3-[1-(3-Aminopropyl)-1H-indol-3-YL]-4-(1-methyl-1H-indol-3-YL)-1H-pyrrole-2,5-dione (BioDeep_00000182975)

   

human metabolite blood metabolite


代谢物信息卡片


3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione

化学式: C24H22N4O2 (398.1743)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 99.14%

分子结构信息

SMILES: CN1C=C(C2=CC=CC=C12)C1=C(C(=O)NC1=O)C1=CN(CCCN)C2=C1C=CC=C2
InChI: InChI=1S/C24H22N4O2/c1-27-13-17(15-7-2-4-9-19(15)27)21-22(24(30)26-23(21)29)18-14-28(12-6-11-25)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12,25H2,1H3,(H,26,29,30)

描述信息

D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D004791 - Enzyme Inhibitors

同义名列表

5 个代谢物同义名

3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione; 3-[1-(3-Aminopropyl)-1H-indol-3-YL]-4-(1-methyl-1H-indol-3-YL)-1H-pyrrole-2,5-dione; 3-[1-(3-aminopropyl)indol-3-yl]-4-(1-methylindol-3-yl)-1H-pyrrole-2,5-dione; Bisindolylmaleimide VIII; Bis VIII



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Jeong-Hun Kang, Daisuke Asai, Riki Toita, Hirotaro Kitazaki, Yoshiki Katayama. Plasma protein kinase C (PKC)alpha as a biomarker for the diagnosis of cancers. Carcinogenesis. 2009 Nov; 30(11):1927-31. doi: 10.1093/carcin/bgp210. [PMID: 19710177]
  • Y Hashimoto, M Togo, H Sato, N Hashimoto, T Watanabe, K Kurokawa, K Nakahara. Characteristics of protein kinase C-independent exocytosis in human platelets. Thrombosis research. 1997 Oct; 88(1):51-8. doi: 10.1016/s0049-3848(97)00190-4. [PMID: 9336873]
  • W B Bollag, J Ducote, C S Harmon. Biphasic effect of 1,25-dihydroxyvitamin D3 on primary mouse epidermal keratinocyte proliferation. Journal of cellular physiology. 1995 May; 163(2):248-56. doi: 10.1002/jcp.1041630205. [PMID: 7706369]
  • A C Newby, K Lim, M A Evans, N P Brindle, R F Booth. Inhibition of rabbit aortic smooth muscle cell proliferation by selective inhibitors of protein kinase C. British journal of pharmacology. 1995 Apr; 114(8):1652-6. doi: 10.1111/j.1476-5381.1995.tb14953.x. [PMID: 7599935]
  • S J Hirst, B L Webb, M A Giembycz, P J Barnes, C H Twort. Inhibition of fetal calf serum-stimulated proliferation of rabbit cultured tracheal smooth muscle cells by selective inhibitors of protein kinase C and protein tyrosine kinase. American journal of respiratory cell and molecular biology. 1995 Feb; 12(2):149-61. doi: 10.1165/ajrcmb.12.2.7865214. [PMID: 7865214]
  • C T Murphy, J Westwick. Role of type 1 and type 2A phosphatases in signal transduction of platelet-activating-factor-stimulated rabbit platelets. The Biochemical journal. 1994 Jul; 301 ( Pt 2)(?):531-7. doi: 10.1042/bj3010531. [PMID: 8042999]
  • Y Hashimoto, M Togo, K Tsukamoto, Y Horie, T Watanabe, K Kurokawa. Protein kinase C-dependent and -independent mechanisms of dense granule exocytosis by human platelets. Biochimica et biophysica acta. 1994 May; 1222(1):56-62. doi: 10.1016/0167-4889(94)90024-8. [PMID: 8186265]
  • W B Bollag, Y Xiong, J Ducote, C S Harmon. Regulation of fos-lacZ fusion gene expression in primary mouse epidermal keratinocytes isolated from transgenic mice. The Biochemical journal. 1994 May; 300 ( Pt 1)(?):263-70. doi: 10.1042/bj3000263. [PMID: 8198544]
  • T A Deisher, T T Sato, T H Pohlman, J M Harlan. A protein kinase C agonist, selective for the beta I isozyme, induces E-selectin and VCAM-1 expression on HUVEC but does not translocate PKC. Biochemical and biophysical research communications. 1993 Jun; 193(3):1283-90. doi: 10.1006/bbrc.1993.1764. [PMID: 7686753]
  • W B Bollag, J Ducote, C S Harmon. Effects of the selective protein kinase C inhibitor, Ro 31-7549, on the proliferation of cultured mouse epidermal keratinocytes. The Journal of investigative dermatology. 1993 Mar; 100(3):240-6. doi: 10.1111/1523-1747.ep12468992. [PMID: 8440894]
  • G I Welsh, C G Proud. Evidence for a role for protein kinase C in the stimulation of protein synthesis by insulin in swiss 3T3 fibroblasts. FEBS letters. 1993 Feb; 316(3):241-6. doi: 10.1016/0014-5793(93)81300-o. [PMID: 8380779]