2,6-Toluenediamine (BioDeep_00000018273)

   

human metabolite


代谢物信息卡片


2-Methyl-1,3-benzenediamine (acd/name 4.0)

化学式: C7H10N2 (122.0844)
中文名称: 2,6-二氨基甲苯
谱图信息: 最多检出来源 Homo sapiens(endogenous) 3.77%

分子结构信息

SMILES: CC1=C(C=CC=C1N)N
InChI: InChI=1S/C7H10N2/c1-5-6(8)3-2-4-7(5)9/h2-4H,8-9H2,1H3

描述信息

2,6-toluenediamine belongs to the family of Toluenes. These are compounds containing a benzene ring which bears a methane group.
D009676 - Noxae > D002273 - Carcinogens
D009676 - Noxae > D009153 - Mutagens

同义名列表

17 个代谢物同义名

2-Methyl-1,3-benzenediamine (acd/name 4.0); 2,6-Diaminotoluene dihydrochloride; 2-Methyl-1,3-phenylenediamine; 2-Methyl-m-phenylenediamine; 2-Methyl-1,3-benzenediamine; 2,6-Diamino-1-methylbenzene; 2-methylbenzene-1,3-diamine; 2,6-Toluylenediamine; 2, 6-Tolylenediamine; 2,6-Tolylenediamine; 2, 6-Diaminotoluene; Toluene-2,6-diamine; 2,6-DIAMINOTOLUENE; 2,6-Toluenediamine; O-Toluene diamine; EINECS 212-513-9; 2,6-DAT



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • G De Palma, Ilenia Cortesi, Roberta Ghitti, Denise Festa, R Bergonzi, P Apostoli. Biological monitoring as a valid tool to assess occupational exposure to mixtures of 2,4-:2,6-toluene diisocyanate. La Medicina del lavoro. 2012 Sep; 103(5):361-71. doi: NULL. [PMID: 23077796]
  • Tom Geens, Sandra Dugardin, Ann Schockaert, Geert De Cooman, Marc van Sprundel. Air exposure assessment of TDI and biological monitoring of TDA in urine in workers in polyurethane foam industry. Occupational and environmental medicine. 2012 Feb; 69(2):93-8. doi: 10.1136/oem.2011.064840. [PMID: 21725071]
  • Lygia T Budnik, Dennis Nowak, Rolf Merget, Catherine Lemiere, Xaver Baur. Elimination kinetics of diisocyanates after specific inhalative challenges in humans: mass spectrometry analysis, as a basis for biomonitoring strategies. Journal of occupational medicine and toxicology (London, England). 2011 Mar; 6(1):9. doi: 10.1186/1745-6673-6-9. [PMID: 21447151]
  • Shaun Austin. Biological monitoring of TDI-derived amines in polyurethane foam production. Occupational medicine (Oxford, England). 2007 Sep; 57(6):444-8. doi: 10.1093/occmed/kqm085. [PMID: 17728315]
  • David Kirkland, Carol Beevers. Induction of LacZ mutations in Muta Mouse can distinguish carcinogenic from non-carcinogenic analogues of diaminotoluenes and nitronaphthalenes. Mutation research. 2006 Sep; 608(1):88-96. doi: 10.1016/j.mrgentox.2006.05.004. [PMID: 16797226]
  • Carl Johan Sennbro, Margareta Littorin, Håkan Tinnerberg, Bo A G Jönsson. Upper reference limits for biomarkers of exposure to aromatic diisocyanates. International archives of occupational and environmental health. 2005 Aug; 78(7):541-6. doi: 10.1007/s00420-005-0619-5. [PMID: 15995877]
  • Tadashi Sakai, Yoko Morita, Jaehoon Roh, Hyoungryoul Kim, Yangho Kim. Improvement in the GC-MS method for determining urinary toluene-diamine and its application to the biological monitoring of workers exposed to toluene-diisocyanate. International archives of occupational and environmental health. 2005 Jul; 78(6):459-66. doi: 10.1007/s00420-004-0571-9. [PMID: 15918038]
  • Carl Johan Sennbro, Christian H Lindh, Håkan Tinnerberg, Hans Welinder, Margareta Littorin, Bo A G Jönsson. Biological monitoring of exposure to toluene diisocyanate. Scandinavian journal of work, environment & health. 2004 Oct; 30(5):371-8. doi: 10.5271/sjweh.825. [PMID: 15534959]
  • Carl Johan Sennbro, Christian H Lindh, Håkan Tinnerberg, Cecilia Gustavsson, Margareta Littorin, Hans Welinder, Bo A G Jönsson. Development, validation and characterization of an analytical method for the quantification of hydrolysable urinary metabolites and plasma protein adducts of 2,4- and 2,6-toluene diisocyanate, 1,5-naphthalene diisocyanate and 4,4'-methylenediphenyl diisocyanate. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2003 May; 8(3-4):204-17. doi: 10.1080/1354750031000090660. [PMID: 12944173]
  • Christina Rosenberg, Kirsi Nikkilä, Maj-Len Henriks-Eckerman, Kimmo Peltonen, Kerstin Engströrm. Biological monitoring of aromatic diisocyanates in workers exposed to thermal degradation products of polyurethanes. Journal of environmental monitoring : JEM. 2002 Oct; 4(5):711-6. doi: 10.1039/b206340a. [PMID: 12400919]
  • Tadashi Sakai, Y Morita, Y Kim, Y X Tao. LC-MS determination of urinary toluenediamine in workers exposed to toluenediisocyanate. Toxicology letters. 2002 Aug; 134(1-3):259-64. doi: 10.1016/s0378-4274(02)00174-1. [PMID: 12191886]
  • K Kääriä, A Hirvonen, H Norppa, P Piirilä, H Vainio, C Rosenberg. Exposure to 2,4- and 2,6-toluene diisocyanate (TDI) during production of flexible foam: determination of airborne TDI and urinary 2,4- and 2,6-toluenediamine (TDA). The Analyst. 2001 Jul; 126(7):1025-31. doi: 10.1039/b102022f. [PMID: 11478630]
  • H Tinnerberg, M Dalene, G Skarping. Air and biological monitoring of toluene diisocyanate in a flexible foam plant. American Industrial Hygiene Association journal. 1997 Mar; 58(3):229-35. doi: 10.1080/15428119791012883. [PMID: 9075314]
  • P Lind, M Dalene, H Tinnerberg, G Skarping. Biomarkers in hydrolysed urine, plasma and erythrocytes among workers exposed to thermal degradation products from toluene diisocyanate foam. The Analyst. 1997 Jan; 122(1):51-6. doi: 10.1039/a606148f. [PMID: 9069099]
  • P Lind, M Dalene, G Skarping, L Hagmar. Toxicokinetics of 2,4- and 2,6-toluenediamine in hydrolysed urine and plasma after occupational exposure to 2,4- and 2,6- toluene diisocyanate. Occupational and environmental medicine. 1996 Feb; 53(2):94-9. doi: 10.1136/oem.53.2.94. [PMID: 8777457]
  • M L Cunningham, H B Matthews. Cell proliferation as a determining factor for the carcinogenicity of chemicals: studies with mutagenic carcinogens and mutagenic noncarcinogens. Toxicology letters. 1995 Dec; 82-83(?):9-14. doi: 10.1016/0378-4274(95)03464-1. [PMID: 8597159]
  • O Sepai, D Henschler, S Czech, P Eckert, G Sabbioni. Exposure to toluenediamines from polyurethane-covered breast implants. Toxicology letters. 1995 May; 77(1-3):371-8. doi: 10.1016/0378-4274(95)03320-3. [PMID: 7618164]
  • M Szycher, A A Siciliano. An assessment of 2,4 TDA formation from Surgitek polyurethane foam under simulated physiological conditions. Journal of biomaterials applications. 1991 Apr; 5(4):323-36. doi: 10.1177/088532829100500404. [PMID: 1856785]
  • T Brorson, G Skarping, C Sangö. Biological monitoring of isocyanates and related amines. IV. 2,4- and 2,6-toluenediamine in hydrolysed plasma and urine after test-chamber exposure of humans to 2,4- and 2,6-toluene diisocyanate. International archives of occupational and environmental health. 1991; 63(4):253-9. doi: 10.1007/bf00386374. [PMID: 1660449]
  • G Skarping, T Brorson, C Sangö. Biological monitoring of isocyanates and related amines. III. Test chamber exposure of humans to toluene diisocyanate. International archives of occupational and environmental health. 1991; 63(2):83-8. doi: 10.1007/bf00379069. [PMID: 1653771]
  • M P Dieter, G A Boorman, C W Jameson, H B Matthews, J E Huff. The carcinogenic activity of commercial grade toluene diisocyanate in rats and mice in relation to the metabolism of the 2,4- and 2,6-TDI isomers. Toxicology and industrial health. 1990 Dec; 6(6):599-621. doi: . [PMID: 1965872]
  • M L Cunningham, L T Burka, H B Matthews. Metabolism, disposition, and mutagenicity of 2,6-diaminotoluene, a mutagenic noncarcinogen. Drug metabolism and disposition: the biological fate of chemicals. 1989 Nov; 17(6):612-7. doi: NULL. [PMID: 2575496]
  • C Rosenberg, H Savolainen. Determination of occupational exposure to toluene diisocyanate by biological monitoring. Journal of chromatography. 1986 Oct; 367(2):385-92. doi: 10.1016/s0021-9673(00)94859-3. [PMID: 3023414]
  • P D Unger, M A Friedman. High-performance liquid chromatography of 2,6- and 2,4-diaminotoluene, and its application to the determination of 2,4-diaminotoluene in urine and plasma. Journal of chromatography. 1979 Jul; 174(2):379-84. doi: 10.1016/s0021-9673(00)86011-2. [PMID: 546895]