Reproterol (BioDeep_00000182896)
human metabolite blood metabolite
代谢物信息卡片
化学式: C18H23N5O5 (389.1699)
中文名称: 瑞普特罗
谱图信息:
最多检出来源 Homo sapiens(blood) 66.67%
分子结构信息
SMILES: CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CCCNCC(C3=CC(=CC(=C3)O)O)O
InChI: InChI=1S/C18H23N5O5/c1-21-16-15(17(27)22(2)18(21)28)23(10-20-16)5-3-4-19-9-14(26)11-6-12(24)8-13(25)7-11/h6-8,10,14,19,24-26H,3-5,9H2,1-2H3
描述信息
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03C - Adrenergics for systemic use > R03CC - Selective beta-2-adrenoreceptor agonists
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03A - Adrenergics, inhalants > R03AC - Selective beta-2-adrenoreceptor agonists
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:135612
- PubChem: 25654
- HMDB: HMDB0257155
- DrugBank: DB12846
- ChEMBL: CHEMBL1095607
- Wikipedia: Reproterol
- chemspider: 23898
- CAS: 54063-54-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- R J B Peters, J E Oosterink, A A M Stolker, C Georgakopoulos, M W F Nielen. Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories.
Analytical and bioanalytical chemistry.
2010 Apr; 396(7):2583-98. doi:
10.1007/s00216-010-3484-3. [PMID: 20155493] - M W F Nielen, J J P Lasaroms, M L Essers, J E Oosterink, T Meijer, M B Sanders, T Zuidema, A A M Stolker. Multiresidue analysis of beta-agonists in bovine and porcine urine, feed and hair using liquid chromatography electrospray ionisation tandem mass spectrometry.
Analytical and bioanalytical chemistry.
2008 May; 391(1):199-210. doi:
10.1007/s00216-007-1760-7. [PMID: 18180910] - Guido Zimmer, Markus Bernhörster, Patrizius Pilz, Jutta Schuchmann-Fix, Rolf Hüggelmeier, Nicole Blüm, Herman Libertus. Mononuclear cell membranes: stabilization by reproterol and cromoglycate, destabilization by fenoterol and salbutamol.
Arzneimittel-Forschung.
2006; 56(2):76-83. doi:
10.1055/s-0031-1296705. [PMID: 16572921] - M K Henze, G Opfermann, H Spahn-Langguth, W Schänzer. Screening of beta-2 agonists and confirmation of fenoterol, orciprenaline, reproterol and terbutaline with gas chromatography-mass spectrometry as tetrahydroisoquinoline derivatives.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Feb; 751(1):93-105. doi:
10.1016/s0378-4347(00)00452-7. [PMID: 11232861] - G Zimmer, A Dahinten, A Fitzner, S Halbig, T Noll, F Treusch, H Libertus. beta-agonistic bronchodilators: comparison of dose/response in working rat hearts.
Chest.
2000 Feb; 117(2):519-29. doi:
10.1378/chest.117.2.519. [PMID: 10669699] - C G Georgakopoulos, C Tsitsimpikou, M H Spyridaki. Excretion study of the beta2-agonist reproterol in human urine.
Journal of chromatography. B, Biomedical sciences and applications.
1999 Apr; 726(1-2):141-8. doi:
10.1016/s0378-4347(99)00033-x. [PMID: 10348180] - R Hermann, P Ruus, E Schneider, C de Mey. Tolerability and in vivo performance of a novel freon-free metered dose inhaler for a fixed combinational product of reproterol and disodium cromoglycate.
Arzneimittel-Forschung.
1998 Jun; 48(6):663-7. doi:
NULL. [PMID: 9689424] - N G Knebel, M Winkler. Rapid and automated determination of the beta2-agonist reproterol in human plasma by atmospheric pressure chemical ionisation high-performance liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications.
1997 Nov; 702(1-2):119-29. doi:
10.1016/s0378-4347(97)00381-2. [PMID: 9449563] - A Boznański, M Domanasiewicz, D Rudzka, I Pirogowicz. [Preliminary evaluation of efficacy for the preparation DNCG-compositum in treatment of atopic bronchial asthma in children].
Pneumonologia i alergologia polska.
1994; 62(1-2):80-3. doi:
NULL. [PMID: 8075618] - J Fritze, E Sofic, T Müller, H Pfüller, M Lanczik, P Riederer. Cholinergic-adrenergic balance: Part 1. Relationship between central and peripheral sensitivities.
Psychiatry research.
1990 Dec; 34(3):259-70. doi:
10.1016/0165-1781(90)90004-o. [PMID: 1963691] - R J Hageman, R A de Zeeuw, J E Greving, J J Krann, G H Koëter. Plasma levels, heart rate, and blood pressure after intravenous, oral, and aerosol administration of reproterol in man.
Biopharmaceutics & drug disposition.
1988 May; 9(3):301-14. doi:
10.1002/bod.2510090308. [PMID: 3395671] - R J Hageman, J E Greving, J H Jonkman, R A De Zeeuw. High-performance liquid chromatographic determination of reproterol in plasma using on-line trace enrichment and amperometric detection with a rotating working electrode.
Journal of chromatography.
1983 May; 274(?):239-53. doi:
10.1016/s0378-4347(00)84427-8. [PMID: 6874825] - N Kucharczyk, J T Yang, R D Sofia. Biotransformation of reproterol in the intestinal tract of the rat.
Arzneimittel-Forschung.
1981; 31(12):2085-8. doi:
NULL. [PMID: 7199302]
