N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide (BioDeep_00000182512)

   

human metabolite blood metabolite


代谢物信息卡片


N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulphonamide

化学式: C17H14ClF2N3O3S (413.0412428000001)
中文名称: N-[3-[(5-氯-1H-吡咯并[2,3-B]吡啶-3-基)羰基]-2,4-二氟苯基]-1-丙磺酰胺
谱图信息: 最多检出来源 Homo sapiens(blood) 41.67%

分子结构信息

SMILES: CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)Cl)F
InChI: InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22)



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Chinenye Jane Ugwah-Oguejiofor, Emeka Patrick Chukwuka, Olayinka Fisayo Onifade, Solomon Tsekohol Agu, Abayomi Emmanuel Adegboyega, Grace Inioluwa Johnson, Olusegun Ifeoluwa Ogunsuyi, Titilayo Omolara Johnson. Computational assessment of chemicals from Morinda citrifolia as potential inhibitors of B-Raf kinase in hepatocellular carcinoma treatment. Journal of biomolecular structure & dynamics. 2023 Jan; ?(?):1-16. doi: 10.1080/07391102.2023.2172459. [PMID: 36709454]
  • Chandrayee Ghosh, Suresh Kumar, Yevgeniya Kushchayeva, Kelli Gaskins, Myriem Boufraqech, Darmood Wei, Sudheer Kumar Gara, Lisa Zhang, Ya-Qin Zhang, Min Shen, Sanjit Mukherjee, Electron Kebebew. A Combinatorial Strategy for Targeting BRAF V600E-Mutant Cancers with BRAFV600E Inhibitor (PLX4720) and Tyrosine Kinase Inhibitor (Ponatinib). Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 04; 26(8):2022-2036. doi: 10.1158/1078-0432.ccr-19-1606. [PMID: 31937621]
  • M Zou, E Y Baitei, R A Al-Rijjal, R S Parhar, F A Al-Mohanna, S Kimura, C Pritchard, H A Binessa, A S Alzahrani, H H Al-Khalaf, A Hawwari, M Akhtar, A M Assiri, B F Meyer, Y Shi. TSH overcomes Braf(V600E)-induced senescence to promote tumor progression via downregulation of p53 expression in papillary thyroid cancer. Oncogene. 2016 Apr; 35(15):1909-18. doi: 10.1038/onc.2015.253. [PMID: 26477313]
  • Shujing Liu, Michael T Tetzlaff, Tao Wang, Ruifeng Yang, Lin Xie, Gao Zhang, Clemens Krepler, Min Xiao, Marilda Beqiri, Wei Xu, Giorgos Karakousis, Lynn Schuchter, Ravi K Amaravadi, Weiting Xu, Zhi Wei, Meenhard Herlyn, Yuan Yao, Litao Zhang, Yingjie Wang, Lin Zhang, Xiaowei Xu. miR-200c/Bmi1 axis and epithelial-mesenchymal transition contribute to acquired resistance to BRAF inhibitor treatment. Pigment cell & melanoma research. 2015 Jul; 28(4):431-41. doi: 10.1111/pcmr.12379. [PMID: 25903073]
  • Rajshekhar Y Gaji, Lisa Checkley, Michael L Reese, Michael T Ferdig, Gustavo Arrizabalaga. Expression of the essential Kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drugs. Antimicrobial agents and chemotherapy. 2014 May; 58(5):2598-607. doi: 10.1128/aac.02261-13. [PMID: 24550330]
  • F Lai, S T Guo, L Jin, C C Jiang, C Y Wang, A Croft, M N Chi, H-Y Tseng, M Farrelly, B Atmadibrata, J Norman, T Liu, P Hersey, X D Zhang. Cotargeting histone deacetylases and oncogenic BRAF synergistically kills human melanoma cells by necrosis independently of RIPK1 and RIPK3. Cell death & disease. 2013 Jun; 4(?):e655. doi: 10.1038/cddis.2013.192. [PMID: 23744355]
  • Devarati Mitra, Xi Luo, Ann Morgan, Jin Wang, Mai P Hoang, Jennifer Lo, Candace R Guerrero, Jochen K Lennerz, Martin C Mihm, Jennifer A Wargo, Kathleen C Robinson, Suprabha P Devi, Jillian C Vanover, John A D'Orazio, Martin McMahon, Marcus W Bosenberg, Kevin M Haigis, Daniel A Haber, Yinsheng Wang, David E Fisher. An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature. 2012 Nov; 491(7424):449-53. doi: 10.1038/nature11624. [PMID: 23123854]
  • Bachir W El Debs, Ulrich Tschulena, Andrew D Griffiths, Christoph A Merten. A competitive co-cultivation assay for cancer drug specificity evaluation. Journal of biomolecular screening. 2011 Sep; 16(8):818-24. doi: 10.1177/1087057111414898. [PMID: 21788393]
  • Pratap Karki, Xiuju Li, David Schrama, Larry Fliegel. B-Raf associates with and activates the NHE1 isoform of the Na+/H+ exchanger. The Journal of biological chemistry. 2011 Apr; 286(15):13096-105. doi: 10.1074/jbc.m110.165134. [PMID: 21345796]
  • Chen Chen Jiang, Fritz Lai, Rick F Thorne, Fan Yang, Hao Liu, Peter Hersey, Xu Dong Zhang. MEK-independent survival of B-RAFV600E melanoma cells selected for resistance to apoptosis induced by the RAF inhibitor PLX4720. Clinical cancer research : an official journal of the American Association for Cancer Research. 2011 Feb; 17(4):721-30. doi: 10.1158/1078-0432.ccr-10-2225. [PMID: 21088259]
  • Dirk B Mendel, A Douglas Laird, Xiaohua Xin, Sharianne G Louie, James G Christensen, Guangmin Li, Randall E Schreck, Tinya J Abrams, Theresa J Ngai, Leslie B Lee, Lesley J Murray, Jeremy Carver, Emily Chan, Katherine G Moss, Joshua O Haznedar, Juthamas Sukbuntherng, Robert A Blake, Li Sun, Cho Tang, Todd Miller, Sheri Shirazian, Gerald McMahon, Julie M Cherrington. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clinical cancer research : an official journal of the American Association for Cancer Research. 2003 Jan; 9(1):327-37. doi: NULL. [PMID: 12538485]