Propentofylline (BioDeep_00000182644)

   

human metabolite blood metabolite


代谢物信息卡片


3-methyl-1-(5-oxohexyl)-7-propyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione

化学式: C15H22N4O3 (306.1691822)
中文名称: 普罗潘非林
谱图信息: 最多检出来源 Homo sapiens(blood) 75%

分子结构信息

SMILES: CCCN1C=NC2=C1C(=O)N(C(=O)N2C)CCCCC(=O)C
InChI: InChI=1S/C15H22N4O3/c1-4-8-18-10-16-13-12(18)14(21)19(15(22)17(13)3)9-6-5-7-11(2)20/h10H,4-9H2,1-3H3

描述信息

N - Nervous system > N06 - Psychoanaleptics > N06B - Psychostimulants, agents used for adhd and nootropics > N06BC - Xanthine derivatives
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
C26170 - Protective Agent > C1509 - Neuroprotective Agent
D020011 - Protective Agents

同义名列表

5 个代谢物同义名

3-methyl-1-(5-oxohexyl)-7-propyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione; 1-(5-Oxohexyl)-3-methyl-7-propylxanthine; propentofylline; HWA-285; HWA 285



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Daniel Janitschke, Anna Andrea Lauer, Cornel Manuel Bachmann, Jakob Winkler, Lea Victoria Griebsch, Sabrina Melanie Pilz, Elena Leoni Theiss, Heike Sabine Grimm, Tobias Hartmann, Marcus Otto Walter Grimm. Methylxanthines Induce a Change in the AD/Neurodegeneration-Linked Lipid Profile in Neuroblastoma Cells. International journal of molecular sciences. 2022 Feb; 23(4):. doi: 10.3390/ijms23042295. [PMID: 35216410]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Daniel Janitschke, Anna A Lauer, Cornel M Bachmann, Martin Seyfried, Heike S Grimm, Tobias Hartmann, Marcus O W Grimm. Unique Role of Caffeine Compared to Other Methylxanthines (Theobromine, Theophylline, Pentoxifylline, Propentofylline) in Regulation of AD Relevant Genes in Neuroblastoma SH-SY5Y Wild Type Cells. International journal of molecular sciences. 2020 Nov; 21(23):. doi: 10.3390/ijms21239015. [PMID: 33260941]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Valerie L Jacobs, Joyce A De Leo. Increased glutamate uptake in astrocytes via propentofylline results in increased tumor cell apoptosis using the CNS-1 glioma model. Journal of neuro-oncology. 2013 Aug; 114(1):33-42. doi: 10.1007/s11060-013-1158-7. [PMID: 23695515]
  • Sui Cheung Man, Kam Wa Chan, Jia-Hong Lu, Siva Sundara Kumar Durairajan, Liang-Feng Liu, Min Li. Systematic review on the efficacy and safety of herbal medicines for vascular dementia. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):426215. doi: 10.1155/2012/426215. [PMID: 22235231]
  • Maria Walczak, Ewelina Kozaczek, Joanna Szymura-Oleksiak, Elżbieta Pękala. Application of liquid chromatography-tandem mass spectrometry method for the simultaneous quantitative analysis of propentofylline and its chiral metabolite M1 in rats. Biomedical chromatography : BMC. 2011 Mar; 25(3):381-90. doi: 10.1002/bmc.1459. [PMID: 21110389]
  • Nai-Kuei Huang, Jung-Hsin Lin, Jiun-Tsai Lin, Chia-I Lin, Eric Minwei Liu, Chun-Jung Lin, Wan-Ping Chen, Yuh-Chiang Shen, Hui-Mei Chen, Jhih-Bin Chen, Hsing-Lin Lai, Chieh-Wen Yang, Ming-Chang Chiang, Yu-Shuo Wu, Chen Chang, Jiang-Fan Chen, Jim-Min Fang, Yun-Lian Lin, Yijuang Chern. A new drug design targeting the adenosinergic system for Huntington's disease. PloS one. 2011; 6(6):e20934. doi: 10.1371/journal.pone.0020934. [PMID: 21713039]
  • Daniel L Lucetti, Elaine Cp Lucetti, Mary Anne M Bandeira, Helenicy Nh Veras, Aline H Silva, Luzia Kalyne Am Leal, Amanda A Lopes, Victor Cc Alves, Gabriela S Silva, Gerly Anne Brito, Glauce B Viana. Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel. Journal of inflammation (London, England). 2010 Dec; 7(?):60. doi: 10.1186/1476-9255-7-60. [PMID: 21167055]
  • Tobias Schulz, Udo Schumacher, Peter Prehm. Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP. The Journal of biological chemistry. 2007 Jul; 282(29):20999-1004. doi: 10.1074/jbc.m700915200. [PMID: 17540771]
  • Sarah V Holdridge, Stacey A Armstrong, Anna M W Taylor, Catherine M Cahill. Behavioural and morphological evidence for the involvement of glial cell activation in delta opioid receptor function: implications for the development of opioid tolerance. Molecular pain. 2007 Mar; 3(?):7. doi: 10.1186/1744-8069-3-7. [PMID: 17352824]
  • F F Youssef, J I Addae, A McRae, T W Stone. Long-term potentiation protects rat hippocampal slices from the effects of acute hypoxia. Brain research. 2001 Jul; 907(1-2):144-50. doi: 10.1016/s0006-8993(01)02594-x. [PMID: 11430897]
  • Y K Ng, E A Ling. Microglial reaction in focal cerebral ischaemia induced by intra-carotid homologous clot injection. Histology and histopathology. 2001 01; 16(1):167-74. doi: 10.14670/hh-16.167. [PMID: 11193192]
  • O S Kwon, J C Ryu. Identification of propentofylline metabolites in rats by gas chromatography/mass spectrometry. Archives of pharmacal research. 2000 Aug; 23(4):374-80. doi: 10.1007/bf02975450. [PMID: 10976586]
  • N Kuroda, Y Hamachi, N Aoki, M Wada, M Tanigawa, K Nakashima. Simple and rapid high-performance liquid chromatography analysis of propentofylline and its main metabolites in serum using a direct injection technique. Biomedical chromatography : BMC. 1999 Aug; 13(5):340-3. doi: 10.1002/(sici)1099-0801(199908)13:5<340::aid-bmc883>3.0.co;2-v. [PMID: 10425024]
  • O S Kwon, Y B Chung, M H Kim, H G Hahn, H K Rhee, J C Ryu. Pharmacokinetics of propentofylline and the quantitation of its metabolite hydroxypropentofylline in human volunteers. Archives of pharmacal research. 1998 Dec; 21(6):698-702. doi: 10.1007/bf02976760. [PMID: 9868540]
  • D G Walker. Expression and regulation of complement C1q by human THP-1-derived macrophages. Molecular and chemical neuropathology. 1998 Jun; 34(2-3):197-218. doi: 10.1007/bf02815080. [PMID: 10327418]
  • Y Numagami, P J Marro, O P Mishra, M Delivoria-Papadopoulos. Effect of propentofylline on free radical generation during cerebral hypoxia in the newborn piglet. Neuroscience. 1998 Jun; 84(4):1127-33. doi: 10.1016/s0306-4522(97)00542-3. [PMID: 9578400]
  • H Sugita, Y Yamaguchi, S Ikei, M Ogawa. Effects of propentofylline on tumor necrosis factor-alpha and cytokine-induced neutrophil chemoattractant production in rats with cerulein-induced pancreatitis and endotoxemia. Pancreas. 1997 Apr; 14(3):267-75. doi: 10.1097/00006676-199704000-00008. [PMID: 9094157]
  • M Minami, H Arai, T Takahashi, M Kimura, I Noguchi, T Suzuki, R Inoue. A preliminary study on plasma concentrations of bifemelane, indeloxazine and propentofylline in aged patients with organic brain disorders. Progress in neuro-psychopharmacology & biological psychiatry. 1995 Jan; 19(1):59-64. doi: 10.1016/0278-5846(94)00104-p. [PMID: 7708932]
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  • C Roul, I Juhan-Vague, D Rahmani-Jourdheuil, Z Mishal, P Vague. [The effect of pentoxifylline and propentofylline on the membrane fluidity of red blood cells in uncontrolled insulin-dependent (type 1) diabetic patients]. Pathologie-biologie. 1988 Oct; 36(8 Pt 2):1081-3. doi: ". [PMID: 3065700]
  • L Rossignol, M Plantavid, H Chap, L Douste-Blazy. Effects of two methylxanthines, pentoxifylline and propentofylline, on arachidonic acid metabolism in platelets stimulated by thrombin. Biochemical pharmacology. 1988 Sep; 37(17):3229-36. doi: 10.1016/0006-2952(88)90632-6. [PMID: 2840908]
  • K Nagata, T Ogawa, M Omosu, K Fujimoto, S Hayashi. In vitro and in vivo inhibitory effects of propentofylline on cyclic AMP phosphodiesterase activity. Arzneimittel-Forschung. 1985; 35(7):1034-6. doi: NULL. [PMID: 2996562]
  • O Hudlicka, J Komarek, A J Wright. The effect of a xanthine derivative, 1-(5' oxohexyl)-3-methyl-7-propylxanthine (HWA 285), on heart performance and regional blood flow in dogs and rabbits. British journal of pharmacology. 1981 Apr; 72(4):723-30. doi: 10.1111/j.1476-5381.1981.tb09154.x. [PMID: 7284688]
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