiocarbamate on TNF-alpha-mediated liver injury in two different models of fulminant hepatitis.
Journal of hepatology.
2008 Mar; 48(3):442-52. doi:
10.1016/j.jhep.2007.10.014. [PMID: 18215436] - Sei-Jung Lee, Kye-Taek Lim. Cell death signal by glycine- and proline-rich plant glycoprotein is transferred from cytochrome c and nuclear factor kappa B to caspase 3 in Hep3B cells.
The Journal of nutritional biochemistry.
2008 Mar; 19(3):166-74. doi:
10.1016/j.jnutbio.2007.02.006. [PMID: 17588735] - Hua Fang, Chang-xi Li, Quan-yun Wang, Jin Liu, Yun-xia Zuo. [Effect of pyrrolidine dithiocarbamate on antioxidation of canine myocardium during ichemia/reperfusion injury].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences.
2008 03; 37(2):193-7. doi:
10.3785/j.issn.1008-9292.2008.02.016. [PMID: 18422282] - Yanhua Zeng, Yimou Wu, Zhongliang Deng, Xiaoxing You, Cuiming Zhu, Minjun Yu, Yanping Wan. Apoptosis induced by lipid-associated membrane proteins from Mycoplasma penetrans is mediated by nuclear factor kappaB activation in mouse macrophage.
Canadian journal of microbiology.
2008 Feb; 54(2):150-8. doi:
10.1139/w07-125. [PMID: 18388985] - Jie Chen, Changsheng Du, Jiuhong Kang, Jianmin Wang. Cu2+ is required for pyrrolidine dithiocarbamate to inhibit histone acetylation and induce human leukemia cell apoptosis.
Chemico-biological interactions.
2008 Jan; 171(1):26-36. doi:
10.1016/j.cbi.2007.09.004. [PMID: 17961528]
