Prizidilol (BioDeep_00000182613)

   

human metabolite blood metabolite


代谢物信息卡片


1-(tert-butylamino)-3-[2-(6-hydrazinylpyridazin-3-yl)phenoxy]propan-2-ol

化学式: C17H25N5O2 (331.200815)
中文名称: 普齐地洛
谱图信息: 最多检出来源 Homo sapiens(blood) 20%

分子结构信息

SMILES: CC(C)(C)NCC(COC1=CC=CC=C1C2=NN=C(C=C2)NN)O
InChI: InChI=1S/C17H25N5O2/c1-17(2,3)19-10-12(23)11-24-15-7-5-4-6-13(15)14-8-9-16(20-18)22-21-14/h4-9,12,19,23H,10-11,18H2,1-3H3,(H,20,22)

描述信息

C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents

同义名列表

8 个代谢物同义名

1-(tert-butylamino)-3-[2-(6-hydrazinylpyridazin-3-yl)phenoxy]propan-2-ol; DL-3-(2-(3-t-Butylamino-2-hydroxypropoxy)phenyl)-6-hydrazinopyridazine; 3-(2-(3-t-Butylamino-2-hydroxy-propoxy)phenyl)-6-hydrazinopyridazine; Prizidilol monosulfate, monohydrate; Prizidilol monohydrate; SK And F-92657; SK And F 92657; Prizidilol



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • C Y Huang, J S Cridland. Thin layer chromatographic assay for prizidilol in serum. Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences. 1987 Oct; 3(10):642-6. doi: NULL. [PMID: 2896251]
  • G S Andersen, O J Hartling, H O Hein, A Leth. Changes in blood pressure, fluid volumes and glomerular filtration rate during long-term treatment with prizidilol, an antihypertensive drug with combined vasodilatator and beta-adrenoceptor blocking actions. Danish medical bulletin. 1985 Oct; 32(5):280-3. doi: NULL. [PMID: 2865088]
  • R Eggertsen, L Hansson. Vasodilators in hypertension--a review with special emphasis on the combined use of vasodilators and beta-adrenoceptor blockers. International journal of clinical pharmacology, therapy, and toxicology. 1985 Aug; 23(8):411-23. doi: NULL. [PMID: 2864319]
  • T X Watanabe, H Sokabe, K Kawashima. An analysis of blood pressure effects of nipradilol and prizidilol in normotensive and spontaneously hypertensive rats. Japanese journal of pharmacology. 1985 Jul; 38(3):273-9. doi: 10.1254/jjp.38.273. [PMID: 3903298]
  • K Kawashima, T X Watanabe, H Sokabe. Pharmacodynamic and pharmacokinetic studies on prizidilol and nipradilol (K-351), antihypertensive drugs with combined vasodilator and beta-adrenoceptor blocking actions, in rabbits. Japanese journal of pharmacology. 1984 Dec; 36(4):519-26. doi: 10.1254/jjp.36.519. [PMID: 6151998]
  • P L Malini, E Strocchi, E Ambrosioni. Comparison of the effects of prizidilol and propranolol on renal haemodynamics at rest and during exercise. British journal of clinical pharmacology. 1984 Mar; 17(3):251-5. doi: 10.1111/j.1365-2125.1984.tb02339.x. [PMID: 6712858]
  • R Pedrinelli, B Abdel-Haq, A Magagna, S Leto di Priolo, N Simonini, A Salvetti. Dose-response relationship of prizidilol hydrochloride (SK&F 92657): a comparison between acute and chronic effects in patients with essential hypertension. International journal of clinical pharmacology research. 1984; 4(2):155-63. doi: NULL. [PMID: 6147320]
  • F V Costa, C Borghi, S Boschi, E Ambrosioni. Cardiovascular response to mental stress: dynamic and isometric exercise in hypertensive patients treated with prizidilol hydrochloride (SK&F 92657). International journal of clinical pharmacology research. 1984; 4(5):373-9. doi: NULL. [PMID: 6151553]
  • H Al-Falahi, P M May, A M Roe, R A Slater, W J Trott, D R Williams. Metal binding by pharmaceuticals. Part 4. A comparative investigation of the interaction of metal ions with hydralazine, prizidilol and related compounds. Agents and actions. 1984 Jan; 14(1):113-20. doi: 10.1007/bf01966843. [PMID: 6702508]
  • M Chaignon, S Decourt, G Guelpa, I Rocher, B Flouvat, J Guédon. Clinical pharmacology and pharmacokinetics of prizidilol in hypertensive patients. Journal of cardiovascular pharmacology. 1983 Nov; 5(6):1068-73. doi: 10.1097/00005344-198311000-00023. [PMID: 6196556]
  • L Andrén, L Hansson, A Svensson. Antihypertensive effect of prizidilol. Journal of cardiovascular pharmacology. 1983 Sep; 5(5):898-900. doi: 10.1097/00005344-198309000-00030. [PMID: 6195483]
  • K Boehringer, P Weidmann, L Link, M G Bianchetti, H Schiffl, F C Reubi. Acute effects of combined vasodilation and beta-adrenoceptor blockade with prizidilol on renal function. British journal of clinical pharmacology. 1983 Feb; 15(2):181-8. doi: 10.1111/j.1365-2125.1983.tb01484.x. [PMID: 6133543]
  • B E Karlberg, R Larsson, K P Ohman, B Norlander, A Wirsen, J Hed, B L Lundh, A Flock. Prizidilol, a combined vasodilatory and beta-adrenoceptor blocking drug, in primary hypertension. A long-term efficacy, tolerance and pharmacokinetic study. European journal of clinical pharmacology. 1983; 25(2):179-86. doi: 10.1007/bf00543788. [PMID: 6138257]
  • P Lund-Johansen, P Omvik. Prizidilol in essential hypertension: long-term effects on plasma volume, extracellular fluid volume, and central hemodynamics at rest and during exercise. Journal of cardiovascular pharmacology. 1982 Nov; 4(6):1012-7. doi: NULL. [PMID: 6185765]
  • M G Bianchetti, K Boehringer, P Weidmann, L Link, H Schiffl, W H Ziegler. Acute effects of prizidilol on blood pressure, heart rate, catecholamines, renin and aldosterone in essential hypertension. European journal of clinical pharmacology. 1982 Oct; 23(4):289-96. doi: 10.1007/bf00613608. [PMID: 6129141]
  • T Lüscher, J Havelka, P Greminger, J Tuma, M Täuber, W Siegenthaler, W Vetter. Prizidilol (SK & F 92657), a new vasodilator with beta-blocking properties in the treatment of essential hypertension. European journal of clinical pharmacology. 1982; 23(5):411-5. doi: 10.1007/bf00605990. [PMID: 6129980]
  • R Fariello, C L Alicandri, E Agabiti-Rosei, G Romanelli, M Castellano, M Beschi, L Platto, S L Di Priolo, G Muiesan. Effects of prizidilol (SKF 92657) on blood pressure, haemodynamics, sympathetic nervous system activity and plasma volume in essential hypertension. Clinical science (London, England : 1979). 1981 Dec; 61 Suppl 7(?):465s-468s. doi: 10.1042/cs061465s. [PMID: 7318352]
  • B E Karlberg, R Larsson, K P Ohman. Prizidilol (SKF 92657) in primary hypertension. Clinical science (London, England : 1979). 1981 Dec; 61 Suppl 7(?):461s-464s. doi: 10.1042/cs061461s. [PMID: 7188585]
  • R Larsson, B E Karlberg, B Norlander, A Wirsén. Prizidilol, an antihypertensive with precapillary vasodilator and beta-adrenoceptor blocking actions, in primary hypertension. Clinical pharmacology and therapeutics. 1981 May; 29(5):588-93. doi: 10.1038/clpt.1981.82. [PMID: 6111409]
  • R Fariello, C Alicandri, E Agabiti-Rosei, G Romanelli, E Montini, M L Muiesan, P Minniti, M Castellano, M Beschi, E Boni, A Zaninelli, P Micheli, L Platto, S Leto Di Priolo, G Muiesan. [Behavior of arterial pressure, hemodynamic parameters, sympathetic nervous system activity and plasma volume during treatment with a vasodilating and beta-blocking drug in essential hypertension patients]. Bollettino della Societa italiana di cardiologia. 1981; 26(11):1871-4. doi: NULL. [PMID: 6129877]
  • E M Taylor, A M Roe, R A Slater. SK&F 92657, a novel antihypertensive acting by precapillary vasodilatation and beta-adrenoreceptor blockade. Clinical science (London, England : 1979). 1979 Dec; 57 Suppl 5(?):433s-436s. doi: 10.1042/cs057433s. [PMID: 44235]