Pradigastat (BioDeep_00000182575)

   

human metabolite blood metabolite


代谢物信息卡片


2-{4-[4-(5-{[6-(trifluoromethyl)pyridin-3-yl]amino}pyridin-2-yl)phenyl]cyclohexyl}acetic acid

化学式: C25H24F3N3O2 (455.182052)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC(CCC1CC(=O)O)C2=CC=C(C=C2)C3=NC=C(C=C3)NC4=CN=C(C=C4)C(F)(F)F
InChI: InChI=1S/C25H24F3N3O2/c26-25(27,28)23-12-10-21(15-30-23)31-20-9-11-22(29-14-20)19-7-5-18(6-8-19)17-3-1-16(2-4-17)13-24(32)33/h5-12,14-17,31H,1-4,13H2,(H,32,33)

描述信息

C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
Pradigastat (LCQ-908) is a potent, selective and orally active diacylglycerol acyltransferase 1 (DGAT1) inhibitor. Pradigastat has anti-obesity and anti-diabetic effects[1][2].

同义名列表

5 个代谢物同义名

2-{4-[4-(5-{[6-(trifluoromethyl)pyridin-3-yl]amino}pyridin-2-yl)phenyl]cyclohexyl}acetic acid; {4-[4-(5-{[6-(trifluoromethyl)pyridin-3-yl]amino}pyridin-2-yl)phenyl]cyclohexyl}acetic acid; 2-{4-[4-(5-{[6-(trifluoromethyl)pyridin-3-yl]amino}pyridin-2-yl)phenyl]cyclohexyl}acetate; Pradigastat; LCQ-908



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

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1 个相关的物种来源信息

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Summon Koul, Suresh Kurhade, Sandeep Bhosale, Keshav Naik, Videsh Salunkhe, Sudhir Ravula, Prasad Punde, Ravikumar Velayutham, Atul Tiwari, Daniela Ahl, Srividya Malkapuram, Vamsi Mudagala, Amol Raje, Dhananjay Umrani, Suhas Tambe, Poonam Patil, Umesh Singh, Debnath Bhuniya, Narayanan Hariharan, Kasim Mookhtiar. Design and synthesis of novel spirocyclic carboxylic acids as potent and orally bioavailable DGAT1 inhibitors and their biological evaluation. Bioorganic & medicinal chemistry letters. 2022 04; 62(?):128632. doi: 10.1016/j.bmcl.2022.128632. [PMID: 35189320]
  • Tyler J Harrison, Daniel Bauer, Alina Berdichevsky, Xin Chen, Rohit Duvadie, Benjamin Hoogheem, Panos Hatsis, Qian Liu, Justin Mao, Vasumathy Miduturu, Erik Rocheford, Frederic Zecri, Richard Zessis, Rui Zheng, Qingming Zhu, Ryan Streeper, Sejal J Patel. Successful Strategies for Mitigation of a Preclinical Signal for Phototoxicity in a DGAT1 Inhibitor. ACS medicinal chemistry letters. 2019 Aug; 10(8):1128-1133. doi: 10.1021/acsmedchemlett.9b00117. [PMID: 31413796]
  • Alana Upthagrove, Jin Chen, Charles D Meyers, Kenneth Kulmatycki, Angela Bretz, Lai Wang, Lana Peng, Safet Palamar, Melissa Lin, Tapan Majumdar, Phi Tran, Heidi J Einolf. Pradigastat disposition in humans: in vivo and in vitro investigations. Xenobiotica; the fate of foreign compounds in biological systems. 2017 Dec; 47(12):1077-1089. doi: 10.1080/00498254.2016.1263405. [PMID: 27855567]
  • Jianwei Yan, Gaihong Wang, Xiangyu Dang, Binbin Guo, Wuhong Chen, Ting Wang, Limin Zeng, Heyao Wang, Youhong Hu. Discovery of a low-systemic-exposure DGAT-1 inhibitor with a picolinoylpyrrolidine-2-carboxylic acid moiety. Bioorganic & medicinal chemistry. 2017 09; 25(17):4701-4714. doi: 10.1016/j.bmc.2017.07.007. [PMID: 28739155]
  • Edward Gane, Catherine Stedman, Kiran Dole, Jin Chen, Charles Daniel Meyers, Brigitte Wiedmann, Jin Zhang, Prakash Raman, Richard A Colvin. A Diacylglycerol Transferase 1 Inhibitor Is a Potent Hepatitis C Antiviral in Vitro but Not in Patients in a Randomized Clinical Trial. ACS infectious diseases. 2017 02; 3(2):144-151. doi: 10.1021/acsinfecdis.6b00138. [PMID: 27788579]
  • Charles D Meyers, Ahmed Amer, Tapan Majumdar, Jin Chen. Pharmacokinetics, pharmacodynamics, safety, and tolerability of pradigastat, a novel diacylglycerol acyltransferase 1 inhibitor in overweight or obese, but otherwise healthy human subjects. Journal of clinical pharmacology. 2015 Sep; 55(9):1031-41. doi: 10.1002/jcph.509. [PMID: 25854859]
  • Masaru Hirano, Dan Meyers, GangaRaju Golla, Parasar Pal, Pascale Pinot, TsuHan Lin, Tapan Majumdar, Sam Rebello, Gangadhar Sunkara, Jin Chen. Effect of Hepatic Impairment on the Pharmacokinetics of Pradigastat, a Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor. Clinical pharmacokinetics. 2015 Jul; 54(7):761-70. doi: 10.1007/s40262-015-0235-9. [PMID: 25633714]
  • Sachiko Mita, Dan Meyers, Parasar Pal, TsuHan Lin, Tapan Majumdar, Sam Rebello, Gangadhar Sunkara, Jin Chen. Effect of Renal Impairment on the Pharmacokinetics of Pradigastat, a Novel Diacylglycerol Acyltransferase1 (DGAT1) Inhibitor. Clinical pharmacokinetics. 2015 Jul; 54(7):751-60. doi: 10.1007/s40262-015-0234-x. [PMID: 25627776]
  • Charles Daniel Meyers, Karine Tremblay, Ahmed Amer, Jin Chen, Liewen Jiang, Daniel Gaudet. Effect of the DGAT1 inhibitor pradigastat on triglyceride and apoB48 levels in patients with familial chylomicronemia syndrome. Lipids in health and disease. 2015 Feb; 14(?):8. doi: 10.1186/s12944-015-0006-5. [PMID: 25889044]
  • Shuwen He, Qingmei Hong, Zhong Lai, David X Yang, Pauline C Ting, Jeffrey T Kuethe, Timothy A Cernak, Kevin D Dykstra, Donald M Sperbeck, Zhicai Wu, Yang Yu, Ginger X Yang, Tianying Jian, Jian Liu, Deodial Guiadeen, Arto D Krikorian, Lisa M Sonatore, Judyann Wiltsie, Jinqi Liu, Judith N Gorski, Christine C Chung, Jack T Gibson, JeanMarie Lisnock, Jianying Xiao, Michael Wolff, Sharon X Tong, Maria Madeira, Bindhu V Karanam, Dong-Ming Shen, James M Balkovec, Shirly Pinto, Ravi P Nargund, Robert J DeVita. Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety. ACS medicinal chemistry letters. 2014 Oct; 5(10):1082-7. doi: 10.1021/ml5003426. [PMID: 25349648]