Pyridone 6 (BioDeep_00000182754)
human metabolite blood metabolite
代谢物信息卡片
化学式: C18H16FN3O (309.1277)
中文名称: 吡啶酮6
谱图信息:
最多检出来源 Homo sapiens(blood) 66.67%
分子结构信息
SMILES: CC(C)(C)C1=NC2=C(N1)C3=C(C=C(C=C3)F)C4=C2C=CNC4=O
InChI: InChI=1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22)
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:87103
- PubChem: 5494425
- HMDB: HMDB0256971
- DrugBank: DB04716
- ChEMBL: CHEMBL21156
- CAS: 457081-03-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Adenike Ogunrinde, Robyn D Pereira, Natalie Beaton, D Hung Lam, Christiane Whetstone, Ceredwyn E Hill. Hepatocellular differentiation status is characterized by distinct subnuclear localization and form of the chanzyme TRPM7.
Differentiation; research in biological diversity.
2017 Jul; 96(?):15-25. doi:
10.1016/j.diff.2017.06.001. [PMID: 28609676] - Shunichi Shimizu, Ryo Yonezawa, Tamio Hagiwara, Takashi Yoshida, Nobuaki Takahashi, Satoshi Hamano, Takaharu Negoro, Takahiro Toda, Minoru Wakamori, Yasuo Mori, Masakazu Ishii. Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca(2+) entry.
European journal of pharmacology.
2014 Nov; 742(?):22-30. doi:
10.1016/j.ejphar.2014.08.023. [PMID: 25179574] - Yuko Matsunaga, Hiromasa Inoue, Satoru Fukuyama, Hideyuki Yoshida, Atsushi Moriwaki, Takafumi Matsumoto, Koichiro Matsumoto, Yukari Asai, Masato Kubo, Akihiko Yoshimura, Yoichi Nakanishi. Effects of a Janus kinase inhibitor, pyridone 6, on airway responses in a murine model of asthma.
Biochemical and biophysical research communications.
2011 Jan; 404(1):261-7. doi:
10.1016/j.bbrc.2010.11.104. [PMID: 21111712] - Gautam Damera, Baoyun Xia, Goverdhan P Sachdev. IL-4 induced MUC4 enhancement in respiratory epithelial cells in vitro is mediated through JAK-3 selective signaling.
Respiratory research.
2006 Mar; 7(?):39. doi:
10.1186/1465-9921-7-39. [PMID: 16551361] - H L ROSENTHAL, G A GOLDSMITH, H P SARETT. Excretion of N1-methylnicotinamide and the 6-pyridone of N1-methylnicotinamide in urine of human subjects.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1953 Oct; 84(1):208-11. doi:
10.3181/00379727-84-20591. [PMID: 13120986] - F ROSEN, W A PERLZWEIG, I G LEDER. A fluorometric method for the determination of the 6-pyridone of N1-methylnicotinamide in urine.
The Journal of biological chemistry.
1949 May; 179(1):157-68. doi:
10.1016/s0021-9258(18)56823-x. [PMID: 18119230] - W E KNOX, W I GROSSMAN. The isolation of the 6-pyridone of N1-methylnicotinamide from urine.
The Journal of biological chemistry.
1947 Apr; 168(1):363-6. doi:
10.1016/s0021-9258(17)35124-4. [PMID: 20291095]
