Polymyxin M (BioDeep_00000182540)
human metabolite blood metabolite
代谢物信息卡片
N-[3-Amino-1-({1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-2,5,8,11,14,17,20-heptahydroxy-3,12-bis(1-hydroxyethyl)-15-(2-methylpropyl)-1,4,7,10,13,16,19-heptaazacyclotricosa-1,4,7,10,13,16,19-heptaen-21-yl]-C-hydroxycarbonimidoyl}propyl)-C-hydroxycarbonimidoyl]-2-hydroxypropyl}-C-hydroxycarbonimidoyl)propyl]-6-methyloctanimidate
化学式: C51H96N16O14 (1156.7291556)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O)C(C)O)C(C)O
InChI: InChI=1S/C51H96N16O14/c1-8-27(4)11-9-10-12-38(71)58-31(13-19-52)46(76)66-40(29(6)69)50(80)63-34(16-22-55)43(73)61-36-18-24-57-49(79)39(28(5)68)65-47(77)35(17-23-56)60-42(72)33(15-21-54)62-51(81)41(30(7)70)67-48(78)37(25-26(2)3)64-44(74)32(14-20-53)59-45(36)75/h26-37,39-41,68-70H,8-25,52-56H2,1-7H3,(H,57,79)(H,58,71)(H,59,75)(H,60,72)(H,61,73)(H,62,81)(H,63,80)(H,64,74)(H,65,77)(H,66,76)(H,67,78)
描述信息
同义名列表
4 个代谢物同义名
N-[3-Amino-1-({1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-2,5,8,11,14,17,20-heptahydroxy-3,12-bis(1-hydroxyethyl)-15-(2-methylpropyl)-1,4,7,10,13,16,19-heptaazacyclotricosa-1,4,7,10,13,16,19-heptaen-21-yl]-C-hydroxycarbonimidoyl}propyl)-C-hydroxycarbonimidoyl]-2-hydroxypropyl}-C-hydroxycarbonimidoyl)propyl]-6-methyloctanimidate; N-[3-amino-1-({1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-3,12-bis(1-hydroxyethyl)-15-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)carbamoyl]-2-hydroxypropyl}carbamoyl)propyl]-6-methyloctanamide; Unk-DL-Dab-DL-xiThr-DL-Dab-DL-Dab(1)-DL-Dab-DL-Leu-DL-xiThr-DL-Dab-DL-Dab-DL-xiThr-(1); Polymyxin M
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Khalid M Badr El-Din, Mahmoud A Abdelmajed, Mahmoud A Omar, Tamer Z Attia. Salvage parenteral antibiotics for multidrug-resistant (MDR) Gram-negative bacteria; a fluorescamine-based technique for ultrasensitive spectrofluorimetric measurement of Polymyxins; human plasma application.
Luminescence : the journal of biological and chemical luminescence.
2022 Jun; 37(6):971-979. doi:
10.1002/bio.4245. [PMID: 35393741] - Viviane Chaiben, Carolina Hikari Yamada, João Paulo Telles, Ana Paula de Andrade, Lavinia Nery Villa Stangler Arend, Victoria Stadler Tasca Ribeiro, Leticia Ramos Dantas, Paula Hansen Suss, Felipe Francisco Tuon. A carbapenem-resistant Acinetobacter baumannii outbreak associated with a polymyxin shortage during the COVID pandemic: an in vitro and biofilm analysis of synergy between meropenem, gentamicin and sulbactam.
The Journal of antimicrobial chemotherapy.
2022 05; 77(6):1676-1684. doi:
10.1093/jac/dkac102. [PMID: 35368079] - Jing Lu, Mohammad A K Azad, Julie L M Moreau, Yan Zhu, Xukai Jiang, Mary Tonta, Rachel Lam, Hasini Wickremasinghe, Jinxin Zhao, Jiping Wang, Harold A Coleman, Luke E Formosa, Tony Velkov, Helena C Parkington, Alexander N Combes, Joseph Rosenbluh, Jian Li. Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity.
Cellular and molecular life sciences : CMLS.
2022 May; 79(6):296. doi:
10.1007/s00018-022-04316-z. [PMID: 35570209] - Lucas Alexandre de Mello Goldin, Leticia Nicoletti Silva, Thiago Florencio da Silva, Vinicius Daher Alvares Delfino. Polymyxin Acute Kidney Injury: a case of severe tubulopathy.
Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia.
2022 Jan; 44(1):112-115. doi:
10.1590/2175-8239-jbn-2019-0191. [PMID: 33891671] - Jon Bruss, Troy Lister, Vipul K Gupta, Emily Stone, Lisa Morelli, Yang Lei, David Melnick. Single- and Multiple-Ascending-Dose Study of the Safety, Tolerability, and Pharmacokinetics of the Polymyxin Derivative SPR206.
Antimicrobial agents and chemotherapy.
2021 09; 65(10):e0073921. doi:
10.1128/aac.00739-21. [PMID: 34339267] - Mekonnen Sisay, Bisrat Hagos, Dumessa Edessa, Yohannes Tadiwos, Abraham Nigussie Mekuria. Polymyxin-induced nephrotoxicity and its predictors: a systematic review and meta-analysis of studies conducted using RIFLE criteria of acute kidney injury.
Pharmacological research.
2021 01; 163(?):105328. doi:
10.1016/j.phrs.2020.105328. [PMID: 33276108] - Alexander J Lepak, Wen Wang, David R Andes. Pharmacodynamic Evaluation of MRX-8, a Novel Polymyxin, in the Neutropenic Mouse Thigh and Lung Infection Models against Gram-Negative Pathogens.
Antimicrobial agents and chemotherapy.
2020 10; 64(11):. doi:
10.1128/aac.01517-20. [PMID: 32868332] - Peile Wang, Qiwen Zhang, Zifei Qin, Han Xing, Min Xu, Hui Pei, Jing Yang, Xiaojian Zhang. A Simple and Robust Liquid Chromatography With Tandem Mass Spectrometry Analytical Method for Therapeutic Drug Monitoring of Plasma and Cerebrospinal Fluid Polymyxin B1 and B2.
Therapeutic drug monitoring.
2020 10; 42(5):716-723. doi:
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Veterinary research.
2020 Sep; 51(1):116. doi:
10.1186/s13567-020-00839-0. [PMID: 32928304] - Xukai Jiang, Shuo Zhang, Mohammad A K Azad, Kade D Roberts, Lin Wan, Bin Gong, Kai Yang, Bing Yuan, Hemayet Uddin, Jingliang Li, Philip E Thompson, Tony Velkov, Jing Fu, Lushan Wang, Jian Li. Structure-Interaction Relationship of Polymyxins with the Membrane of Human Kidney Proximal Tubular Cells.
ACS infectious diseases.
2020 08; 6(8):2110-2119. doi:
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2020 07; 71(2):304-310. doi:
10.1093/cid/ciz816. [PMID: 31545346] - Mustafa Sadek, Laurent Poirel, Patrice Nordmann. Optimal detection of extended-spectrum β-lactamase producers, carbapenemase producers, polymyxin-resistant Enterobacterales, and vancomycin-resistant enterococci from stools.
Diagnostic microbiology and infectious disease.
2020 Jan; 96(1):114919. doi:
10.1016/j.diagmicrobio.2019.114919. [PMID: 31679814] - Pamela Brown, Elizabeth Abbott, Omar Abdulle, Steven Boakes, Scott Coleman, Naomi Divall, Esther Duperchy, Stephen Moss, Dean Rivers, Mona Simonovic, Jaspal Singh, Steven Stanway, Antoinette Wilson, Michael J Dawson. Design of Next Generation Polymyxins with Lower Toxicity: The Discovery of SPR206.
ACS infectious diseases.
2019 10; 5(10):1645-1656. doi:
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2019 Jun; 217(?):155-163. doi:
10.1016/j.saa.2019.03.077. [PMID: 30933779] - David C Bean, Anuradha Agarwal, Benny P Cherian, David W Wareham. Hypermucoviscous polymyxin-resistant Klebsiella pneumoniae from Kolkata, India: Genomic and phenotypic analysis.
Journal of global antimicrobial resistance.
2019 06; 17(?):1-2. doi:
10.1016/j.jgar.2019.02.012. [PMID: 30825699] - K H Huen, F Nik-Ahd, L Chen, S Lerman, J Singer. Neomycin-polymyxin or gentamicin bladder instillations decrease symptomatic urinary tract infections in neurogenic bladder patients on clean intermittent catheterization.
Journal of pediatric urology.
2019 Apr; 15(2):178.e1-178.e7. doi:
10.1016/j.jpurol.2018.12.001. [PMID: 30611650] - Maristela P Freire, Doroti de Oliveira Garcia, Ana Paula Cury, Gabriela R Francisco, Nathamy F Dos Santos, Fernanda Spadão, Maria Fernanda Campagnari Bueno, Carlos Henrique Camargo, Flavio J de Paula, Flavia Rossi, Willian C Nahas, Elias David-Neto, Ligia C Pierrotti. The role of therapy with aminoglycoside in the outcomes of kidney transplant recipients infected with polymyxin- and carbapenem-resistant Enterobacteriaceae.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2019 Apr; 38(4):755-765. doi:
10.1007/s10096-019-03468-4. [PMID: 30680569] - Sandrine Marchand, Nicolas Grégoire, William Couet. Pharmacokinetics of Polymyxins in Animals.
Advances in experimental medicine and biology.
2019; 1145(?):89-103. doi:
10.1007/978-3-030-16373-0_7. [PMID: 31364073] - Jason M Pogue, Vincent H Tam. Toxicity in Patients.
Advances in experimental medicine and biology.
2019; 1145(?):289-304. doi:
10.1007/978-3-030-16373-0_17. [PMID: 31364083] - Mohammad A K Azad, Roger L Nation, Tony Velkov, Jian Li. Mechanisms of Polymyxin-Induced Nephrotoxicity.
Advances in experimental medicine and biology.
2019; 1145(?):305-319. doi:
10.1007/978-3-030-16373-0_18. [PMID: 31364084] - Elijah J Weber, Kevin A Lidberg, Lu Wang, Theo K Bammler, James W MacDonald, Mavis J Li, Michelle Redhair, William M Atkins, Cecilia Tran, Kelly M Hines, Josi Herron, Libin Xu, Maria Beatriz Monteiro, Susanne Ramm, Vishal Vaidya, Martti Vaara, Timo Vaara, Jonathan Himmelfarb, Edward J Kelly. Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity.
JCI insight.
2018 12; 3(24):. doi:
10.1172/jci.insight.123673. [PMID: 30568031] - Valeri V Mossine, Deborah L Chance, James K Waters, Thomas P Mawhinney. Interaction of Bacterial Phenazines with Colistimethate in Bronchial Epithelial Cells.
Antimicrobial agents and chemotherapy.
2018 08; 62(8):. doi:
10.1128/aac.02349-17. [PMID: 29784845] - Martti Vaara, Timo Vaara, Carina Vingsbo Lundberg. Polymyxin derivatives NAB739 and NAB815 are more effective than polymyxin B in murine Escherichia coli pyelonephritis.
The Journal of antimicrobial chemotherapy.
2018 02; 73(2):452-455. doi:
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Journal of global antimicrobial resistance.
2017 12; 11(?):40-44. doi:
10.1016/j.jgar.2017.07.014. [PMID: 28774864] - Jenna Covelli, Donna Ruszaj, Robert Straubinger, Jian Li, Gauri G Rao. The development and validation of a simple liquid chromatography-tandem mass spectrometry method for polymyxin B1 and B2 quantification in different matrices.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Oct; 1065-1066(?):112-118. doi:
10.1016/j.jchromb.2017.09.031. [PMID: 28961485] - Yan-Yan Hu, Yue-Ling Wang, Qiao-Ling Sun, Zi-Xian Huang, Han-Yu Wang, Rong Zhang, Gong-Xiang Chen. Colistin resistance gene mcr-1 in gut flora of children.
International journal of antimicrobial agents.
2017 Oct; 50(4):593-597. doi:
10.1016/j.ijantimicag.2017.06.011. [PMID: 28668691] - Kim H Hee, Yee K J Leaw, Jun L Ong, Lawrence S Lee. Development and validation of liquid chromatography tandem mass spectrometry method quantitative determination of polymyxin B1, polymyxin B2, polymyxin B3 and isoleucine-polymyxin B1 in human plasma and its application in clinical studies.
Journal of pharmaceutical and biomedical analysis.
2017 Jun; 140(?):91-97. doi:
10.1016/j.jpba.2017.03.018. [PMID: 28343078] - Martti Vaara, Timo Vaara, Jonathan M Tyrrell. Structure-activity studies on polymyxin derivatives carrying three positive charges only reveal a new class of compounds with strong antibacterial activity.
Peptides.
2017 05; 91(?):8-12. doi:
10.1016/j.peptides.2017.03.002. [PMID: 28300674] - J M Pogue, J K Ortwine, K S Kaye. Clinical considerations for optimal use of the polymyxins: A focus on agent selection and dosing.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2017 Apr; 23(4):229-233. doi:
10.1016/j.cmi.2017.02.023. [PMID: 28238870] - Sivashangarie Sivanesan, Kade Roberts, Jiping Wang, Soon-Ee Chea, Philip E Thompson, Jian Li, Roger L Nation, Tony Velkov. Pharmacokinetics of the Individual Major Components of Polymyxin B and Colistin in Rats.
Journal of natural products.
2017 01; 80(1):225-229. doi:
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Therapeutic drug monitoring.
2016 12; 38(6):796-803. doi:
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International journal of antimicrobial agents.
2016 Dec; 48(6):622-626. doi:
10.1016/j.ijantimicag.2016.11.001. [PMID: 27876274] - Amber M Vasquez, Noelisa Montero, Mark Laughlin, Ehren Dancy, Russell Melmed, Lynn Sosa, Louise Francois Watkins, Jason P Folster, Nancy Strockbine, Heather Moulton-Meissner, Uzma Ansari, Matthew L Cartter, Maroya Spalding Walters. Investigation of Escherichia coli Harboring the mcr-1 Resistance Gene - Connecticut, 2016.
MMWR. Morbidity and mortality weekly report.
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The Journal of antimicrobial chemotherapy.
2016 08; 71(8):2318-20. doi:
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Transplantation proceedings.
2016 Jul; 48(6):2050-5. doi:
10.1016/j.transproceed.2016.05.005. [PMID: 27569943] - Tony Velkov, Bo Yun, Elena K Schneider, Mohammad A K Azad, Olan Dolezal, Faye C Morris, Roger L Nation, Jiping Wang, Ke Chen, Heidi H Yu, Lv Wang, Philip E Thompson, Kade D Roberts, Jian Li. A Novel Chemical Biology Approach for Mapping of Polymyxin Lipopeptide Antibody Binding Epitopes.
ACS infectious diseases.
2016 05; 2(5):341-51. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Feb; 1012-1013(?):23-36. doi:
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The Journal of antimicrobial chemotherapy.
2016 Feb; 71(2):403-12. doi:
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Antimicrobial agents and chemotherapy.
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Chemical research in toxicology.
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Antimicrobial agents and chemotherapy.
2015 Apr; 59(4):2136-43. doi:
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2015 Mar; 70(3):827-9. doi:
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Analytical chemistry.
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Expert opinion on drug safety.
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PloS one.
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Pharmacotherapy.
2015 Jan; 35(1):34-42. doi:
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Pharmacotherapy.
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Antimicrobial agents and chemotherapy.
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Indian journal of pharmacology.
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International journal of antimicrobial agents.
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Diagnostic microbiology and infectious disease.
2012 Nov; 74(3):213-23. doi:
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Therapeutic drug monitoring.
2012 Aug; 34(4):398-405. doi:
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Biochemical pharmacology.
2012 Aug; 84(3):278-91. doi:
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Peptides.
2012 Jun; 35(2):248-52. doi:
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