Salinazid (BioDeep_00000183133)
human metabolite blood metabolite
代谢物信息卡片
N-[(2-hydroxyphenyl)methylidene]pyridine-4-carbohydrazide
化学式: C13H11N3O2 (241.0851)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: OC1=CC=CC=C1C=NNC(=O)C1=CC=NC=C1
InChI: InChI=1S/C13H11N3O2/c17-12-4-2-1-3-11(12)9-15-16-13(18)10-5-7-14-8-6-10/h1-9,17H,(H,16,18)
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分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jan Bureš, Hana Jansová, Ján Stariat, Tomáš Filipský, Přemysl Mladěnka, Tomáš Šimůnek, Radim Kučera, Jiří Klimeš, Qin Wang, Katherine J Franz, Petra Kovaříková. LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH).
Journal of pharmaceutical and biomedical analysis.
2015 Feb; 105(?):55-63. doi:
10.1016/j.jpba.2014.11.044. [PMID: 25527982] - Eliška Potůčková, Kateřina Hrušková, Jan Bureš, Petra Kovaříková, Iva A Špirková, Kateřina Pravdíková, Lucie Kolbabová, Tereza Hergeselová, Pavlína Hašková, Hana Jansová, Miloslav Macháček, Anna Jirkovská, Vera Richardson, Darius J R Lane, Danuta S Kalinowski, Des R Richardson, Kateřina Vávrová, Tomáš Šimůnek. Structure-activity relationships of novel salicylaldehyde isonicotinoyl hydrazone (SIH) analogs: iron chelation, anti-oxidant and cytotoxic properties.
PloS one.
2014; 9(11):e112059. doi:
10.1371/journal.pone.0112059. [PMID: 25393531] - Eliška Macková, Kateřina Hrušková, Petra Bendová, Anna Vávrová, Hana Jansová, Pavlína Hašková, Petra Kovaříková, Kateřina Vávrová, Tomáš Simůnek. Methyl and ethyl ketone analogs of salicylaldehyde isonicotinoyl hydrazone: novel iron chelators with selective antiproliferative action.
Chemico-biological interactions.
2012 May; 197(2-3):69-79. doi:
10.1016/j.cbi.2012.03.010. [PMID: 22521999] - Katerina Hruskova, Petra Kovarikova, Petra Bendova, Pavlina Haskova, Eliska Mackova, Jan Stariat, Anna Vavrova, Katerina Vavrova, Tomas Simunek. Synthesis and initial in vitro evaluations of novel antioxidant aroylhydrazone iron chelators with increased stability against plasma hydrolysis.
Chemical research in toxicology.
2011 Mar; 24(3):290-302. doi:
10.1021/tx100359t. [PMID: 21214215] - T Simůnek, M Sterba, O Popelová, H Kaiserová, M Adamcová, M Hroch, P Hasková, P Ponka, V Gersl. Anthracycline toxicity to cardiomyocytes or cancer cells is differently affected by iron chelation with salicylaldehyde isonicotinoyl hydrazone.
British journal of pharmacology.
2008 Sep; 155(1):138-48. doi:
10.1038/bjp.2008.236. [PMID: 18536744] - Petra Kovaríková, Zlata Mrkvicková, Jirí Klimes. Investigation of the stability of aromatic hydrazones in plasma and related biological material.
Journal of pharmaceutical and biomedical analysis.
2008 Jun; 47(2):360-70. doi:
10.1016/j.jpba.2008.01.011. [PMID: 18294799] - Joseph M Leimberg, Eugenia Prus, Gabriela Link, Eitan Fibach, Abraham M Konijn. Iron-chelator complexes as iron sources for early developing human erythroid precursors.
Translational research : the journal of laboratory and clinical medicine.
2008 Feb; 151(2):88-96. doi:
10.1016/j.trsl.2007.12.002. [PMID: 18201676] - Maya Shvartsman, Raghavendra Kikkeri, Abraham Shanzer, Z Ioav Cabantchik. Non-transferrin-bound iron reaches mitochondria by a chelator-inaccessible mechanism: biological and clinical implications.
American journal of physiology. Cell physiology.
2007 Oct; 293(4):C1383-94. doi:
10.1152/ajpcell.00054.2007. [PMID: 17670894] - Martin Sterba, Olga Popelová, Tomás Simůnek, Yvona Mazurová, Anna Potácová, Michaela Adamcová, Ivana Guncová, Helena Kaiserová, Vladimír Palicka, Premysl Ponka, Vladimír Gersl. Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: a study of salicylaldehyde isonicotinoyl hydrazone (SIH).
Toxicology.
2007 Jun; 235(3):150-66. doi:
10.1016/j.tox.2007.03.020. [PMID: 17459556] - A Potáčová, M Adamcová, H Čajnáková, L Hrbatová, M Sterba, O Popelová, T Šimůnek, P Ponka, V Gersl. Evaluation of ECG time intervals in a rabbit model of anthracycline-induced cardiomyopathy: a useful tool for assessment of cardioprotective agents.
Physiological research.
2007; 56(2):251-254. doi:
10.33549/physiolres.931113. [PMID: 17504005] - H Kaiserová, G J M den Hartog, T Simůnek, L Schröterová, E Kvasnicková, A Bast. Iron is not involved in oxidative stress-mediated cytotoxicity of doxorubicin and bleomycin.
British journal of pharmacology.
2006 Dec; 149(7):920-30. doi:
10.1038/sj.bjp.0706930. [PMID: 17031387] - Petra Kovaríková, Jirí Klimes, Martin Stĕrba, Olga Popelová, Milan Mokrý, Vladimír Gersl, Premysl Ponka. Development of high-performance liquid chromatographic determination of salicylaldehyde isonicotinoyl hydrazone in rabbit plasma and application of this method to an in vivo study.
Journal of separation science.
2005 Aug; 28(12):1300-6. doi:
10.1002/jssc.200500077. [PMID: 16138682] - Apriliana E R Kartikasari, Niki A Georgiou, Frank L J Visseren, Henny van Kats-Renaud, B Sweder van Asbeck, Joannes J M Marx. Intracellular labile iron modulates adhesion of human monocytes to human endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology.
2004 Dec; 24(12):2257-62. doi:
10.1161/01.atv.0000147406.00871.b3. [PMID: 15486315] - Ivona Klimtová, Tomás Simůnek, Yvona Mazurová, Jana Kaplanová, Martin Sterba, Radomír Hrdina, Vladimír Gersl, Michaela Adamcová, Premysl Ponka. A study of potential toxic effects after repeated 10-week administration of a new iron chelator--salicylaldehyde isonicotinoyl hydrazone (SIH) to rabbits.
Acta medica (Hradec Kralove).
2003; 46(4):163-70. doi:
NULL. [PMID: 14965167]
