Rocepafant (BioDeep_00000182998)

   

human metabolite blood metabolite


代谢物信息卡片


9-(2-chlorophenyl)-N-(4-methoxyphenyl)-3-methyl-17-thia-2,4,5,8,14-pentaazatetracyclo[8.7.0.0^{2,6}.0^{11,16}]heptadeca-1(10),3,5,8,11(16)-pentaene-14-carbothioamide

化学式: C26H23ClN6OS2 (534.1063218)
中文名称: 罗塞帕泛
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=NN=C2N1C3=C(C4=C(S3)CN(CC4)C(=S)NC5=CC=C(C=C5)OC)C(=NC2)C6=CC=CC=C6Cl
InChI: InChI=1S/C26H23ClN6OS2/c1-15-30-31-22-13-28-24(18-5-3-4-6-20(18)27)23-19-11-12-32(14-21(19)36-25(23)33(15)22)26(35)29-16-7-9-17(34-2)10-8-16/h3-10H,11-14H2,1-2H3,(H,29,35)

描述信息

C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors

同义名列表

2 个代谢物同义名

9-(2-chlorophenyl)-N-(4-methoxyphenyl)-3-methyl-17-thia-2,4,5,8,14-pentaazatetracyclo[8.7.0.0^{2,6}.0^{11,16}]heptadeca-1(10),3,5,8,11(16)-pentaene-14-carbothioamide; Rocepafant



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lisa A Teather, Jane E Magnusson, Richard J Wurtman. Platelet-activating factor antagonists decrease the inflammatory nociceptive response in rats. Psychopharmacology. 2002 Oct; 163(3-4):430-3. doi: 10.1007/s00213-002-1039-9. [PMID: 12373444]
  • X H Liu, B L Eun, J D Barks. Platelet-activating factor antagonist BN 50730 attenuates hypoxic-ischemic brain injury in neonatal rats. Pediatric research. 2001 Jun; 49(6):804-11. doi: 10.1203/00006450-200106000-00016. [PMID: 11385142]
  • M A DeCoster, P K Mukherjee, R J Davis, N G Bazan. Platelet-activating factor is a downstream messenger of kainate-induced activation of mitogen-activated protein kinases in primary hippocampal neurons. Journal of neuroscience research. 1998 Aug; 53(3):297-303. doi: 10.1002/(sici)1097-4547(19980801)53:3<297::aid-jnr3>3.0.co;2-5. [PMID: 9698157]
  • J Xie, K O Joseph, G J Bagby, T D Giles, S S Greenberg. Dissociation of TNF-alpha from endotoxin-induced nitric oxide and acute-phase hypotension. The American journal of physiology. 1997 Jul; 273(1 Pt 2):H164-74. doi: 10.1152/ajpheart.1997.273.1.h164. [PMID: 9249487]
  • H E Bazan, L Varner. A mitogen-activated protein kinase (MAP-kinase) cascade is stimulated by platelet activating factor (PAF) in corneal epithelium. Current eye research. 1997 Apr; 16(4):372-9. doi: 10.1076/ceyr.16.4.372.10699. [PMID: 9134327]
  • J M Menerath, J Cluzel, M T Droy-Lefaix, M Doly. Experimental electroretinographic exploration of retinal ischemia: preventive use of free radical scavengers and anti-PAF agents. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 1997 Feb; 13(1):81-8. doi: 10.1089/jop.1997.13.81. [PMID: 9029442]
  • Y Tao, H E Bazan, N G Bazan. Platelet-activating factor enhances urokinase-type plasminogen activator gene expression in corneal epithelium. Investigative ophthalmology & visual science. 1996 Sep; 37(10):2037-46. doi: . [PMID: 8814143]
  • V Cardile, P Mascarucci, M G De Simoni, X Jiang, M Bindoni. The effect of ether lipid 1-O-octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine and its analogues platelet activating factor and carbamyl-platelet activating factor on the biosynthesis of interleukin-6 in human thymic epithelial cells cultivated in vitro. Cytokine. 1996 Sep; 8(9):698-701. doi: 10.1006/cyto.1996.0092. [PMID: 8932980]
  • V Cardile, X Jiang, M Renis, M Bindoni. Effects of ether lipid 1-O-octadecyl-2-methoxy-rac-glycero- 3-phosphocholine and its analogs PAF and CPAF on the release of nitric oxide in primary cultures of rat astrocytes. Brain research. 1996 Apr; 715(1-2):98-103. doi: 10.1016/0006-8993(95)01564-7. [PMID: 8739627]
  • J S Hurst, H E Bazan. Activation of the phospholipase/cyclooxygenase cascade in the rabbit cornea by platelet-activating factor is challenged by PAF receptor antagonists. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 1995; 11(3):329-37. doi: 10.1089/jop.1995.11.329. [PMID: 8590265]
  • A L Pires, P M e Silva, C Pasquale, H C Castro-Faria-Neto, P T Bozza, R S Cordeiro, G A Rae, P Braquet, V Lagente, M A Martins. Long-lasting inhibitory activity of the hetrazepinic BN 50730 on exudation and cellular alterations evoked by PAF and LPS. British journal of pharmacology. 1994 Nov; 113(3):994-1000. doi: 10.1111/j.1476-5381.1994.tb17091.x. [PMID: 7858896]
  • J Girault, J M Malgouyat, D Longueville, G Lecomte, M Revaud, J B Fourtillan. Quantitative measurement of a new synthetic hetrazepine derivative, BN50730, in human plasma and urine by combined liquid chromatography-negative chemical ionization mass spectrometry using a particle beam interface. Journal of chromatography. B, Biomedical applications. 1994 Aug; 658(2):289-301. doi: 10.1016/0378-4347(94)00253-3. [PMID: 7820257]
  • C Celma. Determination of the platelet activating factor antagonist 6-(2- chlorophenyl)-9-[(4-methoxyphenyl)thiocarbamoyl]-1-methyl-7,8,9,10- tetrahydro-4H-pyrido[4',3'-4,5]-thieno[3,2-f][1,2,4]triazolo[4, 3-a][1,4] diazepine in human plasma by liquid chromatography-thermospray mass spectrometry. Journal of chromatography. B, Biomedical applications. 1994 Jul; 657(1):214-8. doi: 10.1016/0378-4347(94)80090-1. [PMID: 7952071]
  • P Guinot. Clinical experience with platelet-activating factor antagonists. Past, present, and near future. Clinical reviews in allergy. 1994; 12(4):397-417. doi: 10.1007/bf02802302. [PMID: 7743464]
  • V Lagente, E Boichot, C Carre, P Guinot, J M Mencia-Huerta, P Braquet. Effects of the platelet activating factor antagonists BN 52021 and BN 50730 on antigen-induced bronchial hyperresponsiveness and eosinophil infiltration in lung from sensitized guinea-pigs. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 1993 Dec; 23(12):1002-10. doi: 10.1111/j.1365-2222.1993.tb00291.x. [PMID: 10779293]
  • H E Bazan, Y Tao, N G Bazan. Platelet-activating factor induces collagenase expression in corneal epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 1993 Sep; 90(18):8678-82. doi: 10.1073/pnas.90.18.8678. [PMID: 8378347]
  • J Hunyadi, A S Kenderessy, E Duda, P Braquet, A Dobozy. Platelet-activating factor antagonists (BN 52021 and BN 50730) inhibit tumor necrosis factor-alfa-mediated cytotoxicity on murine L929 tumor cells. Molecular immunology. 1993 Apr; 30(6):517-9. doi: 10.1016/0161-5890(93)90025-7. [PMID: 7683748]
  • L W Jobe, R Ubungen, C J Goodner, D G Baskin, P Braquet, A Lernmark. Protection from BB rat diabetes by the platelet-activating factor inhibitor BN50730. Autoimmunity. 1993; 16(4):259-66. doi: 10.3109/08916939309014644. [PMID: 8025205]
  • N Ueda, P R Mayeux, P D Walker, S V Shah. Receptor-mediated increase in cytosolic calcium in LLC-PK1 cells by platelet activating factor and thromboxane A2. Kidney international. 1991 Dec; 40(6):1075-81. doi: 10.1038/ki.1991.317. [PMID: 1662319]
  • J M Mencia-Huerta, B Dugas, E Boichot, C Petit-Frère, N Paul-Eugène, V Lagente, M Capron, F T Liu, P Braquet. Pharmacological modulation of the antigen-induced expression of the low-affinity IgE receptor (Fc epsilon RII/CD23) on rat alveolar macrophages. International archives of allergy and applied immunology. 1991; 94(1-4):295-8. doi: 10.1159/000235389. [PMID: 1834581]
  • P Braquet, J P Laurent, A Rolland, C Martin, J Pommier, D Hosford, A Esanu. From ginkgolides to N-substituted piperidino-thieno diazepines, a new series of highly potent dual antagonists. Advances in prostaglandin, thromboxane, and leukotriene research. 1991; 21B(?):929-37. doi: ". [PMID: 1825436]
  • A Muller, F Meynier, C Bonne. PAF-induced conjunctivitis in the rabbit is mediated by peptido-leukotrienes. Journal of ocular pharmacology. 1990; 6(3):227-32. doi: 10.1089/jop.1990.6.227. [PMID: 1963192]