Raxofelast (BioDeep_00000182860)

   

human metabolite blood metabolite


代谢物信息卡片


2-[5-(acetyloxy)-4,6,7-trimethyl-2,3-dihydro-1-benzofuran-2-yl]acetic acid

化学式: C15H18O5 (278.1154178)
中文名称: 2-(5-乙酰氧基-4,6,7-三甲基-2,3-二氢苯并呋喃-2-基)乙酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)OC1=C(C)C(C)=C2OC(CC(O)=O)CC2=C1C
InChI: InChI=1S/C15H18O5/c1-7-8(2)15-12(5-11(20-15)6-13(17)18)9(3)14(7)19-10(4)16/h11H,5-6H2,1-4H3,(H,17,18)

描述信息

C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic

同义名列表

7 个代谢物同义名

2-[5-(acetyloxy)-4,6,7-trimethyl-2,3-dihydro-1-benzofuran-2-yl]acetic acid; [5-(acetyloxy)-4,6,7-trimethyl-2,3-dihydro-1-benzofuran-2-yl]acetic acid; 2-[5-(Acetyloxy)-4,6,7-trimethyl-2,3-dihydro-1-benzofuran-2-yl]acetate; 2-(2,3-Dihydro-5-acetoxy-4,6,7-trimethylbenzofuranyl)acetic acid; Raxofelast; IRFI 016; IRFI-016



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Pietro Antonuccio, Letteria Minutoli, Carmelo Romeo, Piero Antonio Nicòtina, Alessandra Bitto, Salvatore Arena, Domenica Altavilla, Biagio Zuccarello, Francesca Polito, Francesco Squadrito. Lipid peroxidation activates mitogen-activated protein kinases in testicular ischemia-reperfusion injury. The Journal of urology. 2006 Oct; 176(4 Pt 1):1666-72. doi: 10.1016/j.juro.2006.06.086. [PMID: 16952711]
  • Domenica Altavilla, Mariarosaria Galeano, Alessandra Bitto, Letteria Minutoli, Giovanni Squadrito, Paolo Seminara, Francesco S Venuti, Valerio Torre, Margherita Calò, Michele Colonna, Patrizia Lo Cascio, Giovanni Giugliano, Nicolò Scuderi, Chiara Mioni, Sheila Leone, Francesco Squadrito. Lipid peroxidation inhibition by raxofelast improves angiogenesis and wound healing in experimental burn wounds. Shock (Augusta, Ga.). 2005 Jul; 24(1):85-91. doi: 10.1097/01.shk.0000168523.37796.89. [PMID: 15988325]
  • Domenica Altavilla, Herbert Marini, Paolo Seminara, Giovanni Squadrito, Letteria Minutoli, Maria Passaniti, Alessandra Bitto, Gioacchino Calapai, Margherita Calò, Achille P Caputi, Francesco Squadrito. Protective effects of antioxidant raxofelast in alcohol-induced liver disease in mice. Pharmacology. 2005 Apr; 74(1):6-14. doi: 10.1159/000082939. [PMID: 15627848]
  • Carmelo Romeo, Pietro Antonuccio, Maria Esposito, Herbert Marini, Pietro Impellizzeri, Nunzio Turiaco, Domenica Altavilla, Alessandra Bitto, Biagio Zuccarello, Francesco Squadrito. Raxofelast, a hydrophilic vitamin E-like antioxidant, reduces testicular ischemia-reperfusion injury. Urological research. 2004 Oct; 32(5):367-71. doi: 10.1007/s00240-004-0436-4. [PMID: 15316698]
  • Kyung-Hye Lee, SoYeon Lim, Seok-Min Kang, Dae Hyeok Kim, Hong Keun Cho, Ji Hyung Chung, Hyuck Moon Kwon, kwang-Hoe Chung, Hakbae Lee, Yangsoo Jang, Ki-Chul Hwang. Antiproliferative mechanisms of raxofelast (IRFI-016) in H2O2-stimulated rat aortic smooth muscle cells. European journal of pharmacology. 2004 Jan; 484(2-3):119-25. doi: 10.1016/j.ejphar.2003.11.012. [PMID: 14744595]
  • Domenica Altavilla, Ciro Famulari, Maria Passaniti, Giuseppe M Campo, Antonio Macrì, Paolo Seminara, Herbert Marini, Margherita Calò, Letterio B Santamaria, Daniela Bono, Francesco S Venuti, Chiara Mioni, Sheila Leone, Salvatore Guarini, Francesco Squadrito. Lipid peroxidation inhibition reduces NF-kappaB activation and attenuates cerulein-induced pancreatitis. Free radical research. 2003 Apr; 37(4):425-35. doi: 10.1080/1071576031000070093. [PMID: 12747737]
  • M Galeano, V Torre, B Deodato, G M Campo, M Colonna, A Sturiale, F Squadrito, V Cavallari, D Cucinotta, M Buemi, D Altavilla. Raxofelast, a hydrophilic vitamin E-like antioxidant, stimulates wound healing in genetically diabetic mice. Surgery. 2001 Apr; 129(4):467-77. doi: 10.1067/msy.2001.112072. [PMID: 11283539]
  • D Altavilla, A Saitta, D Cucinotta, M Galeano, B Deodato, M Colonna, V Torre, G Russo, A Sardella, G Urna, G M Campo, V Cavallari, G Squadrito, F Squadrito. Inhibition of lipid peroxidation restores impaired vascular endothelial growth factor expression and stimulates wound healing and angiogenesis in the genetically diabetic mouse. Diabetes. 2001 Mar; 50(3):667-74. doi: 10.2337/diabetes.50.3.667. [PMID: 11246889]
  • P J Chowienczyk, S E Brett, N K Gopaul, D Meeking, M Marchetti, D L Russell-Jones, E E Anggård, J M Ritter. Oral treatment with an antioxidant (raxofelast) reduces oxidative stress and improves endothelial function in men with type II diabetes. Diabetologia. 2000 Aug; 43(8):974-7. doi: 10.1007/s001250051478. [PMID: 10990073]
  • L Iuliano, J Z Pedersen, C Camastra, V Bello, S Ceccarelli, F Violi. Protection of low density lipoprotein oxidation by the antioxidant agent IRFI005, a new synthetic hydrophilic vitamin E analogue. Free radical biology & medicine. 1999 Apr; 26(7-8):858-68. doi: 10.1016/s0891-5849(98)00271-8. [PMID: 10232829]
  • G M Campo, F Squadrito, S Campo, D Altavilla, C Quartarone, S Ceccarelli, M Ferlito, A Avenoso, G Squadrito, A Saitta, A P Caputi. Beneficial effect of raxofelast, an hydrophilic vitamin E analogue, in the rat heart after ischemia and reperfusion injury. Journal of molecular and cellular cardiology. 1998 Aug; 30(8):1493-503. doi: 10.1006/jmcc.1998.0713. [PMID: 9737936]
  • G M Campo, F Squadrito, M Ioculano, D Altavilla, B Zingarelli, A M Pollicino, A Rizzo, G Calapai, S Calandra, R Scuri. Protective effects of IRFI-016, a new antioxidant agent, in myocardial damage, following coronary artery occlusion and reperfusion in the rat. Pharmacology. 1994 Mar; 48(3):157-66. doi: 10.1159/000139175. [PMID: 8153143]
  • T Bianco, R Centore, P Giannetti, R Scuri. Compared kinetics of 2-(2,3-dihydro-5-acetoxy-4,6,7-trimethylbenzofuranyl) acetic acid (IRFI 016) and its active metabolite 2-(2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofuranyl) acetic acid (IRFI 005) in plasma and bronchial alveolar liquid in mice. Drugs under experimental and clinical research. 1992; 18(3):93-7. doi: NULL. [PMID: 1425209]
  • R Scuri, P Giannetti, A Paesano. 2-(2,3-Dihydro-5-acetoxy-4,6,7-tribenzofuranyl)acetic acid (IRFI 016): a new antioxidant mucoactive drug. Drugs under experimental and clinical research. 1990; 16(12):649-56. doi: ". [PMID: 2130008]