L-Pyroglutamyl-L-histidyl-3,3-dimethylprolinamide (BioDeep_00000183061)

   

human metabolite blood metabolite


代谢物信息卡片


5-Hydroxy-N-{1-[2-(C-hydroxycarbonimidoyl)-3,3-dimethylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl}-3,4-dihydro-2H-pyrrole-2-carboximidate

化学式: C18H26N6O4 (390.20154360000004)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 90%

分子结构信息

SMILES: CC1(C)CCN(C1C(N)=O)C(=O)C(CC1=CN=CN1)NC(=O)C1CCC(=O)N1
InChI: InChI=1S/C18H26N6O4/c1-18(2)5-6-24(14(18)15(19)26)17(28)12(7-10-8-20-9-21-10)23-16(27)11-3-4-13(25)22-11/h8-9,11-12,14H,3-7H2,1-2H3,(H2,19,26)(H,20,21)(H,22,25)(H,23,27)



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Hong Yang, Michael D Nyby, Yan Ao, Ai Chen, David W Adelson, Victoria Smutko, Janake Wijesuriya, Vay Liang W Go, Michael L Tuck. Role of brainstem thyrotropin-releasing hormone-triggered sympathetic overactivation in cardiovascular mortality in type 2 diabetic Goto-Kakizaki rats. Hypertension research : official journal of the Japanese Society of Hypertension. 2012 Feb; 35(2):157-65. doi: 10.1038/hr.2011.154. [PMID: 21900943]
  • Andreas Stengel, Miriam Goebel, Andrew Luckey, Pu-Qing Yuan, Lixin Wang, Yvette Taché. Cold ambient temperature reverses abdominal surgery-induced delayed gastric emptying and decreased plasma ghrelin levels in rats. Peptides. 2010 Dec; 31(12):2229-35. doi: 10.1016/j.peptides.2010.08.026. [PMID: 20817059]
  • Yan Ao, Vay Liang W Go, Natalie Toy, Tei Li, Yu Wang, Moon K Song, Joseph R Reeve, Yanyun Liu, Hong Yang. Brainstem thyrotropin-releasing hormone regulates food intake through vagal-dependent cholinergic stimulation of ghrelin secretion. Endocrinology. 2006 Dec; 147(12):6004-10. doi: 10.1210/en.2006-0820. [PMID: 16959836]
  • Yan Ao, Natalie Toy, Moon K Song, Vay Liang W Go, Hong Yang. Altered glucose and insulin responses to brain medullary thyrotropin-releasing hormone (TRH)-induced autonomic activation in type 2 diabetic Goto-Kakizaki rats. Endocrinology. 2005 Dec; 146(12):5425-32. doi: 10.1210/en.2005-0553. [PMID: 16179412]
  • Masashi Yoneda, Manabu Goto, Kimihide Nakamura, Tadahito Shimada, Hideyuki Hiraishi, Akira Terano, Masakazu Haneda. Protective effect of central thyrotropin-releasing hormone analog on cerulein-induced acute pancreatitis in rats. Regulatory peptides. 2005 Feb; 125(1-3):119-24. doi: 10.1016/j.regpep.2004.08.015. [PMID: 15582722]
  • Masashi Yoneda, Yoichi Sato, Kimihide Nakamura, Shiro Yokohama, Toru Kono, Hajime Watanobe, Akira Terano. Involvement of calcitonin gene-related peptide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic cytoprotection. European journal of pharmacology. 2003 Oct; 478(2-3):173-7. doi: 10.1016/j.ejphar.2003.08.040. [PMID: 14575802]
  • Yoichi Sato, Masashi Yoneda, Kimihide Nakamura, Isao Makino, Akira Terano. Protective effect of central thyrotropin-releasing hormone on carbon tetrachloride-induced acute hepatocellular necrosis in rats. Journal of hepatology. 2003 Jul; 39(1):47-54. doi: 10.1016/s0168-8278(03)00146-6. [PMID: 12821043]
  • Hong Yang, Yvette Taché, Gordon Ohning, Vay Liang W Go. Activation of raphe pallidus neurons increases insulin through medullary thyrotropin-releasing hormone (TRH)-vagal pathways. Pancreas. 2002 Oct; 25(3):301-7. doi: 10.1097/00006676-200210000-00014. [PMID: 12370543]
  • M Song, H Yang, J H Walsh, G Ohning, H Wong, Y Taché. Intracisternal TRH analog increases gastrin release and corpus histidine decarboxylase activity in rats. The American journal of physiology. 1999 04; 276(4):G901-8. doi: 10.1152/ajpgi.1999.276.4.g901. [PMID: 10198333]
  • N S Morrow, D M Hodgson, T Garrick. Microinjection of thyrotropin-releasing hormone analogue into the central nucleus of the amygdala stimulates gastric contractility in rats. Brain research. 1996 Sep; 735(1):141-8. doi: 10.1016/0006-8993(96)00580-x. [PMID: 8905179]
  • N S Morrow, G Quinonez, H Weiner, Y Taché, T Garrick. Interleukin-1 beta in the dorsal vagal complex inhibits TRH analogue-induced stimulation of gastric contractility. The American journal of physiology. 1995 Aug; 269(2 Pt 1):G196-202. doi: 10.1152/ajpgi.1995.269.2.g196. [PMID: 7653558]
  • A G Lynn, G W Bennett. Development of a radioimmunoassay for RX77368 (pGlu-His-3,3-dimethyl proline amide)--a stable analogue of thyrotrophin releasing hormone (TRH). Journal of pharmaceutical and biomedical analysis. 1991; 9(1):9-18. doi: 10.1016/0731-7085(91)80230-7. [PMID: 1904280]
  • H Modarres-Sadeghi, R J Guiloff. Comparative efficacy and safety of intravenous and oral administration of a TRH analogue (RX77368) in motor neuron disease. Journal of neurology, neurosurgery, and psychiatry. 1990 Nov; 53(11):944-7. doi: 10.1136/jnnp.53.11.944. [PMID: 2126554]
  • K C Fone, J V Johnson, C A Marsden, G W Bennett. Comparative behavioural and biochemical effects of repeated intrathecal administration of thyrotrophin-releasing hormone (TRH) or two analogues of TRH in adult rats. Neuropharmacology. 1989 Aug; 28(8):867-75. doi: 10.1016/0028-3908(89)90180-9. [PMID: 2476681]
  • K C Fone, J V Johnson, G W Bennett, C A Marsden. Effect of intrathecal proctolin administration on the behaviour evoked by the thyrotrophin-releasing hormone (TRH) analogue (RX 77368) and the indoleamine, TRH, substance P and calcitonin gene-related peptide levels and choline acetyltransferase activity in the rat spinal cord. Brain research. 1988 Sep; 460(1):22-8. doi: 10.1016/0006-8993(88)90426-x. [PMID: 2464406]
  • R J Guiloff, D J Eckland, C Demaine, R C Hoare, K D MacRae, S L Lightman. Controlled acute trial of a thyrotrophin releasing hormone analogue (RX77368) in motor neuron disease. Journal of neurology, neurosurgery, and psychiatry. 1987 Oct; 50(10):1359-70. doi: 10.1136/jnnp.50.10.1359. [PMID: 3119776]