Rivoglitazone (BioDeep_00000182965)

   

human metabolite blood metabolite


代谢物信息卡片


5-({4-[(6-methoxy-1-methyl-1H-1,3-benzodiazol-2-yl)methoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione

化学式: C20H19N3O4S (397.1096214000001)
中文名称: 利格列酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1C2=C(C=CC(=C2)OC)N=C1COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4
InChI: InChI=1S/C20H19N3O4S/c1-23-16-10-14(26-2)7-8-15(16)21-18(23)11-27-13-5-3-12(4-6-13)9-17-19(24)22-20(25)28-17/h3-8,10,17H,9,11H2,1-2H3,(H,22,24,25)

描述信息

C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C98241 - Thiazolidinedione Antidiabetic Agent

同义名列表

2 个代谢物同义名

5-({4-[(6-methoxy-1-methyl-1H-1,3-benzodiazol-2-yl)methoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione; Rivoglitazone



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

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1 个相关的物种来源信息

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  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Tsuyoshi Shinozuka, Tomoharu Tsukada, Kunihiko Fujii, Eri Tokumaru, Kousei Shimada, Yoshiyuki Onishi, Yumi Matsui, Satoko Wakimoto, Masanori Kuroha, Tsuneaki Ogata, Kazushi Araki, Jun Ohsumi, Ryoko Sawamura, Nobuaki Watanabe, Hideki Yamamoto, Kazunori Fujimoto, Yoshiro Tani, Makoto Mori, Jun Tanaka. Discovery of DS-6930, a potent selective PPARγ modulator. Part I: Lead identification. Bioorganic & medicinal chemistry. 2018 10; 26(18):5079-5098. doi: 10.1016/j.bmc.2018.09.006. [PMID: 30241907]
  • Takashi Izumi, Fujiko Tsuruta, Tomoko Ishizuka, Kouichi Nakamura, Masakatsu Kothuma, Makoto Takahashi. Stereoselectivity in pharmacokinetics of rivoglitazone, a novel peroxisome proliferator-activated receptor γ agonist, in rats and monkeys: model-based pharmacokinetic analysis and in vitro-in vivo extrapolation approach. Journal of pharmaceutical sciences. 2013 Sep; 102(9):3174-88. doi: 10.1002/jps.23586. [PMID: 23686684]
  • H S Chou, K E Truitt, J B Moberly, D Merante, Y Choi, Y Mun, A Pfützner. A 26-week, placebo- and pioglitazone-controlled monotherapy study of rivoglitazone in subjects with type 2 diabetes mellitus. Diabetes, obesity & metabolism. 2012 Nov; 14(11):1000-9. doi: 10.1111/j.1463-1326.2012.01631.x. [PMID: 22686944]
  • A P S Kong, A Yamasaki, R Ozaki, H Saito, T Asami, S Ohwada, G T C Ko, C K Wong, G T C Leung, K F Lee, C Y Yeung, J C N Chan. A randomized-controlled trial to investigate the effects of rivoglitazone, a novel PPAR gamma agonist on glucose-lipid control in type 2 diabetes. Diabetes, obesity & metabolism. 2011 Sep; 13(9):806-13. doi: 10.1111/j.1463-1326.2011.01411.x. [PMID: 21492364]
  • Minoru Uchiyama, Haruo Iwabuchi, Fujiko Tsuruta, Koji Abe, Makoto Takahashi, Hiroko Koda, Minoru Oguchi, Osamu Okazaki, Takashi Izumi. Pharmacokinetics, metabolism, and disposition of rivoglitazone, a novel peroxisome proliferator-activated receptor γ agonist, in rats and monkeys. Drug metabolism and disposition: the biological fate of chemicals. 2011 Apr; 39(4):653-66. doi: 10.1124/dmd.110.036194. [PMID: 21177486]
  • Aki Hiuge-Shimizu, Norikazu Maeda, Ayumu Hirata, Hideaki Nakatsuji, Kouichi Nakamura, Akira Okuno, Shinji Kihara, Tohru Funahashi, Iichiro Shimomura. Dynamic changes of adiponectin and S100A8 levels by the selective peroxisome proliferator-activated receptor-gamma agonist rivoglitazone. Arteriosclerosis, thrombosis, and vascular biology. 2011 Apr; 31(4):792-9. doi: 10.1161/atvbaha.110.221747. [PMID: 21233451]
  • Shoichi Kanda, Ryutaro Nakashima, Kanako Takahashi, Jun Tanaka, Junko Ogawa, Tsuneaki Ogata, Makoto Yachi, Kazushi Araki, Jun Ohsumi. Potent antidiabetic effects of rivoglitazone, a novel peroxisome proliferator-activated receptor-gamma agonist, in obese diabetic rodent models. Journal of pharmacological sciences. 2009 Oct; 111(2):155-66. doi: 10.1254/jphs.09084fp. [PMID: 19809220]
  • Shashank Rohatagi, Timothy J Carrothers, Jinyan Jin, William J Jusko, Tatiana Khariton, Joseph Walker, Kenneth Truitt, Daniel E Salazar. Model-based development of a PPARgamma agonist, rivoglitazone, to aid dose selection and optimize clinical trial designs. Journal of clinical pharmacology. 2008 Dec; 48(12):1420-9. doi: 10.1177/0091270008323260. [PMID: 18936283]