Proquazone (BioDeep_00000182663)

   

human metabolite blood metabolite


代谢物信息卡片


7-methyl-4-phenyl-1-(propan-2-yl)-1,2-dihydroquinazolin-2-one

化学式: C18H18N2O (278.1419058)
中文名称: 普罗喹宗
谱图信息: 最多检出来源 Homo sapiens(blood) 99%

分子结构信息

SMILES: CC(C)N1C(=O)N=C(C2=CC=CC=C2)C2=CC=C(C)C=C12
InChI: InChI=1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3

描述信息

M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors

同义名列表

7 个代谢物同义名

7-methyl-4-phenyl-1-(propan-2-yl)-1,2-dihydroquinazolin-2-one; 1-Isopropyl-4-phenyl-7-methyl-2-(1H)-quinazoline; 7-methyl-4-phenyl-1-propan-2-ylquinazolin-2-one; 43-715ARTHREX; Proquazone; Biarison; Arthrex



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ekram M Hassan, Azza A Gazy, Mohamed H Abdel-Hay, Tarek S Belal. High-performance liquid chromatographic determination of proquazone and its m-hydroxy metabolite in spiked human plasma and urine. Journal of AOAC International. 2007 Jul; 90(4):971-6. doi: NULL. [PMID: 17760334]
  • Bahar Tunçtan, Sedat Altug, Orhan Uludag, Beray Demirkay, Nurettin Abacioglu. Effects of cyclooxygenase inhibitors on nitric oxide production and survival in a mice model of sepsis. Pharmacological research. 2003 Jul; 48(1):37-48. doi: 10.1016/s1043-6618(03)00064-1. [PMID: 12770513]
  • Ethem Akçil, Gülnur Yavuz, Mehtap Koçak. Effects of inflammation and antiinflammatory treatment on serum trace elements concentrations. Biological trace element research. 2003; 93(1-3):95-104. doi: 10.1385/bter:93:1-3:95. [PMID: 12835494]
  • M Lempiäinen, A L Mäkelä. Determination of proquazone and its m-hydroxy metabolite by high-performance liquid chromatography. Clinical application: pharmacokinetics of proquazone in children with juvenile rheumatoid arthritis. Journal of chromatography. 1985 May; 341(1):105-13. doi: 10.1016/s0378-4347(00)84014-1. [PMID: 4019675]
  • P H Hinderling, A Roos. Pharmacokinetics of the antirheumatic proquazone in healthy humans. Journal of pharmaceutical sciences. 1984 Mar; 73(3):332-40. doi: 10.1002/jps.2600730312. [PMID: 6716240]
  • S Tiitinen, M Nissilä, H M Ruutsalo, H Isomäki. Effect of nonsteroidal anti-inflammatory drugs on the renal excretion of uric acid. Clinical rheumatology. 1983 Sep; 2(3):233-6. doi: 10.1007/bf02041396. [PMID: 6678696]
  • A Roos, P H Hinderling. Protein binding and erythrocyte partitioning of the antirheumatic proquazone. Journal of pharmaceutical sciences. 1981 Mar; 70(3):252-7. doi: 10.1002/jps.2600700306. [PMID: 7264886]
  • F Nimmerfall, J Rosenthaler. Dependence of area under the curve on proquazone particle size and in vitro dissolution rate. Journal of pharmaceutical sciences. 1980 May; 69(5):605-7. doi: 10.1002/jps.2600690538. [PMID: 6770075]
  • E E Ohnhaus. The effect of antacid and food on the absorption of proquazone (Biarison) in man. International journal of clinical pharmacology, therapy, and toxicology. 1980 Mar; 18(3):136-9. doi: NULL. [PMID: 7380586]
  • B Skrifvars, M Nissilä. Immunological effects of Biarison in the treatment of rheumatoid arthritis and systemic lupus erythematosus. A preliminary report. Scandinavian journal of rheumatology. 1980; 9(1):33-8. doi: 10.1080/03009748009098125. [PMID: 7375869]