Ginsenoside-Rd (BioDeep_00000182716)
human metabolite blood metabolite
代谢物信息卡片
2-{[2-(8-{[4,5-dihydroxy-6-(hydroxymethyl)-3-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-5,16-dihydroxy-2,6,6,10,11-pentamethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl)-6-methylhept-5-en-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol
化学式: C48H82O19 (962.5450022)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(C(O6)CO)O)O)O)C)O)C)OC7C(C(C(C(O7)CO)O)O)O)C
InChI: InChI=1S/C48H82O19/c1-21(2)10-9-13-48(8,67-42-38(61)35(58)32(55)26(19-50)64-42)22-11-15-46(6)30(22)23(52)16-28-45(5)14-12-29(53)44(3,4)40(45)24(17-47(28,46)7)62-43-39(36(59)33(56)27(20-51)65-43)66-41-37(60)34(57)31(54)25(18-49)63-41/h10,22-43,49-61H,9,11-20H2,1-8H3
描述信息
同义名列表
3 个代谢物同义名
2-{[2-(8-{[4,5-dihydroxy-6-(hydroxymethyl)-3-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-5,16-dihydroxy-2,6,6,10,11-pentamethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl)-6-methylhept-5-en-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol; 2-(hydroxymethyl)-6-[6-(hydroxymethyl)-2-[[17-[2-[6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-6-methyl-hept-5-en-2-yl]-4,4,8,10,14-pentamethyl-3,12-bis(oxidanyl)-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-b; ginsenoside-Rd
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Eunsoo Jung, Mi-Kyung Pyo, Junghyun Kim. Pectin-Lyase-Modified Ginseng Extract and Ginsenoside Rd Inhibits High Glucose-Induced ROS Production in Mesangial Cells and Prevents Renal Dysfunction in db/db Mice.
Molecules (Basel, Switzerland).
2021 Jan; 26(2):. doi:
10.3390/molecules26020367. [PMID: 33445772] - Jeon-Kyung Kim, Eun Kyu Lee, Chu Hyun Bae, Soo-Dong Park, Jae-Jung Shim, Jung-Lyoul Lee, Hye Hyun Yoo, Dong-Hyun Kim. The Impact of Gut Microbiome on the Pharmacokinetics of Ginsenosides Rd and Rg3 in Mice after Oral Administration of Red Ginseng.
The American journal of Chinese medicine.
2021; 49(8):1897-1912. doi:
10.1142/s0192415x21500890. [PMID: 34961415] - Baobao Zhang, Xiaolong Hu, Huizhe Wang, Rong Wang, Zhongxuan Sun, Xiaomei Tan, Shumeng Liu, Hao Wang. Effects of a dammarane-type saponin, ginsenoside Rd, in nicotine-induced vascular endothelial injury.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2020 Dec; 79(?):153325. doi:
10.1016/j.phymed.2020.153325. [PMID: 32920289] - Min Li, Xuwen Li, Limei Zhou, Yongri Jin. Effects of total saponins from Panacis majoris Rhizoma and its degradation products on myocardial ischemia-reperfusion injury in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Oct; 130(?):110538. doi:
10.1016/j.biopha.2020.110538. [PMID: 32731133] - Haixia Wang, Ning Jiang, Jingwei Lv, Hong Huang, Xinmin Liu. Ginsenoside Rd reverses cognitive deficits by modulating BDNF-dependent CREB pathway in chronic restraint stress mice.
Life sciences.
2020 Oct; 258(?):118107. doi:
10.1016/j.lfs.2020.118107. [PMID: 32682919] - Hui Xiong, Ai-Hua Zhang, Qi-Qi Zhao, Guang-Li Yan, Hui Sun, Xi-Jun Wang. Discovery of quality-marker ingredients of Panax quinquefolius driven by high-throughput chinmedomics approach.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2020 Aug; 74(?):152928. doi:
10.1016/j.phymed.2019.152928. [PMID: 31451286] - Fang Li, Li-Zhi Pang, Ling Zhang, Yu Zhang, Yuan-Yuan Zhang, Bo-Yang Yu, Jun-Ping Kou. YiQiFuMai powder injection ameliorates chronic heart failure through cross-talk between adipose tissue and cardiomyocytes via up-regulation of circulating adipokine omentin.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Nov; 119(?):109418. doi:
10.1016/j.biopha.2019.109418. [PMID: 31505423] - Lan Luo, Jiazhen Kang, Weijun Zhao, Yue Qi, Shengwang Liang. Validated LC-MS/MS method for simultaneous quantification of seven components of Naodesheng in rat serum after oral administration and its application to a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2019 Sep; 174(?):1-7. doi:
10.1016/j.jpba.2019.05.036. [PMID: 31153133] - Lan Luo, Jiazhen Kang, Qiong He, Yue Qi, Xingyu Chen, Shumei Wang, Shengwang Liang. A NMR-Based Metabonomics Approach to Determine Protective Effect of a Combination of Multiple Components Derived from Naodesheng on Ischemic Stroke Rats.
Molecules (Basel, Switzerland).
2019 May; 24(9):. doi:
10.3390/molecules24091831. [PMID: 31086027] - Xiao-Nan Chen, Dan-Qi Li, Meng-di Zhao, Gang-Yan Yu, Shou-Ying Du, Yang Lu, Jie Bai, Peng-Yue Li, Ya-Li Wu, Zhi-Hao Tian, Yan-Ying Zeng. Pharmacokinetics of Panax notoginseng Saponins in Adhesive and Normal Preparation of Fufang Danshen.
European journal of drug metabolism and pharmacokinetics.
2018 Apr; 43(2):215-225. doi:
10.1007/s13318-017-0433-y. [PMID: 28916980] - Lu Wang, Yazheng Zhao, Ye Yang, Yuanjia Hu, Xiaohan Zou, Boyang Yu, Jin Qi. Allergens in red ginseng extract induce the release of mediators associated with anaphylactoid reactions.
Journal of translational medicine.
2017 06; 15(1):148. doi:
10.1186/s12967-017-1249-x. [PMID: 28659175] - Zhen-Dong Zhong, Chun-Mei Wang, Wei Wang, Li Shen, Zhong-Hua Chen. [Major hypoglycemic ingredients of Panax notoginseng saponins for treating diabetes].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2014 Mar; 45(2):235-9. doi:
. [PMID: 24749347] - Eun-Young Park, Mi-Hwi Kim, Eung-Hwi Kim, Eun-Kyu Lee, In-Sun Park, Duck-Choon Yang, Hee-Sook Jun. Efficacy comparison of Korean ginseng and American ginseng on body temperature and metabolic parameters.
The American journal of Chinese medicine.
2014; 42(1):173-87. doi:
10.1142/s0192415x14500128. [PMID: 24467543] - Yun-Xin Zhang, Li Wang, Er-Long Xiao, Si-Jia Li, Jia-Jia Chen, Bei Gao, Guang-Ning Min, Zhi-Ping Wang, Yong-Jie Wu. Ginsenoside-Rd exhibits anti-inflammatory activities through elevation of antioxidant enzyme activities and inhibition of JNK and ERK activation in vivo.
International immunopharmacology.
2013 Dec; 17(4):1094-100. doi:
10.1016/j.intimp.2013.10.013. [PMID: 24455777] - Li Wang, Yunxin Zhang, Jiajia Chen, Sijia Li, Yanhong Wang, Lamei Hu, Lihua Wang, Yongjie Wu. Immunosuppressive effects of ginsenoside-Rd on skin allograft rejection in rats.
The Journal of surgical research.
2012 Jul; 176(1):267-74. doi:
10.1016/j.jss.2011.06.038. [PMID: 21872268] - Dong Sun, Bing Wang, Ming Shi, Yun-Xia Zhang, Lin-Fu Zhou, Zhi-Rong Liu, Zhong-Liang Wu, Wen Jiang, Jun-Liang Han, Li-Ze Xiong, Gang Zhao. Pharmacokinetic, tissue distribution and excretion of ginsenoside-Rd in rodents.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2012 Feb; 19(3-4):369-73. doi:
10.1016/j.phymed.2011.08.061. [PMID: 21899993] - Xing Zeng, Yuanhui Deng, Yi Feng, Yiming Liu, Liu Yang, Yu Huang, Jing Sun, Weixiong Liang, Yongyuan Guan. Pharmacokinetics and safety of ginsenoside Rd following a single or multiple intravenous dose in healthy Chinese volunteers.
Journal of clinical pharmacology.
2010 Mar; 50(3):285-92. doi:
10.1177/0091270009344334. [PMID: 19940231] - Houfu Liu, Junling Yang, Feifei Du, Xiumei Gao, Xutao Ma, Yuhong Huang, Fang Xu, Wei Niu, Fengqing Wang, Yu Mao, Yan Sun, Tong Lu, Changxiao Liu, Boli Zhang, Chuan Li. Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats.
Drug metabolism and disposition: the biological fate of chemicals.
2009 Dec; 37(12):2290-8. doi:
10.1124/dmd.109.029819. [PMID: 19786509] - Bing-Xiang Cai, Xiao-Yan Li, Jing-Hui Chen, Yong-Bo Tang, Guan-Lei Wang, Jia-Guo Zhou, Qin-Ying Qui, Yong-Yuan Guan. Ginsenoside-Rd, a new voltage-independent Ca2+ entry blocker, reverses basilar hypertrophic remodeling in stroke-prone renovascular hypertensive rats.
European journal of pharmacology.
2009 Mar; 606(1-3):142-9. doi:
10.1016/j.ejphar.2009.01.033. [PMID: 19374845] - Liu Yang, Yuanhui Deng, Shunjun Xu, Xing Zeng. In vivo pharmacokinetic and metabolism studies of ginsenoside Rd.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jul; 854(1-2):77-84. doi:
10.1016/j.jchromb.2007.04.014. [PMID: 17526438] - Wei Wang, Guang-Ji Wang, Hai-Tang Xie, Jian-Guo Sun, Shuai Zhao, Xi-ling Jiang, Hao Li, Hua Lv, Mei-Juan Xu, Rui Wang. Determination of ginsenoside Rd in dog plasma by liquid chromatography-mass spectrometry after solid-phase extraction and its application in dog pharmacokinetics studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jun; 852(1-2):8-14. doi:
10.1016/j.jchromb.2006.12.046. [PMID: 17267298] - Zhigang Yang, Aqin Chen, Hongxiang Sun, Yiping Ye, Weihuan Fang. Ginsenoside Rd elicits Th1 and Th2 immune responses to ovalbumin in mice.
Vaccine.
2007 Jan; 25(1):161-9. doi:
10.1016/j.vaccine.2006.05.075. [PMID: 16950547] - Yong-Yuan Guan, Jia-Guo Zhou, Zheng Zhang, Guan-Lei Wang, Bing-Xiang Cai, Liang Hong, Qin-Ying Qiu, Hua He. Ginsenoside-Rd from panax notoginseng blocks Ca2+ influx through receptor- and store-operated Ca2+ channels in vascular smooth muscle cells.
European journal of pharmacology.
2006 Oct; 548(1-3):129-36. doi:
10.1016/j.ejphar.2006.08.001. [PMID: 16973156] - Liu Yang, Shun-jun Xu, Xing Zeng, Yi-ming Liu, Shi-gui Deng, Zhi-feng Wu, Run-mei Ou. [Determination of ginsenoside Rd and its metabolites in rat urine by LC-MS].
Yao xue xue bao = Acta pharmaceutica Sinica.
2006 Aug; 41(8):742-6. doi:
". [PMID: 17039780] - Lie Li, Yu-Xin Sheng, Jin-Lan Zhang, Shan-Shan Wang, De-An Guo. High-performance liquid chromatographic assay for the active saponins from Panax notoginseng in rat tissues.
Biomedical chromatography : BMC.
2006 Apr; 20(4):327-35. doi:
10.1002/bmc.567. [PMID: 16138297] - Osamu Morinaga, Noriko Fukuda, Hiroyuki Tanaka, Yukihiro Shoyama. Chromatographic resolution of glucosidic compounds, ginsenosides on polyethersulphone membrane, and its application to the quantitative immunoassay for ginseng saponins.
Glycobiology.
2005 Oct; 15(10):1061-6. doi:
10.1093/glycob/cwi096. [PMID: 15972894] - Lie Li, Yuxin Sheng, Jinlan Zhang, Chuanshe Wang, Dean Guo. HPLC determination of four active saponins from Panax notoginseng in rat serum and its application to pharmacokinetic studies.
Biomedical chromatography : BMC.
2004 Dec; 18(10):849-56. doi:
10.1002/bmc.400. [PMID: 15484230] - Takako Yokozawa, Akiko Satoh, Eun Ju Cho. Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice.
The Journal of pharmacy and pharmacology.
2004 Jan; 56(1):107-13. doi:
10.1211/0022357022449. [PMID: 14980007] - T Yokozawa, E Dong. Role of ginsenoside-Rd in cisplatin-induced renal injury: special reference to DNA fragmentation.
Nephron.
2001 Dec; 89(4):433-8. doi:
10.1159/000046116. [PMID: 11721162] - T Yokozawa, Z W Liu. The role of ginsenoside-Rd in cisplatin-induced acute renal failure.
Renal failure.
2000 Mar; 22(2):115-27. doi:
10.1081/jdi-100100858. [PMID: 10803758]