4-Amino-1-(6-aminopurin-9-yl)pyrimidin-2-one (BioDeep_00000183222)
human metabolite blood metabolite
代谢物信息卡片
4-amino-1-(6-amino-9H-purin-9-yl)-1,2-dihydropyrimidin-2-one
化学式: C9H8N8O (244.08210379999997)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: C1=CN(C(=O)N=C1N)N2C=NC3=C(N=CN=C32)N
InChI: InChI=1S/C9H8N8O/c10-5-1-2-16(9(18)15-5)17-4-14-6-7(11)12-3-13-8(6)17/h1-4H,(H2,10,15,18)(H2,11,12,13)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Liang Xie, Yuan-Ying Gong, Shi-Gang Lian, Juan Yang, Shou-Jun Gao, Liang-You Xu, Ya-Ping Zhang. A microsatellite polymorphism in IGF1 gene promoter and longevity in a Han Chinese population.
BMC research notes.
2010 Mar; 3(?):55. doi:
10.1186/1756-0500-3-55. [PMID: 20199671] - Silke Meyer, Stephan Schaefer, Diana Ivan, Lisette Stolk, Pascal Arp, André G Uitterlinden, Peter P Nawroth, Ursula Plöckinger, Günter K Stalla, Ulrich Tuschy, Matthias M Weber, Alexander Weise, Andreas Pfützner, Peter H Kann. Growth hormone dose in growth hormone-deficient adults is not associated with IGF-1 gene polymorphisms.
Pharmacogenomics.
2009 Feb; 10(2):293-302. doi:
10.2217/14622416.10.2.293. [PMID: 19207031] - Stuart G Reeves, Dominique Rich, Cliff J Meldrum, Kim Colyvas, Grzegorz Kurzawski, Janina Suchy, Jan Lubinski, Rodney J Scott. IGF1 is a modifier of disease risk in hereditary non-polyposis colorectal cancer.
International journal of cancer.
2008 Sep; 123(6):1339-43. doi:
10.1002/ijc.23668. [PMID: 18623088] - Yumiko Kinoshita, Zenro Kizaki, Yasunori Ishihara, Hisakazu Nakajima, Shinsuke Adachi, Kitaro Kosaka, Akihiko Kinugasa, Tohru Sugimoto. The relationship in Japanese infants between a genetic polymorphism in the promoter region of the insulin-like growth factor I gene and the plasma level.
Neonatology.
2007; 92(2):116-9. doi:
10.1159/000101062. [PMID: 17377412] - Toshihiko Ishimitsu, Hidehiko Ono, Junichi Minami, Hiroaki Matsuoka. Pathophysiologic and therapeutic implications of adrenomedullin in cardiovascular disorders.
Pharmacology & therapeutics.
2006 Sep; 111(3):909-27. doi:
10.1016/j.pharmthera.2006.02.004. [PMID: 16616959] - M Nakamura, S Morimoto, A Ishii, T Higuchi, T Ogihara, K Kakudo. Cytosine-adenine repeat polymorphism at calcitonin gene locus associated with serum osteocalcin level in Japanese women.
Cellular and molecular biology (Noisy-le-Grand, France).
2006 May; 52(3):15-8. doi:
NULL. [PMID: 17535749] - Jung Gu Kim, Seung-Yup Ku, Dong Ock Lee, Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim, Young Min Choi, Shin Yong Moon. Relationship of osteocalcin and matrix Gla protein gene polymorphisms to serum osteocalcin levels and bone mineral density in postmenopausal Korean women.
Menopause (New York, N.Y.).
2006 May; 13(3):467-73. doi:
10.1097/01.gme.0000182803.06762.fb. [PMID: 16735944] - Maja Zecevic, Christopher I Amos, Xiangjun Gu, Imelda M Campos, J Shawn Jones, Patrick M Lynch, Miguel A Rodriguez-Bigas, Marsha L Frazier. IGF1 gene polymorphism and risk for hereditary nonpolyposis colorectal cancer.
Journal of the National Cancer Institute.
2006 Jan; 98(2):139-43. doi:
10.1093/jnci/djj016. [PMID: 16418517] - Jung Gu Kim, Seung Yup Ku, Kyung Sil Lim, Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim, Young Min Choi, Shin Yong Moon. Cytokine production by whole blood cells: relationship to interleukin gene polymorphism and bone mass.
Journal of Korean medical science.
2005 Dec; 20(6):1017-22. doi:
10.3346/jkms.2005.20.6.1017. [PMID: 16361815] - Jung Gu Kim, Young Min Choi, Shin Yong Moon, Jin Yong Lee. Association of the calcitonin gene (CA) polymorphism with bone mass and bone responsiveness to hormone therapy in postmenopausal Korean women.
Menopause (New York, N.Y.).
2003 Nov; 10(6):544-9. doi:
10.1097/01.gme.0000070525.74726.51. [PMID: 14627864] - Toshihiko Ishimitsu, Kohju Tsukada, Junichi Minami, Hidehiko Ono, Masami Ohrui, Jun Hino, Kenji Kangawa, Hiroaki Matsuoka. Microsatellite DNA polymorphism of human adrenomedullin gene in type 2 diabetic patients with renal failure.
Kidney international.
2003 Jun; 63(6):2230-5. doi:
10.1046/j.1523-1755.2003.00020.x. [PMID: 12753312] - I Kato, J Eastham, B Li, M Smith, H Yu. Genotype-phenotype analysis for the polymorphic CA repeat in the insulin-like growth factor-I (IGF-I) gene.
European journal of epidemiology.
2003; 18(3):203-9. doi:
10.1023/a:1023379100539. [PMID: 12800944] - T Gohda, T Shike, K Funabiki, I Shirato, Y Tomino. An (CA)n dinucleotide repeat polymorphism of the interleukin-6 (IL-6) gene is associated with metacarpal bone mineral density in hemodialysis patients.
Clinical nephrology.
2002 May; 57(5):365-70. doi:
10.5414/cnp57365. [PMID: 12036196] - Jung Gu Kim, Kyong Rock Roh, Jin Yong Lee. The relationship among serum insulin-like growth factor-I, insulin-like growth factor-I gene polymorphism, and bone mineral density in postmenopausal women in Korea.
American journal of obstetrics and gynecology.
2002 Mar; 186(3):345-50. doi:
10.1067/mob.2002.120483. [PMID: 11904589] - T Ishimitsu, K Hosoya, K Tsukada, J Minami, H Ono, M Ohrui, J Hino, K Kangawa, H Matsuoka. Chromosomal sublocalization and microsatellite DNA polymorphism of human adrenomedullin gene.
Peptides.
2001 Nov; 22(11):1739-44. doi:
10.1016/s0196-9781(01)00531-9. [PMID: 11754959] - H Yu, B D Li, M Smith, R Shi, H J Berkel, I Kato. Polymorphic CA repeats in the IGF-I gene and breast cancer.
Breast cancer research and treatment.
2001 Nov; 70(2):117-22. doi:
10.1023/a:1012947027213. [PMID: 11768601] - T Ishimitsu, K Hosoya, K Tsukada, J Minami, Y Futoh, H Ono, M Ohrui, J Hino, K Kangawa, H Matsuoka. Microsatellite DNA polymorphism of human adrenomedullin gene in normotensive subjects and patients with essential hypertension.
Hypertension (Dallas, Tex. : 1979).
2001 Jul; 38(1):9-12. doi:
10.1161/01.hyp.38.1.9. [PMID: 11463752]
