N-[4-[2-(6-Cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamide (BioDeep_00000183182)

   

human metabolite blood metabolite


代谢物信息卡片


trans-N-(4-(2-(6-Cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl)cyclohexyl)-4-quinolinecarboxamide

化学式: C28H30N4O (438.241949)
中文名称: SB-277011
谱图信息: 最多检出来源 Homo sapiens(blood) 70%

分子结构信息

SMILES: C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45
InChI: InChI=1S/C28H30N4O/c29-18-21-5-8-23-19-32(16-13-22(23)17-21)15-12-20-6-9-24(10-7-20)31-28(33)26-11-14-30-27-4-2-1-3-25(26)27/h1-5,8,11,14,17,20,24H,6-7,9-10,12-13,15-16,19H2,(H,31,33)

描述信息

同义名列表

5 个代谢物同义名

trans-N-(4-(2-(6-Cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl)cyclohexyl)-4-quinolinecarboxamide; N-{4-[2-(6-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl}quinoline-4-carboxamide; N-[4-[2-(6-Cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamide; N-{4-[2-(6-cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl}quinoline-4-carboxamide; SB-277011



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Rocío Guerrero-Bautista, Aurelio Franco-García, Juana M Hidalgo, Francisco José Fernández-Gómez, Bruno Ribeiro Do Couto, M Victoria Milanés, Cristina Núñez. Distinct Regulation of Dopamine D3 Receptor in the Basolateral Amygdala and Dentate Gyrus during the Reinstatement of Cocaine CPP Induced by Drug Priming and Social Stress. International journal of molecular sciences. 2021 Mar; 22(6):. doi: 10.3390/ijms22063100. [PMID: 33803578]
  • Rocío Guerrero-Bautista, Aurelio Franco-García, Juana M Hidalgo, Francisco Fernández-Gómez, M Victoria Milanés, Cristina Núñez. Blockade of D3 receptor prevents changes in DAT and D3R expression in the mesolimbic dopaminergic circuit produced by social stress- and cocaine prime-induced reinstatement of cocaine-CPP. Journal of psychopharmacology (Oxford, England). 2020 11; 34(11):1300-1315. doi: 10.1177/0269881120936468. [PMID: 32648812]
  • Rocío Guerrero-Bautista, Bruno Ribeiro Do Couto, Juana M Hidalgo, Francisco José Cárceles-Moreno, Guillermo Molina, M Luisa Laorden, Cristina Núñez, M Victoria Milanés. Modulation of stress- and cocaine prime-induced reinstatement of conditioned place preference after memory extinction through dopamine D3 receptor. Progress in neuro-psychopharmacology & biological psychiatry. 2019 06; 92(?):308-320. doi: 10.1016/j.pnpbp.2019.01.017. [PMID: 30707990]
  • Onarae V Rice, Charles R Ashby, Clark Dixon, William Laurenzo, Jason Hayden, Rui Song, Jin Li, Amit K Tiwari, Eliot L Gardner. Selective dopamine D3 receptor antagonism significantly attenuates stress-induced immobility in a rat model of post-traumatic stress disorder. Synapse (New York, N.Y.). 2018 08; 72(8):e22035. doi: 10.1002/syn.22035. [PMID: 29704283]
  • Molly M McGinnis, Cody A Siciliano, Sara R Jones. Dopamine D3 autoreceptor inhibition enhances cocaine potency at the dopamine transporter. Journal of neurochemistry. 2016 09; 138(6):821-9. doi: 10.1111/jnc.13732. [PMID: 27393374]
  • Béla Kiss, István Laszlovszky, Attila Horváth, Zsolt Némethy, Eva Schmidt, Gyula Bugovics, Károly Fazekas, István Gyertyán, Eva Agai-Csongor, György Domány, Zsolt Szombathelyi. Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: I. neurochemical characterisation of RG-15. Naunyn-Schmiedeberg's archives of pharmacology. 2008 Nov; 378(5):515-28. doi: 10.1007/s00210-008-0308-5. [PMID: 18551280]
  • N E Austin, S J Baldwin, L Cutler, N Deeks, P J Kelly, M Nash, C E Shardlow, G Stemp, K Thewlis, A Ayrton, P Jeffrey. Pharmacokinetics of the novel, high-affinity and selective dopamine D3 receptor antagonist SB-277011 in rat, dog and monkey: in vitro/in vivo correlation and the role of aldehyde oxidase. Xenobiotica; the fate of foreign compounds in biological systems. 2001 Aug; 31(8-9):677-86. doi: 10.1080/00498250110056531. [PMID: 11569533]
  • C Reavill, S G Taylor, M D Wood, T Ashmeade, N E Austin, K Y Avenell, I Boyfield, C L Branch, J Cilia, M C Coldwell, M S Hadley, A J Hunter, P Jeffrey, F Jewitt, C N Johnson, D N Jones, A D Medhurst, D N Middlemiss, D J Nash, G J Riley, C Routledge, G Stemp, K M Thewlis, B Trail, A K Vong, J J Hagan. Pharmacological actions of a novel, high-affinity, and selective human dopamine D(3) receptor antagonist, SB-277011-A. The Journal of pharmacology and experimental therapeutics. 2000 Sep; 294(3):1154-65. doi: NULL. [PMID: 10945872]