N~2~,N~2~-Dimethyl-N~1~-(6-oxo-5,6-dihydrophenanthridin-2-YL)glycinamide (BioDeep_00000182493)

   

human metabolite blood metabolite


代谢物信息卡片


N-(oxo-5,6-Dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride

化学式: C17H17N3O2 (295.1320702)
中文名称: PJ34(游离)
谱图信息: 最多检出来源 Mus musculus(blood) 85.71%

分子结构信息

SMILES: CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32
InChI: InChI=1S/C17H17N3O2/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22)

描述信息

同义名列表

12 个代谢物同义名

N-(oxo-5,6-Dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride; N~2~,N~2~-Dimethyl-N~1~-(6-oxo-5,6-dihydrophenanthridin-2-YL)glycinamide; N(2),N(2)-Dimethyl-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)glycinamide; N-(5,6-Dihydro-6-oxophenanthridine-2-yl)-2-(dimethylamino)acetamide; N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)acetamide; 2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide; 2-(Dimethylamino)-N-(6-hydroxyphenanthridin-2-yl)ethanimidate; 2-(Dimethylaminoacetylamino)-5,6-dihydrophenanthridine-6-one; 2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide; PJ 34; PJ-34; PJ34



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jie Luo, Youde Cai, Dingling Wei, Liping Cao, Qiansong He, Yuanhua Wu. Formononetin alleviates cerebral ischemia-reperfusion injury in rats by targeting the PARP-1/PARG/Iduna signaling pathway. Brain research. 2024 Apr; 1829(?):148845. doi: 10.1016/j.brainres.2024.148845. [PMID: 38452845]
  • Ramazan Çınar, Mustafa Nazıroğlu. TRPM2 Channel Inhibition Attenuates Amyloid β42-Induced Apoptosis and Oxidative Stress in the Hippocampus of Mice. Cellular and molecular neurobiology. 2022 Jul; ?(?):. doi: 10.1007/s10571-022-01253-0. [PMID: 35840808]
  • Yener Yazğan, Mustafa Nazıroğlu. Involvement of TRPM2 in the Neurobiology of Experimental Migraine: Focus on Oxidative Stress and Apoptosis. Molecular neurobiology. 2021 Nov; 58(11):5581-5601. doi: 10.1007/s12035-021-02503-w. [PMID: 34370177]
  • Myoung-Jin Kim, Daeun Moon, Sumi Jung, Jehee Lee, Jinu Kim. Cisplatin nephrotoxicity is induced via poly(ADP-ribose) polymerase activation in adult zebrafish and mice. American journal of physiology. Regulatory, integrative and comparative physiology. 2020 05; 318(5):R843-R854. doi: 10.1152/ajpregu.00130.2019. [PMID: 32186196]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Shuai Wang, Fa-Ji Yang, Long-Cheng Shang, Yu-Heng Zhang, Yuan Zhou, Xiao-Lei Shi. Puerarin protects against high-fat high-sucrose diet-induced non-alcoholic fatty liver disease by modulating PARP-1/PI3K/AKT signaling pathway and facilitating mitochondrial homeostasis. Phytotherapy research : PTR. 2019 Sep; 33(9):2347-2359. doi: 10.1002/ptr.6417. [PMID: 31273855]
  • Er-Shun Liang, Wen-Wu Bai, Hao Wang, Jian-Ning Zhang, Fan Zhang, Yang Ma, Fan Jiang, Mei Yin, Ming-Xiang Zhang, Xiao-Mei Chen, Wei-Dong Qin. PARP-1 (Poly[ADP-Ribose] Polymerase 1) Inhibition Protects From Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm in Mice. Hypertension (Dallas, Tex. : 1979). 2018 11; 72(5):1189-1199. doi: 10.1161/hypertensionaha.118.11184. [PMID: 30354818]
  • Jing Pang, Ju Cui, Chao Xi, Tao Shen, Huan Gong, Lin Dou, Yajun Lin, Tiemei Zhang. Inhibition of Poly(ADP-Ribose) Polymerase Increased Lipid Accumulation Through SREBP1 Modulation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 49(2):645-652. doi: 10.1159/000493028. [PMID: 30165350]
  • Sang Pil Yoon, Jinu Kim. Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity. Anatomy & cell biology. 2016 Sep; 49(3):165-176. doi: 10.5115/acb.2016.49.3.165. [PMID: 27722009]
  • Shuai Wang, Xiao-Lei Shi, Min Feng, Xun Wang, Zhi-Heng Zhang, Xin Zhao, Bing Han, Hu-Cheng Ma, Bo Dai, Yi-Tao Ding. Puerarin protects against CCl4-induced liver fibrosis in mice: possible role of PARP-1 inhibition. International immunopharmacology. 2016 Sep; 38(?):238-45. doi: 10.1016/j.intimp.2016.06.008. [PMID: 27318789]
  • Jing Pang, Ju Cui, Huan Gong, Chao Xi, Tie-Mei Zhang. Effect of NAD on PARP-mediated insulin sensitivity in oleic acid treated hepatocytes. Journal of cellular physiology. 2015 Jul; 230(7):1607-13. doi: 10.1002/jcp.24907. [PMID: 25536389]
  • Seulgee Park, Sang Pil Yoon, Jinu Kim. Cisplatin induces primary necrosis through poly(ADP-ribose) polymerase 1 activation in kidney proximal tubular cells. Anatomy & cell biology. 2015 Mar; 48(1):66-74. doi: 10.5115/acb.2015.48.1.66. [PMID: 25806124]
  • Sang Pil Yoon, Jinu Kim. Poly(ADP-ribose) polymerase 1 activation links ischemic acute kidney injury to interstitial fibrosis. The journal of physiological sciences : JPS. 2015 Jan; 65(1):105-11. doi: 10.1007/s12576-014-0346-3. [PMID: 25388944]
  • Rosaria Greco, Cristina Tassorelli, Antonina Stefania Mangione, Giovanna Levandis, Michelangelo Certo, Giuseppe Nappi, Giacinto Bagetta, Fabio Blandini, Diana Amantea. Neuroprotection by the PARP inhibitor PJ34 modulates cerebral and circulating RAGE levels in rats exposed to focal brain ischemia. European journal of pharmacology. 2014 Dec; 744(?):91-7. doi: 10.1016/j.ejphar.2014.10.006. [PMID: 25446913]
  • Go Hatachi, Tomoshi Tsuchiya, Takuro Miyazaki, Keitaro Matsumoto, Naoya Yamasaki, Naoyuki Okita, Atsushi Nanashima, Yoshikazu Higami, Takeshi Nagayasu. The poly(adenosine diphosphate-ribose) polymerase inhibitor PJ34 reduces pulmonary ischemia-reperfusion injury in rats. Transplantation. 2014 Sep; 98(6):618-24. doi: 10.1097/tp.0000000000000305. [PMID: 25221900]
  • W Y Wani, A Sunkaria, D R Sharma, R J L Kandimalla, A Kaushal, E Gerace, A Chiarugi, K D Gill. Caspase inhibition augments Dichlorvos-induced dopaminergic neuronal cell death by increasing ROS production and PARP1 activation. Neuroscience. 2014 Jan; 258(?):1-15. doi: 10.1016/j.neuroscience.2013.11.004. [PMID: 24231740]
  • Judith Michels, Ilio Vitale, Laura Senovilla, David P Enot, Pauline Garcia, Delphine Lissa, Ken A Olaussen, Catherine Brenner, Jean-Charles Soria, Maria Castedo, Guido Kroemer. Synergistic interaction between cisplatin and PARP inhibitors in non-small cell lung cancer. Cell cycle (Georgetown, Tex.). 2013 Mar; 12(6):877-83. doi: 10.4161/cc.24034. [PMID: 23428903]
  • S K Walsh, F A English, I P Crocker, E J Johns, L C Kenny. Contribution of PARP to endothelial dysfunction and hypertension in a rat model of pre-eclampsia. British journal of pharmacology. 2012 Aug; 166(7):2109-16. doi: 10.1111/j.1476-5381.2012.01906.x. [PMID: 22339234]
  • Jinu Kim, Kelly E Long, Kang Tang, Babu J Padanilam. Poly(ADP-ribose) polymerase 1 activation is required for cisplatin nephrotoxicity. Kidney international. 2012 Jul; 82(2):193-203. doi: 10.1038/ki.2012.64. [PMID: 22437413]
  • Elisa B M I Peixoto, Alexandros Papadimitriou, Jacqueline M Lopes de Faria, Jose B Lopes de Faria. Tempol reduces podocyte apoptosis via PARP signaling pathway in experimental diabetes mellitus. Nephron. Experimental nephrology. 2012; 120(2):e81-90. doi: 10.1159/000337364. [PMID: 22555049]
  • Hengmei Zhu, Zongpei Jiang, Ping Lei, Wen Huang, Xueqing Yu. Poly(ADP-ribose) polymerase-1 mediates angiotensin II-induced expression of plasminogen activator inhibitor-1 and fibronectin in rat mesangial cells. Kidney & blood pressure research. 2011; 34(5):320-7. doi: 10.1159/000327344. [PMID: 21613793]
  • Martin Matejovic, Peter Radermacher. Pulmonary and renal protection: targeting PARP to ventilator-induced lung and kidney injury?. Critical care (London, England). 2010; 14(3):147. doi: 10.1186/cc8982. [PMID: 20459596]
  • David H Stone, Hassan Albadawi, Mark F Conrad, Fateh Entabi, Michael C Stoner, Patrick J Casey, Richard P Cambria, Michael T Watkins. PJ34, a poly-ADP-ribose polymerase inhibitor, modulates visceral mitochondrial activity and CD14 expression following thoracic aortic ischemia-reperfusion. American journal of surgery. 2009 Aug; 198(2):250-5. doi: 10.1016/j.amjsurg.2008.09.013. [PMID: 19268911]
  • Dennis J Goebel. Selective blockade of CaMKII-alpha inhibits NMDA-induced caspase-3-dependent cell death but does not arrest PARP-1 activation or loss of plasma membrane selectivity in rat retinal neurons. Brain research. 2009 Feb; 1256(?):190-204. doi: 10.1016/j.brainres.2008.12.051. [PMID: 19135986]
  • M Carbone, M N Rossi, M Cavaldesi, A Notari, P Amati, R Maione. Poly(ADP-ribosyl)ation is implicated in the G0-G1 transition of resting cells. Oncogene. 2008 Oct; 27(47):6083-92. doi: 10.1038/onc.2008.221. [PMID: 18663363]
  • Paola Yam-Canul, Yolanda Irasema Chirino, Dolores Javier Sánchez-González, Claudia María Martínez-Martínez, Cristino Cruz, José Pedraza-Chaverri. PJ34, a poly adenosine diphosphate-ribose polymerase inhibitor, attenuates chromate-induced nephrotoxicity. Basic & clinical pharmacology & toxicology. 2008 May; 102(5):483-8. doi: 10.1111/j.1742-7843.2008.00224.x. [PMID: 18331393]
  • Marlene T Mathews, Bradford C Berk. PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2. Arteriosclerosis, thrombosis, and vascular biology. 2008 Apr; 28(4):711-7. doi: 10.1161/atvbaha.107.156406. [PMID: 18239155]
  • Arda Tasatargil, Nazif Hikmet Aksoy, Selvinaz Dalaklioglu, Gulay Sadan. Poly (ADP-ribose) polymerase as a potential target for the treatment of acute renal injury caused by lipopolysaccharide. Renal failure. 2008; 30(1):115-20. doi: 10.1080/08860220701742195. [PMID: 18197552]
  • Attila Szijártó, Enkhjargal Batmunkh, Oszkár Hahn, Zoltán Mihály, Adám Kreiss, András Kiss, Gábor Lotz, Zsuzsa Schaff, László Váli, Anna Blázovics, Domokos Geró, Csaba Szabó, Péter Kupcsulik. Effect of PJ-34 PARP-inhibitor on rat liver microcirculation and antioxidant status. The Journal of surgical research. 2007 Sep; 142(1):72-80. doi: 10.1016/j.jss.2006.08.003. [PMID: 17612561]
  • R Mota, F Sánchez-Bueno, J J Berenguer-Pina, D Hernández-Espinosa, P Parrilla, J Yélamos. Therapeutic treatment with poly(ADP-ribose) polymerase inhibitors attenuates the severity of acute pancreatitis and associated liver and lung injury. British journal of pharmacology. 2007 Aug; 151(7):998-1005. doi: 10.1038/sj.bjp.0707310. [PMID: 17533414]
  • Csaba Szabó, Alisha Biser, Rita Benko, Erwin Böttinger, Katalin Suszták. Poly(ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice. Diabetes. 2006 Nov; 55(11):3004-12. doi: 10.2337/db06-0147. [PMID: 17065336]
  • James H Black, Patrick J Casey, Hassan Albadawi, Richard P Cambria, Michael T Watkins. Poly adenosine diphosphate-ribose polymerase inhibitor PJ34 abolishes systemic proinflammatory responses to thoracic aortic ischemia and reperfusion. Journal of the American College of Surgeons. 2006 Jul; 203(1):44-53. doi: 10.1016/j.jamcollsurg.2006.04.004. [PMID: 16798486]
  • Ruben A Mota, Francisco Sánchez-Bueno, Luis Saenz, David Hernández-Espinosa, Jaime Jimeno, Pedro L Tornel, Alejandro Martínez-Torrano, Pablo Ramírez, Pascual Parrilla, José Yélamos. Inhibition of poly(ADP-ribose) polymerase attenuates the severity of acute pancreatitis and associated lung injury. Laboratory investigation; a journal of technical methods and pathology. 2005 Oct; 85(10):1250-62. doi: 10.1038/labinvest.3700326. [PMID: 16127429]
  • Katalin Erdèlyi, Andrea Kiss, Edina Bakondi, Péter Bai, Csaba Szabó, Pál Gergely, Ferenc Erdödi, László Virag. Gallotannin inhibits the expression of chemokines and inflammatory cytokines in A549 cells. Molecular pharmacology. 2005 Sep; 68(3):895-904. doi: 10.1124/mol.105.012518. [PMID: 15976037]
  • David H Stone, Hassan Al-Badawi, Mark F Conrad, Michael C Stoner, Fateh Entabi, Richard P Cambria, Michael T Watkins. PJ34, a poly-ADP-ribose polymerase inhibitor, modulates renal injury after thoracic aortic ischemia/reperfusion. Surgery. 2005 Aug; 138(2):368-74. doi: 10.1016/j.surg.2005.06.004. [PMID: 16153449]
  • Terézia B Andrási, Anna Blázovics, Gábor Szabó, Christian F Vahl, Siegfried Hagl. Poly(ADP-ribose) polymerase inhibitor PJ-34 reduces mesenteric vascular injury induced by experimental cardiopulmonary bypass with cardiac arrest. American journal of physiology. Heart and circulatory physiology. 2005 Jun; 288(6):H2972-8. doi: 10.1152/ajpheart.01039.2004. [PMID: 15681711]
  • Ian P Crocker, Louise C Kenny, Wayne A Thornton, Csaba Szabo, Philip N Baker. Excessive stimulation of poly(ADP-ribosyl)ation contributes to endothelial dysfunction in pre-eclampsia. British journal of pharmacology. 2005 Mar; 144(6):772-80. doi: 10.1038/sj.bjp.0706055. [PMID: 15778700]
  • Csaba Szabó, Pál Pacher, Zsuzsanna Zsengellér, Anne Vaslin, Katalin Komjáti, Rita Benkö, Min Chen, Jon G Mabley, Márk Kollai. Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation. Molecular medicine (Cambridge, Mass.). 2004 Jan; 10(1-6):28-35. doi: 10.2119/2004-00001.szabo. [PMID: 15502880]
  • Z Lohinai, J G Mabley, E Fehér, A Marton, K Komjáti, C Szabó. Role of the activation of the nuclear enzyme poly(ADP-ribose) polymerase in the pathogenesis of periodontitis. Journal of dental research. 2003 Dec; 82(12):987-92. doi: 10.1177/154405910308201210. [PMID: 14630900]
  • Balazs Veres, Ferenc Gallyas, Gabor Varbiro, Zoltan Berente, Erzsebet Osz, Gyorgy Szekeres, Csaba Szabo, Balazs Sumegi. Decrease of the inflammatory response and induction of the Akt/protein kinase B pathway by poly-(ADP-ribose) polymerase 1 inhibitor in endotoxin-induced septic shock. Biochemical pharmacology. 2003 Apr; 65(8):1373-82. doi: 10.1016/s0006-2952(03)00077-7. [PMID: 12694878]
  • Prakash Jagtap, Francisco Garcia Soriano, László Virág, Lucas Liaudet, Jon Mabley, Eva Szabó, György Haskó, Anita Marton, Clara Batista Lorigados, Ferenc Gallyas, Balázs Sümegi, Dale G Hoyt, Erkan Baloglu, John VanDuzer, Andrew L Salzman, Garry J Southan, Csaba Szabó. Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents. Critical care medicine. 2002 May; 30(5):1071-82. doi: 10.1097/00003246-200205000-00019. [PMID: 12006805]
  • Roy D Goldfarb, Anita Marton, Eva Szabó, László Virág, Andrew L Salzman, Dana Glock, Imran Akhter, Robert McCarthy, Joseph E Parrillo, Csaba Szabó. Protective effect of a novel, potent inhibitor of poly(adenosine 5'-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis. Critical care medicine. 2002 May; 30(5):974-80. doi: 10.1097/00003246-200205000-00004. [PMID: 12006790]
  • P Pacher, L Liaudet, P Bai, L Virag, J G Mabley, G Haskó, C Szabó. Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failure. The Journal of pharmacology and experimental therapeutics. 2002 Mar; 300(3):862-7. doi: 10.1124/jpet.300.3.862. [PMID: 11861791]
  • Lucas Liaudet, Pál Pacher, Jon G Mabley, László Virág, Francisco G Soriano, György Haskó, Csaba Szabó. Activation of poly(ADP-Ribose) polymerase-1 is a central mechanism of lipopolysaccharide-induced acute lung inflammation. American journal of respiratory and critical care medicine. 2002 Feb; 165(3):372-7. doi: 10.1164/ajrccm.165.3.2106050. [PMID: 11818323]
  • J G Mabley, P Jagtap, M Perretti, S J Getting, A L Salzman, L Virág, E Szabó, F G Soriano, L Liaudet, G E Abdelkarim, G Haskó, A Marton, G J Southan, C Szabó. Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2001 Nov; 50(11):561-9. doi: 10.1007/pl00000234. [PMID: 11766996]
  • G E Abdelkarim, K Gertz, C Harms, J Katchanov, U Dirnagl, C Szabó, M Endres. Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. International journal of molecular medicine. 2001 Mar; 7(3):255-60. doi: 10.3892/ijmm.7.3.255. [PMID: 11179503]