Pyrithioxin (BioDeep_00000182767)

 

Secondary id: BioDeep_00000015161

human metabolite blood metabolite


代谢物信息卡片


5-[({[5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]methyl}disulphanyl)methyl]-4-(hydroxymethyl)-2-methylpyridin-3-ol

化学式: C16H20N2O4S2 (368.0864)
中文名称: 吡硫毒素
谱图信息: 最多检出来源 Homo sapiens(not specific) 50%

分子结构信息

SMILES: CC1=C(O)C(CO)=C(CSSCC2=C(CO)C(O)=C(C)N=C2)C=N1
InChI: InChI=1S/C16H20N2O4S2/c1-9-15(21)13(5-19)11(3-17-9)7-23-24-8-12-4-18-10(2)16(22)14(12)6-20/h3-4,19-22H,5-8H2,1-2H3

描述信息

N - Nervous system > N06 - Psychoanaleptics > N06B - Psychostimulants, agents used for adhd and nootropics
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant

同义名列表

15 个代谢物同义名

5-[({[5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]methyl}disulphanyl)methyl]-4-(hydroxymethyl)-2-methylpyridin-3-ol; 5-[({[5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]methyl}disulfanyl)methyl]-4-(hydroxymethyl)-2-methylpyridin-3-ol; Hydrochloride, pyritinol; Pyritinol hydrochloride; Dipyridoxolyldisulfide; Pyridoxinedisulfide; Pyrithioxine; Pyrithioxin; Encephabol; Piritoxina; Piritinol; Pyritinol; Piriditol; Bonifen; Enerbol



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Irina Mirela Apetrei, Constantin Apetrei. Highly sensitive voltamperometric determination of pyritinol using carbon nanofiber/gold nanoparticle composite screen-printed carbon electrode. International journal of nanomedicine. 2017; 12(?):5177-5188. doi: 10.2147/ijn.s138978. [PMID: 28860746]
  • Dhas Jebasingh, Dhas Devavaram Jackson, S Venkataraman, Ernest Adeghate, Bright Starling Emerald. The protective effects of Cyperus rotundus on behavior and cognitive function in a rat model of hypoxia injury. Pharmaceutical biology. 2014 Dec; 52(12):1558-69. doi: 10.3109/13880209.2014.908395. [PMID: 25026346]
  • Hayder M Alkuraishy, Ali I Al-Gareeb, Ali K Albuhadilly. Vinpocetine and pyritinol: a new model for blood rheological modulation in cerebrovascular disorders—a randomized controlled clinical study. BioMed research international. 2014; 2014(?):324307. doi: 10.1155/2014/324307. [PMID: 25548768]
  • Mohammad Galal El-Bardicy, Hayam Mahmoud Lotfy, Mohammad Abdalla El-Sayed, Mohammad Fayez El-Tarras. Stability-indicating electrochemical methods for the determination of meclophenoxate hydrochloride and pyritinol dihydrochloride using ion-selective membrane electrodes. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2007 Jan; 127(1):201-8. doi: 10.1248/yakushi.127.201. [PMID: 17202801]
  • M M Savula, N S Kravchenko, A I Poznanskiĭ. [Chemotherapy of destructive pulmonary tuberculosis with antioxidants and antihypoxic agents]. Problemy tuberkuleza. 1993; ?(5):18-20. doi: ". [PMID: 8295877]
  • A Pavlík, J Pilar. Protection of cell proteins against free-radical attack by nootropic drugs: scavenger effect of pyritinol confirmed by electron spin resonance spectroscopy. Neuropharmacology. 1989 Jun; 28(6):557-61. doi: 10.1016/0028-3908(89)90133-0. [PMID: 2547179]
  • J Topinka, B Binkova, R J Sram, A N Erin. The influence of alpha-tocopherol and pyritinol on oxidative DNA damage and lipid peroxidation in human lymphocytes. Mutation research. 1989 Mar; 225(3):131-6. doi: 10.1016/0165-7992(89)90130-9. [PMID: 2927430]
  • K J Martin, L Tucker, L Widdowson. Effects of some metabolites of pyritinol (Encephabol) on ACH release from brain slices. Pharmacopsychiatry. 1988 Aug; 21 Suppl 1(?):33-6. doi: 10.1055/s-2007-1017062. [PMID: 3217429]
  • B Faguer de Moustier, M Burgard, C Boitard, N Desplanque, J Fanjoux, G Tchobroutsky. [Auto-immune hypoglycemic syndrome induced by pyritinol]. Diabete & metabolisme. 1988 Jul; 14(4):423-9. doi: NULL. [PMID: 3066650]
  • G W Bielenberg, C Hayn, J Krieglstein. Effects of cerebro-protective agents on enzyme activities of rat primary glial cultures and rat cerebral cortex. Biochemical pharmacology. 1986 Aug; 35(16):2693-702. doi: 10.1016/0006-2952(86)90177-2. [PMID: 2943286]
  • K J Freundt, G Liedy, H O Voigt. Concentrations of D-glucaric acid in human urine after repeated administration of pyrithioxine. International journal of clinical pharmacology, therapy, and toxicology. 1984 Dec; 22(12):639-42. doi: NULL. [PMID: 6526537]
  • W Sobczyk. [Comparative evaluation of the therapeutic effectiveness of drugs of different mechanisms of action in cerebral atherosclerosis]. Neurologia i neurochirurgia polska. 1982 Jul; 16(4):245-60. doi: ". [PMID: 7145012]
  • J Civatte, M Duterque, P Blanchet, S Belaïch, C Lazarovici, P Morel, C Foix, D Fischesser. [Two cases of superficial pemphigus induced by pyritinol (author's transl)]. Annales de dermatologie et de venereologie. 1978 Jun; 105(6-7):573-7. doi: NULL. [PMID: 736425]
  • K Kitao, N Yata, A Kamada. Determination of pyrithioxin and its metabolites in blood and urine of dogs by high-performance liquid chromatography. Chemical & pharmaceutical bulletin. 1977 Jun; 25(6):1335-42. doi: 10.1248/cpb.25.1335. [PMID: 890856]
  • K Kitao, N Yata, M Yamazaki, J Iwane, A Kamada. Blood concentration and urinary excretion profiles following oral administration of esters of pyrithioxin to dogs. Chemical & pharmaceutical bulletin. 1977 Jun; 25(6):1350-6. doi: 10.1248/cpb.25.1350. [PMID: 890858]
  • A G Moiseenok, N P Bobrova, V M Avakumov, M A Kovler. [Characteristics of the antivitamin effect of pyriditol, a disulfide pyridoxine derivative, on animal body]. Farmakologiia i toksikologiia. 1976 May; 39(3):308-11. doi: . [PMID: 1026514]
  • G Werner, G Erdmann, S Thel. [Autoradiographic studies on the distribution of 3H-pyrithioxine in monkey and mouse (author's transl)]. Arzneimittel-Forschung. 1976; 26(5):825-8. doi: NULL. [PMID: 822855]
  • M E Hillbom, A R Pösö. Effects on ethanol on serum electrolytes and respiration in euthyroid and hyperthyroid rats. Toxicology and applied pharmacology. 1975 Apr; 32(1):168-76. doi: 10.1016/0041-008x(75)90207-0. [PMID: 1135872]
  • M E Hillbom, A L Kosunen, P Nikander, A R Pösö. Effects of single doses and daily administration of pyrithioxine (pyritinolum,NFN, RINN) on the alcohol withdrawal syndrome in rats. Acta pharmacologica et toxicologica. 1975; 36(Suppl 5):427-40. doi: 10.1111/j.1600-0773.1975.tb00810.x. [PMID: 1173532]
  • E Stoica, O Enulescu, M Gheorghiu. Facilitation through hyperventilation of therapeutic effect of pyrithioxin in cerebral infarct patients. European neurology. 1975; 13(4):285-303. doi: 10.1159/000114684. [PMID: 1097256]