Praecoxin A (BioDeep_00000182577)
human metabolite blood metabolite
代谢物信息卡片
2-({7,8,9,12,13,14,20,29,30,33,34,35-dodecahydroxy-4,17,25,38-tetraoxo-3,18,21,24,39-pentaoxaheptacyclo[20.17.0.0^{2,19}.0^{5,10}.0^{11,16}.0^{26,31}.0^{32,37}]nonatriaconta-5,7,9,11,13,15,26,28,30,32,34,36-dodecaen-28-yl}oxy)-3,4,5-trihydroxybenzoic acid
化学式: C41H28O27 (952.0817938)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 75%
分子结构信息
SMILES: C1C2C(C3C(C(O2)O)OC(=O)C4=CC(=C(C(=C4C5=C(C(=C(C=C5C(=O)O3)O)O)O)O)O)O)OC(=O)C6=CC(=C(C(=C6C7=C(C(=C(C=C7C(=O)O1)OC8=C(C(=C(C=C8C(=O)O)O)O)O)O)O)O)O)O
InChI: InChI=1S/C41H28O27/c42-12-1-7-20(29(53)24(12)48)21-10(5-16(26(50)30(21)54)64-32-11(36(56)57)4-15(45)25(49)31(32)55)37(58)63-6-17-33(66-38(7)59)34-35(41(62)65-17)68-40(61)9-3-14(44)23(47)28(52)19(9)18-8(39(60)67-34)2-13(43)22(46)27(18)51/h1-5,17,33-35,41-55,62H,6H2,(H,56,57)
描述信息
同义名列表
4 个代谢物同义名
2-({7,8,9,12,13,14,20,29,30,33,34,35-dodecahydroxy-4,17,25,38-tetraoxo-3,18,21,24,39-pentaoxaheptacyclo[20.17.0.0^{2,19}.0^{5,10}.0^{11,16}.0^{26,31}.0^{32,37}]nonatriaconta-5,7,9,11,13,15,26,28,30,32,34,36-dodecaen-28-yl}oxy)-3,4,5-trihydroxybenzoic acid; 2-({7,8,9,12,13,14,20,29,30,33,34,35-dodecahydroxy-4,17,25,38-tetraoxo-3,18,21,24,39-pentaoxaheptacyclo[20.17.0.0²,¹⁹.0⁵,¹⁰.0¹¹,¹⁶.0²⁶,³¹.0³²,³⁷]nonatriaconta-5,7,9,11,13,15,26,28,30,32,34,36-dodecaen-28-yl}oxy)-3,4,5-trihydroxybenzoate; 2-({7,8,9,12,13,14,20,29,30,33,34,35-dodecahydroxy-4,17,25,38-tetraoxo-3,18,21,24,39-pentaoxaheptacyclo[20.17.0.0,.0,.0,.0,.0,]nonatriaconta-5,7,9,11,13,15,26,28,30,32,34,36-dodecaen-28-yl}oxy)-3,4,5-trihydroxybenzoate; praecoxin A
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Stefano Piazza, Giulia Martinelli, Nicole Maranta, Carola Pozzoli, Marco Fumagalli, Vincenzo Nicolaci, Elisa Sonzogni, Luca Colombo, Enrico Sangiovanni, Mario Dell'Agli. Investigation into the Anti-Acne Effects of Castanea sativa Mill Leaf and Its Pure Ellagitannin Castalagin in HaCaT Cells Infected with Cutibacterium acnes.
International journal of molecular sciences.
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Critical reviews in food science and nutrition.
2024; 64(2):280-310. doi:
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Nutrients.
2023 Sep; 15(19):. doi:
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Fitoterapia.
2023 Jan; 164(?):105360. doi:
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Molecules (Basel, Switzerland).
2021 Dec; 27(1):. doi:
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Molecules (Basel, Switzerland).
2021 Nov; 26(21):. doi:
10.3390/molecules26216697. [PMID: 34771107] - Mohamed A A Orabi, Hiroshi Sakagami, Naoki Umemura, Hamad S Alyami, Tsutomu Hatano. Two new C-glycosidic ellagitannins and accompanying tannins from Lawsonia inermis leaves and their cytotoxic effects.
Fitoterapia.
2021 Sep; 153(?):104925. doi:
10.1016/j.fitote.2021.104925. [PMID: 33984438] - Juri Takayoshi, Yong-Lin Huang, Yosuke Matsuo, Yoshinori Saito, Dian-Peng Li, Takashi Tanaka. Ellagitannin Digestion in Moth Larvae and a New Dimeric Ellagitannin from the Leaves of Platycarya strobilacea.
Molecules (Basel, Switzerland).
2021 Jul; 26(14):. doi:
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Food & function.
2021 Jul; 12(13):5779-5792. doi:
10.1039/d1fo00894c. [PMID: 34038498] - Shinji Yoshikawa, Lih-Geeng Chen, Morio Yoshimura, Yoshiaki Amakura, Tsutomu Hatano, Shoko Taniguchi. Barricyclin D1-a dimeric ellagitannin with a macrocyclic structure-and accompanying tannins from Barringtonia racemosa.
Bioscience, biotechnology, and biochemistry.
2021 Jun; 85(7):1609-1620. doi:
10.1093/bbb/zbab073. [PMID: 33890626] - Deming Looi, Boon H Goh, Shafi U Khan, Nafees Ahemad, Uma D Palanisamy. Metabolites of the ellagitannin, geraniin inhibit human ACE; in vitro and in silico evidence.
International journal of food sciences and nutrition.
2021 Jun; 72(4):470-477. doi:
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Molecules (Basel, Switzerland).
2021 Jan; 26(2):. doi:
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Molecules (Basel, Switzerland).
2020 Dec; 25(24):. doi:
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International journal of food sciences and nutrition.
2020 Dec; 71(8):940-953. doi:
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Molecules (Basel, Switzerland).
2020 Oct; 25(20):. doi:
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Phytochemistry.
2020 Sep; 177(?):112429. doi:
10.1016/j.phytochem.2020.112429. [PMID: 32559488] - Michał Majewski, Ewa Kucharczyk, Roman Kaliszan, Michał Markuszewski, Bartosz Fotschki, Jerzy Juśkiewicz, Małgorzata Borkowska-Sztachańska, Katarzyna Ognik. The Characterization of Ground Raspberry Seeds and the Physiological Response to Supplementation in Hypertensive and Normotensive Rats.
Nutrients.
2020 Jun; 12(6):. doi:
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Molecular nutrition & food research.
2020 05; 64(10):e1900800. doi:
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Journal of agricultural and food chemistry.
2020 Apr; 68(14):4176-4186. doi:
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Molecules (Basel, Switzerland).
2020 Feb; 25(5):. doi:
10.3390/molecules25051051. [PMID: 32110993] - Maarit Karonen, Marianne Oraviita, Irene Mueller-Harvey, Juha-Pekka Salminen, Rebecca J Green. Ellagitannins with Glucopyranose Cores Have Higher Affinities to Proteins than Acyclic Ellagitannins by Isothermal Titration Calorimetry.
Journal of agricultural and food chemistry.
2019 Nov; 67(46):12730-12740. doi:
10.1021/acs.jafc.9b04353. [PMID: 31650840] - Elżbieta Karlińska, Łukasz Pecio, Jakub Macierzyński, Anna Stochmal, Monika Kosmala. Structural elucidation of the ellagitannin with a molecular weight of 2038 isolated from strawberry fruit (Fragaria ananassa Duch.) and named fragariin A.
Food chemistry.
2019 Oct; 296(?):109-115. doi:
10.1016/j.foodchem.2019.05.191. [PMID: 31202294] - Caroline Fabri Bittencourt Rodrigues, Marcelo José Pena Ferreira, Mariana Novo Belchor, Caroline R C Costa, Danielle P Novaes, Adeilso Bispo Dos Santos Junior, Cinthia I Tamayose, Marcus Vinícius Terashima Pinho, Marcos Antonio de Oliveira, Marcos Hikari Toyama. Evaluation of the Inhibitory Potential of Casuarictin, an Ellagitannin Isolated from White Mangrove (Laguncularia racemosa) Leaves, on Snake Venom Secretory Phospholipase A2.
Marine drugs.
2019 Jul; 17(7):. doi:
10.3390/md17070403. [PMID: 31288445] - Yoko Nitta, Hideyuki Ito, Hirohumi Komori, Hiroshi Ueno, Daiki Takeshima, Mikiko Ito, Motoyoshi Sakaue, Hiroe Kikuzaki. The ellagitannin trimer rugosin G inhibits recombinant human histidine decarboxylase.
Bioscience, biotechnology, and biochemistry.
2019 Jul; 83(7):1315-1318. doi:
10.1080/09168451.2019.1606695. [PMID: 30995171] - El Hadji Assane Diop, Emerson Ferreira Queiroz, Laurence Marcourt, Sébastien Kicka, Serge Rudaz, Tahir Diop, Thierry Soldati, Jean-Luc Wolfender. Antimycobacterial activity in a single-cell infection assay of ellagitannins from Combretum aculeatum and their bioavailable metabolites.
Journal of ethnopharmacology.
2019 Jun; 238(?):111832. doi:
10.1016/j.jep.2019.111832. [PMID: 30914349] - Yue Chen, Zhongqin Chen, Qingwen Guo, Xudong Gao, Qiqi Ma, Zihan Xue, Nicola Ferri, Min Zhang, Haixia Chen. Identification of Ellagitannins in the Unripe Fruit of Rubus Chingii Hu and Evaluation of its Potential Antidiabetic Activity.
Journal of agricultural and food chemistry.
2019 Jun; 67(25):7025-7039. doi:
10.1021/acs.jafc.9b02293. [PMID: 31240933] - Bartosz Fotschki, Jerzy Juśkiewicz, Adam Jurgoński, Monika Kosmala, Joanna Milala, Zenon Zduńczyk, Jarosław Markowski. Grinding levels of raspberry pomace affect intestinal microbial activity, lipid and glucose metabolism in Wistar rats.
Food research international (Ottawa, Ont.).
2019 06; 120(?):399-406. doi:
10.1016/j.foodres.2019.03.014. [PMID: 31000255] - Douglas Costa Gontijo, Pablo Costa Gontijo, Geraldo Célio Brandão, Marisa Alves Nogueira Diaz, Alaíde Braga de Oliveira, Luciano Gomes Fietto, João Paulo Viana Leite. Antioxidant study indicative of antibacterial and antimutagenic activities of an ellagitannin-rich aqueous extract from the leaves of Miconia latecrenata.
Journal of ethnopharmacology.
2019 May; 236(?):114-123. doi:
10.1016/j.jep.2019.03.007. [PMID: 30853643] - Xiao Yang, Francisco A Tomás-Barberán. Tea Is a Significant Dietary Source of Ellagitannins and Ellagic Acid.
Journal of agricultural and food chemistry.
2019 May; 67(19):5394-5404. doi:
10.1021/acs.jafc.8b05010. [PMID: 30339026] - Nicholas A DaSilva, Pragati P Nahar, Hang Ma, Aseel Eid, Zhengxi Wei, Susan Meschwitz, Nasser H Zawia, Angela L Slitt, Navindra P Seeram. Pomegranate ellagitannin-gut microbial-derived metabolites, urolithins, inhibit neuroinflammation in vitro.
Nutritional neuroscience.
2019 Mar; 22(3):185-195. doi:
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Molecular nutrition & food research.
2019 02; 63(4):e1800958. doi:
10.1002/mnfr.201800958. [PMID: 30471188] - Eman Al-Sayed, Mohamed M Abdel-Daim, Mohamed Abdelrazik Khattab. Hepatoprotective activity of praecoxin A isolated from Melaleuca ericifolia against carbon tetrachloride-induced hepatotoxicity in mice. Impact on oxidative stress, inflammation, and apoptosis.
Phytotherapy research : PTR.
2019 Feb; 33(2):461-470. doi:
10.1002/ptr.6242. [PMID: 30506741] - Manami Era, Yosuke Matsuo, Yoshinori Saito, Koyo Nishida, Zhi-Hong Jiang, Takashi Tanaka. Ellagitannins and Related Compounds from Penthorum chinense.
Journal of natural products.
2019 01; 82(1):129-135. doi:
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Plant biotechnology journal.
2018 07; 16(7):1363-1374. doi:
10.1111/pbi.12875. [PMID: 29271050] - María V Selma, Antonio González-Sarrías, Jordi Salas-Salvadó, Cristina Andrés-Lacueva, Cesarettin Alasalvar, Asım Örem, Francisco A Tomás-Barberán, Juan C Espín. The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome.
Clinical nutrition (Edinburgh, Scotland).
2018 06; 37(3):897-905. doi:
10.1016/j.clnu.2017.03.012. [PMID: 28347564] - Bartosz Fotschki, Jerzy Juśkiewicz, Krzysztof Kołodziejczyk, Adam Jurgoński, Monika Kosmala, Joanna Milala, Katarzyna Ognik, Zenon Zduńczyk. Protective Effects of Ellagitannin-Rich Strawberry Extracts on Biochemical and Metabolic Disturbances in Rats Fed a Diet High in Fructose.
Nutrients.
2018 Apr; 10(4):. doi:
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Molecules (Basel, Switzerland).
2018 Mar; 23(3):. doi:
10.3390/molecules23030552. [PMID: 29498647] - María-Teresa García-Conesa, Karen Chambers, Emilie Combet, Paula Pinto, Mar Garcia-Aloy, Cristina Andrés-Lacueva, Sonia de Pascual-Teresa, Pedro Mena, Alekxandra Konic Ristic, Wendy J Hollands, Paul A Kroon, Ana Rodríguez-Mateos, Geoffrey Istas, Christos A Kontogiorgis, Dilip K Rai, Eileen R Gibney, Christine Morand, Juan Carlos Espín, Antonio González-Sarrías. Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses.
International journal of molecular sciences.
2018 Feb; 19(3):. doi:
10.3390/ijms19030694. [PMID: 29495642] - Gustavo Gabriel Martos, Alicia Mamaní, María Paula Filippone, Atilio Pedro Castagnaro, Juan Carlos Díaz Ricci. The ellagitannin HeT induces electrolyte leakage, calcium influx and the accumulation of nitric oxide and hydrogen peroxide in strawberry.
Plant physiology and biochemistry : PPB.
2018 Feb; 123(?):400-405. doi:
10.1016/j.plaphy.2017.12.035. [PMID: 29306187] - Jussi Suvanto, Petri Tähtinen, Saku Valkamaa, Marica T Engström, Maarit Karonen, Juha-Pekka Salminen. Variability in Foliar Ellagitannins of Hippophaë rhamnoides L. and Identification of a New Ellagitannin, Hippophaenin C.
Journal of agricultural and food chemistry.
2018 Jan; 66(3):613-620. doi:
10.1021/acs.jafc.7b04834. [PMID: 29262676] - Takashi Tanaka, Yosuke Matsuo, Yoshinori Saito. Solubility of Tannins and Preparation of Oil-Soluble Derivatives.
Journal of oleo science.
2018; 67(10):1179-1187. doi:
10.5650/jos.ess18164. [PMID: 30305552] - Stefanie Quosdorf, Anja Schuetz, Herbert Kolodziej. Different Inhibitory Potencies of Oseltamivir Carboxylate, Zanamivir, and Several Tannins on Bacterial and Viral Neuraminidases as Assessed in a Cell-Free Fluorescence-Based Enzyme Inhibition Assay.
Molecules (Basel, Switzerland).
2017 Nov; 22(11):. doi:
10.3390/molecules22111989. [PMID: 29149072] - Yuuki Shimozu, Teruo Kuroda, Tomofusa Tsuchiya, Tsutomu Hatano. Structures and Antibacterial Properties of Isorugosins H-J, Oligomeric Ellagitannins from Liquidambar formosana with Characteristic Bridging Groups between Sugar Moieties.
Journal of natural products.
2017 10; 80(10):2723-2733. doi:
10.1021/acs.jnatprod.7b00496. [PMID: 29019685] - Lydia Ninan Lestario, Luke R Howard, Cindi Brownmiller, Nathan B Stebbins, Rohana Liyanage, Jackson O Lay. Changes in polyphenolics during maturation of Java plum (Syzygium cumini Lam.).
Food research international (Ottawa, Ont.).
2017 10; 100(Pt 3):385-391. doi:
10.1016/j.foodres.2017.04.023. [PMID: 28964361] - Jakub P Piwowarski, Barbara Bobrowska-Korczak, Iwona Stanisławska, Wojciech Bielecki, Robert Wrzesien, Sebastian Granica, Katarzyna Krupa, Anna K Kiss. Evaluation of the Effect of Epilobium angustifolium Aqueous Extract on LNCaP Cell Proliferation in In Vitro and In Vivo Models.
Planta medica.
2017 Oct; 83(14-15):1159-1168. doi:
10.1055/s-0043-109372. [PMID: 28454190] - Sheng Wu, Li Tian. Diverse Phytochemicals and Bioactivities in the Ancient Fruit and Modern Functional Food Pomegranate (Punica granatum).
Molecules (Basel, Switzerland).
2017 Sep; 22(10):. doi:
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Food & function.
2017 Jul; 8(7):2485-2499. doi:
10.1039/c7fo00500h. [PMID: 28640298] - Yi Gong, Ronald B Pegg. Separation of Ellagitannin-Rich Phenolics from U.S. Pecans and Chinese Hickory Nuts Using Fused-Core HPLC Columns and Their Characterization.
Journal of agricultural and food chemistry.
2017 Jul; 65(28):5810-5820. doi:
10.1021/acs.jafc.7b01597. [PMID: 28648053] - Rocío García-Villalba, Hanne Vissenaekens, Judit Pitart, María Romo-Vaquero, Juan C Espín, Charlotte Grootaert, María V Selma, Katleen Raes, Guy Smagghe, Sam Possemiers, John Van Camp, Francisco A Tomas-Barberan. Gastrointestinal Simulation Model TWIN-SHIME Shows Differences between Human Urolithin-Metabotypes in Gut Microbiota Composition, Pomegranate Polyphenol Metabolism, and Transport along the Intestinal Tract.
Journal of agricultural and food chemistry.
2017 Jul; 65(27):5480-5493. doi:
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Bioorganic chemistry.
2017 06; 72(?):293-300. doi:
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The Journal of nutritional biochemistry.
2017 04; 42(?):126-133. doi:
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Molecules (Basel, Switzerland).
2017 Mar; 22(3):. doi:
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Molecular nutrition & food research.
2017 03; 61(3):. doi:
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Anaerobe.
2017 Feb; 43(?):56-60. doi:
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Journal of cosmetic science.
2017 Jan; 68(1):107-113. doi:
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Pharmaceutical biology.
2016 Sep; 54(9):1727-35. doi:
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Molecules (Basel, Switzerland).
2016 Aug; 21(9):. doi:
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Molecules (Basel, Switzerland).
2016 Aug; 21(8):. doi:
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2016 Aug; 41(16):2968-2974. doi:
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Molecules (Basel, Switzerland).
2016 Jul; 21(7):. doi:
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Oncotarget.
2016 Jul; 7(28):43907-43923. doi:
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2016 Jun; 92(?):8-16. doi:
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Journal of natural products.
2016 Apr; 79(4):984-95. doi:
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Journal of basic microbiology.
2016 Apr; 56(4):329-36. doi:
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Food chemistry.
2016 Mar; 194(?):1300-3. doi:
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Natural product research.
2016; 30(2):206-13. doi:
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Journal of agricultural and food chemistry.
2015 Dec; 63(49):10647-54. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2015 Dec; 22(14):1215-22. doi:
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Molecular nutrition & food research.
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Journal of natural products.
2015 Aug; 78(8):2104-9. doi:
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Food & function.
2015 Aug; 6(8):2487-95. doi:
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Phytochemistry.
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Fitoterapia.
2015 Jul; 104(?):55-63. doi:
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Journal of agricultural and food chemistry.
2015 Jun; 63(22):5417-27. doi:
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International immunopharmacology.
2015 Jun; 26(2):367-77. doi:
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Food & function.
2015 May; 6(5):1675-83. doi:
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Food chemistry.
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International journal of food sciences and nutrition.
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Food & function.
2015 Jan; 6(1):305-12. doi:
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International journal of food sciences and nutrition.
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Chemico-biological interactions.
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Journal of ethnopharmacology.
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Food & function.
2014 Aug; 5(8):1939-48. doi:
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Food & function.
2014 Aug; 5(8):1779-84. doi:
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Journal of agricultural and food chemistry.
2014 Jul; 62(30):7631-41. doi:
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Planta medica.
2014 Jul; 80(11):887-95. doi:
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Journal of agricultural and food chemistry.
2014 Jun; 62(25):5871-80. doi:
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Journal of agricultural and food chemistry.
2014 Jun; 62(22):5028-37. doi:
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Food & function.
2014 Jun; 5(6):1167-74. doi:
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Food chemistry.
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Nutrition and cancer.
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Food chemistry.
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Molecular nutrition & food research.
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Food & function.
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Phytotherapy research : PTR.
2013 Sep; 27(9):1313-20. doi:
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Journal of ethnopharmacology.
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Journal of agricultural and food chemistry.
2013 Jan; 61(4):801-10. doi:
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