pyrrolo[2,1-c][1,4]benzodiazepine (BioDeep_00000182783)
human metabolite blood metabolite
代谢物信息卡片
化学式: C12H10N2 (182.0844)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C=CC2=CN=C3C=CC=CC3=CN12
InChI: InChI=1S/C12H10N2/c1-2-6-12-10(4-1)9-14-7-3-5-11(14)8-13-12/h1-6,8-9H,7H2
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Meirambek Ospanov, Suresh P Sulochana, Jason J Paris, John M Rimoldi, Nicole Ashpole, Larry Walker, Samir A Ross, Abbas G Shilabin, Mohamed A Ibrahim. Identification of an Orally Bioavailable, Brain-Penetrant Compound with Selectivity for the Cannabinoid Type 2 Receptor.
Molecules (Basel, Switzerland).
2022 Jan; 27(2):. doi:
10.3390/molecules27020509. [PMID: 35056824] - Lijie Xing, Liang Lin, Tengteng Yu, Yuyin Li, Shih-Feng Cho, Jiye Liu, Kenneth Wen, Phillip A Hsieh, Krista Kinneer, Nikhil Munshi, Kenneth C Anderson, Yu-Tzu Tai. A novel BCMA PBD-ADC with ATM/ATR/WEE1 inhibitors or bortezomib induce synergistic lethality in multiple myeloma.
Leukemia.
2020 08; 34(8):2150-2162. doi:
10.1038/s41375-020-0745-9. [PMID: 32060401] - Kalliopi-Kelli A Vandera, Pietro Picconi, Margarita Valero, Gustavo González-Gaitano, Arcadia Woods, Nur Masirah M Zain, Kenneth D Bruce, Luke A Clifton, Maximilian W A Skoda, Khondaker Miraz Rahman, Richard D Harvey, Cécile A Dreiss. Antibiotic-in-Cyclodextrin-in-Liposomes: Formulation Development and Interactions with Model Bacterial Membranes.
Molecular pharmaceutics.
2020 07; 17(7):2354-2369. doi:
10.1021/acs.molpharmaceut.0c00096. [PMID: 32352791] - Donglu Zhang, Peter S Dragovich, Shang-Fan Yu, Yong Ma, Thomas H Pillow, Jack D Sadowsky, Dian Su, Wei Wang, Andrew Polson, S Cyrus Khojasteh, Cornelis E C A Hop. Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues.
Drug metabolism and disposition: the biological fate of chemicals.
2019 10; 47(10):1146-1155. doi:
10.1124/dmd.119.087023. [PMID: 31358513] - Jason B White, Ryan Fleming, Luke Masterson, Ben T Ruddle, Haihong Zhong, Christine Fazenbaker, Patrick Strout, Kim Rosenthal, Molly Reed, Vanessa Muniz-Medina, Philip Howard, Rakesh Dixit, Herren Wu, Mary Jane Hinrichs, Changshou Gao, Nazzareno Dimasi. Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer.
mAbs.
2019 04; 11(3):500-515. doi:
10.1080/19420862.2019.1578611. [PMID: 30835621] - Tycel Phillips, Paul M Barr, Steven I Park, Kathryn Kolibaba, Paolo F Caimi, Saurabh Chhabra, Edwin C Kingsley, Thomas Boyd, Robert Chen, Anne-Sophie Carret, Elaina M Gartner, Hong Li, Cindy Yu, David C Smith. A phase 1 trial of SGN-CD70A in patients with CD70-positive diffuse large B cell lymphoma and mantle cell lymphoma.
Investigational new drugs.
2019 04; 37(2):297-306. doi:
10.1007/s10637-018-0655-0. [PMID: 30132271] - Sumanta K Pal, Andres Forero-Torres, John A Thompson, John C Morris, Saurabh Chhabra, Christopher J Hoimes, Nicholas J Vogelzang, Thomas Boyd, Paulo G Bergerot, Jacob J Adashek, Hong Li, Xuesong Yu, Elaina M Gartner, Anne-Sophie Carret, David C Smith. A phase 1 trial of SGN-CD70A in patients with CD70-positive, metastatic renal cell carcinoma.
Cancer.
2019 04; 125(7):1124-1132. doi:
10.1002/cncr.31912. [PMID: 30624766] - Puneet Tyagi, Sergei Pechenov, Jonathan RiosDoria, Luke Masterson, Niall J Dickinson, Philip Howard, Shenlan Mao, Jay Harper, Leslie Wetzel, Kwok Yo, J Anand Subramony. Evaluation of Pyrrolobenzodiazepine-Loaded Nanoparticles: A Targeted Drug Delivery Approach.
Journal of pharmaceutical sciences.
2019 04; 108(4):1590-1597. doi:
10.1016/j.xphs.2018.11.023. [PMID: 30472264] - Donglu Zhang, Shang-Fan Yu, S Cyrus Khojasteh, Yong Ma, Thomas H Pillow, Jack D Sadowsky, Dian Su, Katherine R Kozak, Keyang Xu, Andrew G Polson, Peter S Dragovich, Cornelis E C A Hop. Intratumoral Payload Concentration Correlates with the Activity of Antibody-Drug Conjugates.
Molecular cancer therapeutics.
2018 03; 17(3):677-685. doi:
10.1158/1535-7163.mct-17-0697. [PMID: 29348271] - Gary P Wilkinson, James P Taylor, Steve Shnyder, Patricia Cooper, Phil W Howard, David E Thurston, Terence C Jenkins, Paul M Loadman. Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent.
Investigational new drugs.
2004 Aug; 22(3):231-40. doi:
10.1023/b:drug.0000026249.97007.60. [PMID: 15122070]
