Propacetamol (BioDeep_00000182634)
human metabolite blood metabolite
代谢物信息卡片
N, N-Diethylglycine 4-hydroxyacetanilide ester
化学式: C14H20N2O3 (264.147385)
中文名称: 丙帕他莫
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(CC)CC(=O)OC1=CC=C(C=C1)NC(=O)C
InChI: InChI=1S/C14H20N2O3/c1-4-16(5-2)10-14(18)19-13-8-6-12(7-9-13)15-11(3)17/h6-9H,4-5,10H2,1-3H3,(H,15,17)
描述信息
N - Nervous system > N02 - Analgesics > N02B - Other analgesics and antipyretics > N02BE - Anilides
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:135089
- PubChem: 68865
- HMDB: HMDB0256808
- DrugBank: DB09288
- ChEMBL: CHEMBL1851805
- Wikipedia: Propacetamol
- chemspider: 62097
- CAS: 66532-85-2
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Josef Finsterer. Letter to the Editor: Propacetamol-Induced Rhabdomyolysis or COVID-Vaccine-Related Inflammatory Myopathy?.
Journal of Korean medical science.
2022 05; 37(21):e179. doi:
10.3346/jkms.2022.37.e179. [PMID: 35638201] - Irene Sartini, Beata Łebkowska-Wieruszewska, Anna Gajda, Konrad Pietruk, Małgorzata Gbylik-Sikorska, Andrzej Lisowski, Tae Won Kim, Amnart Poapolathep, Mario Giorgi. Propacetamol in dogs: First description of its pharmacokinetics after intravenous and oral administration.
Research in veterinary science.
2022 May; 144(?):11-17. doi:
10.1016/j.rvsc.2022.01.002. [PMID: 35033846] - Lukas Barsch, Robert Werdehausen, Andreas Leffler, Volker Eulenburg. Modulation of Glycinergic Neurotransmission may Contribute to the Analgesic Effects of Propacetamol.
Biomolecules.
2021 03; 11(4):. doi:
10.3390/biom11040493. [PMID: 33805979] - Ming-Shiun Tsai, Ying-Han Wang, Yan-Yun Lai, Hsi-Kai Tsou, Gan-Guang Liou, Jiunn-Liang Ko, Sue-Hong Wang. Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress, inflammation and apoptosis in mice.
Toxicology letters.
2018 Jun; 290(?):97-109. doi:
10.1016/j.toxlet.2018.03.024. [PMID: 29574133] - Florian Schillers, Esther Eberhardt, Andreas Leffler, Mirjam Eberhardt. Propacetamol-Induced Injection Pain Is Associated with Activation of Transient Receptor Potential Vanilloid 1 Channels.
The Journal of pharmacology and experimental therapeutics.
2016 10; 359(1):18-25. doi:
10.1124/jpet.116.233452. [PMID: 27457427] - Ming-Shiun Tsai, Chia-Chih Chien, Ting-Hui Lin, Chia-Chi Liu, Rosa Huang Liu, Hong-Lin Su, Yung-Tsung Chiu, Sue-Hong Wang. Galangin Prevents Acute Hepatorenal Toxicity in Novel Propacetamol-Induced Acetaminophen-Overdosed Mice.
Journal of medicinal food.
2015 Nov; 18(11):1187-97. doi:
10.1089/jmf.2014.3328. [PMID: 26501381] - Sandra A Prins, Monique Van Dijk, Pim Van Leeuwen, Susan Searle, Brian J Anderson, Dick Tibboel, Ron A A Mathot. Pharmacokinetics and analgesic effects of intravenous propacetamol vs rectal paracetamol in children after major craniofacial surgery.
Paediatric anaesthesia.
2008 Jul; 18(7):582-92. doi:
10.1111/j.1460-9592.2008.02619.x. [PMID: 18482233] - K Allegaert, R Verbesselt, M Rayyan, A Debeer, J de Hoon. Urinary metabolites to assess in vivo ontogeny of hepatic drug metabolism in early neonatal life.
Methods and findings in experimental and clinical pharmacology.
2007 May; 29(4):251-6. doi:
10.1358/mf.2007.29.4.1106408. [PMID: 17609736] - Karel Allegaert, Jan de Hoon, Rene Verbesselt, Christine Vanhole, Hugo Devlieger, Dick Tibboel. Intra- and interindividual variability of glucuronidation of paracetamol during repeated administration of propacetamol in neonates.
Acta paediatrica (Oslo, Norway : 1992).
2005 Sep; 94(9):1273-9. doi:
10.1111/j.1651-2227.2005.tb02088.x. [PMID: 16278989] - Valerio Gozzoli, Miriam M Treggiari, Gian-Reto Kleger, Pascale Roux-Lombard, Marc Fathi, Claude Pichard, Jacques-André Romand. Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response.
Intensive care medicine.
2004 Mar; 30(3):401-7. doi:
10.1007/s00134-003-2087-2. [PMID: 14722642] - K Allegaert, R Verbesselt, H Devlieger, J de Hoon, D Tibboel. Cerebrospinal fluid pharmacokinetics of paracetamol after intravenous propacetamol in a former preterm infant.
British journal of clinical pharmacology.
2004 Feb; 57(2):224-5. doi:
10.1046/j.1365-2125.2003.01990.x. [PMID: 14748823] - K Allegaert, C D Van der Marel, A Debeer, M A L Pluim, R A Van Lingen, C Vanhole, D Tibboel, H Devlieger. Pharmacokinetics of single dose intravenous propacetamol in neonates: effect of gestational age.
Archives of disease in childhood. Fetal and neonatal edition.
2004 Jan; 89(1):F25-8. doi:
10.1136/fn.89.1.f25. [PMID: 14711849] - B Flouvat, A Leneveu, S Fitoussi, B Delhotal-Landes, A Gendron. Bioequivalence study comparing a new paracetamol solution for injection and propacetamol after single intravenous infusion in healthy subjects.
International journal of clinical pharmacology and therapeutics.
2004 Jan; 42(1):50-7. doi:
10.5414/cpp42050. [PMID: 14756388] - B Galunska, K Marazova, T Tankova, A Popov, P Frangov, I Krushkov, A Di Massa. Effects of paracetamol and propacetamol on gastric mucosal damage and gastric lipid peroxidation caused by acetylsalicylic acid (ASA) in rats.
Pharmacological research.
2002 Aug; 46(2):141-7. doi:
10.1016/s1043-6618(02)00083-x. [PMID: 12220953] - T T Niemi, J T Backman, M T Syrjälä, L U Viinikka, P H Rosenberg. Platelet dysfunction after intravenous ketorolac or propacetamol.
Acta anaesthesiologica Scandinavica.
2000 Jan; 44(1):69-74. doi:
10.1034/j.1399-6576.2000.440113.x. [PMID: 10669275] - M A Campanero, B Calahorra, E García-Quétglas, A López-Ocáriz, J Honorato. Rapid liquid chromatographic assay for the determination of acetaminophen in plasma after propacetamol administration: application to pharmacokinetic studies.
Journal of pharmaceutical and biomedical analysis.
1999 Jun; 20(1-2):327-34. doi:
10.1016/s0731-7085(99)00051-5. [PMID: 10704039] - P Tauzin-Fin, S Delort-Laval, M C Krol-Houdek, P Maurette, B Bannwarth. Effect of balanced analgesia with buprenorphine on pain response and general anaesthesia requirement during lithotripsy procedures.
European journal of anaesthesiology.
1998 Mar; 15(2):147-52. doi:
10.1111/j.0265-0215.1998.00250.x. [PMID: 9587719] - E Autret, J P Dutertre, M Breteau, A P Jonville, Y Furet, J Laugier. Pharmacokinetics of paracetamol in the neonate and infant after administration of propacetamol chlorhydrate.
Developmental pharmacology and therapeutics.
1993; 20(3-4):129-34. doi:
10.1159/000457553. [PMID: 7828444] - B Bannwarth, P Netter, F Lapicque, P Gillet, P Péré, E Boccard, R J Royer, A Gaucher. Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol.
British journal of clinical pharmacology.
1992 Jul; 34(1):79-81. doi:
10.1111/j.1365-2125.1992.tb04112.x. [PMID: 1633071] - M Depré, A van Hecken, R Verbesselt, T B Tjandra-Maga, M Gerin, P J de Schepper. Tolerance and pharmacokinetics of propacetamol, a paracetamol formulation for intravenous use.
Fundamental & clinical pharmacology.
1992; 6(6):259-62. doi:
10.1111/j.1472-8206.1992.tb00119.x. [PMID: 1487229] - C Baude, D Long, B Chabrol, J F Moskovtchenko. [Postoperative analgesia for nephrectomy].
Cahiers d'anesthesiologie.
1991; 39(8):533-6. doi:
NULL. [PMID: 1806198]