Resiquimod (BioDeep_00000182898)

   

human metabolite blood metabolite


代谢物信息卡片


1-[2-(ethoxymethyl)-4-imino-1H,4H,5H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol

化学式: C17H22N4O2 (314.1742672)
中文名称: 雷西莫特
谱图信息: 最多检出来源 Homo sapiens(blood) 0.68%

分子结构信息

SMILES: CCOCC1=NC2=C(N1CC(C)(C)O)C1=CC=CC=C1NC2=N
InChI: InChI=1S/C17H22N4O2/c1-4-23-9-13-20-14-15(21(13)10-17(2,3)22)11-7-5-6-8-12(11)19-16(14)18/h5-8,22H,4,9-10H2,1-3H3,(H2,18,19)

描述信息

C308 - Immunotherapeutic Agent > C129820 - Antineoplastic Immunomodulating Agent
C274 - Antineoplastic Agent

同义名列表

6 个代谢物同义名

1-[2-(ethoxymethyl)-4-imino-1H,4H,5H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol; 1-[2-(ethoxymethyl)-4-imino-5H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol; R848 Compound; Resiquimod; R-848; R 848



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Abi G Yates, Caroline M Weglinski, Yuxin Ying, Isobel K Dunstan, Tatyana Strekalova, Daniel C Anthony. Nafamostat reduces systemic inflammation in TLR7-mediated virus-like illness. Journal of neuroinflammation. 2022 Jan; 19(1):8. doi: 10.1186/s12974-021-02357-y. [PMID: 34991643]
  • Jaedeok Kwon, Maria Suessmilch, Alison McColl, Jonathan Cavanagh, Brian J Morris. Distinct trans-placental effects of maternal immune activation by TLR3 and TLR7 agonists: implications for schizophrenia risk. Scientific reports. 2021 12; 11(1):23841. doi: 10.1038/s41598-021-03216-9. [PMID: 34903784]
  • Priya A Debisarun, Katharina L Gössling, Ozlem Bulut, Gizem Kilic, Martijn Zoodsma, Zhaoli Liu, Marina Oldenburg, Nadine Rüchel, Bowen Zhang, Cheng-Jian Xu, Patrick Struycken, Valerie A C M Koeken, Jorge Domínguez-Andrés, Simone J C F M Moorlag, Esther Taks, Philipp N Ostermann, Lisa Müller, Heiner Schaal, Ortwin Adams, Arndt Borkhardt, Jaap Ten Oever, Reinout van Crevel, Yang Li, Mihai G Netea. Induction of trained immunity by influenza vaccination - impact on COVID-19. PLoS pathogens. 2021 10; 17(10):e1009928. doi: 10.1371/journal.ppat.1009928. [PMID: 34695164]
  • Laura Roßmann, Katrin Bagola, Tharshana Stephen, Anna-Lisa Gerards, Bianca Walber, Anja Ullrich, Stefan Schülke, Christel Kamp, Ingo Spreitzer, Milena Hasan, Brigitte David-Watine, Spencer L Shorte, Max Bastian, Ger van Zandbergen. Distinct single-component adjuvants steer human DC-mediated T-cell polarization via Toll-like receptor signaling toward a potent antiviral immune response. Proceedings of the National Academy of Sciences of the United States of America. 2021 09; 118(39):. doi: 10.1073/pnas.2103651118. [PMID: 34561306]
  • Kun Huang, Yufei Zhang, Xianfeng Hui, Ya Zhao, Wenxiao Gong, Ting Wang, Shaoran Zhang, Yong Yang, Fei Deng, Qiang Zhang, Xi Chen, Ying Yang, Xiaomei Sun, Huanchun Chen, Yizhi J Tao, Zhong Zou, Meilin Jin. Q493K and Q498H substitutions in Spike promote adaptation of SARS-CoV-2 in mice. EBioMedicine. 2021 May; 67(?):103381. doi: 10.1016/j.ebiom.2021.103381. [PMID: 33993052]
  • Salvatore Calogero Gaglio, Marta Donini, Piyachat Evelyn Denbaes, Stefano Dusi, Massimiliano Perduca. Oxyresveratrol Inhibits R848-Induced Pro-Inflammatory Mediators Release by Human Dendritic Cells Even When Embedded in PLGA Nanoparticles. Molecules (Basel, Switzerland). 2021 Apr; 26(8):. doi: 10.3390/molecules26082106. [PMID: 33916909]
  • Xuanxiao Xie, Jennifer Shrimpton, Gina M Doody, Philip G Conaghan, Frederique Ponchel. B-cell capacity for differentiation changes with age. Aging cell. 2021 04; 20(4):e13341. doi: 10.1111/acel.13341. [PMID: 33711204]
  • Se Gwang Jang, Jaeseon Lee, Seung-Min Hong, Young-Seok Song, Min Jun Kim, Seung-Ki Kwok, Mi-La Cho, Sung-Hwan Park. Niclosamide suppresses the expansion of follicular helper T cells and alleviates disease severity in two murine models of lupus via STAT3. Journal of translational medicine. 2021 02; 19(1):86. doi: 10.1186/s12967-021-02760-2. [PMID: 33632240]
  • Hua Zhang, Wei-Lun Tang, Azadeh Kheirolomoom, Brett Z Fite, Bo Wu, Kenneth Lau, Mo Baikoghli, Marina Nura Raie, Spencer K Tumbale, Josquin Foiret, Elizabeth S Ingham, Lisa M Mahakian, Sarah M Tam, R Holland Cheng, Alexander D Borowsky, Katherine W Ferrara. Development of thermosensitive resiquimod-loaded liposomes for enhanced cancer immunotherapy. Journal of controlled release : official journal of the Controlled Release Society. 2021 02; 330(?):1080-1094. doi: 10.1016/j.jconrel.2020.11.013. [PMID: 33189786]
  • Fei Ma, Yuan-Yi Zhang, Gui Yang, Li-Hua Mo, Da-Bo Liu, Li-Teng Yang, Zhi-Gang Liu, Yan Ning, Ping-Chang Yang. Integrin αvβ6 cooperates with resiquimod to restore antigen-specific immune tolerance in airway allergy. Immunology letters. 2021 02; 230(?):49-58. doi: 10.1016/j.imlet.2020.12.011. [PMID: 33385440]
  • Shuo Zhang, Jingge Qu, Li Wang, Mengtao Li, Dong Xu, Yan Zhao, Fengchun Zhang, Xiaofeng Zeng. Activation of Toll-Like Receptor 7 Signaling Pathway in Primary Sjögren's Syndrome-Associated Thrombocytopenia. Frontiers in immunology. 2021; 12(?):637659. doi: 10.3389/fimmu.2021.637659. [PMID: 33767707]
  • Justyna Agier, Ewa Brzezińska-Błaszczyk, Piotr Witczak, Elżbieta Kozłowska, Paulina Żelechowska. The impact of TLR7 agonist R848 treatment on mast cell phenotype and activity. Cellular immunology. 2021 01; 359(?):104241. doi: 10.1016/j.cellimm.2020.104241. [PMID: 33158544]
  • Wenfeng Lin, Chaoming Li, Naijin Xu, Masami Watanabe, Ruizhi Xue, Abai Xu, Motoo Araki, Ruifen Sun, Chunxiao Liu, Yasutomo Nasu, Peng Huang. Dual-Functional PLGA Nanoparticles Co-Loaded with Indocyanine Green and Resiquimod for Prostate Cancer Treatment. International journal of nanomedicine. 2021; 16(?):2775-2787. doi: 10.2147/ijn.s301552. [PMID: 33880023]
  • Arna Katewa, Eric Suto, Jessica Hui, Jose Heredia, Jie Liang, Jason Hackney, Keith Anderson, Tuija M Alcantar, Natasha Bacarro, Debra Dunlap, Jeffrey Eastham, Andres Paler-Martinez, Xin Y Rairdan, Zora Modrusan, Wyne P Lee, Cary D Austin, Daniel Lafkas, Nico Ghilardi. The peptide symporter SLC15a4 is essential for the development of systemic lupus erythematosus in murine models. PloS one. 2021; 16(1):e0244439. doi: 10.1371/journal.pone.0244439. [PMID: 33444326]
  • Zhimiao Zou, Dunfeng Du, Yan Miao, Yang Yang, Yalong Xie, Zeyang Li, Liang Zhou, Limin Zhang, Ping Zhou, Fengchao Jiang. TJ-M2010-5, a novel MyD88 inhibitor, corrects R848-induced lupus-like immune disorders of B cells in vitro. International immunopharmacology. 2020 Aug; 85(?):106648. doi: 10.1016/j.intimp.2020.106648. [PMID: 32504998]
  • Vivek Choudhary, Shantelle Griffith, Xunsheng Chen, Wendy B Bollag. Pathogen-Associated Molecular Pattern-Induced TLR2 and TLR4 Activation Increases Keratinocyte Production of Inflammatory Mediators and is Inhibited by Phosphatidylglycerol. Molecular pharmacology. 2020 05; 97(5):324-335. doi: 10.1124/mol.119.118166. [PMID: 32173651]
  • Yongcan Zhou, Xiaojuan Chen, Zhenjie Cao, Jianlong Li, Hao Long, Ying Wu, Zhengshi Zhang, Yun Sun. R848 Is Involved in the Antibacterial Immune Response of Golden Pompano (Trachinotus ovatus) Through TLR7/8-MyD88-NF-κB-Signaling Pathway. Frontiers in immunology. 2020; 11(?):617522. doi: 10.3389/fimmu.2020.617522. [PMID: 33537035]
  • Matthew S Block, Wendy K Nevala, Yuan-Ping Pang, Jacob B Allred, Carrie Strand, Svetomir N Markovic. A pilot clinical trial testing topical resiquimod and a xenopeptide as immune adjuvants for a melanoma vaccine targeting MART-1. Melanoma research. 2019 08; 29(4):420-427. doi: 10.1097/cmr.0000000000000556. [PMID: 30520800]
  • Anna K Blakney, Paul F McKay, Dennis Christensen, Bárbara Ibarzo Yus, Yoann Aldon, Frank Follmann, Robin J Shattock. Effects of cationic adjuvant formulation particle type, fluidity and immunomodulators on delivery and immunogenicity of saRNA. Journal of controlled release : official journal of the Controlled Release Society. 2019 06; 304(?):65-74. doi: 10.1016/j.jconrel.2019.04.043. [PMID: 31071377]
  • Takuya Yamamoto, Tomohiro Kanuma, Shokichi Takahama, Tomotaka Okamura, Eiko Moriishi, Ken J Ishii, Kazutaka Terahara, Yasuhiro Yasutomi. STING agonists activate latently infected cells and enhance SIV-specific responses ex vivo in naturally SIV controlled cynomolgus macaques. Scientific reports. 2019 04; 9(1):5917. doi: 10.1038/s41598-019-42253-3. [PMID: 30976083]
  • Mélanie Gaignage, Reece G Marillier, Perrine M Cochez, Laure Dumoutier, Catherine Uyttenhove, Jean-Paul Coutelier, Jacques Van Snick. The TLR7 ligand R848 prevents mouse graft-versus-host disease and cooperates with anti-interleukin-27 antibody for maximal protection and regulatory T-cell upregulation. Haematologica. 2019 02; 104(2):392-402. doi: 10.3324/haematol.2018.195628. [PMID: 30213828]
  • Alexander Wilkinson, Eric Lattmann, Carla B Roces, Gabriel K Pedersen, Dennis Christensen, Yvonne Perrie. Lipid conjugation of TLR7 agonist Resiquimod ensures co-delivery with the liposomal Cationic Adjuvant Formulation 01 (CAF01) but does not enhance immunopotentiation compared to non-conjugated Resiquimod+CAF01. Journal of controlled release : official journal of the Controlled Release Society. 2018 12; 291(?):1-10. doi: 10.1016/j.jconrel.2018.10.002. [PMID: 30291987]
  • Mohamed Sarjoon Abdul-Cader, Upasama De Silva Senapathi, Eva Nagy, Shayan Sharif, Mohamed Faizal Abdul-Careem. Antiviral response elicited against avian influenza virus infection following activation of toll-like receptor (TLR)7 signaling pathway is attributable to interleukin (IL)-1β production. BMC research notes. 2018 Dec; 11(1):859. doi: 10.1186/s13104-018-3975-4. [PMID: 30514372]
  • Zubair Ahmed Laghari, Shan Nan Chen, Li Li, Bei Huang, Zhen Gan, Ying Zhou, Hui Jun Huo, Jing Hou, Pin Nie. Functional, signalling and transcriptional differences of three distinct type I IFNs in a perciform fish, the mandarin fish Siniperca chuatsi. Developmental and comparative immunology. 2018 07; 84(?):94-108. doi: 10.1016/j.dci.2018.02.008. [PMID: 29432791]
  • Shenhong Qu, Taijie Qin, Min Li, Shaojie Zhang, Linsong Ye, Jiazhang Wei, Hua Fan, Baiwen Chen. The effects of resiquimod in an ovalbumin-induced allergic rhinitis model. International immunopharmacology. 2018 Jun; 59(?):233-242. doi: 10.1016/j.intimp.2018.04.015. [PMID: 29665497]
  • Frances E Pearson, Karshing Chang, Yoshihito Minoda, Ingrid M Leal Rojas, Oscar L Haigh, Ghazal Daraj, Kirsteen M Tullett, Kristen J Radford. Activation of human CD141+ and CD1c+ dendritic cells in vivo with combined TLR3 and TLR7/8 ligation. Immunology and cell biology. 2018 04; 96(4):390-400. doi: 10.1111/imcb.12009. [PMID: 29344995]
  • Zongmin Zhao, Brian Harris, Yun Hu, Theresa Harmon, Paul R Pentel, Marion Ehrich, Chenming Zhang. Rational incorporation of molecular adjuvants into a hybrid nanoparticle-based nicotine vaccine for immunotherapy against nicotine addiction. Biomaterials. 2018 Feb; 155(?):165-175. doi: 10.1016/j.biomaterials.2017.11.021. [PMID: 29179132]
  • Mosayeb Rostamian, Fariborz Bahrami, Hamid M Niknam. Vaccination with whole-cell killed or recombinant leishmanial protein and toll-like receptor agonists against Leishmania tropica in BALB/c mice. PloS one. 2018; 13(9):e0204491. doi: 10.1371/journal.pone.0204491. [PMID: 30248142]
  • John Bell, Mike Dymond, Mark Biffen, Stephen Delaney, David Keeling, Hui Zhang, Ian Robinson. Temporal cytokine and lymphoid responses to an inhaled TLR7 antedrug agonist in the cynomolgus monkey demonstrates potential safety and tolerability of this approach. Toxicology and applied pharmacology. 2018 01; 338(?):9-19. doi: 10.1016/j.taap.2017.11.002. [PMID: 29122671]
  • Justine Calise, Susana Marquez Renteria, Peter K Gregersen, Betty Diamond. Lineage-Specific Functionality of an Interferon Regulatory Factor 5 Lupus Risk Haplotype: Lack of B Cell Intrinsic Effects. Frontiers in immunology. 2018; 9(?):996. doi: 10.3389/fimmu.2018.00996. [PMID: 29867973]
  • Mosayeb Rostamian, Hamid M Niknam. Evaluation of the adjuvant effect of agonists of toll-like receptor 4 and 7/8 in a vaccine against leishmaniasis in BALB/c mice. Molecular immunology. 2017 11; 91(?):202-208. doi: 10.1016/j.molimm.2017.09.010. [PMID: 28963929]
  • Yao Mawulikplimi Adzavon, Pengxiang Zhao, Baobei Lv, Mengyu Liu, Xin Zhang, Fei Xie, Linqi Yang, Lei Shang, Mingzi Zhang, Qinjian Li, Xuemei Ma. TLR7 and TLR8 agonist resiquimod (R848) differently regulates MIF expression in cells and organs. Cytokine. 2017 09; 97(?):156-166. doi: 10.1016/j.cyto.2017.06.006. [PMID: 28648870]
  • Esther M Speer, David J Dowling, Lukasz S Ozog, Jianjin Xu, Jie Yang, Geetika Kennady, Ofer Levy. Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns. Pediatric research. 2017 May; 81(5):806-816. doi: 10.1038/pr.2017.6. [PMID: 28072760]
  • Yuan Shen, Menghua Zeng, Feng Qiu, Hua Tang. [Resiquimod (R848) has more stronger immune adjuvantivity than other tested TLR agonists]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2017 May; 33(5):591-596. doi: ". [PMID: 28502294]
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  • Veronika Caisová, Andra Vieru, Zuzana Kumžáková, Simona Glaserová, Hana Husníková, Nikol Vácová, Gabriela Krejčová, Lucie Paďouková, Ivana Jochmanová, Katherine I Wolf, Jindřich Chmelař, Jan Kopecký, Jan Ženka. Innate immunity based cancer immunotherapy: B16-F10 murine melanoma model. BMC cancer. 2016 12; 16(1):940. doi: 10.1186/s12885-016-2982-x. [PMID: 27927165]
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